From: Fast food diet with CCl4 micro-dose induced hepatic-fibrosis –a novel animal model
Gene | Gene expression profile | |||
---|---|---|---|---|
Chow diet | 0.5 ml/Kg B.wt CCl4 | FFD | FFD + 0.5 ml/kg B.wt CCl4 | |
Fibrosis | ||||
TGFβ1 | 1.02 ± 0.09 | 1.00 ± 0.05 | 1.22 ± 0.17 | 1.69 ± 0.14* |
COL1A1 | 1.08 ± 0.17 | 1.56 ± 0.21 | 2.25 ± 0.32 | 13.05 ± 1.88*** |
TIMP1 | 1.00 ± 0.05 | 0.81 ± 0.04 | 1.74 ± 0.15 | 2.41 ± 0.42** |
ACTA2 | 1.08 ± 0.08 | 1.00 ± 0.05 | 1.01 ± 0.12 | 0.87 ± 0.12 |
Inflammation | ||||
TNFα | 1.05 ± 0.13 | 0.62 ± 0.04 | 3.59 ± 0.75** | 1.30 ± 0.23* |
Osetopontin | 1.10 ± 0.34 | 0.86 ± 0.21 | 5.43 ± 1.14 | 9.79 ± 2.43** |
Fatty acid trafficking | ||||
FABP4 | 1.05 ± 0.15 | 1.59 ± 0.28 | 5.63 ± 0.57 | 45.46 ± 8.64*** |