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Table 3 Logistic regression analysis evaluating SCFAs in patients with MASLD grouped according to histological severity

From: Targeted metabolomics reveals plasma short-chain fatty acids are associated with metabolic dysfunction-associated steatotic liver disease

SCFAs

Fibrosis

OR (95% CI)

p

Steatosis

OR (95% CI)

p

Lobular inflammation

OR (95% CI)

p

Ballooning

OR (95% CI)

p

Acetate

1.08

(0.59–1.96)

0.80

0.74

(0.4–1.38)

0.35

0.87

(0.38–1.99)

0.74

0.86

(0.44–1.68)

0.65

Propionate

2.23

(1.13–4.43)

0.02

0.38

(0.19–0.74)

0.004

0.61

(0.29–1.28)

0.19

0.94

(0.48–1.82)

0.85

Formate

1.48

(0.72–3.04)

0.29

0.57

(0.27–1.20)

0.14

0.50

(0.17–1.46)

0.21

1.06

(0.46–2.47)

0.89

Butyrate

1.87

(1.50–3.32)

0.03

0.75

(0.46–1.22)

0.25

0.71

(0.37–1.33)

0.28

0.92

(0.53–1.60)

0.76

Valerate

1.56

(1.03–2.36)

0.03

0.78

(0.54–1.12)

0.18

0.81

(0.49–1.35)

0.42

1.13

(0.72–1.77)

0.59

α-methylbutyrate

3.40

(1.22–9.5)

0.02

0.34

(0.14–0.86)

0.02

0.31

(0.10–0.93)

0.04

0.58

(0.23–1.45)

0.25

Isobutyrate

2.30

(0.97–5.44)

0.06

0.33

(0.014–0.80)

0.01

0.38

(0.14–1.02)

0.054

0.75

(0.34–1.73)

0.52

Isovalerate

0.98

(0.52–1.84)

0.96

0.59

(0.29–1.22)

0.15

0.57

(0.19–1.74)

0.33

1.06

(0.53–2.15)

0.86

  1. Adjusted OR with (95% CI) and p values from logistic regression analysis evaluating SCFAs in patients with MASLD grouped according to histological severity. The analyses evaluate fibrosis (significant, F2-F4), steatosis (severe, S2/3) and the presence of lobular inflammation and ballooning. Analyses are adjusted for age and sex. SCFAs Short chain fatty acids