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  1. Improving prediction of treatment outcomes in chronic hepatitis C (CHC) genotype 4 (G4) is necessary to increase sustained viral response (SVR) rates. Vitamin D related and interferon stimulated genes are good...

    Authors: M. O. El-Derany, N. M. Hamdy, N. L. Al-Ansari and H. O. El-Mesallamy
    Citation: BMC Gastroenterology 2016 16:19
  2. Although heavy drinking is known to lead to liver injury, some recent studies have reported that light alcohol consumption (LAC) may play a protective role against fatty liver in the general population, and ma...

    Authors: Masahiro Sogabe, Toshiya Okahisa, Tadahiko Nakagawa, Hiroshi Fukuno, Masahiko Nakasono, Tetsu Tomonari, Takahiro Tanaka, Hironori Tanaka, Tatsuya Taniguchi, Naoki Muguruma and Tetsuji Takayama
    Citation: BMC Gastroenterology 2016 16:17
  3. Acute cholangitis is a life-threatening bacterial infection of the biliary tract. Main focus of this study was to create a useful risk prediction model that helps physicians to assign patients with acute chola...

    Authors: Jochen Schneider, Alexander Hapfelmeier, Sieglinde Thöres, Andreas Obermeier, Christoph Schulz, Dominik Pförringer, Simon Nennstiel, Christoph Spinner, Roland M. Schmid, Hana Algül, Wolfgang Huber and Andreas Weber
    Citation: BMC Gastroenterology 2016 16:15
  4. Non-alcoholic fatty liver disease, the most prevalent liver disease in developed countries, remains difficult to manage with no proven safe and effective pharmacotherapy available. While weight reduction is th...

    Authors: Elena S. Papamiltiadous, Stuart K. Roberts, Amanda J. Nicoll, Marno C. Ryan, Catherine Itsiopoulos, Agus Salim and Audrey C. Tierney
    Citation: BMC Gastroenterology 2016 16:14
  5. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for hepatocellular carcinoma (HCC) and present in 80 to 90 % of patients with HCC. Current genetically engineered mouse models for HC...

    Authors: Sook In Chung, Hyuk Moon, Dae Yeong Kim, Kyung Joo Cho, Hye-Lim Ju, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han and Simon Weonsang Ro
    Citation: BMC Gastroenterology 2016 16:13
  6. Fundamental researches suggest that ileum presents greater adaptive potential than the jejunum. However, few studies estimate the association between ileum and adaptive potential in human. To discover the asso...

    Authors: Wencheng Kong, Jian Wang, Rongchao Ying, Yousheng Li, Huicheng Jin, Qi Mao, Danhua Yao and Mingxiao Guo
    Citation: BMC Gastroenterology 2016 16:12
  7. Hepatocellular carcinoma (HCC) with biliary tumor thrombus (BTT) is rare and its impact on postoperative prognosis remains controversial. The aim of this study was to evaluate the published evidence concerning...

    Authors: Wenhui Qiao, Feng Yu, Lupeng Wu, Bin Li and Yanming Zhou
    Citation: BMC Gastroenterology 2016 16:11
  8. Although deleterious mutations in interleukin-10 and its receptor molecules cause severe infantile-onset inflammatory bowel disease, there are no reports of mutations affecting this signaling pathway in Japane...

    Authors: Tadahiro Yanagi, Tatsuki Mizuochi, Yugo Takaki, Keisuke Eda, Keiichi Mitsuyama, Masataka Ishimura, Hidetoshi Takada, Dror S. Shouval, Alexandra E. Griffith, Scott B. Snapper, Yushiro Yamashita and Ken Yamamoto
    Citation: BMC Gastroenterology 2016 16:10
  9. Laparoscopic cholecystectomy (LC) has become the ‘gold standard’ for the treatment of symptomatic gallstones. Innovative methods are being introduced, and these procedures include transgastric or transcolonic ...

