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  1. Patients using opioids to treat chronic non-cancer pain often experience side effects that may affect health-related quality of life (HRQOL). These side effects include opioid-induced constipation (OIC), sedat...

    Authors: Michelle S. Keller, Alma Jusufagic and Brennan M. R. Spiegel

    Citation: BMC Gastroenterology 2019 19:182

    Content type: Research article

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  2. Pneumatic dilation (PD) is often billed as a “short term” treatment for achalasia but anecdotally can last years. This study sought to explore how long a single pneumatic dilation may induce symptom remission ...

    Authors: Abid T. Javed, Kevin Batte, Mohamed Khalaf, Mustafa Abdul-Hussein, Pooja S. Elias and Donald O. Castell

    Citation: BMC Gastroenterology 2019 19:181

    Content type: Research article

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  3. A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn’s disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients...

    Authors: Xue-hua Li, Zhuang-nian Fang, Tian-ming Guan, Jin-jiang Lin, Can-hui Sun, Si-yun Huang, Ren Mao, Bao-lan Lu, Qing-hua Cao, Shi-ting Feng and Zi-ping Li

    Citation: BMC Gastroenterology 2019 19:180

    Content type: Research article

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  4. Studies indicate that gastric cancer (GC) incidence has decreased, whereas signet ring cell carcinoma (SRC) incidence has increased. However, recent trends in GC incidence are unclear. We used our hospital can...

    Authors: Hiroshi Ohyama, Dai Yoshimura, Yosuke Hirotsu, Kenji Amemiya, Hiroyuki Amano, Yuko Miura, Hiroshi Ashizawa, Keiko Nakagomi, Shinya Takaoka, Kenji Hosoda, Yoji Suzuki, Toshio Oyama, Masao Hada, Yuichiro Kojima, Hitoshi Mochizuki and Masao Omata

    Citation: BMC Gastroenterology 2019 19:178

    Content type: Research article

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  5. Choledocholithiasis is an endemic condition in the world. Although rare, foreign body migration with biliary complications needs to be considered in the differential diagnosis for patients presenting with typi...

    Authors: Min Yu, Bowen Huang, Ye Lin, Yuxue Nie, Zixuan Zhou, Shanshan Liu and Baohua Hou

    Citation: BMC Gastroenterology 2019 19:177

    Content type: Case report

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  6. Colonoscopy is associated with a risk of peritonitis in patients on peritoneal dialysis. However, no study has yet described the risk factors in play.

    Authors: Tae-Geun Gweon, Sung Hoon Jung, Sang Woo Kim, Kang-Moon Lee, Dae Young Cheung, Bo-In Lee and Hwang Choi

    Citation: BMC Gastroenterology 2019 19:175

    Content type: Research article

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  7. To compare the outcomes of submucosal tunneling endoscopic resection (STER) and submucosal excavation (ESE) for the treatment of submucosal tumors (SMTs) arising from the muscularis propria (MP) at the esophag...

    Authors: Hong-wei Xu, Qi Zhao, Shu-xia Yu, Ying Jiang, Jing-hua Hao and Bin Li

    Citation: BMC Gastroenterology 2019 19:174

    Content type: Research article

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  8. Molecular characteristics of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been well documented in Western, but not in Chinese, populations.

    Authors: Jiang Liu, Li Tang, Jinhua Yi, Guimei Li, Youwang Lu, Yu Xu, Shuhua Zhao, Rui Mao, Xiaolu Li, Li Ren and Kunhua Wang

    Citation: BMC Gastroenterology 2019 19:173

    Content type: Research article

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  9. Hepatolithiasis, featuring high incidence, severe symptoms, and common recurrence, poses a heavy disease burden. Endoscopic management provides an opportunity to cure hepatolithiasis, but fails to properly res...

    Authors: Jianying Lou, Qida Hu, Tao Ma, Wei Chen, Ji Wang and Prasoon Pankaj

    Citation: BMC Gastroenterology 2019 19:172

    Content type: Technical advance

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  10. The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infli...

