Table 2 Comparison of basic characteristics of people with and without hepatic fibrosis
Variables | Total (n = 876) | Non-hepatic fibrosis group (n = 725) | Hepatic fibrosis group (n = 151) | P |
|---|---|---|---|---|
Age, years, Mean (S.E) | 52.37 (1.18) | 52.11 (1.14) | 53.83 (2.24) | 0.379 |
Gender, n (%) | 0.687 | |||
Male | 407 (50.07) | 325 (50.58) | 82 (47.24) | |
Female | 469 (49.93) | 400 (49.42) | 69 (52.77) | |
Race, n (%) | 0.606 | |||
Mexican American | 154 (11.52) | 128 (11.30) | 26 (12.75) | |
Other Hispanic | 96 (6.79) | 76 (6.25) | 20 (9.84) | |
Non-Hispanic White | 308 (62.25) | 254 (62.50) | 54 (60.90) | |
Non-Hispanic Black | 162 (8.86) | 138 (9.23) | 24 (6.83) | |
Other Race | 156 (10.58) | 129 (10.73) | 27 (9.69) | |
Education level, n (%) | 0.248 | |||
High school degree or less | 222 (15.10) | 191 (15.54) | 31 (12.68) | |
High school education | 214 (32.53) | 176 (31.26) | 38 (39.69) | |
High school degree or above | 429 (51.71) | 351 (52.67) | 78 (46.34) | |
Unknown | 11 (0.65) | 7 (0.53) | 4 (1.30) | |
Family PIR, Mean (S.E) | 2.80 (0.10) | 2.86 (0.11) | 2.45 (0.16) | 0.040 |
Drinking status, n (%) | 0.031 | |||
No | 116 (9.73) | 93 (8.52) | 23 (16.51) | |
Yes | 760 (90.27) | 632 (91.48) | 128 (83.49) | |
Smoking status, n (%) | 0.556 | |||
Never smoked | 457 (49.28) | 391 (50.05) | 66 (44.98) | |
Used to smoke and now quit | 255 (30.88) | 200 (29.90) | 55 (36.34) | |
Still smoking | 164 (19.85) | 134 (20.05) | 30 (18.68) | |
Physical activity, n (%) | 0.092 | |||
≤ 750 MET∙ min | 605 (61.46) | 495 (59.54) | 110 (72.21) | |
> 750 MET∙ min | 271 (38.54) | 230 (40.46) | 41 (27.79) | |
SBP, mmHg, Mean (S.E) | 131.37 (0.63) | 131.38 (0.67) | 131.31 (2.01) | 0.974 |
DBP, mmHg, Mean (S.E) | 76.09 (0.64) | 76.75 (0.75) | 72.36 (1.48) | 0.023 |
Hepatitis, n (%) | 0.345 | |||
No | 797 (93.57) | 663 (94.18) | 134 (90.18) | |
Yes | 79 (6.43) | 62 (5.82) | 17 (9.83) | |
CKD, n (%) | 0.055 | |||
No | 811 (95.27) | 678 (95.80) | 133 (92.32) | |
Yes | 65 (4.73) | 47 (4.20) | 18 (7.68) | |
CVD, n (%) | 0.013 | |||
No | 592 (71.57) | 506 (74.23) | 86 (56.71) | |
Yes | 284 (28.43) | 219 (25.77) | 65 (43.29) | |
ALT, U/L, Mean (S.E) | 27.25 (1.04) | 25.62 (0.99) | 36.35 (3.05) | 0.003 |
AST, U/L, Mean (S.E) | 23.48 (0.81) | 22.03 (0.73) | 31.56 (3.27) | 0.011 |
ALP, IU/L, Mean (S.E) | 81.61 (0.83) | 80.95 (1.10) | 85.32 (3.74) | 0.334 |