    Authors: Nan Ge, Siyu Sun, Shiwei Sun, Sheng Wang, Xiang Liu and Guoxin Wang
    Citation: BMC Gastroenterology 2016 16:9
  10. The incidence of the para-aortic lymph node metastasis (PALM) in patients with advanced gastric cancer is 6 to 33 %. The prognosis is poor and the 5-year survival rate is only 12 to 23 % after gastrectomy with...

    Authors: Qi He, Long Ma, Yang Li and Guoli Li
    Citation: BMC Gastroenterology 2016 16:8
  11. In pancreaticobiliary maljunction (PBM), the sphincter of Oddi can not control bile and pancreatic juice flow, which may lead to two-way reflux of bile and pancreatic juice, thus causing chronic inflammation, ...

    Authors: Shun-gen Huang, Wan-liang Guo, Zhi-cheng Zhou, Jun-jie Li, Fu-bin Yang and Jian Wang
    Citation: BMC Gastroenterology 2016 16:7
  12. The surveillance of subjects at risk of pancreatic cancer is restricted to clinical research; the incidence of familial pancreatic cancer needs to be better established. Thus, we aimed to evaluate the frequenc...

    Authors: Martina Mughetti, Lucia Calculli, Anna Maria Chiesa, Federica Ciccarese, Odeta Rrusho and Raffaele Pezzilli
    Citation: BMC Gastroenterology 2016 16:6
  13. Hemorrhage from the pancreatic duct, or hemosuccus pancreaticus (HP), is an unusual cause of intermittent gastrointestinal bleeding. HP is most often diagnosed in patients with chronic pancreatitis, and is usu...

    Authors: Hye Ryoung Sul, Hyun Woong Lee, Jeong Wook Kim, Sung Jae Cha, Yoo Shin Choi, Gi Hyeon Kim and Byung Kook Kwak
    Citation: BMC Gastroenterology 2016 16:5
  14. The association of minimal change esophagitis (MCE) with GERD is controversial. i-Scan endoscopy (SE) provides high resolution and modulation of images that may improve minimal change lesion (MCL) detection. W...

    Authors: Nisa Netinatsunton, Jaksin Sottisuporn, Siriboon Attasaranya, Teepawit Witeerungrot, Naichaya Chamroonkul, Theeratus Jongboonyanuparp, Alan Geater and Bancha Ovartlarnporn
    Citation: BMC Gastroenterology 2016 16:4
  15. Pancreatic hamartoma is an extremely rare benign disease of the pancreas. Only 30 cases have been reported to date.

    Authors: Daisuke Matsushita, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Michiyo Higashi, Satoshi Iino, Masahiko Sakoda, Hiroyuki Shinchi, Shinichi Ueno and Shoji Natsugoe
    Citation: BMC Gastroenterology 2016 16:3
  16. In China, the incidence of Inflammatory bowel disease (IBD) has shown a significant growth trend. Analysis of the epidemiology, clinical manifestations, diagnostic means, and treatment of IBD will further impr...

    Authors: Huihong Zhai, Aiqin Liu, Wenyu Huang, Xin Liu, Shanshan Feng, Jing Wu, Yuping Yao, Chao Wang, Qianqian Li, Qian Hao, Jianguo Hu and Shutian Zhang
    Citation: BMC Gastroenterology 2016 16:2
  17. Celiac disease (CD) may affect healthcare use in children and young adults. Socio-economic factors may act as a confounder or effect modifier. We assessed such hypotheses in a population-based birth cohort of ...

    Authors: Cristina Canova, Gisella Pitter, Jonas F. Ludvigsson, Pierantonio Romor, Loris Zanier, Renzo Zanotti and Lorenzo Simonato
    Citation: BMC Gastroenterology 2016 16:1
  18. To assess correlation between liver or spleen stiffness measurement by transient elastography (TE) and hepatic venous pressure gradient (HVPG) in patients with chronic liver disease as well find optimal and ru...

    Authors: Romanas Zykus, Laimas Jonaitis, Vitalija Petrenkienė, Andrius Pranculis and Limas Kupčinskas
    Citation: BMC Gastroenterology 2015 15:183

    The Erratum to this article has been published in BMC Gastroenterology 2016 16:53

  19. Laparoscopic distal pancreatectomy (LDP) showed advantage of perioperation outcomes for benign and low-grade tumor of the pancreas. The application of LDP for pancreatic ductal adenocarcinoma (PDAC) didn’t gai...

