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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics. Among these medications, corticos...

    Authors: Tomotaka Tanaka, Shinichiro Sugiyama, Hirokazu Goishi, Tsuyoshi Kajihara, Morihisa Akagi and Toshio Miura

    Citation: BMC Gastroenterology 2013 13:130

    Content type: Research article

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  2. The diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness of this condition. In patients with undiagnosed HAE, abdominal symptoms often create the risk of unnecessary surgical oper...

    Authors: Isao Ohsawa, Seiji Nagamachi, Hiyori Suzuki, Daisuke Honda, Nobuyuki Sato, Hiroyuki Ohi, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Gastroenterology 2013 13:123

    Content type: Research article

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  3. Endovascular revascularization has recently been established as a less invasive treatment method for chronic mesenteric ischemia. However, intestinal necrosis caused by distal embolization following this proce...

    Authors: Takuro Shirasu, Akihiro Hosaka, Hiroyuki Okamoto, Kunihiro Shigematsu, Yasushi Takeda, Tetsuro Miyata and Toshiaki Watanabe

    Citation: BMC Gastroenterology 2013 13:118

    Content type: Case report

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  4. Oral immunization with vaccines may be an effective strategy for prevention of Clostridium difficile infection (CDI). However, application of previously developed vaccines for preventing CDI has been limited due ...

    Authors: Xiao-qiang Yang, Ya-gang Zhao, Xue-qing Chen, Bo Jiang and Da-yong Sun

    Citation: BMC Gastroenterology 2013 13:117

    Content type: Research article

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  5. Coeliac disease (CD), due to its protean clinical manifestation, is still very under diagnosed in adults and delays in diagnosis may take years and even decades. Simple tools to find cases in primary care may ...

    Authors: Alina Popp, Mariana Jinga, Ciprian Jurcut, Vasile Balaban, Catalina Bardas, Kaija Laurila, Florina Vasilescu, Adina Ene, Ioana Anca and Markku Mäki

    Citation: BMC Gastroenterology 2013 13:115

    Content type: Research article

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  6. Celiac disease (CD) is an autoimmune disorder of the small intestine which is triggered by dietary gluten in genetically predisposed (HLA-DQ2/DQ8 positive) individuals. Only a fraction of HLA-DQ2/DQ8 positive ...

    Authors: Jing Cheng, Marko Kalliomäki, Hans GHJ Heilig, Airi Palva, Hannu Lähteenoja, Willem M de Vos, Jarkko Salojärvi and Reetta Satokari

    Citation: BMC Gastroenterology 2013 13:113

    Content type: Research article

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  7. The intestinal microbiota has been proposed to play a pathogenic role in coeliac disease (CD). Although antibiotics are common environmental factors with a profound impact on intestinal microbiota, data on ant...

    Authors: Karl Mårild, Weimin Ye, Benjamin Lebwohl, Peter HR Green, Martin J Blaser, Tim Card and Jonas F Ludvigsson

    Citation: BMC Gastroenterology 2013 13:109

    Content type: Research article

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  8. Treatment of low-dose aspirin (LDA)-induced small-bowel injury has not been established. Polaprezinc, a chelate of zinc and L-carnosine, may be efficacious for such injury. We conducted a pilot randomized cont...

    Authors: Ikue Watari, Shiro Oka, Shinji Tanaka, Taiki Aoyama, Hiroki Imagawa, Takayoshi Shishido, Shigeto Yoshida and Kazuaki Chayama

    Citation: BMC Gastroenterology 2013 13:108

    Content type: Research article

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  9. Complications of chronic anal fissure (CAF) treatments are prompting interest in lower-risk therapies. This study was conducted to compare nitroglycerin (NTG) 0.4% ointment with placebo for pain associated wit...

    Authors: Scott M Berry, Charles F Barish, Raj Bhandari, Gemma Clark, Gregory V Collins, Julian Howell, John E Pappas, Dennis S Riff, Michael Safdi and Ann Yellowlees

    Citation: BMC Gastroenterology 2013 13:106

    Content type: Research article

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  10. The advent of double-balloon enteroscopy has enabled more accurate diagnosis and treatment of small bowel disorders. Single-balloon enteroscopy permits visualization of the entire small intestine less often th...

