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  1. It is believed that the development of gastric cancer (GC) before the age of 50 has a hereditary basis. Blood group A and history of gastric cancer in first-degree relatives have been shown to be risk factors ...

    Authors: Mohammad Yaghoobi, Naser Rakhshani, Farhad Sadr, Raheleh Bijarchi, Yasamin Joshaghani, Ashraf Mohammadkhani, Arezou Attari, Mohammad Reza Akbari, Mahshid Hormazdi and Reza Malekzadeh

    Citation: BMC Gastroenterology 2004 4:28

    Content type: Research article

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  2. Guidelines for management of peptic ulcer patients after the treatment are largely directed to detection of H. pylori infection using only non-invasive tests. We compared the diagnostic value of non-invasive and ...

    Authors: Heidi-Ingrid Maaroos, Helena Andreson, Krista Lõivukene, Pirje Hütt, Helgi Kolk, Ingrid Kull, Katrin Labotkin and Marika Mikelsaar

    Citation: BMC Gastroenterology 2004 4:27

    Content type: Research article

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  3. Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation an...

    Authors: David L Suskind, Karen Murray and Dennis Christie

    Citation: BMC Gastroenterology 2004 4:26

    Content type: Case report

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  4. Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from...

    Authors: Bodil Ohlsson, Jens F Rehfeld and Mary L Forsling

    Citation: BMC Gastroenterology 2004 4:25

    Content type: Research article

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  5. The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the...

    Authors: Ahmed Shafik, Ali A Shafik, Olfat El Sibai and Randa M Mostafa

    Citation: BMC Gastroenterology 2004 4:24

    Content type: Research article

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  6. As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in p...

    Authors: Fusun F Bolukbas, Cengiz Bolukbas, Mehmet Horoz, Mahmut Gumus, Mehmet Erdogan, Fadile Zeyrek, Ali Yayla and Oya Ovunc

    Citation: BMC Gastroenterology 2004 4:23

    Content type: Research article

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  7. Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.

    Authors: Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Raafat Mahmoud, Samira Abdallah and Mostafa El-Serafi

    Citation: BMC Gastroenterology 2004 4:22

    Content type: Research article

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  8. The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in th...

    Authors: Eric L Klett, Mi-Hye Lee, David B Adams, Kenneth D Chavin and Shailendra B Patel

    Citation: BMC Gastroenterology 2004 4:21

    Content type: Research article

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  9. Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the ex...

    Authors: Ioannis S Papanikolaou, Andreas Ch Lazaris, Periklis Apostolopoulos, Nikos Kavantzas, Maria G Papas, Christos Mavrogiannis, Efstratios S Patsouris and Athanasios Archimandritis

    Citation: BMC Gastroenterology 2004 4:20

    Content type: Research article

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  10. Esophagectomy is considered the gold standard for the treatment of high-grade dysplasia in Barrett's esophagus (BE) and for noninvasive adenocarcinoma (ACA) of the distal esophagus. If all of the metaplastic e...

    Authors: Herbert C Wolfsen, Lois L Hemminger and Kenneth R DeVault

    Citation: BMC Gastroenterology 2004 4:18

    Content type: Research article

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  11. Increased hepatic iron is assumed to potentiate progression towards liver fibrosis in chronic hepatitis C virus (HCV) infection. In this study we have evaluated the potentiating effect of marked hepatic iron o...

    Authors: Farid Azmoudeh Ardalan, Mohammad RF Osquei, Mohsen N Toosi and Guiti Irvanloo

    Citation: BMC Gastroenterology 2004 4:17

    Content type: Research article

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  12. Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various ...

    Authors: Anna Berg, Stefan Redeen, Ann-Charlott Ericson and Sven Erik Sjöstrand

    Citation: BMC Gastroenterology 2004 4:16

    Content type: Research article

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  13. Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. The ectopic involvement is either a result of Parasite migration or perhap...

