From: Zinc treatment ameliorates diarrhea and intestinal inflammation in undernourished rats
Nourished | Undernourished | |||||||
---|---|---|---|---|---|---|---|---|
Outcomes | PBS | PBS | P | Zn | P (Zn vs PBS) | Lac | Zn + lac | P (Zn + Lac vs Lac) |
Biochemisty | ||||||||
Zinc serum levels (mg/L) (n) | 1.089 ± 0.08 (n = 11) | 0.712 ± 0.10 (n = 10) | < 0.0001 | 1.57 ± 0.12 (n = 8) | < 0.0001 | 1.12 ± 0.24 (n = 12) | 2.04 ± 0.50 (n = 8) | < 0.0001 |
Jejunal morphology* | ||||||||
Villus height (μm) | 826.3 ± 92.2 | 587.9 ± 98.3 | < 0.0001 | 704.2 ± 113.9 | 0.001 | 686 ± 103.2 | 667.9 ± 78.2 | 0.359 |
Crypt length (μm) | 151.5 ± 36.5 | 187.7 ± 66.7 | < 0.0001 | 169.8 ± 49.0 | 0.007 | 141.6 ± 27.7 | 127.2 ± 20.3 | < 0.0001 |
Villus/crypt ratio | 6.03 ± 1.7 | 3.7 ± 1.4 | < 0.0001 | 5.15 ± 2.82 | 0.0322 | 5.1 ± 0.8 | 5.4 ± 1.19 | 0.235 |