    Authors: Varayu Prachayakul, Morakod Deesomsak, Pitulak Aswakul and Somchai Leelakusolvong

    Citation: BMC Gastroenterology 2013 13:103

    Content type: Research article

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  11. The objective is to compare primary repair vs intestinal resection in cases of intestinal typhoid perforations. In addition, we hypothesised the usefulness of laparostomy for the early diagnosis and treatment ...

    Authors: Roberto Caronna, Alassan Kadiri Boukari, Dieudonnè Zaongo, Thierry Hessou, Rènè Castro Gayito, Cesar Ahononga, Sosten Adeniran and Giambattista Priuli

    Citation: BMC Gastroenterology 2013 13:102

    Content type: Research article

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  12. How to maintain “gut health” is a goal for scientists throughout the world. Therefore, microbiota management models for testing probiotics, prebiotics, and synbiotics have been developed.

    Authors: Katia Sivieri, Martha L Villarreal Morales, Maria A Tallarico Adorno, Isabel Kimiko Sakamoto, Susana M Isay Saad and Elizeu A Rossi

    Citation: BMC Gastroenterology 2013 13:100

    Content type: Research article

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  13. An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases.

    Authors: Michael J Stewart, Eldon Shaffer, Stephan J Urbanski, Paul L Beck and Martin A Storr

    Citation: BMC Gastroenterology 2013 13:96

    Content type: Research article

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  14. Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-t...

    Authors: Xavier Sáez-Llorens, F Raúl Velázquez, Pio Lopez, Felix Espinoza, Alexandre C Linhares, Hector Abate, Ernesto Nuñez, Guillermo Venegas, Rodrigo Vergara, Ana L Jimenez, Maribel Rivera, Carlos Aranza, Vesta Richardson, Mercedes Macias-Parra, Guillermo Ruiz Palacios, Luis Rivera…

    Citation: BMC Gastroenterology 2013 13:95

    Content type: Research article

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  15. Cereals of baking quality with absent or reduced toxicity are actively sought as alternative therapy to a gluten-free diet (GFD) for patients with coeliac disease (CD). Triticum monococcum, an ancient wheat, is a...

    Authors: Barbara Zanini, Beatrice Petroboni, Tarcisio Not, Nicola Di Toro, Vincenzo Villanacci, Francesco Lanzarotto, Norberto Pogna, Chiara Ricci and Alberto Lanzini

    Citation: BMC Gastroenterology 2013 13:92

    Content type: Research article

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  16. Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal...

    Authors: Maria F Servidoni, Marisa Sousa, Adriana M Vinagre, Silvia R Cardoso, Maria A Ribeiro, Luciana R Meirelles, Rita B de Carvalho, Karl Kunzelmann, Antônio F Ribeiro, José D Ribeiro and Margarida D Amaral

    Citation: BMC Gastroenterology 2013 13:91

    Content type: Research article

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  17. There is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine the prevalence of microscopic colitis and inflammation in Malaysian IBS patients with diarrhoea (...

    Authors: Ida Hilmi, Juanda Leo Hartono, Jayalakshmi Pailoor, Sanjiv Mahadeva and Khean-Lee Goh

    Citation: BMC Gastroenterology 2013 13:80

    Content type: Research article

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  18. Some studies have shown that endoscopist specialty is associated with colorectal cancers missed by colonoscopy. We sought to examine the relationship between endoscopist specialty and polypectomy rate, a colon...

    Authors: Mengzhu Jiang, Maida J Sewitch, Alan N Barkun, Lawrence Joseph and Robert J Hilsden

    Citation: BMC Gastroenterology 2013 13:78

    Content type: Research article

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  19. Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn’s disease (CD).

    Authors: Carsten Posovszky, Veronika Pfalzer, Georgia Lahr, Jan Hendrik Niess, Jochen Klaus, Benjamin Mayer, Klaus-Michael Debatin and Georg BT von Boyen

    Citation: BMC Gastroenterology 2013 13:77

    Content type: Research article

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  20. Intra-abdominal infections are one of the most common infections encountered by a general surgeon. However, despite this prevalence, standardized guidelines outlining the proper use of antibiotic therapy are p...

