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  1. Pancreatic adenocarcinoma is a highly invasive neoplasm. Epidermal growth factor (EGF) and its receptor are over expressed in pancreatic cancer, and expression correlates with invasion and metastasis. We hypot...

    Authors: Andrew J Shirk and Rahul Kuver

    Citation: BMC Gastroenterology 2005 5:12

    Content type: Research article

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  2. In primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) fatigue is a major clinical problem. Abnormal amino acid (AA) patterns have been implicated in the development of fatigue in several ...

    Authors: Pieter CJ ter Borg, Durk Fekkes, Jan Maarten Vrolijk and Henk R van Buuren

    Citation: BMC Gastroenterology 2005 5:11

    Content type: Research article

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  3. Colorectal cancer screening is widely recommended, but often under-utilized. In addition, significant demographic differences in screening utilization exist. Insurance coverage may be one factor influencing ut...

    Authors: Cynthia W Ko, William Kreuter and Laura-Mae Baldwin

    Citation: BMC Gastroenterology 2005 5:10

    Content type: Research article

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  4. Inconsistent findings have been reported on the occurrence and relevance of creatine kinase (CK) isoenzymes in mammalian liver cells. Part of this confusion might be due to induction of CK expression during me...

    Authors: Georg Meffert, Frank N Gellerich, Raimund Margreiter and Markus Wyss

    Citation: BMC Gastroenterology 2005 5:9

    Content type: Research article

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  5. The biological basis of pain in chronic pancreatitis is poorly understood. Mast cells have been implicated in the pathogenesis of pain in other conditions. We hypothesized that mast cells play a role in the pa...

    Authors: Willemijntje A Hoogerwerf, Kelly Gondesen, Shu-Yuan Xiao, John H Winston, William D Willis and Pankaj J Pasricha

    Citation: BMC Gastroenterology 2005 5:8

    Content type: Research article

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  6. The exogenous administration of Insulin-like Growth Factor-I (IGF-I) induces hepatoprotective and antifibrogenic actions in experimental liver cirrhosis. To better understand the possible pathways behind the b...

    Authors: María García-Fernández, Inma Castilla-Cortázar, Matías Díaz-Sanchez, Iñigo Navarro, Juan Enrique Puche, Alberto Castilla, Amelia Díaz Casares, Encarna Clavijo and Salvador González-Barón

    Citation: BMC Gastroenterology 2005 5:7

    Content type: Research article

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  7. The etiology of ulcerative colitis (UC) is to be understood. The basic pathological feature of UC is intestinal chronic inflammation. Superantigen, such as Staphylococcus enterotoxin B (SEB), is reported to co...

    Authors: Ping-Chang Yang, Chang-Sheng Wang and Zi-Yuan An

    Citation: BMC Gastroenterology 2005 5:6

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2006 6:23

  8. Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide...

    Authors: Johannes J Tebbe, Clemens G Tebbe, Silke Mronga, Michael Ritter and Martin KH Schäfer

    Citation: BMC Gastroenterology 2005 5:5

    Content type: Research article

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  9. Helicobacter pylori, occurring throughout the world and causing gastroduodenal diseases, is one of the most common chronic bacterial agents in humans. The purpose of this study was to measure the general practit...

    Authors: Sevgi Canbaz, Ahmet Tevfik Sunter, Yildiz Peksen and Hakan Leblebicioglu

    Citation: BMC Gastroenterology 2005 5:4

    Content type: Research article

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  10. Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune res...

    Authors: Jonathan Miner, M Monem Gillan, Philip Alex and Michael Centola

    Citation: BMC Gastroenterology 2005 5:3

    Content type: Case report

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  11. Hiatus hernia (HH) has major pathophysiological effects favoring gastroesophageal reflux and hence contributing to esophageal mucosa injury, especially in patients with severe gastroesophageal disease. However...

    Authors: Anthie Gatopoulou, Konstantinos Mimidis, Alexandra Giatromanolaki, Vassilios Papadopoulos, Alexandros Polychronidis, Nikolaos Lyratzopoulos, Efthimios Sivridis and Georgios Minopoulos

    Citation: BMC Gastroenterology 2005 5:2

    Content type: Research article

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  12. Nidation of floating tumour cells initiates peritoneal carcinosis and limits prognosis of gastro-intestinal tumours. Adhesion of tumour cells to extracellular matrix components is a pivotal step in developing ...

