Comparative analysis of inflamed and non-inflamed colon biopsies reveals strong proteomic inflammation profile in patients with ulcerative colitis

Table 3 Biological processes associated with identified proteins with references to results obtained in earlier studies

Biological process	Protein name
Energy generation	triosephosphate isomerase^1,3,4, glycerol-3-phosphate-dehydrogenase, alpha enolase^2,3, isocitrate dehydrogenase, L-lactate dehydrogenase B-chain, inorganic pyrophosphatase, enoyl-CoA hydratase
Response to oxidative stress	selenium binding protein^1,2, superoxide dismutase, thioredoxin-dependent peroxide reductase¹, peroxiredoxin-1⁴, peroxiredoxin-4, peroxiredoxin-6
Stress response proteins	Alpha-enolase³, Hsp60^1,3, Hsp70^1,4

¹Different protein level between diseased UC versus normal colon mucosa tissues using colon biopsies [22]. ²Different protein level between inflamed and non-inflamed tissue regions in single UC patients as identified in purified epithelial cells from biopsies [19]. ³Different protein level in mucosal tissue biopsies from patients with chronic refractory pouchitis before and after antibiotic/probiotic therapy [34]. ⁴Different protein level between intestinal epithelial cells from healthy subjects and CD patients [35].

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