Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

Shidham, Vinod B; Chang, Chung-Che; Shidham, Ganesh; Ghazala, Farrukh; Lindholm, Paul F; Kampalath, Bal; George, Varghese; Komorowski, Richard

doi:10.1186/1471-230X-3-5

Table 2 Comparison of histological features in group A with A-GVHD and negative controls in group B & C.

From: Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

			Frequency of the histological features in %
Histological features evaluated				Negative control
			A-GVHD Grp A (n= 44)	Grp B (n= 27)	Grp C (n= 21)
A	Reduced mucosal thickness		47.73%	0.00%*	0.00%*
B	Mucosal ulceration		27.27%	0.00%*	0.00%*
C	Reactive changes in superficial epithelium		41.86%	0.00%*	0.00%*
D₁		Size variation	97.73%	29.63%*	14.28%*
D₂	Crypt abnormalities	Irregular distribution	63.64%	3.70%*	0.00%*
D₃		Crypt dropout	30.23%	0.00%*	0.00%*
E	Crypt dilatation		72.73%	3.70%*	0.00%*
F	Cryptitis and crypt abscess		2.27%	0.00%	4.76%
G	Increased intraepithelial lymphocytes in superficial epithelium		6.98%	0.00%	0.00%
H	Increased intraepithelial lymphocytes in crypts		6.98%	0.00%	0.00%
I	Intraepithelial neutrophils in superficial epithelium		9.30%	0.00%	0.00%
J	Intraepithelial neutrophils in crypts		6.82%	0.00%	0.00%
K₁		Intraepithelial in SE	76.74%	77.78%	57.4%
K₂		Intracryptal ("popcorn")	90.91%	11.11%*	14.28%*
K₃	Distribution of apoptosis	Lamina propria, near SE	79.55%	70.37%	85.7%
K₄		Pericryptal	70.45%	22.22%*	4.76%*
L₀		None	59.09%	74.07%	57.14%
L₁	Neutrophils in lamina propria	Marked increase	4.55%	18.52%	00.00%
L₂		Mild increase	36.36%	11.11%	42.85%
M₀	Eosinophils in lamina propria	Few to none	100%	96.30%	100.00%
M₁		many	0.00%	3.70%	0.00%
N	Focal periglandular infiltrate		6.98%	0.00%	0.00%
O₁	Edema in lamina propria	Focal	86.36%	88.88%	28.57%
O₂		Diffuse	4.55%	0.00%	0.00%
P	Muciphages in lamina propria		43.18%	0.00%*	4.76%*
Q	Increased microvessel network in lamina propria		61.36%	0.00%*	0.00%*
R	Clusters of enterochromaffin cells		0.00%	0.00%	0.00%
S₁	Fibrosis in lamina propria	Focal	47.73%	0.00%*	0.00%*
S₂		Diffuse	2.27%	0.00%	0.00%

n, total number of cases in a group; SE, surface epithelium. * Statistically significant difference with p values less than 0.002 with Fisher's exact test when A was compared with B and C individually.

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ISSN: 1471-230X

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