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  1. Many patients with IBS suffer on-going symptoms. The evidence base is poor for IBS drugs but they are widely prescribed and advised in Guidelines. Cognitive Behavioural Therapy (CBT) can be helpful, but availa...

    Authors: Hazel Everitt, Rona Moss-Morris, Alice Sibelli, Laura Tapp, Nicholas Coleman, Lucy Yardley, Peter Smith and Paul Little
    Citation: BMC Gastroenterology 2013 13:68
    Content type: Research article Published on:

  2. FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by star...

    Authors: Chaofeng Yang, Weiqin Lu, Tao Lin, Pan You, Min Ye, Yanqing Huang, Xianhan Jiang, Cong Wang, Fen Wang, Mong-Hong Lee, Sai-Ching J Yeung, Randy L Johnson, Chongjuan Wei, Robert Y Tsai, Marsha L Frazier, Wallace L McKeehan…
    Citation: BMC Gastroenterology 2013 13:67
    Content type: Research article Published on:

  3. Colorectal cancer (CRC) is common, with surgery as the main curative treatment. The prevalence of chronic liver disease has increased, but knowledge is limited on postoperative mortality in patients with liver...

    Authors: Jonathan Montomoli, Rune Erichsen, Christian Fynbo Christiansen, Sinna Pilgaard Ulrichsen, Lars Pedersen, Tove Nilsson and Henrik Toft Sørensen
    Citation: BMC Gastroenterology 2013 13:66
    Content type: Research article Published on:

  4. Endoscopic transpapillary pernasal gallbladder drainage and endoscopicgallbladder stenting (EGS) have recently been reported to be useful inpatients with acute cholecystitis for whom a percutaneous approach is...

    Authors: Satoshi Maekawa, Ryosuke Nomura, Takayuki Murase, Yasuyoshi Ann, Masayuki Oeholm and Masaru Harada
    Citation: BMC Gastroenterology 2013 13:65
    Content type: Research article Published on:

  5. Primary biliary cirrhosis (PBC) is a liver specific chronic disease with unclear pathogenesis, especially for the early stage molecular events. The mitochondrion is a multi-functional organelle associated with...

    Authors: Guang Song, Chaojun Hu, Huishan Zhu, Xi Li, Liying Zhao, Renfang Zhou, Xuan Zhang, Fengchun Zhang, Lin Wu and Yongzhe Li
    Citation: BMC Gastroenterology 2013 13:64
    Content type: Research article Published on:

  6. Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided...

    Authors: José Celso Ardengh, César Vivian Lopes, Rafael Kemp, Filadélfio Venco, Eder Rios de Lima-Filho and José Sebastião dos Santos
    Citation: BMC Gastroenterology 2013 13:63
    Content type: Research article Published on:

  7. Only one case of santorinicele without pancreas divisum pathophysiology (SWOPP) was previously reported. The purpose of the study was to determine the gross prevalence of SWOPP and santorinicele with pancreas ...

    Authors: Wataru Gonoi, Hiroyuki Akai, Kazuchika Hagiwara, Masaaki Akahane, Naoto Hayashi, Eriko Maeda, Takeharu Yoshikawa, Shigeru Kiryu, Minoru Tada, Kansei Uno, Naoki Okura, Kazuhiko Koike and Kuni Ohtomo
    Citation: BMC Gastroenterology 2013 13:62
    Content type: Research article Published on:

  8. This study investigated a possible role of Escherichia coli in propagation and perpetuation of the chronic inflammation in ulcerative colitis (UC). The lesions of UC are located superficially on the rectal and/or...

    Authors: Magdalena Pilarczyk-Zurek, Agnieszka Chmielarczyk, Tomasz Gosiewski, Anna Tomusiak, Pawel Adamski, Malgorzata Zwolinska-Wcislo, Tomasz Mach, Piotr B Heczko and Magdalena Strus
    Citation: BMC Gastroenterology 2013 13:61
    Content type: Research article Published on:

  9. Although transarterial chemoembolization (TACE) has been used extensively for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), no consensus has been reached and an evidence base ...

    Authors: Tong-Chun Xue, Xiao-Ying Xie, Lan Zhang, Xin Yin, Bo-Heng Zhang and Zheng-Gang Ren
    Citation: BMC Gastroenterology 2013 13:60
    Content type: Research article Published on:

  10. Orbital myositis is a rare extra-intestinal manifestation of inflammatory bowel disease. Seventeen cases of Crohn’s disease associated orbital myositis and 3 cases of ulcerative colitis associated orbital myos...

