Male-specific association between MT-ND4 11719 A/G polymorphism and ulcerative colitis: a mitochondria-wide genetic association study

Table 1 Results from the single SNP association analysis for SNPs with a two-sided p value < 0.01 from Fisher’s exact test in the initial sample or in one of the sex-specific subgroups

mtSNP^a	BP^b	A1^c	A2^d	Subsample	Initial analysis				Replication				Combined^g
					p	OR^e	A1^c frequency		p	OR^e	A1 frequency		p	OR^e
					p	OR^e	Cases	Ctrls^f	p	OR^e	Cases	Ctrls^f	p	OR^e
rs2853495	11719	G	A	Total	0.007	1.22 [1.06; 1.40]	0.528	0.478	0.011	1.17 [1.04; 1.31]	0.525	0.486	1.921⋅10⁻⁴	1.19 [1.09; 1.30]
				Males	0.002	1.40 [1.13; 1.73]	0.562	0.479	0.002	1.32 [1.10; 1.57]	0.551	0.482	1.512⋅10⁻⁵	1.35 [1.18; 1.55]
				Females	0.328	1.10 [0.91; 1.34]	0.502	0.477	–	–	–	–	–	–
rs3899498	13368	A	G	Total	0.005	0.71 [0.56; 0.91]	0.085	0.115	0.334	0.90 [0.74; 1.10]	0.091	0.100	1.012⋅10⁻²	0.82 [0.70; 0.95]
				Males	0.126	0.75 [0.53; 1.07]	0.090	0.117	–	–	–	–	–	–
				Females	0.026	0.68 [0.49; 0.96]	0.080	0.113	–	–	–	–	–	–

^aMitochondrial single nucleotide polymorphism; ^bBase-pair position according to UCSC version hg19; ^cEffect allele; ^dSecond allele; ^eOdds ratio with 95 % confidence interval; ^fControls; ^gCombined analysis of initial and replication data

ISSN: 1471-230X