    Authors: Fausto Catena, Carlo Vallicelli, Luca Ansaloni, Massimo Sartelli, Salomone Di Saverio, Riccardo Schiavina, Eddi Pasqualini, Annalisa Amaduzzi, Federico Coccolini, Michele Cucchi, Daniel Lazzareschi, Gian Luca Baiocchi and Antonio D Pinna

    Citation: BMC Gastroenterology 2013 13:76

    Content type: Research article

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  21. Evidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these...

    Authors: Pilvi Paarlahti, Kalle Kurppa, Anniina Ukkola, Pekka Collin, Heini Huhtala, Markku Mäki and Katri Kaukinen

    Citation: BMC Gastroenterology 2013 13:75

    Content type: Research article

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  22. Chronic diarrhea in adults is a common symptom with a wide range of underlying etiologies. Although various strategies have been proposed for evaluation, there are still cases with undetermined origins even af...

    Authors: Chen Wang, Yue Li, Yali Jin, Weixun Zhou, Yanlin Zhu, Fang Yao and Jiaming Qian

    Citation: BMC Gastroenterology 2013 13:71

    Content type: Case report

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  23. Intestinal ischemia-reperfusion injury (IRI) can occur in clinical scenarios such as organ transplantation, trauma and cardio-pulmonary bypass, as well as in neonatal necrotizing enterocolitis or persistent du...

    Authors: Steven SC Cho, Ina Rudloff, Philip J Berger, Michael G Irwin, Marcel F Nold, Wei Cheng and Claudia A Nold-Petry

    Citation: BMC Gastroenterology 2013 13:69

    Content type: Research article

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  24. Many patients with IBS suffer on-going symptoms. The evidence base is poor for IBS drugs but they are widely prescribed and advised in Guidelines. Cognitive Behavioural Therapy (CBT) can be helpful, but availa...

    Authors: Hazel Everitt, Rona Moss-Morris, Alice Sibelli, Laura Tapp, Nicholas Coleman, Lucy Yardley, Peter Smith and Paul Little

    Citation: BMC Gastroenterology 2013 13:68

    Content type: Research article

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  25. This study investigated a possible role of Escherichia coli in propagation and perpetuation of the chronic inflammation in ulcerative colitis (UC). The lesions of UC are located superficially on the rectal and/or...

    Authors: Magdalena Pilarczyk-Zurek, Agnieszka Chmielarczyk, Tomasz Gosiewski, Anna Tomusiak, Pawel Adamski, Malgorzata Zwolinska-Wcislo, Tomasz Mach, Piotr B Heczko and Magdalena Strus

    Citation: BMC Gastroenterology 2013 13:61

    Content type: Research article

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  26. Orbital myositis is a rare extra-intestinal manifestation of inflammatory bowel disease. Seventeen cases of Crohn’s disease associated orbital myositis and 3 cases of ulcerative colitis associated orbital myos...

    Authors: Sanam Verma, Karen I Kroeker and Richard N Fedorak

    Citation: BMC Gastroenterology 2013 13:59

    Content type: Case report

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  27. Inflammatory bowel diseases (IBD) are chronic diseases of unknown etiology and pathogenesis in which genetic factors contribute to development of disease. MDR1/ABCB1 is an interesting candidate gene for IBD. The ...

    Authors: Marko Brinar, Silvija Cukovic-Cavka, Nada Bozina, Katja Grubelic Ravic, Pave Markos, Agata Ladic, Marijana Cota, Zeljko Krznaric and Boris Vucelic

    Citation: BMC Gastroenterology 2013 13:57

    Content type: Research article

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  28. Constipation is one of the most common gastrointestinal complaints with a highly prevalent and often chronic functional gastrointestinal disorder affecting health-related quality of life. The aim of the presen...

    Authors: Mengyi Zhou, Ping Jia, Jinping Chen, Aihui Xiu, Yue Zhao, Yibei Zhan, Peng Chen and Jianfa Zhang

    Citation: BMC Gastroenterology 2013 13:52

    Content type: Research article

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  29. The US CDC estimates over 2 million foodborne illnesses are annually caused by 4 major enteropathogens: non-typhoid Salmonella spp., Campylobacter spp., Shigella spp. and Yersinia enterocoltica. While data sugges...

