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  1. Systemic sclerosis (SSc) is a generalized disorder of unknown etiology affecting the connective tissue of the body. It affects the skin and various internal organs. Gastrointestinal tract involvement is seen i...

    Authors: Tasleem Arif, Qazi Masood, Jaswinder Singh and Iffat Hassan
    Citation: BMC Gastroenterology 2015 15:24
    Content type: Research article Published on:

  2. Empiric triple treatments for Helicobacter pylori (H. pylori) are increasingly unsuccessful. We evaluated factors associated with failure of these treatments in the central region of Portugal.

    Authors: Nuno Almeida, Maria Manuel Donato, José Manuel Romãozinho, Cristina Luxo, Olga Cardoso, Maria Augusta Cipriano, Carol Marinho, Alexandra Fernandes, Carlos Calhau and Carlos Sofia
    Citation: BMC Gastroenterology 2015 15:23
    Content type: Research article Published on:

  3. Non-alcoholic steatohepatitis (NASH) is associated with hepatic fibrogenesis. Despite well-known cholesterol-lowering action of statins, their mechanisms against NASH-mediated fibrogenesis remain unclear. This...

    Authors: Lee-Won Chong, Yi-Chao Hsu, Ting-Fang Lee, Yun Lin, Yung-Tsung Chiu, Kuo-Ching Yang, Jaw-Ching Wu and Yi-Tsau Huang
    Citation: BMC Gastroenterology 2015 15:22
    Content type: Research article Published on:

  4. We have demonstrated previously that NFKB1 single nucleotide polymorphism (SNP) rs4648068 GG homozygote was associated with the increased risk of gastric cancer in Chinese Han population. In this study, we con...

    Authors: Ying Chen, Renquan Lu, Hui Zheng, Ran Xiao, Jingjing Feng, Hongling Wang, Xiang Gao and Lin Guo
    Citation: BMC Gastroenterology 2015 15:21
    Content type: Research article Published on:

  5. Liver surgery in perihilar cholangiocarcinoma (PHC) is associated with high postoperative morbidity because the tumor typically causes biliary obstruction. Preoperative biliary drainage is used to create a saf...

    Authors: Jimme K Wiggers, Robert JS Coelen, Erik AJ Rauws, Otto M van Delden, Casper HJ van Eijck, Jeroen de Jonge, Robert J Porte, Carlijn I Buis, Cornelis HC Dejong, I Quintus Molenaar, Marc GH Besselink, Olivier RC Busch, Marcel GW Dijkgraaf and Thomas M van Gulik
    Citation: BMC Gastroenterology 2015 15:20
    Content type: Study protocol Published on:

  6. Pancreatitis induced by hypertriglyceridemia (HTG) has gained much attention. However, very limited numbers of studies have focused on the clinical significance of TG elevation in non-HTG induced pancreatitis,...

    Authors: Long Cheng, Zhulin Luo, Ke Xiang, Jiandong Ren, Zhu Huang, Lijun Tang and Fuzhou Tian
    Citation: BMC Gastroenterology 2015 15:19
    Content type: Research article Published on:

  7. Although numerous epidemiological studies on appendicitis have been conducted worldwide, only a few studies have paid attention to the effect of socioeconomic status on appendicitis, particularly studies focus...

    Authors: Kai-Biao Lin, Chien-Lung Chan, Nan-Ping Yang, Robert K Lai, Yuan-Hung Liu, Shun-Zhi Zhu and Ren-Hao Pan
    Citation: BMC Gastroenterology 2015 15:18
    Content type: Research article Published on:

  8. Gastric epithelial dysplasia (GED) can be morphologically categorized into adenomatous and foveolar types. To date, there have been few studies on the clinical characteristics of GEDs according to the morpholo...

