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Table 1 Serum aminotransferases, liver lipid peroxdation, myeloperoxidase activity and TNFα mRNA when pretreated with isoflurane

From: Isoflurane Preconditioning at Clinically Relevant Doses Induce Protective Effects of Heme Oxygenase-1 on Hepatic Ischemia Reperfusion in Rats

 

Sham

IR

ISO

Znpp/ISO

Znpp

Hemin

ALT (IU.l-1)

39 ± 14*

3336 ± 393

2787 ± 209*

3677 ± 249

3106 ± 327

2290 ± 334*

AST (IU.l-1)

31 ± 25*

3792 ± 326

2867 ± 475*

4149 ± 401

3904 ± 414

2149 ± 509*

Hepatic TNFα mRNA (fold of Sham)

-

12.8 ± 7.2

6.7 ± 3.5*

14.5 ± 7.8

13.6 ± 6.9

7.5 ± 4.9*

MDA (μmol.l-1)

4.8 ± 1.6*

29.6 ± 7.2

13.1 ± 1.8*

39.4 ± 10.6

37.6 ± 8.8

19.8 ± 4.7*

MPO (U.g tissue-1)

1.5 ± 0.3*

3.5 ± 0.3

2.2 ± 0.4*

3.7 ± 0.5

4.1 ± 0.7

2.0 ± 0.3*

  1. * P < 0.05 vs. IR group value. Values are mean ± SD of 12 animals in each group.
  2. IR = ischemia reperfusion injury; ISO = isoflurane; Znpp = zinc protoporphyrin; ALT = alanine aminotransferase; AST = aspartate aminotransferase; TNFα = tumor necrosis factor α; MDA = malondialdehyde; MPO = myeloperoxidase