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  1. Methylation at certain human CpG rich sequences increases with age. The mechanisms underlying such age-related changes are unclear, but methylation may accumulate slowly in a clock-like manner from birth and r...

    Authors: Jung Yeon Kim, Robert W Beart and Darryl Shibata
    Citation: BMC Gastroenterology 2005 5:19
  2. Gastric ileus is an unsolved clinical problem and current treatment is limited to supportive measures. Models of ileus using anesthetized animals, muscle strips or isolated smooth muscle cells do not adequatel...

    Authors: Matthew A Firpo, Michael D Rollins, Aniko Szabo, Justin D Gull, Jeffrey D Jackson, Yuanlin Shao, Robert E Glasgow and Sean J Mulvihill
    Citation: BMC Gastroenterology 2005 5:18
  3. Although most patients with hereditary haemochromatosis have HFE C282Y mutations, the lifetime risk to HFE C282Y homozygotes of developing fatal diseases such as hepatocellular carcinoma is uncertain. We have car...

    Authors: Gavin Willis, Vicky Bardsley, Ian W Fellows, Ray Lonsdale, Jennie Z Wimperis and Barbara A Jennings
    Citation: BMC Gastroenterology 2005 5:17
  4. Steatosis is occasionally reported during screening ultrasonography in patients with hepatitis C virus (HCV). We conducted a retrospective observational study to assess the factors associated with steatosis on...

    Authors: Matthew J Hepburn, Jeffrey A Vos, Eric P Fillman and Eric J Lawitz
    Citation: BMC Gastroenterology 2005 5:14
  5. The development of biosensors, based on surface plasmon resonance (SPR) technology, enables monitoring of a variety of biospecific interactions without the need for chemical-, biological- or radiological-label...

    Authors: Fariba Nayeri, Daniel Aili, Tayeb Nayeri, Junyang Xu, Sven Almer, Ingemar Lundström, Britt Åkerlind and Bo Liedberg
    Citation: BMC Gastroenterology 2005 5:13
  6. Pancreatic adenocarcinoma is a highly invasive neoplasm. Epidermal growth factor (EGF) and its receptor are over expressed in pancreatic cancer, and expression correlates with invasion and metastasis. We hypot...

    Authors: Andrew J Shirk and Rahul Kuver
    Citation: BMC Gastroenterology 2005 5:12
  7. In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several ...

    Authors: Pieter CJ ter Borg, Durk Fekkes, Jan Maarten Vrolijk and Henk R van Buuren
    Citation: BMC Gastroenterology 2005 5:11
  8. Colorectal cancer screening is widely recommended, but often under-utilized. In addition, significant demographic differences in screening utilization exist. Insurance coverage may be one factor influencing ut...

    Authors: Cynthia W Ko, William Kreuter and Laura-Mae Baldwin
    Citation: BMC Gastroenterology 2005 5:10
  9. Inconsistent findings have been reported on the occurrence and relevance of creatine kinase (CK) isoenzymes in mammalian liver cells. Part of this confusion might be due to induction of CK expression during me...

    Authors: Georg Meffert, Frank N Gellerich, Raimund Margreiter and Markus Wyss
    Citation: BMC Gastroenterology 2005 5:9
  10. The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pa...

    Authors: Willemijntje A Hoogerwerf, Kelly Gondesen, Shu-Yuan Xiao, John H Winston, William D Willis and Pankaj J Pasricha
    Citation: BMC Gastroenterology 2005 5:8
  11. The exogenous administration of Insulin-like Growth Factor-I (IGF-I) induces hepatoprotective and antifibrogenic actions in experimental liver cirrhosis. To better understand the possible pathways behind the b...

    Authors: María García-Fernández, Inma Castilla-Cortázar, Matías Díaz-Sanchez, Iñigo Navarro, Juan Enrique Puche, Alberto Castilla, Amelia Díaz Casares, Encarna Clavijo and Salvador González-Barón
    Citation: BMC Gastroenterology 2005 5:7
  12. The etiology of ulcerative colitis (UC) is to be understood. The basic pathological feature of UC is intestinal chronic inflammation. Superantigen, such as Staphylococcus enterotoxin B (SEB), is reported to co...

    Authors: Ping-Chang Yang, Chang-Sheng Wang and Zi-Yuan An
    Citation: BMC Gastroenterology 2005 5:6

    The Erratum to this article has been published in BMC Gastroenterology 2006 6:23

  13. Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide...

