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Fig. 5 | BMC Gastroenterology

Fig. 5

From: The P2Y1 receptor in the colonic myenteric plexus of rats and its correlation with opioid-induced constipation

Fig. 5

Spontaneous contractive amplide and the interaction among EM2, ADPβS (an agonist of P2Y1), and MRS2500 (an antagonist of P2Y1) on the motility of circular muscle strips of the rat colon. (A-B) ADPβS reduced the effect of EM2(*P<0.05). (C-D) ADPβS inhibited the spontaneous contraction, and the continued addition of EM2 alleviated this effect (*P<0.05). (E-H) MRS2500 promoted the distal colon spontaneous contractive amplide (*P<0.05), adding EM2 and β-FNA did not have any effect of MRS2500(*P>0.05)

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BMC Gastroenterology

ISSN: 1471-230X

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