Figure 7
ML 3000 inhibits acid accumulation in rabbit gastric parietal cells. (A) Dose-dependent inhibition by ML 3000 of histamine-stimulated (100 μM) acid accumulation by rabbit gastric parietal cells (IC50 = 40 μM). (B) Dose-dependent inhibition by ML 3000 of forskolin-stimulated (100 μM) acid accumulation by rabbit gastric parietal cells (IC50 = 45 μM). The data-points show mean ± s.e. from four independent assays in each of which acid accumulation into parietal cells was measured in duplicate.