    Authors: Dong Hoon Baek, Gwang Ha Kim, Do Youn Park, Bong Eun Lee, Hye Kyung Jeon, Won Lim and Geun Am Song
    Citation: BMC Gastroenterology 2015 15:17
    Content type: Research article Published on:

  9. Alpha-fetoprotein (AFP)-producing pancreatic neuroendocrine tumors (pNETs) are rare, and the few reported cases usually coexisted with other malignant components such as adenocarcinoma or hepatoid carcinoma. W...

    Authors: Xiang Zhu, Huijuan Yong, Li Zhang, Yonghui Huang, Jie Zheng, Cuiling Liu, Dianrong Xiu and Pan Zhang
    Citation: BMC Gastroenterology 2015 15:16
    Content type: Case report Published on:

  10. Gastrointestinal endoscopy plays a crucial role in the diagnosis and management of gastrointestinal disorders. When endoscopy is indicated during pregnancy, concerns about the effects on pregnancy outcome ofte...

    Authors: Alison De Lima, Boris Galjart, Pieter HA Wisse, Wichor M Bramer and C Janneke van der Woude
    Citation: BMC Gastroenterology 2015 15:15
    Content type: Research article Published on:

  11. Tofacitinib, a novel, oral Janus kinase inhibitor, demonstrated a dose-dependent efficacy for induction of clinical response and remission in patients with active ulcerative colitis (UC). The objective of the ...

    Authors: Julián Panés, Chinyu Su, Andrew G Bushmakin, Joseph C Cappelleri, Carla Mamolo and Paul Healey
    Citation: BMC Gastroenterology 2015 15:14
    Content type: Research article Published on:

  13. Cross-sectional imaging techniques as magnetic resonance enterography (MRE) may offer additional information on transmural inflammation, stricturing and fistulising complications in Crohn’s disease (CD). The p...

    Authors: Feng Qi, Shen Jun, Qiao Yu Qi, Peng Jiang Chen, Geng Xiao Chuan, Zhu Jiong and Xu Jian Rong
    Citation: BMC Gastroenterology 2015 15:12
    Content type: Research article Published on:

  14. Colonoscopy offers limited protection against right-sided colon cancer, a significant proportion of which arise from the serrated pathway of carcinogenesis. The aim of this study was to compare cap-assisted co...

    Authors: Fadi Rzouq, Neil Gupta, Sachin Wani, Prateek Sharma, Ajay Bansal and Amit Rastogi
    Citation: BMC Gastroenterology 2015 15:11
    Content type: Research article Published on:

  15. Although poor sleep is common in numerous gastrointestinal diseases, data are scarce on the risk of poor sleep in celiac disease. The objective of this study was to estimate the risk of repeated use of hypnoti...

    Authors: Karl Mårild, Timothy I Morgenthaler, Virend K Somers, Suresh Kotagal, Joseph A Murray and Jonas F Ludvigsson
    Citation: BMC Gastroenterology 2015 15:10
    Content type: Research article Published on:

  16. Environmental and genetic factors contribute to variation in irritable bowel syndrome (IBS), anxiety and depression. Comorbidity between these disorders is high. A previous investigation of our population-base...

    Authors: May-Bente Bengtson, Geir Aamodt, Morten H Vatn and Jennifer R Harris
    Citation: BMC Gastroenterology 2015 15:9
    Content type: Research article Published on:

  17. Endoscopic biliary stenting (EBS) is one of the most important palliative treatments for biliary tract cancer. However, reflux cholangitis arising from bacterial adherence to the inner wall of the stent must b...

    Authors: Noritoshi Kobayashi, Seitaro Watanabe, Kunihiro Hosono, Kensuke Kubota, Atsushi Nakajima, Takashi Kaneko, Kazuya Sugimori, Motohiko Tokuhisa, Ayumu Goto, Ryutaro Mori, Koichi Taniguchi, Ryusei Matsuyama, Itaru Endo, Shin Maeda and Yasushi Ichikawa
    Citation: BMC Gastroenterology 2015 15:8
    Content type: Technical advance Published on:

  18. Intra-tumor heterogeneity is a potential cause for failure of targeted therapy in gastric cancer, but the extent of heterogeneity of established (HER2) or potential (EGFR, CCND1) target genes and prognostic ge...

