Table 1 Characteristics of the cohort before delivery

Age at IBD diagnosis

Mean 21.5 +/- 7

Median 22 (IQR 17–26)

22 +/- 7

22 (17–25)

22 +/- 6

31 (17–26)

0.818

Age at first delivery

Mean 30 +/- 5

Median 30 (IQR 26–33)

30 +/- 7

30 (27–34)

30 +/- 5

30 (26–33)

0.840

Interval between diagnosis and first delivery (years)

Median 8 (4–13)

Mean 9 +/- 6

9 (5–10)

9 +/- 5

8 (4–13)

9 +/- 7

0.894

BMI at delivery

Mean 27 +/- 6

Median 25 (23–30)

29 +/- 8

27 (IQR 23–32)

26 +/- 6

25 (22.5–29)

0.086

IBD diagnosis

0.026

 CD

 UC

154 (81%)

36 (19%)

19 (100%)

0

135 (78%)

36 (21%)

Comorbidities

 Hypertension

 Diabetes

 Dyslipidemia

 Chronic kidney failure

 Cardiac disease

 COPD

 Chronic liver disease

 Vasculopathy

3 (2%)

3 (2%)

1 (0.5%)

1 (0.5%)

4 (2%)

6 (3%)

3 (2%)

1 (0.5%)

1 (5%)

1 (5%)

0

1 (5%)

1 (5%)

0

0

0

2 (1%)

2 (1%)

1 (1%)

0

3 (2%)

6 (3.5%)

3 (2%)

1 (1%)

0.174

0.174

0.738

0.003

0.312

0.407

0.561

0.738

Smoking

51 (27%)

7 (37%)

44 (26%)

0.300

Previous abdominal surgery for IBD

 TPC + EI

 TPC + IPAA

 ICR or BR

 Stricturoplasty

 TC + IR anastomosis

 Colon resection

 Other

71 (37%)

7 (4%)

13 (7%)

42 (22%)

1 (0.5%)

3 (2%)

9 (5%)

1 (0.5%)

11 (58%)

2 (10%)

1 (5%)

7 (37%)

0

0

2 (10%)

0

60 (35%)

5 (3%)

12 (7%)

35 (20%)

1 (1%)

3 (2%)

7 (4%)

1 (1%)

0.051

0.095

0.774

0.103

0.738

0.561

0.210

Montreal classification – Age (years)

0.740

 1 < 16

 2 17–40 years

 3 > 40 years

34/154 (22%)

116/154 (76%)

3/154 (2%)

5 (26%)

14 (73%)

0

29 922%)

102 (76%)

3 (2%)

Montreal classification – Behavior

0.108

 1 Nonpenetrating, nonstricturing

 2 Stricturing

 3 Penetrating

80/154 (52%)

47/154 (30%)

27/154 (17%)

6 (32%)

7 (37%)

6 (32%)

74 (54%)

40 (30%)

21 (16%)

Montreal classification – Location

0.047

 1 Ileal

 2 Colonic

 3 Ileocolonic

43/154 (28%)

32/154 (21%)

79/154 (51%)

1 (5%)

4 (21%)

14 (74%)

42 (31%)

28 921%)

65 (48%)

Montreal classification – UC

-

 1 Proctitis

 2 Left-sided

 3 Pancolitis

8/36 (22%)

6/36 (17%)

22/36 (61%)

8/36 (22%)

6/36 (17%)

22/36 (61%)

Perianal disease

 Perianal fistula

 Rectovaginal fistula

 Both

40 (21%)

33 (17%)

3 (2%)

4 (2%)

15 (79%)

12/15 (80%)

2/15 (13%)

1/15 (7%)

25 (15%)

21/25 (84%)

1/25 (4%)

3/25 (12%)

< 0.001

0.503

Surgery for perianal disease

 EUA

 Abscess drainage

 Seton

 Fistulotomy

 LIFT

 Mucosal advancement flap

 Gracilis flap

 Martius flap

 10 Other

28/40 (70%, 14% of entire cohort)

9 (5%)

21 (11%)

23 (12%)

8 (4%)

2 (1%)

4 (2%)

1 (0.5%)

0

2 (1%)

12/15 (80%, 63% of entire cohort)

4 (21%)

10 (53%)

10 (53%)

4 (21%)

2 (10%)

2 (10%)

0

0

1 (5%)

16/25 (64%)

5 (3%)

11 (6%)

13 (8%)

4 (2%)

0

2 (1%)

1 (1%)

1 (1%)

1 (1%)

0.385

Deliveries

0.251

 One

 Two

 Three or more

80 (42%)

88 (46%)

22 (12%)

9 (47%)

10 (53%)

0

71 (41%)

78 (46%)

22 (13%)

Median follow up (months)

65 (IQR 38–95)

98 (40–110)

< 0.001