Patients and Methods | |||||||||||
Sample Collection Time [Minutes] | 30 | 60 | 30 | 60 | 30 | 30 | 30 | 30 | 30 | 30 | 60 |
Age Limits [Years] | 0.3–5 | 5–8 | 8–11 | 11–14 | 14–18 | ||||||
Number of Tests | 251 | 251 | 251 | 251 | 138 | 289 | 383 | 278 | 137 | 1223 | 1232 |
Method of Analysis | LR | LR | BM | BM | BM | BM | BM | BM | BM | BM | BM |
Histology used | Yes | Yes | Yes | Yes | No | No | No | No | No | No | No |
Threshold Results | |||||||||||
Threshold from Logistic Regression (LR) [‰Δδ] | 5.29 | 6.76 | |||||||||
SD [‰Δδ] | 0.3 | 0.5 | |||||||||
R2 LR | 0.91 | 0.85 | |||||||||
Threshold from Specificity [‰Δδ] | 5.66 | 6.72 | 9.10 | 5.57 | 6.83 | 6.46 | 4.97 | 5.78 | 6.19 | ||
SD [‰Δδ] | 4.46 | 1.22 | 0.86 | 1.05 | 1.46 | 0.45 | 0.42 | ||||
Positive plus Negative Predictive Values [‰Δδ] | 5.54 | 6.53 | 12.25 | 7.78 | 8.11 | 7.24 | 5.56 | 7.19 | 7.55 | ||
SD [‰Δδ] | 5.10 | 1.66 | 1.00 | 1.19 | 1.76 | 0.56 | 0.53 | ||||
Performance Results | |||||||||||
Sensitivity | 0.95 | 0.93 | 0.91 | 0.94 | 0.94 | 0.91 | 0.98 | 0.98 | 0.97 | 0.96 | 0.96 |
Specificity | 0.97 | 0.95 | 0.96 | 0.97 | 0.95 | 0.94 | 0.98 | 0.97 | 0.96 | 0.96 | 0.95 |
Positive predictive value | 0.97 | 0.96 | 0.95 | 0.97 | 0.95 | 0.94 | 0.98 | 0.98 | 0.96 | 0.96 | 0.95 |
Negative predictive value | 0.95 | 0.92 | 0.89 | 0.92 | 0.98 | 0.97 | 0.99 | 0.99 | 0.98 | 0.99 | 0.99 |
AUROC | 0.94 | 0.98 | 0.98 | 0.99 | 0.98 | 0.97 | 0.99 | 0.99 | 0.99 | 0.99 | 0.99 |