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  1. Approximately 1% of the population suffer from coeliac disease. However, the disease is heavily underdiagnosed. Unexplained symptoms may lead to incremented medical consultations and productivity losses. The a...

    Authors: Anniina Ukkola, Kalle Kurppa, Pekka Collin, Heini Huhtala, Leena Forma, Leila Kekkonen, Markku Mäki and Katri Kaukinen
    Citation: BMC Gastroenterology 2012 12:136
  2. Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitati...

    Authors: James P Franciosi, Kevin A Hommel, Allison B Greenberg, Charles W DeBrosse, Alexandria J Greenler, J Pablo Abonia, Marc E Rothenberg and James W Varni
    Citation: BMC Gastroenterology 2012 12:135
  3. G protein-coupled receptors (GPCRs) represent one of the largest families of transmembrane receptors and the most common drug target. The Adhesion subfamily is the second largest one of GPCRs and its several memb...

    Authors: Luca Badiali, Jonathan Cedernaes, Pawel K Olszewski, Olof Nylander, Anna V Vergoni and Helgi B Schiöth
    Citation: BMC Gastroenterology 2012 12:134
  4. In this post-hoc analysis of a randomized, double blind, placebo controlled trial, we measured the sensitivity and specificity of Helicobacter pylori IgG-antibody titer changes, hematoxylin and eosin (H&E) stains...

    Authors: Harald E Vonkeman, HTJI deLeest, MAFJ van deLaar, J vanBaarlen, KSS Steen, WF Lems, JWJ Bijlsma, EJ Kuipers, HHML Houben, M Janssen and BAC Dijkmans
    Citation: BMC Gastroenterology 2012 12:133
  5. Observational cohort study to assess the association between adherence to oral 5-aminosalicylates (5-ASAs) and all-cause costs and health care utilization among patients with active ulcerative colitis (UC) in ...

    Authors: Debanjali Mitra, Paul Hodgkins, Linnette Yen, Keith L Davis and Russell D Cohen
    Citation: BMC Gastroenterology 2012 12:132
  6. Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30–80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of ...

    Authors: Sara Fill Malfertheiner, Maximilian V Malfertheiner, Siegfried Kropf, Serban-Dan Costa and Peter Malfertheiner
    Citation: BMC Gastroenterology 2012 12:131
  7. People vary in how they respond to symptoms. The purpose of this study was to assess whether serious disease is more likely to be present in patients who report that they take any symptoms less seriously than ...

    Authors: Barbara-Ann Adelstein, Petra Macaskill, Robin M Turner and Les Irwig
    Citation: BMC Gastroenterology 2012 12:130
  8. Short bowel syndrome (SBS) may induce a plethora of clinical symptoms ranging from underweight to nutrient-, vitamin- and electrolyte deficiencies. The objective of this case report is to illustrate how demand...

    Authors: Markus Hahn, Martin Raithel, Alexander Hagel, Teresa Biermann and Bernhard Manger
    Citation: BMC Gastroenterology 2012 12:129
  9. Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts. The aim of the study was to investigate the expression pattern of selecte...

    Authors: Klaus Mönkemüller, Thomas Wex, Doerthe Kuester, Lucia C Fry, Arne Kandulski, Siegfried Kropf, Albert Roessner and Peter Malfertheiner
    Citation: BMC Gastroenterology 2012 12:128
  10. There is no standard therapeutic procedure for the hepatocellular carcinoma (HCC) in patients with poor hepatic reserve function. With the approval of newly developed chemotherapeutic agent of miriplatin, we h...

    Authors: Kenya Kamimura, Takeshi Suda, Yasushi Tamura, Masaaki Takamura, Takeshi Yokoo, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto and Yutaka Aoyagi
    Citation: BMC Gastroenterology 2012 12:127
  11. A gluten-free diet is the only available treatment for celiac disease. Our aim was to investigate the effect of a gluten-free diet on celiac disease related symptoms, health care consumption, and the risk of d...

    Authors: Fredrik Norström, Olof Sandström, Lars Lindholm and Anneli Ivarsson
    Citation: BMC Gastroenterology 2012 12:125
  12. Gastric subepithelial tumors are usually asymptomatic and observed incidentally during endoscopic examination. Although most of these tumors are considered benign, some have a potential for malignant transform...

    Authors: Yin-Yi Chu, Jau-Min Lien, Ming-Hung Tsai, Cheng-Tang Chiu, Tse-Ching Chen, Kuo-Ching Yang and Soh-Ching Ng
    Citation: BMC Gastroenterology 2012 12:124
  13. Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study i...