    Authors: Lisa Horgan, Siobhain Mulrennan, Lloyd D’Orsogna and Andrew McLean-Tooke

    Citation: BMC Gastroenterology 2019 19:171

    Content type: Case report

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  11. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) can induce a stronger regenerative ability than traditional 2-stage hepatectomy (TSH). ALPPS has become popular for achieving...

    Authors: Xukun Wu, Jiawei Rao, Xiaozhuan Zhou, Ronghai Deng and Yi Ma

    Citation: BMC Gastroenterology 2019 19:170

    Content type: Research article

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  12. Pruritus is a common symptom seen in patients with chronic liver disease. However, frequency and severity of pruritus in patients with chronic liver disease is unclear. We investigated frequency, severity and ...

    Authors: Hatsue Fujino, Mio Tanaka, Michio Imamura, Kei Morio, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Tomokazu Kawaoka, Shoichi Takahashi, Daiki Miki, Masataka Tsuge, Akira Hiramatsu, Hiroshi Aikata, C. Nelson Hayes and Kazuaki Chayama

    Citation: BMC Gastroenterology 2019 19:169

    Content type: Research article

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  13. The efficacy of some therapeutic methods (open surgical debridement (OSD), conservative treatment (CST) and minimally invasive drainage (MID)) for severe acute pancreatitis (SAP) and moderately severe acute pa...

    Authors: Kai Zhang, Xiaole Zhu, Chaoqun Hou, Chenyuan Shi, Yi Miao and Qiang Li

    Citation: BMC Gastroenterology 2019 19:168

    Content type: Research article

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  14. To investigate the von Willebrand factor to ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma (HCC) in cirrhosis.

    Authors: Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Keisuke Nakanishi, Yuki Tsuji, Naotaka Shimozato, Kei Moriya, Kenichiro Seki, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Ryuichi Noguchi, Masanori Matsumoto…

    Citation: BMC Gastroenterology 2019 19:167

    Content type: Research article

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  15. A nested qualitative interview study within the CONSTRUCT trial was conducted to explore experiences and perceptions of patients with acute severe ulcerative colitis following treatment with infliximab or cicl...

    Authors: Frances Rapport, Clare Clement, Anne C. Seagrove, Laith Alrubaiy, Hayley A. Hutchings and John G. Williams

    Citation: BMC Gastroenterology 2019 19:166

    Content type: Research article

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  16. Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review...

    Authors: Shiwei Zhu, Ben Wang, Qiong Jia and Liping Duan

    Citation: BMC Gastroenterology 2019 19:165

    Content type: Research article

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  17. Small nucleolar RNA host gene 6 (SNHG6) regulates diverse biological processes in cancers. Potential function of SNHG6 in human colon and rectal adenocarcinoma (CRC) was evaluated.

    Authors: Qianwen Shao, Jing Xu, Rong Deng, Wei Wei, Bing Zhou, Chao Yue, Miaoling Zhu and Haitao Zhu

    Citation: BMC Gastroenterology 2019 19:163

    Content type: Research article

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  18. Plaque psoriasis and inflammatory bowel disease (IBD) are both chronic immune-mediated inflammatory diseases with an overlapping genetic profile and have been linked in epidemiological studies. Psoriasis and I...

    Authors: Matthew K. Smith, Jay Pai, Remo Panaccione, Paul Beck, Jose G. Ferraz and Humberto Jijon

    Citation: BMC Gastroenterology 2019 19:162

    Content type: Case report

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  19. The Fecal Occult Blood Test (FOBT) is one of the diagnostic modalities indicated for screening patients for Colorectal Cancer (CRC). Despite being approved only for screening for CRC, numerous studies in the p...