    Authors: Phillip Stahl, Carsten Seeschaaf, Patrick Lebok, Asad Kutup, Maximillian Bockhorn, Jakob R Izbicki, Carsten Bokemeyer, Ronald Simon, Guido Sauter and Andreas H Marx
    Citation: BMC Gastroenterology 2015 15:7
    Content type: Research article Published on:

  19. Patients with chronic liver disease frequently suffer from malnutrition, together with a decline in their health-related quality of life.

    Authors: María Teresa García-Rodríguez, María del Carmen Piñón-Villar, Beatriz López-Calviño, Alejandra Otero-Ferreiro, Francisco Suárez-López, Manuel Gómez-Gutiérrez and Salvador Pita-Fernández
    Citation: BMC Gastroenterology 2015 15:6
    Content type: Study protocol Published on:

  20. In this study, we evaluated the technical feasibility of mucosal approximation of large ulcers via an endoscopic suturing system after endoscopic submucosal dissection (ESD), assessed the durability of these s...

    Authors: Masakuni Kobayashi, Kazuki Sumiyama, Yamato Ban, Akira Dobashi, Tomohiko Richard Ohya, Daisuke Aizawa, Shinichi Hirooka, Kiyokazu Nakajima and Hisao Tajiri
    Citation: BMC Gastroenterology 2015 15:5
    Content type: Research article Published on:

  21. Celiac disease (CD) is a global health problem and its prevalence is underestimated, especially in Latin American populations. Our aim was to evaluate the clinical features, psychological factors, and health-r...

    Authors: Karen Lizzete Ramírez-Cervantes, José María Remes-Troche, María del Pilar Milke-García, Viridiana Romero and Luis F Uscanga
    Citation: BMC Gastroenterology 2015 15:4
    Content type: Research article Published on:

  22. The prevalence of obesity has increased at alarming rates, particularly because of the increased consumption of high-fat diets (HFDs). The influence of HFDs on intrinsic innervation and the intestinal wall has...

    Authors: Angelica Soares, Evandro José Beraldi, Paulo Emílio Botura Ferreira, Roberto Barbosa Bazotte and Nilza Cristina Buttow
    Citation: BMC Gastroenterology 2015 15:3
    Content type: Research article Published on:

  23. MicroRNA-21 (miR-21) is an oncogenic microRNA that regulates the expression of multiple cancer-related target genes. miR-21 has been associated with progression of some types of cancer. Metastasis-associated p...

    Authors: Won Kyung Kang, Jin Kwon Lee, Seong Taek Oh, Sung Hak Lee and Chan Kwon Jung
    Citation: BMC Gastroenterology 2015 15:2
    Content type: Research article Published on:

  24. Esophageal stenosis following endoscopic submucosal dissection (ESD) is a serious adverse event that makes subsequent management more difficult.

    Authors: Hiroaki Takahashi, Yoshiaki Arimura, Satoshi Okahara, Junichi Kodaira, Kaku Hokari, Hiroyuki Tsukagoshi, Yasuhisa Shinomura and Masao Hosokawa
    Citation: BMC Gastroenterology 2015 15:1
    Content type: Research article Published on:

  25. Activated hepatic stellate cells are the main source of excessive collagen deposition in liver fibrosis. Here we report the inhibitory effects of the combinational treatment of two natural products, astragalus...

    Authors: Jin Zheng, Li-tian Ma, Qin-you Ren, Lu Li, Yi Zhang, Heng-jun Shi, Yi Liu, Cheng-hua Li, Yong-qi Dou, Shao-dan Li, Hui Zhang and Ming-hui Yang
    Citation: BMC Gastroenterology 2014 14:224
    Content type: Research article Published on:

  26. Investigations of genetic alterations and correlations with histology or morphology could provide further insights into colorectal carcinogenesis. Nevertheless, such genetic changes were less investigated in a...