    Authors: Miaozun Zhang, Ren Fang, Yiping Mou, Ronggao Chen, Xiaowu Xu, Renchao Zhang, Jiafei Yan, Weiwei Jin and Harsha Ajoodhea
    Citation: BMC Gastroenterology 2015 15:182
  20. Celiac Disease occurs at a 5–10 fold greater prevalence in patients with type-1 diabetes (T1D), despite this increased risk, there is limited objective evidence regarding the impact of a Gluten-Free Diet (GFD)...

    Authors: Esther Assor, Margaret A. Marcon, Natasha Hamilton, Marilyn Fry, Tammy Cooper and Farid H. Mahmud
    Citation: BMC Gastroenterology 2015 15:181
  21. Anastomotic leakage (AL) remains the most dreaded complication after colorectal surgery and causes high morbidity and mortality. The pathophysiology of AL remains unclear, despite numerous studies that have be...

    Authors: Joanna W. A. M. Bosmans, Audrey C. H. M. Jongen, Nicole D. Bouvy and Joep P. M. Derikx
    Citation: BMC Gastroenterology 2015 15:180
  22. Authors: Judith R. Kelsen, Noor Dawany, Alejandro Martinez, Christopher M. Grochowski, Kelly Maurer, Eric Rappaport, David A. Piccoli, Robert N. Baldassano, Petar Mamula, Kathleen E. Sullivan and Marcella Devoto
    Citation: BMC Gastroenterology 2015 15:179

    The original article was published in BMC Gastroenterology 2015 15:160

  23. Although many factors and molecules that are closely associated with non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) have been reported, the role of endothelial nitric oxide synt...

    Authors: Yuichi Nozaki, Koji Fujita, Koichiro Wada, Masato Yoneda, Yoshiyasu Shinohara, Kento Imajo, Yuji Ogawa, Takaomi Kessoku, Makoto Nakamuta, Satoru Saito, Naohiko Masaki, Yoji Nagashima, Yasuo Terauchi and Atsushi Nakajima
    Citation: BMC Gastroenterology 2015 15:177
  24. The management of hepatocellular carcinoma (HCC) is limited by the lack of adequate screening biomarkers and chemotherapy. In response, there has been much interest in tumor metabolism as a therapeutic target....

    Authors: Mamatha Bhat, Nicolas Skill, Victoria Marcus, Marc Deschenes, Xianming Tan, Jeanne Bouteaud, Sarita Negi, Zuhier Awan, Reid Aikin, Janet Kwan, Ramila Amre, Sebastien Tabaries, Mazen Hassanain, Nabil G. Seidah, Mary Maluccio, Peter Siegel…
    Citation: BMC Gastroenterology 2015 15:176
  25. Non-alcoholic steatohepatitis (NASH) is often seen together with components of metabolic syndrome. The aim of this study was to assess the risk of de novo post-transplant type 2 diabetes (DM) in liver transpla...

    Authors: Maria Stepanova, Linda Henry, Rishi Garg, Shirley Kalwaney, Sammy Saab and Zobair Younossi
    Citation: BMC Gastroenterology 2015 15:175
  26. The clinical significance of non-alcoholic fatty pancreatic disease (NAFPD) or fatty pancreas is largely unknown. It is often an incidental finding on abdominal ultrasound, which is not explored further, espec...

    Authors: Cosmas Rinaldi A. Lesmana, Levina S. Pakasi, Sri Inggriani, Maria L. Aidawati and Laurentius A. Lesmana
    Citation: BMC Gastroenterology 2015 15:174
  27. Intestinal intraepithelial lymphocytes that reside within the epithelium of the intestine form one of the main branches of the immune system. A majority of IELs express CD8α homodimer together with other molec...

    Authors: Di Zhao, Antao Xu, Zhanghan Dai, Jiangchen Peng, Mingming Zhu, Jun Shen, Qing Zheng and Zhihua Ran
    Citation: BMC Gastroenterology 2015 15:173
  28. The relationship between nutrition and Crohn’s disease (CD) is complex and involves several therapeutic possibilities including: nutrition treatment for malnourished patients, optimization of growth and develo...

