Table 3 GST genotype distribution according to predicted enzyme activity
GST | GST genotypes | Predicted enzyme activity | ESCC (n = 106)# | EAC (n = 327)# | Controls (n = 592)# |
|---|---|---|---|---|---|
GST M1 | *1/*1 & *1/*0 | High-Intermediate | 48 (45.7%) | 156 (47.7%) | 273 (46.2%) |
*0/*0 | Low | 57 (54.3%) | 171 (52.3%) | 318 (53.8%) | |
GST A1 | *1a/*1a | High | 43 (41.3%) | 131 (42.1%) | 214 (37.2%) |
*1a/*1b | Intermediate | 50 (48.1%) | 133 (42.8%) | 277 (48.2%) | |
*1b/*1b | Low | 11 (10.6%) | 47 (15.1%) | 84 (14.6%) | |
GST P1 I105V | Ile / Ile | High | 48 (45.7%) | 119 (37.5%) | 246 (41.6%) |
Ile / Val | Intermediate | 42 (40.0%) | 157 (49.5%) | 261 (44.2%) | |
Val / Val | Low | 15 (14.3%) | 41 (12.9%) | 84 (14.2%) | |
GST P1 A114V | Ala / Ala | High | 92 (86.8%) | 262 (82.6%) | 485 (83.5%) |
Ala / Val | Intermediate | 14 (13.2%) | 52 (16.4%) | 91 (15.7%) | |
Val / Val | Low | 0 | 3 (0.9%) | 5 (0.9%) | |
GST T1 | *1/*1 & *1/*0 | High-Intermediate | 87 (82.9%) | 248 (75.8%) | 463 (78.3%) |
*0/*0 | Low | 18 (17.1%) | 79 (24.2%) | 128 (21.7%) |