    Authors: Marc Jansen, Karl-Heinz Treutner, Britta Schmitz, Jens Otto, Petra Lynen Jansen, S Neuss and Volker Schumpelick

    Citation: BMC Gastroenterology 2004 4:33

    Content type: Research article

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  13. Gastrointestinal symptoms are common in patients with Chronic Fatigue Syndrome (CFS). The objective of this study was to determine the frequency of these symptoms and explore their relationship with objective ...

    Authors: Richard B Burnet and Barry E Chatterton

    Citation: BMC Gastroenterology 2004 4:32

    Content type: Research article

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  14. A marked expansion of the connective tissue population and an abnormal deposition of extracellular matrix proteins are hallmarks of chronic and acute injuries to liver tissue. Liver connective tissue cells, al...

    Authors: Alvaro T Geremias, Marcelo A Carvalho, Radovan Borojevic and Alvaro NA Monteiro

    Citation: BMC Gastroenterology 2004 4:30

    Content type: Research article

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  15. In the hypothesis that the increased collagen metabolism in the intestinal wall of patients affected by inflammatory bowel disease (IBD) is reflected in the systemic circulation, we aimed the study to evaluate...

    Authors: Matilde De Simone, Ugo Cioffi, Ettore Contessini-Avesani, Barbara Oreggia, Roberta Paliotti, Alberto Pierini, Gianni Bolla, Elide Oggiano, Stefano Ferrero, Fabio Magrini and Michele M Ciulla

    Citation: BMC Gastroenterology 2004 4:29

    Content type: Research article

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  16. It is believed that the development of gastric cancer (GC) before the age of 50 has a hereditary basis. Blood group A and history of gastric cancer in first-degree relatives have been shown to be risk factors ...

    Authors: Mohammad Yaghoobi, Naser Rakhshani, Farhad Sadr, Raheleh Bijarchi, Yasamin Joshaghani, Ashraf Mohammadkhani, Arezou Attari, Mohammad Reza Akbari, Mahshid Hormazdi and Reza Malekzadeh

    Citation: BMC Gastroenterology 2004 4:28

    Content type: Research article

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  17. Guidelines for management of peptic ulcer patients after the treatment are largely directed to detection of H. pylori infection using only non-invasive tests. We compared the diagnostic value of non-invasive and ...

    Authors: Heidi-Ingrid Maaroos, Helena Andreson, Krista Lõivukene, Pirje Hütt, Helgi Kolk, Ingrid Kull, Katrin Labotkin and Marika Mikelsaar

    Citation: BMC Gastroenterology 2004 4:27

    Content type: Research article

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  18. Disorders of coagulation have long been associated with inflammatory bowel disease. Children, as well as adults, with both active and inactive ulcerative colitis have been found to have abnormal coagulation an...

    Authors: David L Suskind, Karen Murray and Dennis Christie

    Citation: BMC Gastroenterology 2004 4:26

    Content type: Case report

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  19. Cholecystokinin (CCK) concentrations in plasma have been shown to be significantly higher in colectomised subjects compared to healthy controls. This has been ascribed to reduced inhibition of CCK release from...

    Authors: Bodil Ohlsson, Jens F Rehfeld and Mary L Forsling

    Citation: BMC Gastroenterology 2004 4:25

    Content type: Research article

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  20. The role of the crural diaphragm during increased intra-abdominal pressure is not exactly known. We investigated the hypothesis that the crural diaphragm undergoes reflex phasic contraction on elevation of the...

    Authors: Ahmed Shafik, Ali A Shafik, Olfat El Sibai and Randa M Mostafa

    Citation: BMC Gastroenterology 2004 4:24

    Content type: Research article

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  21. As anorexia and hypermetabolism are common in cirrhosis, leptin levels may be increased in this disease. In this study, we investigated the relation between the severity of disease and serum leptin levels in p...

    Authors: Fusun F Bolukbas, Cengiz Bolukbas, Mehmet Horoz, Mahmut Gumus, Mehmet Erdogan, Fadile Zeyrek, Ali Yayla and Oya Ovunc

    Citation: BMC Gastroenterology 2004 4:23

    Content type: Research article

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  22. Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer.

