Fig. 1

Schematic representation of the experimental protocol. In set one of the experiments, rats received 3-AB or vehicle (i.v.) at 30 min before induction with sodium taurocholate. All rats that survived were sacrificed via intracardiac puncture at respective time points postoperatively. Adrenal and pancreas tissue specimens were collected for ultrastructural morphologic, histopathologic and western analysis. In set two, rats were monitored for a 30-h observation period to examine survival