    Authors: Xiaona Hu, Yiqin Huang, Zhijun Bao, Yiqian Wang, Dongmei Shi, Fang Liu, Zhanjuan Gao and Xiaofeng Yu
    Citation: BMC Gastroenterology 2012 12:123
  14. Blastocystosis is a frequent bowel disease. We planned to to evaluate the prevalence of Blastocystis spp. in patients who applied to the same internal medicine-gastroenterology clinic with or without gastrointes...

    Authors: Ayhan Hilmi Cekin, Yesim Cekin, Yesim Adakan, Ezel Tasdemir, Fatma Gulsun Koclar and Basak Oguz Yolcular
    Citation: BMC Gastroenterology 2012 12:122
  15. Patients with irritable bowel syndrome (IBS) seen by a gastroenterologist often utilize medications that may alter intestinal homeostasis. The question arises whether exposure to these drugs is associated with...

    Authors: Daniel Keszthelyi, Gwen H Dackus, Gwen M Masclee, Joanna W Kruimel and Ad AM Masclee
    Citation: BMC Gastroenterology 2012 12:121
  16. The instrument channels of gastrointestinal (GI) endoscopes may be heavily contaminated with bacteria even after high-level disinfection (HLD). The British Society of Gastroenterology guidelines emphasize the ...

    Authors: King-Wah Chiu, Ming-Chao Tsai, Keng-Liang Wu, Yi-Chun Chiu, Ming-Tzung Lin and Tsung-Hui Hu
    Citation: BMC Gastroenterology 2012 12:120
  17. MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic dec...

    Authors: Anibh M Das, Sabine Drache, Nils Janzen and Andreas Franke
    Citation: BMC Gastroenterology 2012 12:119
  18. Dysregulation of autophagy is important in the pathogenesis of many diseases, including cancer. Several aspects of the biological role of autophagy are however still unclear and the relationship between apopto...

    Authors: Andromachi Kotsafti, Fabio Farinati, Romilda Cardin, Umberto Cillo, Donato Nitti and Marina Bortolami
    Citation: BMC Gastroenterology 2012 12:118
  19. Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease (CLD). About 80% of those exposed to the virus develop a chronic infection. Hyperhomocysteinemia, which is an independent...

    Authors: Mubin Mustafa, Sofia Hussain, Saleem Qureshi, Salman Akbar Malik, Ali Raza Kazmi and Muhammad Naeem
    Citation: BMC Gastroenterology 2012 12:117
  20. Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addi...

    Authors: Weifeng Shi, Chaodong Zhu, Wei Zheng, Michael J Carr, Desmond G Higgins and Zhong Zhang
    Citation: BMC Gastroenterology 2012 12:116
  21. Chronic pancreatitis is characterized by progressive fibrosis, pain and loss of exocrine and endocrine functions. The long-standing chronic pancreatitis and its associated pancreatic fibrosis are the most comm...

    Authors: Han Bai, Xiaokai Chen, Lin Zhang and Xiaoguang Dou
    Citation: BMC Gastroenterology 2012 12:115
  22. Portal vein thrombosis is a frequent complication in end-stage cirrhosis with a considerable peri-operative risk for liver transplant candidates. We aimed to characterize the pre-transplant portal vein thrombo...

    Authors: Rosa Ayala, Silvia Grande, Rosalía Bustelos, Carmen Ribera, Alvaro García-Sesma, Carlos Jimenez, Enrique Moreno and Joaquín Martínez-López
    Citation: BMC Gastroenterology 2012 12:114
  23. Reduced adiponectin is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH), and the I148M Patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism pre...

    Authors: Luca Valenti, Raffaela Rametta, Massimiliano Ruscica, Paola Dongiovanni, Liliana Steffani, Benedetta Maria Motta, Elena Canavesi, Anna Ludovica Fracanzani, Enrico Mozzi, Giancarlo Roviaro, Paolo Magni and Silvia Fargion
    Citation: BMC Gastroenterology 2012 12:111
  24. Primary biliary cirrhosis (PBC) is a disease with genetic and environmental pathogenetic background. Chemicals, infectious agents, hormone therapy, reproductive history and surgical interventions have been imp...

    Authors: Aikaterini Mantaka, Mairi Koulentaki, Gregory Chlouverakis, Jean Marie Enele-Melono, Aikaterini Darivianaki, Maria Tzardi and Elias A Kouroumalis
    Citation: BMC Gastroenterology 2012 12:110
  25. Controversy exists regarding the role of PD1 and its ligand PD-L1 in chronic hepatitis B infection. In some studies, persistent HBV infection has been attributed to high levels of PD-1 and PD-L1 expression on ...

    Authors: Zhang Wenjin, Peng Chuanhui, Wan Yunle, Shaikh Abdul Lateef and Zheng Shusen
    Citation: BMC Gastroenterology 2012 12:109
  26. The purpose of this study was to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs).