    Authors: Li-Chun Chang, Han-Mo Chiu, Chia-Tung Shun, Jin-Tung Liang, Jaw-Town Lin, Chien-Chuan Chen, Yi-Chia Lee and Ming-Shiang Wu
    Citation: BMC Gastroenterology 2014 14:221
    Content type: Research article Published on:

  27. Precise diagnostics of inflammatory bowel disease (IBD) and identification of potentially more aggressive phenotypes of Crohn’s disease (CD) is urgently needed. The aim of our prospective study was to assess t...

    Authors: Darina Kohoutova, Marcela Drahosova, Paula Moravkova, Stanislav Rejchrt and Jan Bures
    Citation: BMC Gastroenterology 2014 14:190
    Content type: Research article Published on:

  28. Wireless pH-monitoring is an accurate method for diagnosing adults with gastroesophageal reflux disease (GERD). The aim of this study was to evaluate the use of the Bravo capsule on children investigated for G...

    Authors: Michaela Boström, Ola Thorsson, Ervin Toth and Daniel Agardh
    Citation: BMC Gastroenterology 2014 14:9001
    Content type: Research article Published on:

  30. Helicobacter pylori chronic infection is associated with chronic gastritis, peptic ulcer, and gastric cancer. Cytotoxin-associated gene A (cagA)-positive H. pylori strains increase the risk of gastric pathology....

    Authors: Fredy Omar Beltrán-Anaya, Tomás Manuel Poblete, Adolfo Román-Román, Salomón Reyes, José de Sampedro, Oscar Peralta-Zaragoza, Miguel Ángel Rodríguez, Oscar del Moral-Hernández, Berenice Illades-Aguiar and Gloria Fernández-Tilapa
    Citation: BMC Gastroenterology 2014 14:223
    Content type: Research article Published on:

  31. Faecal immunochemical tests (FITs) are commonly used in colorectal cancer (CRC) screening. Diagnostic accuracy of FIT differs between males and females. This so far unexplained difference could result in a dis...

    Authors: Sietze T van Turenhout, Frank A Oort, René WM van der Hulst, Arjen P Visscher, Jochim S Terhaar sive Droste, Pieter Scholten, Anneke A Bouman, Gerrit A Meijer, Chris JJ Mulder, Leo GM van Rossum and Veerle MH Coupé
    Citation: BMC Gastroenterology 2014 14:217
    Content type: Research article Published on:

  32. Non-adherence to aminosalicylates is observed among 30% to 45% of patients with ulcerative colitis and increases the risk of relapse. The Health Belief Model is a theoretical model that could offer a broader p...

    Authors: Aki Kawakami, Makoto Tanaka, Masakazu Nishigaki, Naoki Yoshimura, Ryoichi Suzuki, Shin Maeda, Reiko Kunisaki and Noriko Yamamoto-Mitani
    Citation: BMC Gastroenterology 2014 14:220
    Content type: Research article Published on:

  33. Non-invasive models and methods to substitute liver biopsy in chronic hepatitis B (CHB) patients were investigated but their roles as predictors of significant liver histology for diagnosis of HBeAg-negative C...

    Authors: Surat Praneenararat, Naichaya Chamroonkul, Pimsiri Sripongpun, Samornmas Kanngurn, Roongrueng Jarumanokul and Teerha Piratvisuth
    Citation: BMC Gastroenterology 2014 14:218
    Content type: Research article Published on:

  34. HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of reactivation in patients with psoriasis receiving IT. Th...

    Authors: Filomena Morisco, Maria Guarino, Serena La Bella, Luisa Di Costanzo, Nicola Caporaso, Fabio Ayala and Nicola Balato
    Citation: BMC Gastroenterology 2014 14:214
    Content type: Research article Published on:

  35. We aimed at assessing the factors that can influence results of the dissemination of an already validated, new generation commercial Point-of-Care Test (POCT) for detecting celiac disease (CD), in the Mediterr...

