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Table 4 Incidence of AOM-induced tumors at 17 weeks post-AOM *

From: Lack of efficacy of blueberry in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon

 

Male

Female

 

# rats per group

Control

(73)

10% BB

(74)

Control

(74)

10% BB

(74)

 
     

Gender effect

   Proximal colon

5.5 (4)

4.1 (3)

1.4 (1)

2.7 (2)

NS

   Middle colon

31.5 (23)

20.3 (15)

8.1 (6)

10.8 (8)

P < 0.001

   Distal colon

10.9 (8)

10.8 (8)

0 (0)

2.7 (2)

P < 0.01

   Entire colon

41.1 (30)

29.7 (22)

9.5 (7)

16.2 (12)

P < 0.001

   Proximal SI **

23.3 (17)

12.2 (9)

6.8 (5)

6.8 (5)

P < 0.01

   Middle SI

1.4 (1)

1.4 (1)

0 (0)

0 (0)

NS

   Distal SI

0 (0)

0 (0)

0 (0)

0 (0)

NS

   Entire SI

24.7 (18)

13.5 (10)

6.8 (5)

6.8 (5)

P < 0.01

   Colon + SI

56.2 (41) a

41.8 (31) b

16.2 (12)

23.0 (17)

P < 0.001

  1. * Incidence is percentage of tumor-bearing animals; actual number of animals with each tumor is shown in parentheses; gender effects were calculated from combined diet groups; six rectal tumors, two mammary tubular adenomas, one biliary cystadenoma, two cecal tumors, one stomach tumor, one spleen tumor, and a number of nodules representing focal areas of lymphoid hyperplasia [38] also were found; all were excluded from calculations of small intestine and colon tumor indices.
  2. ** SI: small intestine (almost all tumors were found in duodenum; with the exception of two in the jejunum).
  3. a, b indicate a tendency for a difference (P = 0.081); NS: P > 0.1