    Authors: Stefan Schreiber, Julián Panés, Edouard Louis, Derek Holley, Mandy Buch and Kristine Paridaens
    Citation: BMC Gastroenterology 2012 12:108
  27. To evaluate the prevalence of more virulent H. pylori genotypes in relatives of gastric cancer patients and in patients without family histories of gastric cancer.

    Authors: Dulciene MM Queiroz, Cícero ISM Silva, Maria HRB Goncalves, Manuel B Braga-Neto, Andréa BC Fialho, André MN Fialho, Gifone A Rocha, Andreia MC Rocha, Sérgio A Batista, Richard L Guerrant, Aldo AM Lima and Lucia LBC Braga
    Citation: BMC Gastroenterology 2012 12:107
  28. Enteroaggregative Escherichia coli (EAEC) causes diarrhea, malnutrition and poor growth in children. Human breast milk decreases disease-causing bacteria by supplying nutrients and antimicrobial factors such as l...

    Authors: Eunice B Carvalho, Elizabeth A Maga, Josiane S Quetz, Ila FN Lima, Hemerson YF Magalhães, Felipe AR Rodrigues, Antônio VA Silva, Mara MG Prata, Paloma A Cavalcante, Alexandre Havt, Marcelo Bertolini, Luciana R Bertolini and Aldo AM Lima
    Citation: BMC Gastroenterology 2012 12:106
  29. Previous research has shown variation in the effects of patient factors, including hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study attempts to identify explanat...

    Authors: Sheng-Hung Chen, Yu-Fen Li, Hsueh-Chou Lai, Jung-Ta Kao, Cheng-Yuan Peng, Po-Heng Chuang, Wen-Pang Su and I-Ping Chiang
    Citation: BMC Gastroenterology 2012 12:105
  30. Irritable bowel syndrome (IBS) is a common gastrointestinal disorder. The prevalence of IBS in Asian countries varies from 2.9% to 15.6%. IBS does not result in increased mortality, but is associated with psyc...

    Authors: Yu Tien Wang, Hwee Yong Lim, David Tai, Thinesh L Krishnamoorthy, Tira Tan, Sylvaine Barbier and Julian Thumboo
    Citation: BMC Gastroenterology 2012 12:104
  31. Endoscopic biliary drainage of hilar cholangiocarcinoma is controversial with respect to the optimal types of stents and the extent of drainage. This study evaluated endoscopic palliation in patients with hila...

    Authors: Manuel José Antunes Liberato and Jorge Manuel Tavares Canena
    Citation: BMC Gastroenterology 2012 12:103
  32. Glycoprotein 2 (GP2) was discovered as the major autoantigen of Crohn’s disease (CD)-specific pancreatic autoantibodies (PAB). We investigated anti-GP2 IgA and IgG antibodies as novel serological parameters in...

    Authors: Dimitrios P Bogdanos, Dirk Roggenbuck, Dirk Reinhold, Thomas Wex, Polychronis Pavlidis, Ulrike von Arnim, Peter Malfertheiner, Alastair Forbes, Karsten Conrad and Martin W Laass
    Citation: BMC Gastroenterology 2012 12:102
  33. A retrospective study was performed to assess the causes, diagnostic methods for, and clinical features of, jejunoileal hemorrhage in Shandong province, China and to derive recommendations for management of th...

    Authors: Da-lei Jiang, Hui-ya Liu, Yong Yuan, Jian-chao Sui, Chang-chun Jing, Kai-tong Jiang, Qing-cai Wang, Sheng-an Yuan, Hai-ying Chen and Yan-jing Gao
    Citation: BMC Gastroenterology 2012 12:101
  34. Little data exists on the factors associated with health care seeking behaviour for primary symptoms of colorectal cancer (CRC). This study aimed to identify individual, provider and psychosocial factors assoc...

    Authors: Ryan J Courtney, Christine L Paul, Robert W Sanson-Fisher, Finlay A Macrae, John Attia and Mark McEvoy
    Citation: BMC Gastroenterology 2012 12:100
  35. The “Rusch” intubation stylet is used to make endotracheal tube intubation easy. We designed this study to evaluate the usage of this equipment in the guidance of nasogastric tube (NGT) insertion.

    Authors: Yung-Fong Tsai, Chiao-Fen Luo, Amina Illias, Chih-Chung Lin and Huang-Ping Yu
    Citation: BMC Gastroenterology 2012 12:99
  36. Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate ...

    Authors: Yoichi Hamai, Jun Hihara, Manabu Emi, Yoshiro Aoki, Kei Kushitani, Kazuaki Tanabe and Morihito Okada
    Citation: BMC Gastroenterology 2012 12:98
  37. Mice lacking Foxp3+ regulatory T (Treg) cells develop severe tissue inflammation in lung, skin, and liver with premature death, whereas the intestine remains uninflamed. This study aims to demonstrate the importa...