    Authors: Sanam Verma, Karen I Kroeker and Richard N Fedorak
    Citation: BMC Gastroenterology 2013 13:59
    Content type: Case report Published on:

  11. Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate. The MELD score has been implied as a prognostic tool in ALF. Hyponatremia is associated with lethal outcome in ALF. Incl...

    Authors: Paul Manka, Lars P Bechmann, Frank Tacke, Jan-Peter Sowa, Martin Schlattjan, Julia Kälsch, Christoph Jochum, Andreas Paul, Fuat H Saner, Christian Trautwein, Guido Gerken and Ali Canbay
    Citation: BMC Gastroenterology 2013 13:58
    Content type: Research article Published on:

  12. Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology and pathogenesis in which genetic factors contribute to development of disease. MDR1/ABCB1 is an interesting candidate gene for IBD. The ...

    Authors: Marko Brinar, Silvija Cukovic-Cavka, Nada Bozina, Katja Grubelic Ravic, Pave Markos, Agata Ladic, Marijana Cota, Zeljko Krznaric and Boris Vucelic
    Citation: BMC Gastroenterology 2013 13:57
    Content type: Research article Published on:

  13. The treatment for the eradication of Helicobacter pylori (H. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. In developing countries, increased resistance to antibiotics...

    Authors: Tomás Navarro-Rodriguez, Fernando Marcuz Silva, Ricardo Correa Barbuti, Rejane Mattar, Joaquim Prado Moraes-Filho, Maricê Nogueira de Oliveira, Cristina S Bogsan, Décio Chinzon and Jaime Natan Eisig
    Citation: BMC Gastroenterology 2013 13:56
    Content type: Research article Published on:

  14. Patients with suspected alcoholic hepatitis and a Discriminant Function ≥32 underwent liver biopsy to confirm the diagnosis. Of these (n = 58), 43 had histological features of alcoholic hepatitis and 15 (25%) ...

    Authors: Timothy Hardy, Christopher Wells, Stuart Kendrick, Mark Hudson, Christopher P Day, Alastair D Burt, Steven Masson and Stephen F Stewart
    Citation: BMC Gastroenterology 2013 13:55
    Content type: Research article Published on:

  15. Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adver...

    Authors: Kentaro Sugano, Yoshikazu Kinoshita, Hiroto Miwa and Tsutomu Takeuchi
    Citation: BMC Gastroenterology 2013 13:54
    Content type: Research article Published on:

  16. Three-dimensional (3D) whole-liver perfusion magnetic resonance(MR) imaging with parallel imaging, a novel imaging method to characterize tumor vascularization in vivo, has recently been applied to comprehensivel...

    Authors: Sheng-Xiang Rao, Cai-Zhong Chen, Hao Liu, Meng-Su Zeng and Xu-Dong Qu
    Citation: BMC Gastroenterology 2013 13:53
    Content type: Research article Published on:

  17. Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the presen...

    Authors: Mengyi Zhou, Ping Jia, Jinping Chen, Aihui Xiu, Yue Zhao, Yibei Zhan, Peng Chen and Jianfa Zhang
    Citation: BMC Gastroenterology 2013 13:52
    Content type: Research article Published on:

  18. Long-term outcomes of partial liver resection of hepatocellular carcinoma (HCC) remain satisfactory due to high incidences of recurrence. This study was intended to see whether preoperative transcatheter arter...

    Authors: Yanming Zhou, Xiaofeng Zhang, Lupeng Wu, Feng Ye, Xu Su, Lehua Shi and Bin Li
    Citation: BMC Gastroenterology 2013 13:51
    Content type: Research article Published on:

  19. Chronic hepatitis C virus (HCV) infection is frequently associated with extrahepatic autoimmune disorders while interferon (IFN) and ribavirin treatment may exacerbate these conditions. Autoantibodies from HCV...

    Authors: Laura M Stinton, Robert P Myers, Carla S Coffin and Marvin J Fritzler
    Citation: BMC Gastroenterology 2013 13:50
    Content type: Research article Published on:

  20. In current practice, patients with chronic pancreatitis undergo surgical intervention in a late stage of the disease, when conservative treatment and endoscopic interventions have failed. Recent evidence sugge...

