Table 3 Studies showing p16 alterations in tissue specimen of primary pancreatic ductal adenocarcinomas.
From: Alterations of tumor suppressor gene p16 INK4ain pancreatic ductal carcinoma
Study | Number of cases | p16 gene alterations | ||
|---|---|---|---|---|
| Â | Â | Homozygous deletion | Mutation | Methylation |
Huang et al (1996) | 30 | 10% | 17% | NE |
Zhonghua et al (2000) | 35 | 35% | 20% | NE |
Moore et al (2002) | 34 | NE | 23% | 15% |
Gerdes et al (2002) | 40 | ND | 22.5% | 27.5% |
Ohtsubo et al (2003) | 60 | ND | 15% | 3.3% |
Present study | 25 | 12% | 16% | 52% |