    Authors: Chad K Porter, Daniel Choi, Brooks Cash, Mark Pimentel, Joseph Murray, Larissa May and Mark S Riddle

    Citation: BMC Gastroenterology 2013 13:46

    Content type: Research article

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  30. Irritable Bowel Syndrome (IBS) is a common condition characterised by pain, distension and altered bowel habit. Evidence suggests functional foods containing probiotics improve gastrointestinal transit, howeve...

    Authors: Lesley M Roberts, Deborah McCahon, Roger Holder, Sue Wilson and FD Richard Hobbs

    Citation: BMC Gastroenterology 2013 13:45

    Content type: Research article

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  31. Microscopic polyangiitis is characterized by pauci-immune, necrotizing small-vessel vasculitis and an anti-neutrophil cytoplasmic antibody-associated vasculitis. Although gastrointestinal involvement in micros...

    Authors: Masashi Fukushima, Satoko Inoue, Yuichiro Ono, Yoshitaka Tamaki, Hajime Yoshimura, Yukihiro Imai and Tetsuro Inokuma

    Citation: BMC Gastroenterology 2013 13:42

    Content type: Case report

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  32. Patients with ulcerative colitis (UC) are treated with prednisolone (PSL), which causes adverse side effects. Extracorporeal granulocyte/monocyte adsorption (GMA) with an Adacolumn depletes elevated/activated ...

    Authors: Keiichi Tominaga, Masakazu Nakano, Mina Hoshino, Kazunari Kanke and Hideyuki Hiraishi

    Citation: BMC Gastroenterology 2013 13:41

    Content type: Research article

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  33. Patients with persistent symptoms and/or villous atrophy despite strict adherence to a gluten-free diet (GFD) have non-responsive celiac disease (NRCD). A subset of these patients has refractory celiac disease...

    Authors: Justin R Hollon, Pamela A Cureton, Margaret L Martin, Elaine L Leonard Puppa and Alessio Fasano

    Citation: BMC Gastroenterology 2013 13:40

    Content type: Research article

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  34. A high prevalence of chronic fatigue has previously been reported following giardiasis after a large waterborne outbreak in Bergen, Norway in 2004. The aim of this study was to describe and evaluate differenti...

    Authors: Kristine Mørch, Kurt Hanevik, Ann C Rivenes, Jørn E Bødtker, Halvor Næss, Bjarte Stubhaug, Knut-Arne Wensaas, Guri Rortveit, Geir E Eide, Trygve Hausken and Nina Langeland

    Citation: BMC Gastroenterology 2013 13:28

    Content type: Research article

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  35. Adsorptive granulocyte and monocyte apheresis (GMA) with an Adacolumn in patients with ulcerative colitis (UC) has been applied as a non-pharmacological treatment strategy, but the efficacy has been encouragin...

    Authors: Yoko Yokoyama, Mikio Kawai, Ken Fukunaga, Koji Kamikozuru, Kazuko Nagase, Koji Nogami, Tomoaki Kono, Yoshio Ohda, Masaki Iimuro, Nobuyuki Hida, Shiro Nakamura, Hiroto Miwa and Takayuki Matsumoto

    Citation: BMC Gastroenterology 2013 13:27

    Content type: Research article

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  36. The cavitating mesenteric lymph node syndrome (CMLNS) is a rare manifestation of celiac disease, with an estimated mortality rate of 50%. Specific infections and malignant lymphoma may complicate its clinical ...

    Authors: Cristina Pojoga, Lidia Ciobanu, Alexandru Florin Badea, Emil Boţan, Cosmin Caraiani, Claudia Hagiu, Grigore Băciuţ and Radu Badea

    Citation: BMC Gastroenterology 2013 13:26

    Content type: Case report

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  37. Although high non-adherence to medication has been noticed for ulcerative colitis (UC), little is known about adherence to mesalamine treatments and determinants that can predict adherence. The objective of th...

    Authors: Jean Lachaine, Linnette Yen, Catherine Beauchemin and Paul Hodgkins

    Citation: BMC Gastroenterology 2013 13:23

    Content type: Research article

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  38. Alterations in the fecal bacterial flora occur in inflammatory bowel disease (IBD). We examined the abundance and diversity of Clostridium leptum group, an important group of carbohydrate-fermenting bacteria, in ...

