Group 1 | Group 2 | ||||||
---|---|---|---|---|---|---|---|
Characteristic | Included N = 170 | Non-included N = 62 | Significance p | Included N = 97 | Non-included N = 69 | Significance p | Significance p training vs validation |
Demographics | |||||||
Age at biopsy, mean (se), years | 52.8 (0.87) | 54.9 (1.47) | 0.18 | 48.5 (1.28) | 49.1 (1.45) | 0.18 | 0.01 |
Male, n (%) | 98 (58) | 39 (63) | 57 (59) | 38 (69) | 0.64 | 0.86 | |
Metabolic factor (%) | |||||||
Diabetes | 61/170 (36) | 10/62 (16) | 0.004 | 31/97 (32) | 8/97 (12) | 0.62 | 0.001 |
Arterial Hypertension | 53/170 (31) | 6/62 (10) | 0.14 | 15/97 (16) | 16/97 (23) | 0.21 | 0.001 |
BMI greater than 27 kg/m2 | 85/141 (60) | 12/21 (57) | 0.78 | 43/97 (44) | 22/97 (32) | 0.11 | 0.42 |
Triglycerides greater than 1.5 | 68/161 (42) | 17/42 (40) | 0.87 | 35/97 (36) | 15/97 (22) | 0.047 | 0.33 |
HDL cholesterol lower than 40 mg/L | 36/151 (24) | 6/38 (16) | 0.29 | 15/94 (16) | 15/66 (23) | 0.28 | 0.14 |
Metabolic factor | |||||||
None | 21/170 (24) | 34/62 (55) | P < 0.0001 | P < 0.0001 | |||
At least one | 134/170 (79) | 28/62 (45) | |||||
Alcohol consumption, n (%) | |||||||
No | 118/170 (69) | 51/62 (79) | 0.63 | 57/97 (59) | 41/69 (59) | 0.63 | 0.20 |
Yes | 52/170 (31) | 11/62 (21) | 40/97 (41) | 28/69 (41) | |||
Fibrosis stage, n (%) | |||||||
Non advanced fibrosis | 130/170 (76) | 59/60(98) | 0.001 | 66/97(68) | 51/69(74) | 0.48 | 0.13 |
No fibrosis (F0) | 77/170 (45) | 39/60 (65) | 26/97 (27) | 21/69 (30) | |||
Perisinusoidal or periportal (F1) | 54/170 (31) | 20/60 (33) | 40/97 (41) | 30/69 (43) | |||
1A: mild, zone 3, perisinusoidal | 29/170 (17) | 19/60 (31) | 18/97 (19) | 18/69 (25) | |||
1B: moderate, zone 3, perisinusoidal | 2/170 (1) 1/60 (2) | 0/97 (0) 22/97 (22) | 0/69 (0) 12/69 (18) | ||||
1C: portal/periportal | 22/170 (13) | 0/60 (0) | 31/97 (32) | 18/69(26) | |||
Advanced Fibrosis | 40/170 (24) | 1/60(2) | 15/97 (15) | 13/69 (19) | |||
Perisinusoidal and portal/periportal (F2) | 20/170 (12) 11/170 (7) | 0/60 (0) 0/60 (0) | 12/97 (12) 4/97 (4) | 2/69 (3) 3/69 (4) | |||
Bridging (F3) | 9/170 (5) | 1/60 (2) | |||||
Cirrhosis (F4) | |||||||
Non alcoholo-steato-hepatitis, n (%) | |||||||
No | 75/170 (44) | 25/60 (41) | 0.15 | 29/97 (30) | 40/69(58) | 0.001 | 0.003 |
Borderline (Probable) | 67/170 (39) | 26/60 (44) | 35/97 (36) | 19/69 (28) | |||
Yes | 28/170 (17) | 9/60 (15) | 33/97 (34) | 10/69 (14) | |||
Steatosis | |||||||
Histology | |||||||
Absence or <5% | 22/170 (13) | 12/60 (20) | 0.38 | 19/97 (20) | 13/69 (19) | 0.38 | 0.22 |
6–32 | 57/170 (34) | 14/60 (23) | 22/97 (23) | 27/69 (39) | |||
33–65 | 43/170 (25) | 16/60 (27) | 27/97 (28) | 10/69 (14) | |||
66–100 | 48/170 (28) | 18/60 (30) | 29/97 (30) | 19/60 (28) | |||
Interval between biopsy and serum, | |||||||
median | 0 | -100 | <0.001 | 0 | 0 | 0.90 | 0.07 |
(95%CI), | [0; 1] | [-215; 0] | [0; 0] | [0; 0] | |||
Range days | -87;+89 | -538; +540 | -24;+49 | -42; +40 | |||
Biopsy quality mean (se) | |||||||
Sample size | 20.0 (0.5) | 19.7 (0.9) | 0.68 | 17.8 (0.7) | 21.4 (0.9) | 0.001 | 0.007 |
Number of fragment | 2.3 (0.2) | 2.3 (0.2) | 0.41 | 2.3 (0.2) | 2.2 (0.2) | 0.76 | 0.52 |
Number of portal tracts | 16.3 (0.6) | 16.3 (1.1) | 0.79 | 13.6 (0.6) | 17.1 (1.0) | 0.008 | 0.01 |
Serum biochemical markers, mean (se) | |||||||
α2-macroglobulin (g/L) | 1.68 (0.05) | 1.78 (0.11) | 0.26 | 1.72 (0.06) | 1.76 (0.08) | 0.47 | 0.38 |
ALT (IU) | 71 (3) | 64 (6) | 0.26 | 79 (5) | 84 (10) | 0.64 | 0.23 |
AST (IU) † | 50 (3) | 42 (3) | 0.10 | 45 (3) | 52 (5) | 0.10 | 0.009 |
Apolipoprotein A1(g/L) | 1.47 (0.03) | 1.46 (0.07) | 0.84 | 1.59 (0.07) | 1.53 (0.04) | 0.80 | 0.07 |
GGT (IU/L) | 110 (11) | 113 (19) | 0.96 | 132 (12) | 158 (19) | 0.96 | 0.03 |
Haptoglobin (g/L) | 1.10 (0.04) | 1.19 (0.15) | 0.69 | 1.12 (0.10) | 1.02 (0.05) | 0.16 | 0.28 |
Total bilirubin (μmol/L) | 14.5 (3.1) | 12.8 (2.0) | 0.43 | 12.6 (0.6) | 13.6 (1.0) | 0.89 | 0.64 |
FibroTest (0.00–1.00) | 0.30 (0.02) | 0.37 (0.05) | 0.18 | 0.29 (0.02) | 0.33 (0.02) | 0.21 | 0.84 |
ActiTest (0.00–1.00) | 0.39 (0.02) | 0.34 (0.04) | 0.24 | 0.41 (0.02) | 0.43 (0.03) | 0.55 | 0.26 |