    Authors: Johannes J Tebbe, Clemens G Tebbe, Silke Mronga, Michael Ritter and Martin KH Schäfer
    Citation: BMC Gastroenterology 2005 5:5
  14. Helicobacter pylori, occurring throughout the world and causing gastroduodenal diseases, is one of the most common chronic bacterial agents in humans. The purpose of this study was to measure the general practit...

    Authors: Sevgi Canbaz, Ahmet Tevfik Sunter, Yildiz Peksen and Hakan Leblebicioglu
    Citation: BMC Gastroenterology 2005 5:4
  15. Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune res...

    Authors: Jonathan Miner, M Monem Gillan, Philip Alex and Michael Centola
    Citation: BMC Gastroenterology 2005 5:3
  16. Hiatus hernia (HH) has major pathophysiological effects favoring gastroesophageal reflux and hence contributing to esophageal mucosa injury, especially in patients with severe gastroesophageal disease. However...

    Authors: Anthie Gatopoulou, Konstantinos Mimidis, Alexandra Giatromanolaki, Vassilios Papadopoulos, Alexandros Polychronidis, Nikolaos Lyratzopoulos, Efthimios Sivridis and Georgios Minopoulos
    Citation: BMC Gastroenterology 2005 5:2
  17. Nidation of floating tumour cells initiates peritoneal carcinosis and limits prognosis of gastro-intestinal tumours. Adhesion of tumour cells to extracellular matrix components is a pivotal step in developing ...

    Authors: Marc Jansen, Karl-Heinz Treutner, Britta Schmitz, Jens Otto, Petra Lynen Jansen, S Neuss and Volker Schumpelick
    Citation: BMC Gastroenterology 2004 4:33
  18. Gastrointestinal symptoms are common in patients with Chronic Fatigue Syndrome (CFS). The objective of this study was to determine the frequency of these symptoms and explore their relationship with objective ...

    Authors: Richard B Burnet and Barry E Chatterton
    Citation: BMC Gastroenterology 2004 4:32
  19. A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, al...

    Authors: Alvaro T Geremias, Marcelo A Carvalho, Radovan Borojevic and Alvaro NA Monteiro
    Citation: BMC Gastroenterology 2004 4:30
  20. In the hypothesis that the increased collagen metabolism in the intestinal wall of patients affected by inflammatory bowel disease (IBD) is reflected in the systemic circulation, we aimed the study to evaluate...

    Authors: Matilde De Simone, Ugo Cioffi, Ettore Contessini-Avesani, Barbara Oreggia, Roberta Paliotti, Alberto Pierini, Gianni Bolla, Elide Oggiano, Stefano Ferrero, Fabio Magrini and Michele M Ciulla
    Citation: BMC Gastroenterology 2004 4:29
  21. It is believed that the development of gastric cancer (GC) before the age of 50 has a hereditary basis. Blood group A and history of gastric cancer in first-degree relatives have been shown to be risk factors ...

    Authors: Mohammad Yaghoobi, Naser Rakhshani, Farhad Sadr, Raheleh Bijarchi, Yasamin Joshaghani, Ashraf Mohammadkhani, Arezou Attari, Mohammad Reza Akbari, Mahshid Hormazdi and Reza Malekzadeh
    Citation: BMC Gastroenterology 2004 4:28
  22. Guidelines for management of peptic ulcer patients after the treatment are largely directed to detection of H. pylori infection using only non-invasive tests. We compared the diagnostic value of non-invasive and ...

    Authors: Heidi-Ingrid Maaroos, Helena Andreson, Krista Lõivukene, Pirje Hütt, Helgi Kolk, Ingrid Kull, Katrin Labotkin and Marika Mikelsaar
    Citation: BMC Gastroenterology 2004 4:27
  23. Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation an...

    Authors: David L Suskind, Karen Murray and Dennis Christie
    Citation: BMC Gastroenterology 2004 4:26
  24. Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from...

    Authors: Bodil Ohlsson, Jens F Rehfeld and Mary L Forsling
    Citation: BMC Gastroenterology 2004 4:25
  25. The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the...

    Authors: Ahmed Shafik, Ali A Shafik, Olfat El Sibai and Randa M Mostafa
    Citation: BMC Gastroenterology 2004 4:24
  26. As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in p...

    Authors: Fusun F Bolukbas, Cengiz Bolukbas, Mehmet Horoz, Mahmut Gumus, Mehmet Erdogan, Fadile Zeyrek, Ali Yayla and Oya Ovunc
    Citation: BMC Gastroenterology 2004 4:23
  27. Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.

    Authors: Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Raafat Mahmoud, Samira Abdallah and Mostafa El-Serafi
    Citation: BMC Gastroenterology 2004 4:22
  28. The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in th...