    Authors: Sarthak Soin, Olalekan Akanbi, Abdullah Ahmed, Yunha Kim, Sarbagya Pandit, Igor Wroblewski and Nasir Saleem

    Citation: BMC Gastroenterology 2019 19:161

    Content type: Research article

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  20. Extracorporeal liver support therapies (ELS) are technical options (for bridge-to-recovery as well as bridge-to-transplant) in patients with acute liver dysfunction (e.g. acute liver failure (ALF), acute-on ch...

    Authors: Thomas Wiesmann, Dominic Hoenl, Hinnerk Wulf and Marc Irqsusi

    Citation: BMC Gastroenterology 2019 19:160

    Content type: Research article

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  21. The pathways and mechanism by which associations between the gut microbiome and the brain, termed the microbiome-gut-brain axis (MGBA), are manifest but remain to be fully elucidated. This study aims to use bi...

    Authors: Sa’ed H. Zyoud, Simon Smale, W. Stephen Waring, Waleed M. Sweileh and Samah W. Al-Jabi

    Citation: BMC Gastroenterology 2019 19:158

    Content type: Research article

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  22. An intestinal stoma, though a life-saving procedure on the care of many gastrointestinal conditions, carries significant number of complications. This study describes the common indications, complications, and...

    Authors: Alicia Massenga, Alfred Chibwae, Aloyce A. Nuri, Merchades Bugimbi, Yasin K. Munisi, Ramadhani Mfinanga and Phillipo L. Chalya

    Citation: BMC Gastroenterology 2019 19:157

    Content type: Research article

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  23. Haemolytic uraemic syndrome is a rarely seen in adults often leading to critical illness. This case highlights how difficult it can be to establish a diagnosis and treat when a patient presents with bloody dia...

    Authors: Shiva Thambiah Radhakrishnan, Aruchuna Ruban, Aarthy Kanmany Uthayakumar, Patrizia Cohen, Jeremy Levy and Julian Teare

    Citation: BMC Gastroenterology 2019 19:156

    Content type: Case report

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  24. Intramural esophageal bronchogenic cyst is very rare. Surgical removal of the cysts is advised even the patients are asymptomatic, since the cyst can lead to complications, and there is a risk of malignant tra...

    Authors: Xun Yang, Ye Zong, Hai-Ying Zhao, Yong-Dong Wu and Ming Ji

    Citation: BMC Gastroenterology 2019 19:155

    Content type: Case report

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  25. Systemic lupus erythematosus is an autoimmune disease which can affect multiple organs, resulting in significant mortality and morbidity. Lupus enteritis is one of the rare complications of SLE, defined as vas...

    Authors: Xiu-Li Zhu, Xue-Mei Xu, Si Chen, Qiao-Min Wang and Kai-Guang Zhang

    Citation: BMC Gastroenterology 2019 19:154

    Content type: Case report

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  26. Primary sclerosing cholangitis is a chronic cholestatic liver disease. The pathomechanism is still not fully understood, but there is evidence that immune-mediated processes may contribute to disease progression.

    Authors: Theresa Hippchen, Peter Sauer, Benjamin Göppert, Peter Schirmacher, Daniel Nils Gotthardt, Karl-Heinz Weiss, Wolfgang Stremmel and Christian Rupp

    Citation: BMC Gastroenterology 2019 19:153

    Content type: Research article

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  27. With the development and application of endoscopic technology, most pedunculated polyps can be absolutely resected with a complete specimen by hot snare polypectomy (HSP). Brunner’s gland hamartoma (BGH) is a ...

    Authors: Lizhi Yi, Zhengyu Cheng, Huarong Qiu, Jianjun Yang, Tao Wang and Ke Liu

    Citation: BMC Gastroenterology 2019 19:151

    Content type: Case report

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  28. Alcoholic liver disease (ALD) is the leading cause of liver transplantation (LT). The magnitude and risk factors of post-LT alcohol relapse are not well described. We conducted a meta-analysis to evaluate alco...

