Parameters | Baseline (Before TF on PPIs) | 6-month (off PPIs) | 12-month (off PPIs) | p value (6-month vs. baseline) | p value (12-month vs. baseline) | p value (6-month vs. 12-month) |
---|---|---|---|---|---|---|
Reflux disease questionnaire (RDQ) | 2.91 (1.32) | 0.35 (0.53) | 0.50 (0.73) | < 0.001 | < 0.001 | 0.772 |
Heartburn (RDQ) | 2.99 (2.55) | 0.45 (0.86) | 0.63 (1.01) | < 0.001 | < 0.001 | 0.776 |
Dyspepsia (RDQ) | 2.81 (1.57) | 0.42 (0.83) | 0.53 (0.88) | < 0.001 | < 0.001 | 0.917 |
Regurgitation (RDQ) | 2.94 (1.45) | 0.19 (0.40) | 0.33 (0.69) | < 0.001 | < 0.001 | 0.791 |
Gastroesophageal reflux disease health-related quality of life (GERD-HRQL) | 26.25 (10.51) | 5.23 (7.14) | 5.41 (6.80) | < 0.001 | < 0.001 | 0.995 |
Heartburn (GERD-HRQL) | 17.69 (7.51) | 3.74 (5.51) | 3.76 (4.50) | < 0.001 | < 0.001 | > 0.999 |
Reflux Symptom Index | 22.00 (9.63) | 4.64 (5.53) | 4.79 (6.67) | < 0.001 | < 0.001 | 0.995 |
Hoarseness | 1.76 (1.56) | 0.18 (0.60) | 0.33 (0.90) | < 0.001 | < 0.001 | 0.810 |
Throat clearing | 2.90 (1.37) | 0.87 (1.28) | 0.72 (1.10) | < 0.001 | < 0.001 | 0.851 |
Excess throat mucus or postnasal drip | 2.77 (1.51) | 0.87 (1.20) | 0.79 (1.06) | < 0.001 | < 0.001 | 0.961 |
Difficulty swallowing foods, liquids or pills | 1.92 (1.44) | 0.33 (0.77) | 0.46 (0.88) | < 0.001 | < 0.001 | 0.858 |
Coughing after eating or after lying down | 2.46 (1.54) | 0.44 (1.02) | 0.44 (0.88) | < 0.001 | < 0.001 | > 0.999 |
Breathing difficulties or choking episodes | 1.85 (1.60) | 0.13 (0.41) | 0.33 (0.96) | < 0.001 | < 0.001 | 0.690 |
Troublesome or annoying cough | 2.21 (1.49) | 0.49 (1.19) | 0.54 (1.12) | < 0.001 | < 0.001 | 0.983 |
Sensation or something sticking or a lump in the throat (globus) | 2.74 (1.41) | 0.41 (0.94) | 0.44 (0.75) | < 0.001 | < 0.001 | 0.994 |
Heartburn, chest pain, indigestion or stomach acid coming up | 3.38 (1.39) | 0.92 (1.22) | 0.87 (1.26) | < 0.001 | < 0.001 | 0.983 |
Excess flatulence | 2.36 (1.65) | 0.72 (1.19) | 0.68 (1.1) | < 0.001 | < 0.001 | 0.990 |