    Authors: Camila Ortiz Prospero Cavalcante Costa, Flair José Carrilho, Valeria Sutti Nunes, Aytan Miranda Sipahi and Maraci Rodrigues
    Citation: BMC Gastroenterology 2015 15:172
  29. Malignant bile duct obstruction is a common problem among cancer patients with hepatic or lymphatic metastases. Endoscopic retrograde cholangiography (ERC) with the placement of a stent is the method of choice...

    Authors: Georg-Martin Haag, Thomas Herrmann, Dirk Jaeger, Wolfgang Stremmel, Peter Schemmer, Peter Sauer and Daniel Nils Gotthardt
    Citation: BMC Gastroenterology 2015 15:171
  30. Eradication rates of standard triple therapy for Helicobacter pylori infections have decreased in recent years due to a worldwide increase in bacterial resistance. Sequential therapy has the advantage of a two-ph...

    Authors: Chung-Chuan Chan, Nai-Hsuan Chien, Chia-Long Lee, Yi-Chen Yang, Chih-Sheng Hung, Tien-Chien Tu and Chi-Hwa Wu
    Citation: BMC Gastroenterology 2015 15:170
  31. Evidence for the role of the gut microbiome in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) is emerging. Strategies to manipulate the gut microbiota towards a healthier community structure are...

    Authors: Jennifer E. Lambert, Jill A. Parnell, Bertus Eksteen, Maitreyi Raman, Marc R. Bomhof, Kevin P. Rioux, Karen L. Madsen and Raylene A. Reimer
    Citation: BMC Gastroenterology 2015 15:169
  32. Irritable Bowel Syndrome (IBS) is a functional somatic syndrome characterized by patterns of persistent bodily complaints for which a thorough diagnostic workup does not reveal adequate explanatory structural ...

    Authors: Carla E. Flik, Wijnand Laan, André J. P. M. Smout, Bas L. A. M. Weusten and Niek J. de Wit
    Citation: BMC Gastroenterology 2015 15:168
  33. Recommended treatment for type 1 hepatorenal syndrome consists of albumin and vasoconstrictor. The optimal albumin dose remains poorly characterized. This meta-analysis aimed to determine the impact of albumin...

    Authors: Francesco Salerno, Roberta J. Navickis and Mahlon M. Wilkes
    Citation: BMC Gastroenterology 2015 15:167
  34. Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease characterized by gastrointestinal hamartomatous polyps and mucocutaneous melanin spots. Germline mutation of the serine/threonine kin...

    Authors: Zhiheng Huang, Shijian Miao, Lin Wang, Ping Zhang, Bingbing Wu, Jie Wu and Ying Huang
    Citation: BMC Gastroenterology 2015 15:166
  35. Studies have shown an increased prevalence of irritable bowel syndrome (IBS) after acute gastroenteritis. Food as a precipitating and perpetuating factor in IBS has gained recent interest, but food intolerance...

    Authors: Sverre Litleskare, Knut-Arne Wensaas, Geir Egil Eide, Kurt Hanevik, Gudrun Elise Kahrs, Nina Langeland and Guri Rortveit
    Citation: BMC Gastroenterology 2015 15:164
  36. Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active Crohn’s disease (CD). However, with routine weekly therapy, it may take several weeks to achieve remission. This s...

    Authors: Naoki Yoshimura, Yoko Yokoyama, Katsuyoshi Matsuoka, Hiroki Takahashi, Ryuichi Iwakiri, Takayuki Yamamoto, Tomoo Nakagawa, Takumi Fukuchi, Satoshi Motoya, Reiko Kunisaki, Shingo Kato, Fumihito Hirai, Yoh Ishiguro, Satoshi Tanida, Sakiko Hiraoka, Keiichi Mitsuyama…
    Citation: BMC Gastroenterology 2015 15:163
  37. A clinical risk index employing age, sex, family history of colorectal cancer (CRC), smoking history and body mass index (BMI) may be useful for prioritizing screening with colonoscopy. The aim of this study w...