    Authors: Eric L Klett, Mi-Hye Lee, David B Adams, Kenneth D Chavin and Shailendra B Patel
    Citation: BMC Gastroenterology 2004 4:21
  29. Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the ex...

    Authors: Ioannis S Papanikolaou, Andreas Ch Lazaris, Periklis Apostolopoulos, Nikos Kavantzas, Maria G Papas, Christos Mavrogiannis, Efstratios S Patsouris and Athanasios Archimandritis
    Citation: BMC Gastroenterology 2004 4:20
  30. Esophagectomy is considered the gold standard for the treatment of high-grade dysplasia in Barrett's esophagus (BE) and for noninvasive adenocarcinoma (ACA) of the distal esophagus. If all of the metaplastic e...

    Authors: Herbert C Wolfsen, Lois L Hemminger and Kenneth R DeVault
    Citation: BMC Gastroenterology 2004 4:18
  31. Increased hepatic iron is assumed to potentiate progression towards liver fibrosis in chronic hepatitis C virus (HCV) infection. In this study we have evaluated the potentiating effect of marked hepatic iron o...

    Authors: Farid Azmoudeh Ardalan, Mohammad RF Osquei, Mohsen N Toosi and Guiti Irvanloo
    Citation: BMC Gastroenterology 2004 4:17
  32. Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various ...

    Authors: Anna Berg, Stefan Redeen, Ann-Charlott Ericson and Sven Erik Sjöstrand
    Citation: BMC Gastroenterology 2004 4:16
  33. Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. The ectopic involvement is either a result of Parasite migration or perhap...

    Authors: Mohammad Reza Zali, Tahereh Ghaziani, Saeed Shahraz, Azita Hekmatdoost and Ali Radmehr
    Citation: BMC Gastroenterology 2004 4:15
  34. Biliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease sugges...

    Authors: David L Suskind, Philip Rosenthal, Melvin B Heyman, Denice Kong, Greg Magrane, Lee-Ann Baxter-Lowe and Marcus O Muench
    Citation: BMC Gastroenterology 2004 4:14
  35. Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). An effective treatment has not been defined. Recently, a large proportion of ...

    Authors: Pieter CJ ter Borg, Erik van Os, Walter W van den Broek, Bettina E Hansen and Henk R van Buuren
    Citation: BMC Gastroenterology 2004 4:13
  36. Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the a...

    Authors: Inma Castilla-Cortázar, María Pascual, Elena Urdaneta, Javier Pardo, Juan Enrique Puche, Bárbara Vivas, Amelia Díaz-Casares, María García, Matías Díaz-Sánchez, Isabel Varela-Nieto, Alberto Castilla and Salvador González-Barón
    Citation: BMC Gastroenterology 2004 4:12
  37. After perinatal transmission of hepatitis B virus, infants of anti-HBe positive HBsAg carrier mothers may develop fulminant hepatitis B. Previously it has been suggested, that fulminant hepatitis B in adults w...

    Authors: Michael Friedt, Patrick Gerner, Philip Wintermeyer and Stefan Wirth
    Citation: BMC Gastroenterology 2004 4:11
  38. Celiac disease is a common cause of chronic diarrhea and malabsorption syndrome all over the world. Though it was considered uncommon in India in past, it is being described frequently recently. Some patients ...

    Authors: Uday C Ghoshal, Ujjala Ghoshal, Asha Misra and Gourdas Choudhuri
    Citation: BMC Gastroenterology 2004 4:10
  39. Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized...

    Authors: Adnan Giral, Kemal Memişoğlu, Yücel Gültekin, Neşe İmeryüz, Cem Kalaycı, Nefise B Ulusoy and Nurdan Tözün
    Citation: BMC Gastroenterology 2004 4:7
  40. Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the intestinal microflora by antibi...

    Authors: Michael Schultz, Antje Timmer, Hans H Herfarth, R Balfour Sartor, Jon A Vanderhoof and Heiko C Rath
    Citation: BMC Gastroenterology 2004 4:5
  41. ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal a...

    Authors: Adam J Smolka, James R Goldenring, Sandeep Gupta and Charles E Hammond
    Citation: BMC Gastroenterology 2004 4:4
  42. Infections caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) are considered to be important health problems worldwide. The purpose of this study was to measure the general practitioners (GPs)' basi...

    Authors: Yildiz Peksen, Sevgi Canbaz, Hakan Leblebicioglu, Mustafa Sunbul, Saban Esen and Ahmet Tevfik Sunter
    Citation: BMC Gastroenterology 2004 4:3

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