    Authors: Franziska Boehm, Maria Martin, Rebecca Kesselring, Gabriela Schiechl, Edward K Geissler, Hans-Jürgen Schlitt and Stefan Fichtner-Feigl
    Citation: BMC Gastroenterology 2012 12:97
  38. To correlate CD44/CD24 expression with gastric cancer recurrence and prognosis. Gastric cancer is the second leading cause of cancer mortality due to the high recurrence rate, of which the molecular signature ...

    Authors: Ching-Shya Yong, Chih-Ming Ou Yang, Yenn-Hwei Chou, Chao-Sheng Liao, Chung-Wei Lee and Chin-Cheng Lee
    Citation: BMC Gastroenterology 2012 12:95
  39. Given the increasing burden on colonoscopy capacity, it has been suggested that faecal immunochemical test (FIT) results could guide surveillance colonoscopy intervals. Against this background, we have evaluat...

    Authors: Jochim S Terhaar sive Droste, Sietze T van Turenhout, Frank A Oort, René WM van der Hulst, Vincent A Steeman, Usha Coblijn, Lisette van der Eem, Ruud Duijkers, Anneke A Bouman, Gerrit A Meijer, Annekatrien CTM Depla, Pieter Scholten, Ruud JLF Loffeld, Veerle MH Coupé and Chris JJ Mulder
    Citation: BMC Gastroenterology 2012 12:94
  40. Studies with healthy volunteers have demonstrated that antidepressants can improve immunoregulatory activity and thus they may have a potential to positively impact the disease course in inflammatory bowel dis...

    Authors: Antonina A Mikocka-Walus, Andrea L Gordon, Benjamin J Stewart and Jane M Andrews
    Citation: BMC Gastroenterology 2012 12:93
  41. Unlike other autoimmune liver diseases, primary biliary cirrhosis (PBC) has never been reported in early childhood, while type 2 autoimmune hepatitis (AIH) is eminently a paediatric disease.

    Authors: Pietro Invernizzi, Maria Grazia Alessio, Daniel S Smyk, Ana Lleo, Aurelio Sonzogni, Luca Fabris, Manila Candusso, Dimitrios P Bogdanos, Raffaele Iorio and Giuliano Torre
    Citation: BMC Gastroenterology 2012 12:92
  42. Irritable bowel syndrome (IBS) is a common functional bowel disorder. The post-infectious IBS (PI-IBS) occurs in IBS patients with a history of intestinal infection preceding the onset of symptoms. However, th...

    Authors: Ji Chen, Yangde Zhang and Zhansheng Deng
    Citation: BMC Gastroenterology 2012 12:91
  43. Video capsule endoscopy (VCE) is mainly used to evaluate patients with celiac disease in whom their course after diagnosis has been unfavorable and the diagnosis of adenocarcinoma, lymphoma or refractory celia...

    Authors: Matthew S Chang, Moshe Rubin, Suzanne K Lewis and Peter H Green
    Citation: BMC Gastroenterology 2012 12:90
  44. The interaction between Src homology 2 domain-containing protein tyrosine phosphatase (SHP-2) of gastric epithelial cells and cagA from H. pylori plays a crucial role in developments of gastric atrophy and gastri...

    Authors: Jing Jiang, Zhi-Fang Jia, Fei Kong, Mei-Shan Jin, Yin-Ping Wang, Suyan Tian, Jian Suo and Xueyuan Cao
    Citation: BMC Gastroenterology 2012 12:89
  45. Hepatocytes and stem cells transplantation may be an alternative to liver transplantation in acute or chronic liver disease. We aimed to evaluate the therapeutic potential of mesenchymal stem cells from human ...

    Authors: Patrizia Burra, Diletta Arcidiacono, Debora Bizzaro, Tatiana Chioato, Rosa Di Liddo, Antara Banerjee, Andrea Cappon, Patrizio Bo, Maria Teresa Conconi, Pier Paolo Parnigotto, Silvia Mirandola, Enrico Gringeri, Amedeo Carraro, Umberto Cillo and Francesco Paolo Russo
    Citation: BMC Gastroenterology 2012 12:88
  46. Hyperactivation of nuclear factor-κB (NF-κB) is associated with various types of tumors. This study investigated the susceptibility of the rs4648068 A/G genotype in the intron region of NFKB1 to gastric cancer an...

    Authors: Renquan Lu, Xiang Gao, Yin Chen, Jian Ni, Yongfu Yu, Sheng Li and Lin Guo
    Citation: BMC Gastroenterology 2012 12:87

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