    Authors: Jayakanthan Kabeerdoss, Vijayalakshmi Sankaran, Srinivasan Pugazhendhi and Balakrishnan S Ramakrishna

    Citation: BMC Gastroenterology 2013 13:20

    Content type: Research article

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  39. Internet websites are a resource for patients seeking information about probiotics. We examined a sample of 71 websites presenting probiotic information. We found that descriptions of benefits far outnumbered ...

    Authors: Margaret A Brinich, Mary Beth Mercer and Richard R Sharp

    Citation: BMC Gastroenterology 2013 13:5

    Content type: Correspondence

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  40. There is lack of data on prevalence of celiac disease (CD) in children with type 1 diabetes (T1D) in Arabs in the Middle East. The present investigation aims to study the prevalence rate and clinical character...

    Authors: Abdulrahman Al-Hussaini, Nimer Sulaiman, Musa Al-Zahrani, Ahmed Alenizi and Imad El Haj

    Citation: BMC Gastroenterology 2012 12:180

    Content type: Research article

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  41. Gastrointestinal dysmotility may be involved in the development of bacterial translocation and infection in patients with liver cirrhosis. The aim of the present study was to describe gastric, small intestinal...

    Authors: Stine Karlsen, Lotte Fynne, Henning Grønbæk and Klaus Krogh

    Citation: BMC Gastroenterology 2012 12:176

    Content type: Research article

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  42. Patients with Crohn’s disease (CD) have been shown to present dyspeptic symptoms more frequently than the general population. Some of these symptoms could be related to motility disorders to some degree. Then,...

    Authors: Ana Carolina Mello Nóbrega, Bruno Roberto Silva Ferreira, Graciela Josué Oliveira, Kamila Maria Oliveira Sales, Armênio Aguiar Santos, Miguel Ângelo Nobre e Souza, Lúcia Libanês Bessa Campelo Braga, Luizde Almeida Ernesto de Almeida Troncon and Marcellus Henrique Loiola Ponte Souza

    Citation: BMC Gastroenterology 2012 12:175

    Content type: Research article

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  43. Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells demonstrate advantages over natural Treg (nTreg) cells in ...

    Authors: Anna Majowicz, Sander van der Marel, Anje A te Velde, Sybren L Meijer, Harald Petry, Sander J van Deventer and Valerie Ferreira

    Citation: BMC Gastroenterology 2012 12:172

    Content type: Research article

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  44. Patients with Irritable Bowel Syndrome (IBS) often relate their symptoms to the intake of food and modify their diet. IgE-mediated food allergy is uncommon in IBS, but the role of IgG-mediated food hypersensit...

    Authors: Solveig C Ligaarden, Stian Lydersen and Per G Farup

    Citation: BMC Gastroenterology 2012 12:166

    Content type: Research article

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  45. To compare the characteristics between 22-channel water-perfusion manometry (WPM) and solid-state manometry (SSM) with 36 sensors of the pressure measurements, as well as patients’ discomfort indices in nose a...

    Authors: Kun Wang, Li-ping Duan, Ying Ge, Zhi-wei Xia and Zhi-jie Xu

    Citation: BMC Gastroenterology 2012 12:157

    Content type: Research article

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  46. Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion. In a mous...

    Authors: Robert C De Lisle

    Citation: BMC Gastroenterology 2012 12:156

    Content type: Research article

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  47. Pancreatic Stone Protein (PSP) is a protein naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that blood PSP levels rise in the presence of inflamma...

    Authors: Christoph Tschuor, Dimitri Aristotle Raptis, Përparim Limani, Thomas Bächler, Christian Eugen Oberkofler, Stefan Breitenstein and Rolf Graf

    Citation: BMC Gastroenterology 2012 12:154

    Content type: Study protocol

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  48. Sleep disturbances are increasingly recognized as a common problem for children and adolescents with chronic pain conditions, but little is known about the prevalence, type, and impact of sleep problems in ped...

    Authors: Jennifer Verrill Schurman, Craig A Friesen, Hongying Dai, Caroline Elder Danda, Paul E Hyman and Jose T Cocjin

    Citation: BMC Gastroenterology 2012 12:142

    Content type: Research article

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