    Authors: Arlinda Ruco, David Stock, Robert J. Hilsden, S. Elizabeth McGregor, Lawrence F. Paszat, Refik Saskin and Linda Rabeneck
    Citation: BMC Gastroenterology 2015 15:162
  38. Only few case reports of mucinous cystic pancreatic neoplasm containing an undifferentiated carcinoma with osteoclast-like giant cells have been described in the literature. In the majority of cases this unusu...

    Authors: Marco Chiarelli, Angelo Guttadauro, Martino Gerosa, Alessandro Marando, Francesco Gabrielli, Matilde De Simone and Ugo Cioffi
    Citation: BMC Gastroenterology 2015 15:161
  39. Children with very early-onset inflammatory bowel disease (VEO-IBD), those diagnosed at less than 5 years of age, are a unique population. A subset of these patients present with a distinct phenotype and more ...

    Authors: Judith R. Kelsen, Noor Dawany, Alejuandro Martinez, Christopher M. Grochowski, Kelly Maurer, Eric Rappaport, David A. Piccoli, Robert N. Baldassano, Petar Mamula, Kathleen E. Sullivan and Marcella Devoto
    Citation: BMC Gastroenterology 2015 15:160

    The Erratum to this article has been published in BMC Gastroenterology 2015 15:179

  40. Liver sinusoidal endothelial cells (SECs), hepatic stellate cells (HSCs) and Kupffer cells (KCs) are involved in the development of liver fibrosis and represent a potential therapeutic target. The therapeutic ...

    Authors: Cheng Liu, Zongguo Yang, Lei Wang, Yunfei Lu, Bozong Tang, Hui Miao, Qingnian Xu and Xiaorong Chen
    Citation: BMC Gastroenterology 2015 15:159
  41. The diagnosis of associated choledocholithiasis prior to cholecystectomy for patients with gallstones is important for the surgical decision and treatment efficacy. However, whether ultrasound is sufficient fo...

    Authors: Yan Qiu, Zhengpeng Yang, Zhituo Li, Weihui Zhang and Dongbo Xue
    Citation: BMC Gastroenterology 2015 15:158
  42. Gastric cancer is usually diagnosed in an advanced stage of disease and treatment options are sparse. Trastuzumab was recently approved for metastatic or locally advanced carcinomas arising in the stomach or i...

    Authors: Renato Santos Laboissiere, Marcelo Araújo Buzelin, Débora Balabram, Marina De Brot, Cristiana Buzelin Nunes, Rafael Malagoli Rocha, Mônica Maria Demas Álvares Cabral and Helenice Gobbi
    Citation: BMC Gastroenterology 2015 15:157
  43. The malignant form of atrophic papulosis (Köhlmeier-Degos disease) is a rare thrombo-occlusive vasculopathy that can affect multiple organ systems. Patients typically present with distinctive skin lesions refl...

    Authors: A. E. Toledo, L. S. Shapiro, J. F. Farrell, C. M. Magro and J. Polito
    Citation: BMC Gastroenterology 2015 15:156
  44. Magnifying endoscopy with narrow-band imaging (ME-NBI) is more reliable than chromoendoscopy (CE) for delineating the horizontal extent of early gastric cancers prior to endoscopic submucosal dissection (ESD)....

    Authors: Kunihisa Uchita, Kenshi Yao, Noriya Uedo, Toshio Shimokawa, Takehiro Iwasaki, Koji Kojima, Ai Kawada, Mizu Nakayama, Michiyo Okazaki and Shinichi Iwamura
    Citation: BMC Gastroenterology 2015 15:155
  45. Gut-derived bacterial endotoxin is an important cofactor in the pathogenesis of IBD. Regulatory T cells (Tregs) are essential for maintenance of peripheral tolerance and can prevent and alleviate IBD. To deter...

    Authors: Ami Ben Yaʼacov, Yoav Lichtenstein, Lidya Zolotarov and Yaron Ilan
    Citation: BMC Gastroenterology 2015 15:154

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