    Authors: Usama Ahmed Ali, Yama Issa, Marco J Bruno, Harry van Goor, Hjalmar van Santvoort, Olivier RC Busch, Cornelis HC Dejong, Vincent B Nieuwenhuijs, Casper H van Eijck, Hendrik M van Dullemen, Paul Fockens, Peter D Siersema, Dirk J Gouma, Jeanin E van Hooft, Yolande Keulemans, Jan W Poley…
    Citation: BMC Gastroenterology 2013 13:49
    Content type: Study protocol Published on:

  21. Surface electrogastrography (EGG) is a non-invasive method for clinical assessment of gastric myoelectrical activity. Different forms of general anaesthesia might have various effects on porcine EGG. The aim o...

    Authors: Ilja Tachecí, Jaroslav Květina, Martin Kuneš, Michal Pavlík, Marcela Kopáčová, Vladimír Černý, Stanislav Rejchrt, Jithinraj Edakkanambeth Varayil and Jan Bureš
    Citation: BMC Gastroenterology 2013 13:48
    Content type: Research article Published on:

  22. The principle to avoid surgery for haemorrhoids and/or anal fissure in Crohn’s disease (CD) patients is still currently valid despite advances in medical and surgical treatments. In this study we report our pr...

    Authors: Stefano D'Ugo, Luana Franceschilli, Federica Cadeddu, Laura Leccesi, Giovanna Del Vecchio Blanco, Emma Calabrese, Giovanni Milito, Nicola Di Lorenzo, Achille L Gaspari and Pierpaolo Sileri
    Citation: BMC Gastroenterology 2013 13:47
    Content type: Research article Published on:

  23. The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data sugges...

    Authors: Chad K Porter, Daniel Choi, Brooks Cash, Mark Pimentel, Joseph Murray, Larissa May and Mark S Riddle
    Citation: BMC Gastroenterology 2013 13:46
    Content type: Research article Published on:

  24. Irritable Bowel Syndrome (IBS) is a common condition characterised by pain, distension and altered bowel habit. Evidence suggests functional foods containing probiotics improve gastrointestinal transit, howeve...

    Authors: Lesley M Roberts, Deborah McCahon, Roger Holder, Sue Wilson and FD Richard Hobbs
    Citation: BMC Gastroenterology 2013 13:45
    Content type: Research article Published on:

  26. Less than 67% of patients with intermediate risk for common bile duct (CBD) stones require therapeutic intervention. It is important to have an accurate, safe, and reliable method for the definitive diagnosis ...

    Authors: Hoi-Hung Chan, E-Ming Wang, Meng-Shun Sun, Ping-I Hsu, Wei-Lun Tsai, Tzung-Jiun Tsai, Kai-Ming Wang, Wen-Chi Chen, Huay-Min Wang, Huei-Lung Liang, Kwok-Hung Lai and William Robert Brugge
    Citation: BMC Gastroenterology 2013 13:44
    Content type: Research article Published on:

  27. Haemobilia usually occurs secondary to accidental or iatrogenic hepatobiliary trauma. It can occasionally present with cataclysmal upper gastrointestinal haemorrhage posing as a life threatening emergency. Hae...

    Authors: Hazrah Priya, Gupta Anshul, Tiwari Alok, Kale Saurabh, Nath Ranjit, Lal Romesh and Sharma Deborshi
    Citation: BMC Gastroenterology 2013 13:43
    Content type: Case report Published on:

  28. Microscopic polyangiitis is characterized by pauci-immune, necrotizing small-vessel vasculitis and an anti-neutrophil cytoplasmic antibody-associated vasculitis. Although gastrointestinal involvement in micros...

    Authors: Masashi Fukushima, Satoko Inoue, Yuichiro Ono, Yoshitaka Tamaki, Hajime Yoshimura, Yukihiro Imai and Tetsuro Inokuma
    Citation: BMC Gastroenterology 2013 13:42
    Content type: Case report Published on:

  29. Patients with ulcerative colitis (UC) are treated with prednisolone (PSL), which causes adverse side effects. Extracorporeal granulocyte/monocyte adsorption (GMA) with an Adacolumn depletes elevated/activated ...