    Authors: Stefano Costa, Luca Astarita, Mongi Ben-Hariz, Giovanni Currò, Jernej Dolinsek, Aydan Kansu, Giuseppe Magazzu’, Stefania Marvaso, Dusanka Micetic-Turku, Salvatore Pellegrino, Giuseppe Primavera, Pasqualino Rossi, Andrea Smarrazzo, Francesca Tucci, Carmela Arcidiaco and Luigi Greco
    Citation: BMC Gastroenterology 2014 14:219
    Content type: Research article Published on:

  36. Functional gastrointestinal disorders (FGID) are defined by a combination of chronic or recurrent gastrointestinal symptoms. Prevalence rates of FGID are high. Symptoms are associated with distress, and suffer...

    Authors: Charlotte Markert, Kerstin Suarez-Hitz, Ulrike Ehlert and Urs M Nater
    Citation: BMC Gastroenterology 2014 14:215
    Content type: Research article Published on:

  37. Obesity and related metabolic abnormalities, including excess oxidative stress and chronic inflammation, are associated with colorectal carcinogenesis. Astaxanthin, a xanthophyll carotenoid found in aquatic an...

    Authors: Takahiro Kochi, Masahito Shimizu, Takafumi Sumi, Masaya Kubota, Yohei Shirakami, Takuji Tanaka and Hisataka Moriwaki
    Citation: BMC Gastroenterology 2014 14:212
    Content type: Research article Published on:

  38. Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn’s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has n...

    Authors: Abra Y Guo, Betsy W Stevens, Robin G Wilson, Caitlin N Russell, Melissa A Cohen, Holly C Sturgeon, Anna Thornton, Cosmas Giallourakis, Hamed Khalili, Deanna D Nguyen, Jenny Sauk, Vijay Yajnik, Ramnik J Xavier and Ashwin N Ananthakrishnan
    Citation: BMC Gastroenterology 2014 14:216
    Content type: Research article Published on:

  39. Visceral obesity is often accompanied by non-alcoholic fatty liver disease (NAFLD). Activation of NACHT, LRR and PYD domains-containing proteins (NALPs) may contribute to the release of pro-inflammatory cytoki...

    Authors: Rohini Mehta, Arpan Neupane, Lei Wang, Zachary Goodman, Ancha Baranova and Zobair M Younossi
    Citation: BMC Gastroenterology 2014 14:208
    Content type: Research article Published on:

  40. Whether non-alcoholic fatty liver disease (NAFLD) is a risk factor for gallstones remains uncertain. Few longitudinal or cohort studies have been used to identify this relationship. The aim of this study was t...

    Authors: Jia Liu, Haiyan Lin, Chengqi Zhang, Lu Wang, Shuo Wu, Dongzhi Zhang, Fang Tang, Fuzhong Xue and Yanxun Liu
    Citation: BMC Gastroenterology 2014 14:213
    Content type: Research article Published on:

  41. Women treated with gonadotropin-releasing hormone (GnRH) analogs may develop enteric neuropathy and dysmotility. Administration of a GnRH analog to rats leads to similar degenerative neuropathy and ganglioneur...

    Authors: Elin Sand, Bodil Roth, Björn Weström, Peter Bonn, Eva Ekblad and Bodil Ohlsson
    Citation: BMC Gastroenterology 2014 14:209
    Content type: Research article Published on:

  42. Trends in gastroenteritis-associated mortality are changing over time with development of antibiotic resistant strains of certain pathogens, improved diagnostic methods, and changing healthcare. In 1999, ICD-1...

    Authors: Jyotsna S Jagai, Genee S Smith, Judith E Schmid and Timothy J Wade
    Citation: BMC Gastroenterology 2014 14:211
    Content type: Research article Published on:

  43. Upper gastrointestinal bleeding (UGIB) remains a common medical problem worldwide that has significant associated morbidity, mortality, and health care resource use. This study outlines the aetiology, clinical...

