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Table 1 Intestinal mucosal parameters

From: Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat

 

CONTR

CONTR-ARG

MTX

MTX-ARG

Bowel weight

    

(mg/cm/100 mg body weight)

    

   Jejunum

23 ± 1

21 ± 1

17 ± 0.3 *

19 ± 1 *†

   Ileum

21 ± 1

19 ± 1

17 ± 1 *

21 ± 1 *†

Mucosal weight

    

(mg/cm/100 mg body weight)

    

   Jejunum

9.4 ± 0.5

7.6 ± 0.5 *

5.1 ± 0.6 *

6.2 ± 0.6

   Ileum

9.1 ± 0.5

6.7 ± 0.5 *

4.7 ± 0.5 *

6.1 ± 0.6 *†

Mucosal DNA

    

(μg/cm/100 mg body weight)

    

   Jejunum

45 ± 7

30 ± 4 *

22 ± 5 *

25 ± 3 *

   Ileum

47 ± 6

52 ± 4

19 ± 4 *

38 ± 9 †

Mucosal protein

    

(μg/cm/100 mg body weight)

    

   Jejunum

94 ± 21

60 ± 11

58 ± 10 *

58 ± 5 *

   Ileum

54 ± 10

44 ± 8

32 ± 5 *

51 ± 8 †

Villus height (μm)

    

   Jejunum

434 ± 29

345 ± 56

314 ± 33 *

413 ± 18 †

   Ileum

371 ± 26

287 ± 19 *

217 ± 52 *

300 ± 23 *†

Crypt depth (μm)

    

   Jejunum

183 ± 17

131 ± 8 *

112 ± 4 *

126 ± 11

   Ileum

161 ± 16

120 ± 8 *

101 ± 15 *

131 ± 10 *†

  1. CONTR- control, MTX-methotrexate, ARG-arginine
  2. * P < 0.05 All groups vs CONTR rats, † P < 0.05 MTX-ARG vs MTX rats.