Esophageal cancer: a twenty-four-year experience at a tertiary care center with an evaluation of the prognostic significance of the neutrophil-lymphocyte ratio

Table 5 Predictors of mortality at 24 months in patients with esophageal cancer

	Unadjusted HR (95%Cl)	P-value	Adjusted^a HR (95%Cl)	P-value
Age at time of diagnosis	1.033 [0.996,1.071]	0.083	1.027 [0.972,1.085]	0.338
Tumor stage at diagnosis > 2	1.683 [0.383, 7.390]	0.490
Anaplastic or high grade^b	0.591 [0.173,2.018]	0.402
Adenocarcinoma^c	0.969 [0.427, 2.916]	0.939
NLR > 3.5	4.511 [0.958,21.249]	0.057	5.059 [1.054,24.270]	0.043*

^a Cox regression model adjusted for age at time of diagnosis and neutrophil/lymphocyte ratio (NLR)
HR hazard ratio, CI confidence interval
^b Compared to intermediate (moderately differentiated) and low grade (well-differentiated)
^c Compared to squamous cell carcinoma
*Designates a significant difference between the two groups with P-value < 0.05

ISSN: 1471-230X