Table 3 Indications, MRE findings and clinical outcome of pregnant CD patients

1

20 years duration

1/23

Clinical exacerbation of known CD

Phlegmon, sinus tract and fistula

Prednisone therapy and IV antibiotics

No improvement on medical treatment

Inflammatory phenotype

Ileocolonic distribution

No current treatment

1/26

Clinical exacerbation

Small abscess 3 weeks later

Abscess not accessible to drainage, conservative treatment with steroids and IV antibiotics

Clinical deterioration, surgical intervention one month post-delivery, including ileostomy and cecectomy.

Spontaneous VD at 34 weeks, healthy newborn

2

9 years duration

2/19

Clinical exacerbation of known CD

Active disease, no complications, no obstruction

Addition of IV steroids

Clinical response and discharge

Spontaneous VD at 38 weeks, healthy newborn

Inflammatory phenotype

Ileocolonic distribution

Tx: Azathioprine

3

16 years duration

1/31

Clinical exacerbation of known CD new onset of cholestasis

Scant signs of active disease, no complications, no obstruction

UDCA and prednisone added to maintenance treatment with 6 MP

Improvement of CD symptoms, persistent cholestasis

Induced preterm vaginal delivery for cholestatsis at 35 weeks healthy newborn

Fibrostenotic phenotype

s/p ileocecectomy

Ileocolonic distribution

Tx: 6-MP

4

15 years duration

2/22

Clinical exacerbation of known CD

Active disease phlegmon and fistulae

Enteral nutrition modulation a

Partial response phlegmon and fistulae in CT post- delivery, antibiotics: Adalimumab was after delivery

Spontaneous vaginal delivery at 38 weeks, healthy newborn

Fibrostenotic and inflammatory phenotype

Ileocolonic distribution

Tx: Azathioprine

5

4 years duration

1/37

Clinical exacerbation of known CD preeclampsia

Some signs of active disease, no complications

IV steroids and antibiotics

Preeclampsia Urgent delivery

Spontaneous onset of labor, vaginal delivery converted to C/S, at 37 weeks healthy newborn

Inflammatory phenotype

Inactive perianal disease

Crohn’s colitis

Tx: infliximab

6

10 years duration

2/20

Recurrent abscess in right groin, fistula?

Phlegmon in RLQ fistula to right groin

IV and PO antibiotics and abscess drainage prior to MR

Clinical improvement

Spontaneous delivery, healthy newborn at week 38

Inflammatory phenotype

Ileocolonic distribution

Tx: Azathioprine

7

2 years duration

2/25

Clinical exacerbation of known CD

Signs of active disease, new phlegmon in RLQ

Conservative treatment with steroids and IV antibiotics emergency cerclage

Temporary clinical improvement hypoalumiemia & anasarca

Spontaneous vaginal delivery at 28 weeks healthy very low birth weight newborn

Inflammatory phenotype

Ileocolonic distribution

Tx: 6-MP and adalimumab

8

No known disease

1/26

Suspected CD

Bowel normal

No treatment

Abdominal symptoms resolved

Healthy twins newborns C/S at 32 w

9

No known disease

?/11

Uncertain diagnosis of UC, suspected CD

MRE signs of UC

NA

NA

Spontaneous delivery with a healthy newborn at week 41S