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Table 3 List of steroid response genes screened in biomarker assay

From: Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

Gene

Name

Gene ID

Reference

Sreening result

TLR9

Toll-like receptor 9

54106

19, 20

3

TSP-1

Thrombospondin-1

7057

19

5

TSP-2

Thrombospondin-2

7058

19

1

IDO

Indoleamine 2,3-dioxygenase 1

3620

19

4

MARCO

Macrophage receptor with collagenous structure

8685

19

4

IL-1β

Interleukin 1, beta

3553

19

1

IL-1RI

Interleukin-1 receptor type 1

3554

19

4

IL-1RII

Interleukin-1 receptor type 2

7850

19, 21

5

IL-1Rα

Interleukin-1 receptor antagonist

3557

19

3

IL-1RAP

IL-1 receptor accessory protein

3556

20

3

IL-7Rα

Interleukin 7 receptor, alpha

3575

19

1

IL-13Rα2

Interleukin-13 receptor subunit, alpha 2

3598

19

1

CD163

Antigen CD163

9332

19

5

GZMA

Granzyme 1, serine esterase 3

3001

19

4

GILZ

Glucocorticoid-induced leucine zipper

1831

19

1

CD49D

Antigen CD49D; integrin alpha 4

3676

19

1

GRα

Glucocorticoid nuclear receptor, isoform alpha

2908

5, 20

3

GRβ

Glucocorticoid nuclear receptor, isoform beta

2908

19, 20

3

GRγ

Glucocorticoid nuclear receptor, isoform gamma

2908

20

3

HSP90α

Heat shock protein HSP 90, alpha

3320

22

2

HSP90β

Heat shock protein HSP 90, beta

3326

22

2

UGT2

UDP glucuronosyltransferase 2

7362

23

2

IRS-1

Insulin receptor substrate 1

3667

23

4

FoxP3

Forkhead box protein P3

50943

24

4

CFL1

Cofilin 1

1072

25

1

HDAC2

Histone deacetylase 2

3066

26

1

IGFBP2

Insulin-like growth factor binding protein 2

3485

27

1

MDR1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

5243

4

1

VitD3R

Vitamin D (1,25- dihydroxyvitamin D3) receptor

7421

17

1

FKBP51

FK506 binding protein 5

2289

28

3

GROα

Growth-regulated gene-alpha

2919

29

3

VEGFA

Vascular endothelial growth factor

7422

30

2

SGK

Serum- and glucocorticoid-inducible protein kinase

6446

31

1

IFNγR1

Interferon gamma receptor 1

3459

32

1

  1. (1)Excluded because of too high individual variability in healthy volunteers.
  2. (2)Excluded because Dexamethasone (Dex) response in healthy volunteers was not reliable.
  3. (3)Excluded because difference in Dex response between steroid resistant patients and healthy volunteers was not reliable.
  4. (4)Excluded because of missing or not reliable synergistic effect when stimulated with Dex and DIMS0150.
  5. (5)Selected as potential biomarker because all four criteria were fulfilled (see text).
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BMC Gastroenterology

ISSN: 1471-230X

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