Table 1 Serum ALT levels in ALF mice
2 h | 6 h | 9 h | 12 h | 24 h | ||
|---|---|---|---|---|---|---|
Groups | Number of mice | ALT | ALT | ALT | ALT | ALT |
(U/L) | (U/L) | (U/L) | (U/L) | (U/L) | ||
NS | 8 | 30.0 ± 0.3 | 29.3 ± 1.0 | 36.8 ± 2.3 | 32.5 ± 0.7 | 30.7 ± 0.4 |
LPS | 8 | 29.4 ± 0.8 | 27.1 ± 2.0 | 40.7 ± 7.0 | 34.5 ± 3.4 | 29.1 ± 1.7 |
GalN | 8 | 44.2 ± 0.4 | 63.4 ± 1.0 | 110.1 ± 2.5 | 97.4 ± 1.2 | 164.1 ± 10.6 |
GalN/LPS | 8 | 22.2 ± 2.8 | 2513.2 ± 874.2a | 6235.5 ± 912.4a | 10215.8 ± 967.7a | 10250.6 ± 1045.8a |
TNF-alpha | 8 | 34.3 ± 3.4 | 32.7 ± 4.6 | 33.4 ± 2.1 | 34.6 ± 3.9 | 30.9 ± 8.8 |
GalN/TNFalpha | 8 | 33.7 ± 2.9 | 204.1 ± 82.1a | 4774.8 ± 1118.0a | 6177.8 ± 1280.9a | 4204.6 ± 1118.6a |
anti-TNF-alpha-IgG+GalN/LPS | 8 | -- | -- | 257.1 ± 83.2b | -- | -- |
anti-TNF-alpha R-IgG+GalN/LPS | 8 | -- | -- | 907.3 ± 551.6b | -- | -- |