Characteristic | No NASH vs Borderline or NASH | NASH vs Borderline or No NASH | |||||||
---|---|---|---|---|---|---|---|---|---|
No NASH n = 98 | Borderline NASH n = 96 | NASH n = 63 | Univariate analysis P-value | Multivariate analysis P value | Odds Ratio (95% CI) | Univariate analysis P-value | Multivariate analysis P value | Odds Ratio (95% CI) | |
Demographics | |||||||||
Age at biopsy, years | 49.4 (1.2) | 51.4 (1.2) | 53.8 (1.5) | 0.045 | 0.75 | 1.00 (0.97;1.04) | 0.04 | 0.99 | 1.00 (0.97;1.33) |
Male gender | 56/98 (57%) | 66/96 (69%) | 31/63 (49%) | 0.54 | 0.82 | 1.10 (0.48;2.56) | 0.054 | 0.04 | 2.54 (1.03;6.26) |
Weight, kg | 75.2 (1.4) | 86.8 (1.4) | 82.3 (1.8) | < 0.0001 | < 0.0001 | 1.06 (1.03;1.08) | 0.25 | 0.86 | 1.00 (0.97;1.02) |
Height, meter | 1.68 (0.01) | 1.69 (0.01) | 1.67 (0.01) | 0.87 | 0.15 | 0.03 (0.00;3.34) | 0.22 | 0.66 | 0.33 (0.00;47.2) |
Biochemical markers | |||||||||
α2-macroglobulin, g/L | 1.58 (0.07) | 1.73 (0.07) | 1.86 (0.08) | 0.02 | 0.15 | 0.33 (0; 1050) | 0.01 | 0.16 | 0.72 (0.46;1.14) |
ALT, IU/L | 67 (5) | 74 (5) | 88 (6) | 0.005 | 0.90 | 1.00 (0.99;1.01) | 0.004 | 0.24 | 0.99 (0.99;1.00) |
AST, IU/L | 40 (3) | 48 (3) | 60 (4) | 0.0004 | 0.007 | 1.02 (1.01;1.04) | 0.001 | 0.25 | 0.99 (0.98;1.01) |
Apolipoprotein A1, g/L | 1.61 (0.05) | 1.43 (0.05) | 1.50 (0.06) | 0.08 | 0.27 | 0.53 (0.17;1.67) | 0.62 | 0.71 | 1.14 (0.57;2.28) |
Haptoglobin, g/L | 1.14 (0.10) | 1.11 (0.07) | 1.02 (0.09) | 0.87 | 0.50 | 0.83 (0.47;1.44) | 0.41 | 0.18 | 1.56 (0.81;2.99) |
GGT, IU/L | 133 (14) | 98 (14) | 128 (17) | 0.002 | 0.005 | 1.00 (0.993;0.998) | 0.48 | 0.37 | 1.00 (0.998;1.00) |
Total bilirubin, μmol/L | 11.2 (0.6) | 12.0 (0.6) | 12.5 (0.8) | 0.87 | 0.22 | 1.04 (0.98;1.09) | 0.30 | 0.35 | 0.98 (0.93;1.02) |
Glucose mmol/L | 5.5 (0.2) | 6.0 (0.2) | 7.2 (0.3) | 0.005 | 0.05 | 1.20 (0.999;1.45) | < 0.0001 | 0.0009 | 0.77 (0.67;0.90) |
Cholesterol mmol/L | 5.4 (0.1) | 5.5 (0.1) | 5.4 (0.2) | 0.68 | 0.25 | 1.17 (0.90;1.53) | 0.77 | 0.95 | 1.01 (0.78;1.30) |
Triglycerides | 1.4 (0.2) | 2.0 (0.2) | 2.0 (0.2) | < 0.0001 | 0.23 | 1.19 (0.90;1.57) | 0.007 | 0.90 | 1.01 (0.83;1.24) |
FibroTest | 0.25 (0.02) | 0.31 (0.01) | 0.35 (0.02) | 0.03 | Not included | Not included | 0.008 | Not included | Not included |
SteatoTest | 0.60 (0.02) | 0.70 (0.02) | 0.72 (0.03) | < 0.0001 | Not included | Not included | 0.007 | Not included | Not included |