GGT, IU/L, Mean (S.E) | 36.13 (1.94) | 32.75 (1.57) | 55.06 (6.87) | 0.005 |
TC, mg/dL, Mean (S.E) | 191.01 (3.62) | 191.97 (3.35) | 185.58 (6.05) | 0.153 |
LDL-C, mg/dL, Mean (S.E) | 114.49 (2.57) | 115.17 (2.32) | 110.62 (5.13) | 0.281 |
Hs-CRP, mg/L, Mean (S.E) | 5.22 (0.50) | 4.95 (0.57) | 6.71 (1.09) | 0.174 |
Platelet count, 1000 cells/uL, Mean (S.E) | 245.33 (3.66) | 247.28 (4.06) | 234.42 (4.97) | 0.031 |
Total bilirubin, umol/L, Mean (S.E) | 8.12 (0.24) | 8.01 (0.25) | 8.70 (0.37) | 0.087 |
Serum creatinine, mg/dL, Mean (S.E) | 0.87 (0.01) | 0.87 (0.01) | 0.87 (0.03) | 0.892 |
Urinary creatinine, mg/dL, Mean (S.E) | 139.13 (5.45) | 139.34 (6.58) | 137.99 (12.73) | 0.933 |
Serum ALB, g/L, Mean (S.E) | 39.79 (0.26) | 39.96 (0.23) | 38.85 (0.47) | 0.008 |
Urinary ALB, mg/L, Mean (S.E) | 57.03 (8.94) | 45.93 (7.36) | 119.26 (32.68) | 0.036 |
Drug for diabetes, n (%) | < 0.001 | |||
No | 634 (77.36) | 553 (80.49) | 81 (59.81) | |
Yes | 242 (22.64) | 172 (19.51) | 70 (40.19) | |
Drug for hypertension, n (%) | 0.329 | |||
No | 472 (57.54) | 409 (59.01) | 63 (49.30) | |
Yes | 404 (42.46) | 316 (40.99) | 88 (50.71) | |
Drug for dyslipidemia, n (%) | 0.934 | |||
No | 591 (69.83) | 500 (69.76) | 91 (70.23) | |
Yes | 285 (30.17) | 225 (30.24) | 60 (29.77) | |
Antiviral agents, n (%) | ||||
No | 874 (99.92) | 723 (99.91) | 151 (100.00) | |
Yes | 2 (0.08) | 2 (0.10) | 0 (0.00) | |
Glucocorticoids, n (%) | 0.018 | |||
No | 854 (97.73) | 705 (97.42) | 149 (99.45) | |
Yes | 22 (2.27) | 20 (2.58) | 2 (0.55) | |
Drug induce hepatic steatosis n (%) | 0.666 | |||
No | 859 (97.67) | 710 (97.81) | 149 (96.84) | |
Yes | 17 (2.33) | 15 (2.19) | 2 (3.16) | |
Energy, Mean (S.E) | 2220.76 (50.98) | 2230.40 (53.05) | 2166.76 (106.88) | 0.565 |
Carbohydrate, Mean (S.E) | 258.88 (6.21) | 261.61 (6.74) | 243.59 (15.49) | 0.304 |
Protein, Mean (S.E) | 83.54 (2.04) | 83.31 (2.41) | 84.85 (5.29) | 0.809 |
Total fat, Mean (S.E) | 91.19 (2.41) | 91.22 (2.66) | 91.03 (4.93) | 0.972 |
Vitamin E, Mean (S.E) | 0.67 (0.18) | 0.70 (0.21) | 0.53 (0.28) | 0.629 |
METS-IR, Mean (S.E) | 53.19 (1.03) | 51.64 (0.84) | 61.89 (1.92) | < 0.001 |
TyG index, Mean (S.E) | 9.14 (0.04) | 9.11 (0.05) | 9.27 (0.07) | 0.097 |
HOMA-IR, Mean (S.E) | 6.49 (0.37) | 5.76 (0.30) | 10.56 (1.98) | 0.036 |
TyG-WHtR, Mean (S.E) | 6.05 (0.07) | 5.92 (0.06) | 6.79 (0.12) | < 0.001 |