From: Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat
 | CONTR | CONTR-ARG | MTX | MTX-ARG |
---|---|---|---|---|
Bowel weight | Â | Â | Â | Â |
(mg/cm/100 mg body weight) | Â | Â | Â | Â |
   Jejunum | 23 ± 1 | 21 ± 1 | 17 ± 0.3 * | 19 ± 1 *†|
   Ileum | 21 ± 1 | 19 ± 1 | 17 ± 1 * | 21 ± 1 *†|
Mucosal weight | Â | Â | Â | Â |
(mg/cm/100 mg body weight) | Â | Â | Â | Â |
   Jejunum | 9.4 ± 0.5 | 7.6 ± 0.5 * | 5.1 ± 0.6 * | 6.2 ± 0.6 |
   Ileum | 9.1 ± 0.5 | 6.7 ± 0.5 * | 4.7 ± 0.5 * | 6.1 ± 0.6 *†|
Mucosal DNA | Â | Â | Â | Â |
(μg/cm/100 mg body weight) |  |  |  |  |
   Jejunum | 45 ± 7 | 30 ± 4 * | 22 ± 5 * | 25 ± 3 * |
   Ileum | 47 ± 6 | 52 ± 4 | 19 ± 4 * | 38 ± 9 †|
Mucosal protein | Â | Â | Â | Â |
(μg/cm/100 mg body weight) |  |  |  |  |
   Jejunum | 94 ± 21 | 60 ± 11 | 58 ± 10 * | 58 ± 5 * |
   Ileum | 54 ± 10 | 44 ± 8 | 32 ± 5 * | 51 ± 8 †|
Villus height (μm) |  |  |  |  |
   Jejunum | 434 ± 29 | 345 ± 56 | 314 ± 33 * | 413 ± 18 †|
   Ileum | 371 ± 26 | 287 ± 19 * | 217 ± 52 * | 300 ± 23 *†|
Crypt depth (μm) |  |  |  |  |
   Jejunum | 183 ± 17 | 131 ± 8 * | 112 ± 4 * | 126 ± 11 |
   Ileum | 161 ± 16 | 120 ± 8 * | 101 ± 15 * | 131 ± 10 *†|