    Authors: Lancharat Chuncharunee, Noriyo Yamashiki, Ammarin Thakkinstian and Abhasnee Sobhonslidsuk

    Citation: BMC Gastroenterology 2019 19:150

    Content type: Research article

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  29. To evaluate the role of colonoscopy in infants and young children and clarify the distribution of colonoscopy-requiring diseases in this age group.

    Authors: Ryusuke Nambu, Shin-ichiro Hagiwara, Fumihiko Kakuta, Tomoko Hara, Hirotaka Shimizu, Daiki Abukawa, Itaru Iwama, Seiichi Kagimoto and Katsuhiro Arai

    Citation: BMC Gastroenterology 2019 19:149

    Content type: Research article

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  30. Caspase-1 is an evolutionarily conserved enzyme that proteolytically cleaves the precursors of the inflammatory cytokines interleukin 1β and interleukin 18. However, the role of caspase-1 in determining the se...

    Authors: Xiangying Zhang, Peiling Dong, Lin Xu, Yuan Tian, Huayin Sun, Hongbo Shi, Zhongping Duan, Liyan Chen and Feng Ren

    Citation: BMC Gastroenterology 2019 19:148

    Content type: Research article

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  31. Prior hepatitis B virus infection (PBI) may increase the risk of developing hepatocellular carcinoma (HCC), but the impact of PBI on clinical outcomes following treatment for HCC remains unknown. The aim of th...

    Authors: Yutaka Midorikawa, Tadatoshi Takayama, Hisashi Nakayama, Tokio Higaki, Masamichi Moriguchi, Kyoji Moriya, Tatsuo Kanda, Shunichi Matsuoka and Mitsuhiko Moriyama

    Citation: BMC Gastroenterology 2019 19:147

    Content type: Research article

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  32. Microvessel density (MVD), as a derived marker for angiogenesis, has been associated with poor outcome in several types of cancer. This study aimed to evaluate the prognostic value of MVD in stage II and III c...

    Authors: Sjoerd H. den Uil, Evert van den Broek, Veerle M. H. Coupé, Thomas T. Vellinga, Pien M. Delis-van Diemen, Herman Bril, Eric J. Th. Belt, Onno Kranenburg, Hein B. A. C. Stockmann, Jeroen A. M. Belien, Gerrit A. Meijer and Remond J. A. Fijneman

    Citation: BMC Gastroenterology 2019 19:146

    Content type: Research article

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  33. This study aimed to understand the disease characteristics and treatment outcomes of Crohn’s disease (CD) in a real-world setting in China.

    Authors: Yue Li, Baili Chen, Xiang Gao, Naizhong Hu, Meifang Huang, Zhihua Ran, Zhanju Liu, Jie Zhong, Duowu Zou, Xiaoping Wu, Jianlin Ren, Jianqiu Sheng, Ping Zheng, Huahong Wang, Minhu Chen, Junrong Chen…

    Citation: BMC Gastroenterology 2019 19:145

    Content type: Research article

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  34. Splenic nodules are uncommon entities that occur rarely in the general population. Although an infectious etiology (primarily bacteria, followed by mycobacteria) is usually found, noninfectious diseases, inclu...

    Authors: D. F. Bavaro, G. Ingravallo, F. Signorile, F. Fortarezza, F. Di Gennaro, G. Angarano and A. Saracino

    Citation: BMC Gastroenterology 2019 19:144

    Content type: Case report

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  35. Reports showed adenoma miss rates (AMRs) of 22.5–27% in the right colon and 23.4–33.3% in the proximal colon. Missed lesions could contribute to postcolonoscopy cancers. Water exchange (WE) with near-complete ...

    Authors: Chi-Liang Cheng, Yen-Lin Kuo, Yu-Hsi Hsieh, Jui-Hsiang Tang and Felix W. Leung

    Citation: BMC Gastroenterology 2019 19:143

    Content type: Research article

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  36. Paragangliomas, also known as chemodectomas, are rare tumors arise from chemoreceptor tissue, and most commonly locate at the bifurcation of the common carotid, the jugular foramen, aortic arch, and retroperit...

