Characteristic | Controls (N=14) | Patients with cirrhosis without inflammation (N = 13) | Patients with cirrhosis and inflammation (N = 22) | P value |
---|---|---|---|---|
Years of age – median (range) | 39 (22–52) | 55 (37–81) | 65 (44–82) | <0.001 |
Male sex – no. (%) | 8 (57%) | 7 (54%) | 14 (64%) | n.s. |
Positive Epstein-Barr virus serology – no. (%) | 12/14 (85%) | 11/11 (100%) | 25/25 (100%) | n.s. |
LBP serum concentration (μg/ml) – median (range) | 14 (7–22) | 30 (12–44) | 33 (10–50) | 0.002 |
IL-10 serum concentration (pg/ml) – median (range) | 4 (3–7) | 10 (6–37) | 14 (7–51) | <0.001 |
Alcoholic aetiology of cirrhosis – no. (%) |  | 8 (62%) | 15 (68%) | n.s. |
Child-Pugh stage A/B/C – no. | 6/4/3 | 2/3/17* | 0.005 | |
Child-Pugh score – median (range) | 7 (5–13) | 10 (6–13)* | 0.005 | |
Ascites – no. (%) | 5 (38%) | 19 (86%)* | 0.007 | |
MELD score – median (range) | 12 (6–24) | 16 (7–33) | n.s | |
Laboratory values - median (range) | Â | Â | Â | |
Total serum bilirubin - μmol/l | 31 (5–504) | 49 (7–324) | n.s | |
International normalized ratio | 1.2 (0.9–2.0) | 1.4 (1.1–2.2)* | 0.029 | |
Creatinine - μmol/l | 76 (50–129) | 91 (52–235) | n.s | |
Aspartate aminotransferase - μmol/l×s | 0.78 (0.46–4.16) | 1.23 (0.30–3.42) | n.s | |
Alanine aminotransferase - μmol/l×s | 0.77 (0.36–2.68) | 0.61 (0.24–1.10) | n.s | |
White blood cell count – Gpt/l | 5.8 (2.4–7.2) | 6.6 (3.6–16.8)* | 0.034 | |
C-reactive protein – mg/l | 4.9 (2.0–10.0) | 25.5 (12.6–91.9)* | <0.001 | |
Serum Albumin – g/l | 31 (19–40) | 27 (17–35) | n.s. |