    Authors: Keiichi Tominaga, Masakazu Nakano, Mina Hoshino, Kazunari Kanke and Hideyuki Hiraishi
    Citation: BMC Gastroenterology 2013 13:41
    Content type: Research article Published on:

  30. Patients with persistent symptoms and/or villous atrophy despite strict adherence to a gluten-free diet (GFD) have non-responsive celiac disease (NRCD). A subset of these patients has refractory celiac disease...

    Authors: Justin R Hollon, Pamela A Cureton, Margaret L Martin, Elaine L Leonard Puppa and Alessio Fasano
    Citation: BMC Gastroenterology 2013 13:40
    Content type: Research article Published on:

  31. Gastrointestinal reflux disease (GERD) is a common disorder that negatively impacts health-related quality of life (HRQL) and work productivity. Many patients have only a partial response to proton pump inhibi...

    Authors: Stanislas Bruley des Varannes, Helena Granstedt Löfman, Maria Karlsson, Peter Wahlqvist, Magnus Ruth, Mary Lou Furstnau, Nicolas Despiégel and Nils-Olov Stålhammar
    Citation: BMC Gastroenterology 2013 13:39
    Content type: Research article Published on:

  33. Advanced liver disease predisposes to bacterial translocation and endotoxaemia which can contribute to elevated circulating levels of IL-10 and down-regulation of MHC class II on antigen-presenting cells. We s...

    Authors: Jack Peter, Oliver Frey, Andreas Stallmach and Tony Bruns
    Citation: BMC Gastroenterology 2013 13:37
    Content type: Research article Published on:

  34. There is uncertainty on the benefit of adjuvant chemotherapy in patients with stage II colorectal cancers. The aim of this study is to investigate the combined role of clinical, pathological and molecular para...

    Authors: Marisa Donada, Serena Bonin, Renzo Barbazza, Daniel Pettirosso and Giorgio Stanta
    Citation: BMC Gastroenterology 2013 13:36
    Content type: Research article Published on:

  35. A reliable and accurate estimation of liver size by physical examination is an important aspect of the clinical assessment of a patient. The scratch test uses auscultation to detect the lower liver edge by usi...

    Authors: Krishan Gupta, Akash Dhawan, Christian Abel, Nicholas Talley and John Attia
    Citation: BMC Gastroenterology 2013 13:35
    Content type: Research article Published on:

  38. Earlier, we reported a highly statistically significant association between T-helper 1 (Th1) and Th2 cytokine genotypes and hepatocellular carcinoma (HCC) risk among natives of southern Guangxi, China, a hyper...

    Authors: Jian-Min Yuan, Yunhua Fan, Simona Ognjanovic, Renwei Wang, David Van Den Berg, Sugantha Govindarajan and Mimi C Yu
    Citation: BMC Gastroenterology 2013 13:32
    Content type: Research article Published on:

  39. Although endoscopic biliary stents have been accepted as part of palliative therapy for cases of malignant hilar obstruction, the optimal endoscopic management regime remains controversial. In this study, we e...

    Authors: Osamu Inatomi, Shigeki Bamba, Makoto Shioya, Yosuke Mochizuki, Hiromitsu Ban, Tomoyuki Tsujikawa, Yasuharu Saito, Akira Andoh and Yoshihide Fujiyama
    Citation: BMC Gastroenterology 2013 13:31
    Content type: Research article Published on:

  40. Gallstone disease is associated with p.D19H of ABCG8 as well as alterations of cholesterol and bile acid metabolism. However, molecular mechanisms have not been fully elucidated. It is important to understand the...

    Authors: Olga Renner, Dieter Lütjohann, Dominique Richter, André Strohmeyer, Silke Schimmel, Oliver Müller, Eduard F Stange and Simone Harsch
    Citation: BMC Gastroenterology 2013 13:30
    Content type: Research article Published on:

  41. The transcription factor nuclear factor-κB (NF-κB) has been implicated in gastric cancer metastasis, but the underlying molecular mechanisms remain unclear. We investigated the role of the interaction between ...

    Authors: Jiyeon Yoon, Sung Jin Cho, Young San Ko, Jinju Park, Dong Hoon Shin, In Chan Hwang, Sang Yeun Han, Seon Young Nam, Min A Kim, Mee Soo Chang, Hye Seung Lee, Woo Ho Kim and Byung Lan Lee
    Citation: BMC Gastroenterology 2013 13:29
    Content type: Research article Published on:

  42. A high prevalence of chronic fatigue has previously been reported following giardiasis after a large waterborne outbreak in Bergen, Norway in 2004. The aim of this study was to describe and evaluate differenti...

