Table 3 Diagnosis of significant fibrosis (F2–4) in low and high replication HBV patients based on the four biomarkers
From: Diminished accuracy of biomarkers of fibrosis in low replicative chronic hepatitis B
Fibrosis Biomarker | Total (n = 113) | HBV DNA < 20,000 IU/mL (n = 40) | HBV DNA > 20,000 IU/mL (n = 73) | P value |
|---|---|---|---|---|
AST-Platelet Ratio Index (APRI) | ||||
≥0.5 | 67 (62.0) | 19 (48.7) | 48 (69.6) | 0.032 |
≥0.7 | 46 (42.6) | 13 (32.3) | 33 (47.8) | 0.143 |
≥1.0 | 26 (24.1) | 7 (17.9) | 19 (27.5) | 0.263 |
≥1.5 | 11 (10.2) | 2 (5.1) | 9 (13.0) | 0.191 |
AST/ALT Ratio (AAR) | ||||
>1.0 | 29 (25.9) | 15 (37.5) | 14 (19.4) | 0.037 |
FIB-4 | ||||
≥1.45 | 35 (32.4) | 14 (35.9) | 21 (30.4) | 0.560 |
≥2.0 | 25 (23.1) | 9 (23.1) | 16 (23.2) | 0.999 |
≥3.25 | 10 (9.3) | 6 (15.4) | 4 (5.8) | 0.164 |
Age-Platelet Index (API) | ||||
>4 | 34 (30.1) | 15 (37.5) | 19 (26.0) | 0.204 |
>5 | 21 (8.6) | 9 (22.5) | 12 (6.4) | 0.428 |
>6 | 12 (10.6) | 6 (15.0) | 6 (8.2) | 0.263 |
>7 | 5 (4.4) | 3 (7.5) | 2 (2.7) | 0.344 |