Variables (SI-units if not indicated otherwise) | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | |
Age (≤65 years vs > 65 years) | 1.598 | 0.957-2.669 | 0.073 | |||
Sex (m vs f) | 0.777 | 0.457-1.332 | 0.352 | |||
BMI (≤30 kg/m2 vs > 30 kg/m2) | 0.573 | 0.216-1.518 | 0.263 | |||
Etiology (alcohol vs viral vs other) | 0.095 | |||||
BCLC stage | 0.014 | |||||
CLIP | 0.031 | |||||
Size of largest nodule (>5 cm vs ≤ 5 cm) | 1.991 | 0.993-3.992 | 0.052 | |||
Portal vein thrombosis (yes vs no) | 1.859 | 1.066-3.241 | 0.029 | 1.559 | 0.676-3.596 | 0.298 |
Extrahepatic metastasis (yes vs no) | 2.104 | 1.248-3.549 | 0.005 | 2.844 | 1.098-7.368 | 0.031 |
Ascites | 1.181 | 0.575-2.428 | 0.651 | |||
Number of lesions (one vs two vs multinodular) | 0.204 | |||||
Steatosis (yes vs no) | 0.576 | 0.248-1.340 | 0.200 | |||
AFP | 1.0 | 0.999-1.000 | 0.031 | 1.0 | 0.999-1.001 | 0.323 |
CA 19-9 | 1.0 | 0.999-1.001 | 0.969 | |||
Hemoglobin | 0.963 | 0.790-1.174 | 0.709 | |||
ALAT | 1.060 | 0.864-1.302 | 0.575 | |||
ASAT | 1.158 | 1.000-1.340 | 0.050 | 0.999 | 0.629-1.586 | 0.997 |
Albumin | 0.975 | 0.941-1.010 | 0.152 | |||
Bilirubin | 1.001 | 0.997-1.006 | 0.484 | |||
Alcaline phosphatase | 0.993 | 0.955-1.032 | 0.724 | |||
GGT | 1.021 | 0.974-1.071 | 0.386 | |||
Quick | 0.990 | 0.977-1.002 | 0.112 | |||
PTT | 1.057 | 1.007-1.110 | 0.026 | 1.057 | 0.891-1.255 | 0.524 |
Platelets | 1.002 | 1.000-1.004 | 0.049 | 1.004 | 1.001-1.007 | 0.006 |
Ferritin | 1.0 | 1.000-1.001 | 0.455 | |||
Creatinine | 0.997 | 0.992-1.002 | 0.231 | |||
Urea nitrogen | 0.966 | 0.914-1.020 | 0.212 | |||
Diabetes mellitus (yes vs no) | 1.246 | 0.564-2.753 | 0.586 | |||
Nicotine (yes vs no) | 1.239 | 0.632-2.428 | 0.532 | |||
ECOG status (1 or 2 vs 0) | 1.965 | 1.129- 3.417 | 0.017 | 1.645 | 0.681-3.968 | 0.269 |
Aim of treatment (palliative vs curative) | 1.044 | 0.616-1.770 | 0.873 |