    Authors: Kristine Mørch, Kurt Hanevik, Ann C Rivenes, Jørn E Bødtker, Halvor Næss, Bjarte Stubhaug, Knut-Arne Wensaas, Guri Rortveit, Geir E Eide, Trygve Hausken and Nina Langeland
    Citation: BMC Gastroenterology 2013 13:28
    Content type: Research article Published on:

  43. Adsorptive granulocyte and monocyte apheresis (GMA) with an Adacolumn in patients with ulcerative colitis (UC) has been applied as a non-pharmacological treatment strategy, but the efficacy has been encouragin...

    Authors: Yoko Yokoyama, Mikio Kawai, Ken Fukunaga, Koji Kamikozuru, Kazuko Nagase, Koji Nogami, Tomoaki Kono, Yoshio Ohda, Masaki Iimuro, Nobuyuki Hida, Shiro Nakamura, Hiroto Miwa and Takayuki Matsumoto
    Citation: BMC Gastroenterology 2013 13:27
    Content type: Research article Published on:

  44. The cavitating mesenteric lymph node syndrome (CMLNS) is a rare manifestation of celiac disease, with an estimated mortality rate of 50%. Specific infections and malignant lymphoma may complicate its clinical ...

    Authors: Cristina Pojoga, Lidia Ciobanu, Alexandru Florin Badea, Emil Boţan, Cosmin Caraiani, Claudia Hagiu, Grigore Băciuţ and Radu Badea
    Citation: BMC Gastroenterology 2013 13:26
    Content type: Case report Published on:

  45. Cirrhotic patients with ascites are prone to develop various infectious diseases. This study aimed to evaluate the occurrence and effect of major infectious diseases on the mortality of cirrhotic patients with...

    Authors: Tsung-Hsing Hung, Chih-Wei Tseng, Yu-Hsi Hsieh, Kuo-Chih Tseng, Chih-Chun Tsai and Chen-Chi Tsai
    Citation: BMC Gastroenterology 2013 13:25
    Content type: Research article Published on:

  46. Although high non-adherence to medication has been noticed for ulcerative colitis (UC), little is known about adherence to mesalamine treatments and determinants that can predict adherence. The objective of th...

    Authors: Jean Lachaine, Linnette Yen, Catherine Beauchemin and Paul Hodgkins
    Citation: BMC Gastroenterology 2013 13:23
    Content type: Research article Published on:

  47. Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma wa...

    Authors: Hitomi Minami, Naoyuki Yamaguchi, Kayoko Matsushima, Yuko Akazawa, Ken Ohnita, Fuminao Takeshima, Toshiyuki Nakayama, Tomayoshi Hayashi, Haruhiro Inoue, Kazuhiko Nakao and Hajime Isomoto
    Citation: BMC Gastroenterology 2013 13:22
    Content type: Research article Published on:

  48. Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor, on liver injury induced by...

    Authors: Yoshiro Tomishima, Yoichi Ishitsuka, Naoya Matsunaga, Minako Nagatome, Hirokazu Furusho, Mitsuru Irikura, Shigehiro Ohdo and Tetsumi Irie
    Citation: BMC Gastroenterology 2013 13:21
    Content type: Research article Published on:

  49. Alterations in the fecal bacterial flora occur in inflammatory bowel disease (IBD). We examined the abundance and diversity of Clostridium leptum group, an important group of carbohydrate-fermenting bacteria, in ...

    Authors: Jayakanthan Kabeerdoss, Vijayalakshmi Sankaran, Srinivasan Pugazhendhi and Balakrishnan S Ramakrishna
    Citation: BMC Gastroenterology 2013 13:20
    Content type: Research article Published on:

  50. The objective of this study was to compare celiac disease (CD)– specific antibody tests to determine if they could replace jejunal biopsy in patients with a high pretest probability of CD.

    Authors: Annemarie Bürgin-Wolff, Buser Mauro and Hadziselimovic Faruk
    Citation: BMC Gastroenterology 2013 13:19
    Content type: Research article Published on:
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