Table 3 Descriptive statistics for TILs and macrophages in the primary tumour, metastatic lymph nodes and non affected lymph nodes for intraepithelial and stromal location.
Cells per mm2 | Mean | |||||
|---|---|---|---|---|---|---|
| Â | Primary tumour | Metastatic lymph node | Uninvolved lymph node | |||
| Â | epithelial | stromal | epithelial | stromal | lymphatic tissue | Â |
CD3 | 122.8 | 895.7 | 63.5 | 645.1 | 3710.1 | 7686.7 |
CD8 | 114.5 | 424.4 | 98.0 | 358.2 | 1071.9 | 2436.1 |
CD20 | 18.9 | 438.7 | 9.4 | 351.4 | 5612.7 | n.d. |
CD68 | 18.7 | 482.7 | 17.9 | 617.1 | 1457.8 | 506.4 |
FoxP3 | 14.3 | 187.5 | 12.1 | 90.2 | 532.0 | 337.0 |
Gran.B | 3.0 | 39.8 | 0.8 | 42.3 | 89.4 | 46.9 |
Cells per mm 2 | 95% confidence interval of mean | |||||
| Â | Primary tumour | Metastatic lymph node | Uninvolved lymph node | |||
| Â | epithelial | stromal | epithelial | stromal | lymphatic tissue | Â |
CD3 | 71.2 - 174.5 | 714.6 - 1076.8 | 3.7 - 123.3 | 389.4 - 900.9 | 3149.5 - 4270.7 | 7088.1 - 8285.4 |
CD8 | 51.1 - 178.0 | 299.6 - 549.2 | 0 (-35.3) - 231.3 | 146.2 - 570.3 | 696.9 - 1447.0 | 2203.2 - 2669.0 |
CD20 | 0 (-0.1) - 37.9 | 249.7 - 627.7 | 0 (-2.1) - 20.9 | 180.9 - 521.8 | 4800.7 - 6424.8 | n.d. |
CD68 | 12.5 - 24.9 | 407.6 - 557.7 | 2.2 - 33.6 | 388.6 - 845.6 | 1051.8 - 1863.9 | 451.5 - 561.4 |
FoxP3 | 6.5 - 22.2 | 142.0 - 233.0 | 5.7 - 18.5 | 51.5 - 128.8 | 179.3 - 884.7 | 256.2 - 417.7 |
Gran.B | 0.6 - 5.4 | 28.3 - 51.2 | 0 - 1.7 | 21.4 - 63.2 | 17.7 - 161.1 | 32.8 - 61.0 |
Cells per mm 2 | Median | |||||
| Â | Primary tumor | Metastatic lymph node | Uninvolved lymph node | |||
| Â | epithelial | stromal | epithelial | stromal | lymphatic tissue | Â |
CD3 | 40.9 | 752.1 | 18.3 | 366.2 | 3625.3 | 7752.0 |
CD8 | 21.6 | 212.7 | 2.8 | 203.7 | 888.5 | 2433.4 |
CD20 | 0 | 146.7 | 0 | 242.8 | 5855.7 | n.d. |
CD68 | 11.5 | 480.9 | 2.3 | 487.5 | 1238.8 | 478.6 |
FoxP3 | 3.6 | 125.9 | 8.0 | 75.6 | 225.7 | 245.4 |
Gran.B | 0 | 26.7 | 0 | 23.4 | 42.9 | 34.1 |