    Authors: Mohammad Reza Zali, Tahereh Ghaziani, Saeed Shahraz, Azita Hekmatdoost and Ali Radmehr

    Citation: BMC Gastroenterology 2004 4:15

    Content type: Case report

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  14. Biliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease sugges...

    Authors: David L Suskind, Philip Rosenthal, Melvin B Heyman, Denice Kong, Greg Magrane, Lee-Ann Baxter-Lowe and Marcus O Muench

    Citation: BMC Gastroenterology 2004 4:14

    Content type: Research article

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  15. Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). An effective treatment has not been defined. Recently, a large proportion of ...

    Authors: Pieter CJ ter Borg, Erik van Os, Walter W van den Broek, Bettina E Hansen and Henk R van Buuren

    Citation: BMC Gastroenterology 2004 4:13

    Content type: Research article

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  16. Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the a...

    Authors: Inma Castilla-Cortázar, María Pascual, Elena Urdaneta, Javier Pardo, Juan Enrique Puche, Bárbara Vivas, Amelia Díaz-Casares, María García, Matías Díaz-Sánchez, Isabel Varela-Nieto, Alberto Castilla and Salvador González-Barón

    Citation: BMC Gastroenterology 2004 4:12

    Content type: Research article

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  17. After perinatal transmission of hepatitis B virus, infants of anti-HBe positive HBsAg carrier mothers may develop fulminant hepatitis B. Previously it has been suggested, that fulminant hepatitis B in adults w...

    Authors: Michael Friedt, Patrick Gerner, Philip Wintermeyer and Stefan Wirth

    Citation: BMC Gastroenterology 2004 4:11

    Content type: Research article

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  18. Celiac disease is a common cause of chronic diarrhea and malabsorption syndrome all over the world. Though it was considered uncommon in India in past, it is being described frequently recently. Some patients ...

    Authors: Uday C Ghoshal, Ujjala Ghoshal, Asha Misra and Gourdas Choudhuri

    Citation: BMC Gastroenterology 2004 4:10

    Content type: Case report

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  19. Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized...

    Authors: Adnan Giral, Kemal Memişoğlu, Yücel Gültekin, Neşe İmeryüz, Cem Kalaycı, Nefise B Ulusoy and Nurdan Tözün

    Citation: BMC Gastroenterology 2004 4:7

    Content type: Research article

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  20. Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the intestinal microflora by antibi...

    Authors: Michael Schultz, Antje Timmer, Hans H Herfarth, R Balfour Sartor, Jon A Vanderhoof and Heiko C Rath

    Citation: BMC Gastroenterology 2004 4:5

    Content type: Research article

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  21. ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal a...

    Authors: Adam J Smolka, James R Goldenring, Sandeep Gupta and Charles E Hammond

    Citation: BMC Gastroenterology 2004 4:4

    Content type: Research article

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  22. Infections caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) are considered to be important health problems worldwide. The purpose of this study was to measure the general practitioners (GPs)' basi...

    Authors: Yildiz Peksen, Sevgi Canbaz, Hakan Leblebicioglu, Mustafa Sunbul, Saban Esen and Ahmet Tevfik Sunter

    Citation: BMC Gastroenterology 2004 4:3

    Content type: Research article

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  23. Patients with new onset constipation or presumed hemorrhoid bleeding frequently require the use of both fiber supplements and diagnostic colonoscopy. We sought to determine whether preliminary fiber supplement...

    Authors: Walter A Salwen and Marc D Basson

    Citation: BMC Gastroenterology 2004 4:2

    Content type: Research article

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  24. Xanthine oxidoreductase has been proposed to play a role in the development of local and systemic effects of acute pancreatitis. Under physiologic conditions, the enzyme exists mainly as xanthine dehydrogenase...

    Authors: Susana Granell, Oriol Bulbena, Meritxell Genesca, Luis Sabater, Juan Sastre, Emilio Gelpi and Daniel Closa

    Citation: BMC Gastroenterology 2004 4:1

    Content type: Research article

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  25. Biliary ascariasis is regarded as possible etiological factor for hepatolithiasis. Here we report one case of a patient with hepatolithiasis with biliary ascariasis who developed a liver abscess, which was tre...

