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Table 5 Risk of −1018 GG homozygote for the development of CDH1 methylation

From: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1in the gastric epithelium

Overall (527)

GG

GA

AA

GG vs A carrier; OR (95%C.I.)

p value

unmethylated (281)

197

78

6

reference

-

methylated (246)

204

41

1

2.07 (1.35-3.17)

0.0009

non-GC (412)

     

unmethylated (262)

180

76

6

reference

-

methylated (150)

125

24

1

2.25 (1.35-3.75)

0.0019

GC (115)

     

(non cancerous mucosa)

     

unmethylated (19)

17

2

0

reference

-

methylated (96)

79

17

0

0.579 (0.120-2.80)

0.50

(cancer lesion)

     

unmethylated (37)

30

7

0

reference

-

methylated (78)

66

12

0

1.50 (0.507-4.42)

0.47

  1. by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
  2. (): the number of subject.