    Authors: Olusegun I Alatise, Adeniyi S Aderibigbe, Adewale O Adisa, Olusegun Adekanle, Augustine E Agbakwuru and Anthony O Arigbabu
    Citation: BMC Gastroenterology 2014 14:210
    Content type: Research article Published on:

  44. Intestinal capillariasis is one of the common causes of malabsorption in the East. Reports emphasizing the roles of clinical, endoscopic and radiologic findings of intestinal capillariasis are limited.

    Authors: Julajak Limsrivilai, Supot Pongprasobchai, Piyaporn Apisarnthanarak and Sathaporn Manatsathit
    Citation: BMC Gastroenterology 2014 14:207
    Content type: Research article Published on:

  45. The pathogenesis of inflammatory bowel disease (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosal immune responses through the pattern recognition receptor. ...

    Authors: Nezha Senhaji, Brehima Diakité, Nadia Serbati, Younes Zaid, Wafaa Badre and Sellama Nadifi
    Citation: BMC Gastroenterology 2014 14:206
    Content type: Research article Published on:

  46. The aim of this study was to analyse the risk of uncomplicated peptic ulcer disease (PUD) in a cohort of new users of low-dose acetylsalicylic acid (ASA) for secondary prevention of cardiovascular events in a ...

    Authors: Ana Ruigómez, Saga Johansson, Péter Nagy, Mar Martín-Pérez and Luis A García Rodríguez
    Citation: BMC Gastroenterology 2014 14:205
    Content type: Research article Published on:

  47. Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the ...

    Authors: Vincenzo Cardinale, Guido Carpino, Raffaele Gentile, Chiara Napoletano, Hassan Rahimi, Antonio Franchitto, Rossella Semeraro, Marianna Nuti, Paolo Onori, Pasquale Bartolomeo Berloco, Massimo Rossi, Daniela Bosco, Roberto Brunelli, Alice Fraveto, Cristina Napoli, Alessia Torrice…
    Citation: BMC Gastroenterology 2014 14:204
    Content type: Research article Published on:

  48. The incidence of early-onset (under 50 years of age) colorectal cancer (CRC) in the Vietnamese has been reported to be quite higher than that in the Japanese. To clarify the differences in genetic alterations ...

    Authors: Tomohiro Miwata, Toru Hiyama, Duc Trong Quach, Huy Minh Le, Ha Ngoc Thi Hua, Shiro Oka, Shinji Tanaka, Koji Arihiro and Kazuaki Chayama
    Citation: BMC Gastroenterology 2014 14:203
    Content type: Research article Published on:

  49. Serotonin exhibits a vast repertoire of actions including cell proliferation and differentiation. The effect of serotonin, as an incomplete mitogen, on liver regeneration has recently been unveiled and is medi...

    Authors: Konstantinos N Tzirogiannis, Kalliopi T Kourentzi, Sofia Zyga, Vassiliki Papalimneou, Maria Tsironi, Agni D Grypioti, Ioannis Protopsaltis, Dimitrios Panidis and Georgios I Panoutsopoulos
    Citation: BMC Gastroenterology 2014 14:201
    Content type: Research article Published on:

  50. Small bowel angioectasia is reported as the most common cause of bleeding in patients with obscure gastrointestinal bleeding. Although the safety and efficacy of endoscopic treatment have been demonstrated, re...

    Authors: Eiji Sakai, Hiroki Endo, Masataka Taguri, Harunobu Kawamura, Leo Taniguchi, Yasuo Hata, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Ken Ishii, Jun Arimoto, Eiji Yamada, Hidenori Ohkubo, Takuma Higurashi, Tomoko Koide, Takashi Nonaka…
    Citation: BMC Gastroenterology 2014 14:200
    Content type: Research article Published on:
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BMC Gastroenterology

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