Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

Table 1 Metabolic pathways regulated by the considered genes, effect of polymorphisms on protein function and metabolic parameters.

Gene	Function	Polymorphism	Effect	Previous association
PPARα	Induces lipolysis	Lys162Val (rs1800206)	-	Insulin resistance Dyslipidemia Diabetes [29]
PPARγ2	Induces lipogenesis in adipose tissue	Pro12Ala (rs1801282)	-	Insulin sensitivity [32, 40]

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