    Authors: KS Pilankar, AD Amarapurkar, RM Joshi, TS Shetty, AS Khithani and VV Chemburkar

    Citation: BMC Gastroenterology 2003 3:35

    Content type: Case report

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  26. The role of mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in chronic pancreatitis is still a matter of debate. Active SPINK1 is thought to antagonize activated trypsin. Cases of SPINK1 mut...

    Authors: Peter Felderbauer, Peter Hoffmann, Henrik Einwächter, Kerem Bulut, Nikolaus Ansorge, Frank Schmitz and Wolfgang E Schmidt

    Citation: BMC Gastroenterology 2003 3:34

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2004 4:6

  27. Studies on Health Related Quality of Life (HRQoL) of chronic liver patients were performed in clinical populations. These studies included various disease stages but small variations in aetiology and no transp...

    Authors: Simone M van der Plas, Bettina E Hansen, Josien B de Boer, Theo Stijnen, Jan Passchier, Robert A de Man and Solko W Schalm

    Citation: BMC Gastroenterology 2003 3:33

    Content type: Research article

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  28. Helicobacter pylori is a Gram negative bacterium that plays a central role in the etiology of chronic gastritis and peptic ulcer diseases. However, not all H. pylori positive cases develop advanced disease. This...

    Authors: Awasthi Shanjana and Ayyagari Archana

    Citation: BMC Gastroenterology 2003 3:31

    Content type: Research article

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  29. Primary adenocarcinomas of the appendix are uncommon. Mucoceles that result from mucinous adenocarcinomas of the appendix may be incidentally detected on imaging.

    Authors: Michail Pitiakoudis, Paraskevi I Argyropoulou, Alexandra K Tsaroucha, Panos Prassopoulos and Constantinos Simopoulos

    Citation: BMC Gastroenterology 2003 3:30

    Content type: Case report

    Published on:

  30. Transforming growth factor-β (TGF-β) is a key mediator in establishing liver fibrosis. Therefore, TGF-β as a causative agent may serve as a primary target for antifibrotic gene therapy approaches. We have prev...

    Authors: Monica Arias, Sibille Sauer-Lehnen, Jens Treptau, Nora Janoschek, Ingo Theuerkauf, Reinhard Buettner, Axel M Gressner and Ralf Weiskirchen

    Citation: BMC Gastroenterology 2003 3:29

    Content type: Research article

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  31. Although several studies have been performed on risk factors and natural course of NASH, it seems that NASH tends to be more than a disease confined to strict boundaries. The objective of this study was to ass...

    Authors: Hossein Bahrami, Nasser Ebrahimi Daryani, Shahram Mirmomen, Farin Kamangar, Babak Haghpanah and Mehdi Djalili

    Citation: BMC Gastroenterology 2003 3:27

    Content type: Research article

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  32. Botulinum toxin blocks acetylcholine release from nerve endings and acts as a long term, reversible inhibitor of muscle contraction as well as of salivary, sweat gland, adrenal and prostatic secretions. The ai...

    Authors: Matteo Runfola, Simone Rossi, Simona Panunzi, Pier Luigi Spada and Daniele Gui

    Citation: BMC Gastroenterology 2003 3:26

    Content type: Research article

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  33. p8 is a DNA-binding protein induced in many tissues in response to LPS treatment. Hence, p8 could be a mediator of LPS-associated effects or, on the contrary, p8 expression may be part of the protective mechan...

    Authors: Sophie Vasseur, Albrecht Hoffmeister, Andrés Garcia-Montero, Marc Barthet, Laure Saint-Michel, Patrice Berthézène, Fritz Fiedler, Daniel Closa, Jean Charles Dagorn and Juan Lucio Iovanna

    Citation: BMC Gastroenterology 2003 3:25

    Content type: Research article

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  34. Evidence based medicine depends on unbiased selection of completed randomized controlled trials. For completeness it is important to publish all trials. This report describes the first large randomised control...