    Authors: Abeer A Bahnassy, Abdel-Rahman N Zekri, Soumaya El-Houssini, Amal MR El-Shehaby, Moustafa Raafat Mahmoud, Samira Abdallah and Mostafa El-Serafi

    Citation: BMC Gastroenterology 2004 4:22

    Content type: Research article

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  23. The molecular mechanisms that regulate the entry of dietary sterols into the body and their removal via hepatobiliary secretion are now beginning to be defined. These processes are specifically disrupted in th...

    Authors: Eric L Klett, Mi-Hye Lee, David B Adams, Kenneth D Chavin and Shailendra B Patel

    Citation: BMC Gastroenterology 2004 4:21

    Content type: Research article

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  24. Natural killer (NK) cells represent a first line of defence against a developing cancer; however, their exact role in colorectal cancer remains undetermined. The aim of the present study was to evaluate the ex...

    Authors: Ioannis S Papanikolaou, Andreas Ch Lazaris, Periklis Apostolopoulos, Nikos Kavantzas, Maria G Papas, Christos Mavrogiannis, Efstratios S Patsouris and Athanasios Archimandritis

    Citation: BMC Gastroenterology 2004 4:20

    Content type: Research article

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  25. Esophagectomy is considered the gold standard for the treatment of high-grade dysplasia in Barrett's esophagus (BE) and for noninvasive adenocarcinoma (ACA) of the distal esophagus. If all of the metaplastic e...

    Authors: Herbert C Wolfsen, Lois L Hemminger and Kenneth R DeVault

    Citation: BMC Gastroenterology 2004 4:18

    Content type: Research article

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  26. Increased hepatic iron is assumed to potentiate progression towards liver fibrosis in chronic hepatitis C virus (HCV) infection. In this study we have evaluated the potentiating effect of marked hepatic iron o...

    Authors: Farid Azmoudeh Ardalan, Mohammad RF Osquei, Mohsen N Toosi and Guiti Irvanloo

    Citation: BMC Gastroenterology 2004 4:17

    Content type: Research article

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  27. Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various ...

    Authors: Anna Berg, Stefan Redeen, Ann-Charlott Ericson and Sven Erik Sjöstrand

    Citation: BMC Gastroenterology 2004 4:16

    Content type: Research article

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  28. Fasciola hepatica primarily involves the liver, however in some exceptional situations other organs have been reported to be involved. The ectopic involvement is either a result of Parasite migration or perhap...

    Authors: Mohammad Reza Zali, Tahereh Ghaziani, Saeed Shahraz, Azita Hekmatdoost and Ali Radmehr

    Citation: BMC Gastroenterology 2004 4:15

    Content type: Case report

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  29. Biliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease sugges...

    Authors: David L Suskind, Philip Rosenthal, Melvin B Heyman, Denice Kong, Greg Magrane, Lee-Ann Baxter-Lowe and Marcus O Muench

    Citation: BMC Gastroenterology 2004 4:14

    Content type: Research article

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  30. Fatigue is a major clinical problem in many patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). An effective treatment has not been defined. Recently, a large proportion of ...

    Authors: Pieter CJ ter Borg, Erik van Os, Walter W van den Broek, Bettina E Hansen and Henk R van Buuren

    Citation: BMC Gastroenterology 2004 4:13

    Content type: Research article

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  31. Previous results have shown that in rats with non-ascitic cirrhosis there is an altered transport of sugars and amino acids associated with elongated microvilli. These alterations returned to normal with the a...

    Authors: Inma Castilla-Cortázar, María Pascual, Elena Urdaneta, Javier Pardo, Juan Enrique Puche, Bárbara Vivas, Amelia Díaz-Casares, María García, Matías Díaz-Sánchez, Isabel Varela-Nieto, Alberto Castilla and Salvador González-Barón

    Citation: BMC Gastroenterology 2004 4:12

    Content type: Research article

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  32. After perinatal transmission of hepatitis B virus, infants of anti-HBe positive HBsAg carrier mothers may develop fulminant hepatitis B. Previously it has been suggested, that fulminant hepatitis B in adults w...

    Authors: Michael Friedt, Patrick Gerner, Philip Wintermeyer and Stefan Wirth

    Citation: BMC Gastroenterology 2004 4:11

    Content type: Research article

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  33. Celiac disease is a common cause of chronic diarrhea and malabsorption syndrome all over the world. Though it was considered uncommon in India in past, it is being described frequently recently. Some patients ...