    Authors: Zhao-Ru Dong, Yan-Ni Xia, Yue-Yi Zhao, Rui Wu, Kai-Xuan Liu, Kai Shi, Lun-Jie Yan, Cheng-Yu Yao, Yu-Chuan Yan and Tao Li

    Citation: BMC Gastroenterology 2019 19:142

    Content type: Case report

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:152

  37. Abdominal compartment syndrome (ACS) is associated with mortality in patients with critical illness such as severe acute pancreatitis, but it remains unclear whether decompressive laparotomy for ACS can improv...

    Authors: Shinya Ikeda, Takuma Kagami, Shinya Tani, Takahiro Uotani, Mihoko Yamade, Yasushi Hamaya, Yoshifumi Morita, Takanori Sakaguchi, Satoshi Osawa and Ken Sugimoto

    Citation: BMC Gastroenterology 2019 19:141

    Content type: Case report

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  38. Individuals can be infected with multiple strains of Helicobacter pylori. However, the differences among co-infecting strains have not been well analyzed yet. This study aimed to investigate whether the virulence...

    Authors: Ji Won Seo, Jae Yong Park, Tae-Seop Shin and Jae Gyu Kim

    Citation: BMC Gastroenterology 2019 19:140

    Content type: Research article

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  39. Endoscopic transpapillary cannulation of the gallbladder is useful but challenging. This study aimed to investigate cystic duct anatomy patterns, which may guide cystic duct cannulation.

    Authors: Jun Cao, Xiwei Ding, Han Wu, Yonghua Shen, Ruhua Zheng, Chunyan Peng, Lei Wang and Xiaoping Zou

    Citation: BMC Gastroenterology 2019 19:139

    Content type: Research article

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  40. The increasing life expectancy of individuals with Cystic Fibrosis (CF) is likely to be associated with new age-related challenges, colorectal cancer (CRC) most notably; recent consensus recommendations for CRC s...

    Authors: James M. Abraham, Kathleen Mahan, Tetyana Mettler, Jordan M. Dunitz and Alexander Khoruts

    Citation: BMC Gastroenterology 2019 19:137

    Content type: Case report

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  41. Risk stratification for patients with nonvariceal upper gastrointestinal (NVUGI) bleeding is crucial for successful prognosis and treatment. Recently, the AIMS65 score has been used to predict mortality risk a...

    Authors: Min Seong Kim, Jeongmin Choi and Won Chang Shin

    Citation: BMC Gastroenterology 2019 19:136

    Content type: Research article

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  42. This study aims to evaluate the efficacy and safety of detecting and removing residual common bile duct stones (CBDS) using direct peroralcholangioscopy (DPOC) after performing endoscopic retrograde cholangiop...

    Authors: Jun-Jie Yang, Xiong-Chang Liu, Xiao-Qin Chen, Qi-Yong Zhang and Tian-Rang Liu

    Citation: BMC Gastroenterology 2019 19:135

    Content type: Research article

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  43. In cirrhosis upper-gastrointestinal-endoscopy (UGIE) identifies oesophageal varices (OV). UGIE is unavailable in most resource-limited settings. Therefore, we assessed prediction of presence of OV using hemato...

    Authors: K. Perera, S. K. Kodisinghe, D. S. Ediriweera, D. Moratuwagama, S. Williams, A. Pathmeswaran, M. A. Niriella and H. J. de Silva

    Citation: BMC Gastroenterology 2019 19:134

    Content type: Research article

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  44. The aim of the present study was to evaluate the effects of curcumin supplementation on inflammatory indices, and hepatic features in patients with non-alcoholic fatty liver disease (NAFLD).

    Authors: Saeede Saadati, Amir Sadeghi, Asieh Mansour, Zahra Yari, Hossein Poustchi, Mehdi Hedayati, Behzad Hatami and Azita Hekmatdoost

    Citation: BMC Gastroenterology 2019 19:133

    Content type: Research article

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