    Authors: Bart J Veldt, Johannes T Brouwer, Michael Adler, Frederik Nevens, Peter Michielsen, Jean Delwaide, Bettina E Hansen and Solko W Schalm

    Citation: BMC Gastroenterology 2003 3:24

    Content type: Research article

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  35. Anal sphincter defects have been shown to increase pressure asymmetry within the anal canal in patients with fecal incontinence. However, this correlation is far from perfect, and other factors may play a role...

    Authors: Henri Damon, Luc Henry, Sabine Roman, Xavier Barth and François Mion

    Citation: BMC Gastroenterology 2003 3:23

    Content type: Research article

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  36. Since esophageal variceal bleeding is associated with a high mortality rate, prevention of bleeding might be expected to result in improved survival. The first trials to evaluate prophylactic sclerotherapy fou...

    Authors: Henk R van Buuren, Marijke C Rasch, Piet L Batenburg, Clemens JM Bolwerk, Jan J Nicolai, Sjoerd DJ van der Werf, Joost Scherpenisse, Lidia R Arends, Jan van Hattum, Erik AJ Rauws and Solko W Schalm

    Citation: BMC Gastroenterology 2003 3:22

    Content type: Research article

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  37. In this study, we evaluated the prevalence of primary resistance of Brazilian H. pylori isolates to metronidazole, clarithromycin, amoxicillin, tetracycline, and furazolidone. In addition, the vacA, iceA, cagA an...

    Authors: Anita Paula Ortiz Godoy, Marcelo Lima Ribeiro, Yune Helena Borges Benvengo, Lea Vitiello, Maira de Carvalho Bueno Miranda, Sergio Mendonça and José Pedrazzoli Jr

    Citation: BMC Gastroenterology 2003 3:20

    Content type: Research article

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  38. Hepatocellular carcinoma (HCC) is one of the most common malignancies in South East Asia. Although activation of the MEK-MAPK is often associated with cellular growth, the role of MEK-MAPK in growth and surviv...

    Authors: Hung Huynh, Thi Thanh Tuyen Nguyen, Kah-Hoe Kah-Pierce Chow, Puay Hoon Tan, Khee Chee Soo and Evelyne Tran

    Citation: BMC Gastroenterology 2003 3:19

    Content type: Research article

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  39. Although endometriosis with sigmoid serosal involvement is not uncommon in women of childbearing age, the mucosal involvement is rare and differential diagnosis from colon cancer may be difficult due to the la...

    Authors: Philippos Dimoulios, Ioannis E Koutroubakis, Maria Tzardi, Pavlos Antoniou, Ioannis M Matalliotakis and Elias A Kouroumalis

    Citation: BMC Gastroenterology 2003 3:18

    Content type: Case report

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  40. We previously identified eight known and novel genes differentially expressed in the small intestines of wild type and W/W V mice, which have greatly reduced populations of ...

    Authors: Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders and Masayuki A Fujino

    Citation: BMC Gastroenterology 2003 3:17

    Content type: Research article

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  41. Endoscopic colorectal cancer (CRC) screening is currently implemented in many countries. Since endoscopes cannot be sterilised, the transmission of infectious agents through endoscopes has been a matter of con...

    Authors: Michael Bretthauer, Anita Jørgensen, Bjørn Erik Kristiansen, Bjørn Hofstad and Geir Hoff

    Citation: BMC Gastroenterology 2003 3:15

    Content type: Research article

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  42. The muscle layers of murine gastric fundus have no interstitial cells of Cajal at the level of the myenteric plexus and only possess intramuscular interstitial cells and this tissue does not generate electric ...

    Authors: Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders and Masayuki A Fujino

    Citation: BMC Gastroenterology 2003 3:14

    Content type: Research article

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