    Authors: Uday C Ghoshal, Ujjala Ghoshal, Asha Misra and Gourdas Choudhuri

    Citation: BMC Gastroenterology 2004 4:10

    Content type: Case report

    Published on:

  34. Although lateral internal sphincterotomy is the gold-standard treatment for chronic anal fissure, intrasphincteric injection of botulinum toxin seems to be a reliable new option. The aim of this non-randomized...

    Authors: Adnan Giral, Kemal Memişoğlu, Yücel Gültekin, Neşe İmeryüz, Cem Kalaycı, Nefise B Ulusoy and Nurdan Tözün

    Citation: BMC Gastroenterology 2004 4:7

    Content type: Research article

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  35. Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the intestinal microflora by antibi...

    Authors: Michael Schultz, Antje Timmer, Hans H Herfarth, R Balfour Sartor, Jon A Vanderhoof and Heiko C Rath

    Citation: BMC Gastroenterology 2004 4:5

    Content type: Research article

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  36. ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal a...

    Authors: Adam J Smolka, James R Goldenring, Sandeep Gupta and Charles E Hammond

    Citation: BMC Gastroenterology 2004 4:4

    Content type: Research article

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  37. Infections caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) are considered to be important health problems worldwide. The purpose of this study was to measure the general practitioners (GPs)' basi...

    Authors: Yildiz Peksen, Sevgi Canbaz, Hakan Leblebicioglu, Mustafa Sunbul, Saban Esen and Ahmet Tevfik Sunter

    Citation: BMC Gastroenterology 2004 4:3

    Content type: Research article

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  38. Patients with new onset constipation or presumed hemorrhoid bleeding frequently require the use of both fiber supplements and diagnostic colonoscopy. We sought to determine whether preliminary fiber supplement...

    Authors: Walter A Salwen and Marc D Basson

    Citation: BMC Gastroenterology 2004 4:2

    Content type: Research article

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  39. Xanthine oxidoreductase has been proposed to play a role in the development of local and systemic effects of acute pancreatitis. Under physiologic conditions, the enzyme exists mainly as xanthine dehydrogenase...

    Authors: Susana Granell, Oriol Bulbena, Meritxell Genesca, Luis Sabater, Juan Sastre, Emilio Gelpi and Daniel Closa

    Citation: BMC Gastroenterology 2004 4:1

    Content type: Research article

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  40. Biliary ascariasis is regarded as possible etiological factor for hepatolithiasis. Here we report one case of a patient with hepatolithiasis with biliary ascariasis who developed a liver abscess, which was tre...

    Authors: KS Pilankar, AD Amarapurkar, RM Joshi, TS Shetty, AS Khithani and VV Chemburkar

    Citation: BMC Gastroenterology 2003 3:35

    Content type: Case report

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  41. The role of mutations in the serine protease inhibitor Kazal type 1 (SPINK1) gene in chronic pancreatitis is still a matter of debate. Active SPINK1 is thought to antagonize activated trypsin. Cases of SPINK1 mut...

    Authors: Peter Felderbauer, Peter Hoffmann, Henrik Einwächter, Kerem Bulut, Nikolaus Ansorge, Frank Schmitz and Wolfgang E Schmidt

    Citation: BMC Gastroenterology 2003 3:34

    Content type: Research article

    Published on:

    The Erratum to this article has been published in BMC Gastroenterology 2004 4:6

  42. Studies on Health Related Quality of Life (HRQoL) of chronic liver patients were performed in clinical populations. These studies included various disease stages but small variations in aetiology and no transp...

    Authors: Simone M van der Plas, Bettina E Hansen, Josien B de Boer, Theo Stijnen, Jan Passchier, Robert A de Man and Solko W Schalm

    Citation: BMC Gastroenterology 2003 3:33

    Content type: Research article

    Published on:

  43. Helicobacter pylori is a Gram negative bacterium that plays a central role in the etiology of chronic gastritis and peptic ulcer diseases. However, not all H. pylori positive cases develop advanced disease. This...

    Authors: Awasthi Shanjana and Ayyagari Archana

    Citation: BMC Gastroenterology 2003 3:31

    Content type: Research article

    Published on:

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