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Table 4 Univariate and multivariate analysis of NED-survival according to Cox's proportional hazards model.

From: Stromal regulatory T-cells are associated with a favourable prognosis in gastric cancer of the cardia

 

Univariate Analysis

Multivariate Analysis

Variable

Hazard ratio

95% C.I.

P

Hazard ratio

95% C.I.

P

Age, years (continuous)

1.01

0.96-1.06

0.78

-

-

-

Gender (female [n = 12] vs male [n = 40])

0.48

0.11-2.10

0.33

-

-

-

Stage (UICC II and higher [n = 32] vs. UICC I [n = 20])

3.72

1.07-12.98

0.04

2.00

0.42-9.09

0.39

Grade (3+4 [n = 22] vs. 1+2 [n = 30])

1.43

0.55-3.71

0.46

-

-

-

T category (T3/T4 [n = 8] vs. T1/T2 [n = 44])

2.48

0.80-7.68

0.11

-

-

-

N category (. N+ [n = 28] vs N0 [n = 24])

3.27

1.06-10.02

0.04

2.04

0.51-8.33

0.32

Number of metastatic lymph nodes (continuous)

1.35

1.17-1.56

<0.001

-

-

-

TILs and macrophages in primary tumour site (high vs. low)

 

Hazard ratio

95% C.I.

P

Hazard ratio

95% C.I.

P

Intraepithelial

      

CD3+ TIL

0.76

0.29-1.98

0.58

-

-

-

CD8+ TIL

1.26

0.48-3.32

0.63

-

-

-

CD20+ TIL

2.05

0.79-5.32

0.14

-

-

-

CD68+ TIM

0.69

0.27-1.80

0.45

-

-

-

FoxP3+ TIL

0.78

0.30-2.03

0.61

-

-

-

Granzyme B+ TIL

0.72

0.21-2.53

0.61

-

-

-

Stromal

   

-

-

-

CD3+ TIL

0.86

0.33-2.23

0.76

-

-

-

CD8+ TIL

0.85

0.33-2.20

0.74

-

-

-

CD20+ TIL

0.80

0.31-2.08

0.65

-

-

-

CD68+ TIM

0.81

0.31-2.10

0.66

-

-

-

FoxP3+ TIL

0.23

0.08-0.72

0.01

0.25

0.08-0.78

0.016

Granzyme B+ TIL

0.87

0.33-2.29

0.78

-

-

-

Ratio stromal CD68 (primary tumour)/stromal FoxP3 (primary tumour)

4.02

1.31-12.36

0.02

   

TIL and macrophages in metastatic tissue (high vs. low)

Intraepithelial

Hazard ratio

95% C.I.

P

   

   CD3+ TIL

0.32

0.09-1.12

0.07

   

   CD8+ TIL

1.14

0.35-3.76

0.83

   

   CD20+ TIL

0.20

0.03-1.58

0.13

   

   CD68+ TIM

0.96

0.29-3.16

0.95

   

   FoxP3+ TIL

0.58

0.17-1.99

0.39

   

   Granzyme B+ TIL

0.88

0.19-4.09

0.87

   

Stromal

      

   CD3+ TIL

0.61

0.19-2.03

0.42

   

   CD8+ TIL

1.16

0.35-3.81

0.81

   

   CD20+ TIL

0.51

0.15-1.75

0.28

   

   CD68+ TIM

1.30

0.40-4.28

0.66

   

   FoxP3+ TIL

0.81

0.25-2.69

0.74

   

   Granzyme B+ TIL

0.75

0.23-2.46

0.63

   

Lymphocytes and macrophages in uninvolved regional lymph node (high vs. low)

 

Hazard ratio

95% C.I.

P

   

CD3+

0.47

0.17-1.26

0.13

   

CD8+

0.84

0.32-2.19

0.72

   

CD20+

      

CD68+

0.56

0.21-1.47

0.24

   

FoxP3+

1.03

0.40-2.68

0.95

   

Granzyme B+

0.35

0.12-0.99

0.05

   
  1. For multivariate Cox's proportional hazards model UICC-stage and nodal status were adopted as covariates. Median values were used as cut-off.
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BMC Gastroenterology

ISSN: 1471-230X

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