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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Splenic abscesses in children are rare. In recent years aseptic abscesses have been recognized as a new disease entity, especially in adults.

    Authors: Alexander J Jordan, Klaus-Peter Becker, Metin Sertemir, K Wolfgang Neff, Rüdiger Adam, Horst Schroten and Tobias Tenenbaum

    Citation: BMC Gastroenterology 2014 14:20

    Content type: Case report

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  2. Environmental enteropathy (EE) is an asymptomatic abnormality of small bowel structure and function, which may underlie vaccine inefficacy in the developing world. HIV infection co-exists in many of these popu...

    Authors: John Louis-Auguste, Stephen Greenwald, Michelo Simuyandi, Rose Soko, Rose Banda and Paul Kelly

    Citation: BMC Gastroenterology 2014 14:15

    Content type: Research article

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  3. Brunner’s gland hamartoma is a rare tumor, predominantly found in the fifth to sixth decades of life. Generally, it is a single pedunculated polyp, rarely larger than 5 cm. Asymptomatic cases are found inciden...

    Authors: Mayumi Akaki, Shoji Taniguchi, Kinta Hatakeyama, Ryoji Kushima and Hiroaki Kataoka

    Citation: BMC Gastroenterology 2014 14:14

    Content type: Case report

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  4. Ulcerative colitis (UC) is a chronic, inflammatory bowel disease which may lead to dysplasia and adenocarcinoma in patients when long-lasting. Short telomeres have been reported in mucosal cells of UC patients...

    Authors: Mariann Friis-Ottessen, Laila Bendix, Steen Kølvraa, Solveig Norheim-Andersen, Paula M De Angelis and Ole Petter F Clausen

    Citation: BMC Gastroenterology 2014 14:8

    Content type: Research article

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  5. Bisphosphonates have a widespread indication for osteoporosis and are also applied in cancer patients with skeletal-related conditions. Bisphosphonate-associated osteonecrosis of the jaw (BRONJ) is a feared si...

    Authors: Raimund HM Preidl, Tobias Ebker, Martin Raithel, Falk Wehrhan, Friedrich W Neukam and Philipp Stockmann

    Citation: BMC Gastroenterology 2014 14:6

    Content type: Case report

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  6. Allopurinol is a frequently prescribed drug. In inflammatory bowel disease patients who shunt thiopurine metabolism towards more toxic and less desirable pathways, allopurinol is proving to be an effective add...

    Authors: Muhammad W Fazal, Matt P Doogue, Rupert W Leong, Peter A Bampton and Jane M Andrews

    Citation: BMC Gastroenterology 2013 13:172

    Content type: Case report

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  7. We sought to define the sensitivity and specificity of intraperitoneal (IP) and intraluminal (IL) microdialysate metabolites in depicting ex vivo small intestinal total ischemia during GI-tract surgery. We hyp...

    Authors: Lauri Pynnönen, Minna Minkkinen, Anders Perner, Sari Räty, Isto Nordback, Juhani Sand and Jyrki Tenhunen

    Citation: BMC Gastroenterology 2013 13:170

    Content type: Research article

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  8. Inflammatory bowel disease (IBD) is characterized by disturbance of pro-inflammatory cytokines and anti-inflammatory cytokines. Previous studies have demonstrated the effect of anti-inflammatory cytokines, suc...

    Authors: Jing Xiong, Ying-Hao Lin, Li-Hong Bi, Ji-De Wang, Yang Bai and Si-De Liu

    Citation: BMC Gastroenterology 2013 13:165

    Content type: Research article

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  9. Berberine, an isoquinoline alkaloid, has shown inhibitory effects on growth of several tumor cell lines in vitro. The aim of this study was to investigate chemopreventive effects of berberine on intestinal tumor ...

    Authors: Hailong Cao, Shuli Song, Hui Zhang, Yujie Zhang, Rui Qu, Boli Yang, Yang Jing, Tianhui Hu, Fang Yan and Bangmao Wang

    Citation: BMC Gastroenterology 2013 13:163

    Content type: Research article

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  10. Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammatory and neoplastic diseases. Here we report the first ...

    Authors: Silvia Sedda, Roberta Caruso, Irene Marafini, Elena Campione, Augusto Orlandi, Francesco Pallone and Giovanni Monteleone

    Citation: BMC Gastroenterology 2013 13:162

    Content type: Case report

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  11. Several studies show that psychological treatments relieve symptoms for patients suffering from irritable bowel syndrome (IBS). However, there are no consistent findings that show what patient characteristics ...

    Authors: Brjánn Ljótsson, Erik Andersson, Perjohan Lindfors, Jeffrey M Lackner, Karin Grönberg, Katarina Molin, Johanna Norén, Karin Romberg, Evelyn Andersson, Timo Hursti, Hugo Hesser and Erik Hedman

    Citation: BMC Gastroenterology 2013 13:160

    Content type: Research article

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  12. The aim of this study is to evaluate the role of NADPH oxidase in primary intestinal epithelial cells during the active phase of UC.

    Authors: Rima Ramonaite, Jurgita Skieceviciene, Gediminas Kiudelis, Laimas Jonaitis, Algimantas Tamelis, Paulius Cizas, Vilmante Borutaite and Limas Kupcinskas

    Citation: BMC Gastroenterology 2013 13:159

    Content type: Research article

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  13. Celiac disease (CD) is an autoimmune disorder, characterized by the presence of gastrointestinal and multisystem symptoms, which occasionally mimic those of Irritable Bowel Syndrome (IBS) and Fibromyalgia Synd...

    Authors: Luis Rodrigo, Ignacio Blanco, Julio Bobes and Frederick J de Serres

    Citation: BMC Gastroenterology 2013 13:157

    Content type: Research article

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  14. Clinical algorithms for the workup of celiac disease often recommend the use of serologic assays for initial screening, followed by duodenal biopsy for histologic confirmation. However, the majority of duodena...

    Authors: Homer O Wiland 4th, Walter H Henricks and Thomas M Daly

    Citation: BMC Gastroenterology 2013 13:156

    Content type: Research article

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  15. Acute lower gastrointestinal hemorrhage originating from the appendix is rare and often intractable, because it is almost impossible to approach the bleeding point by endoscopy. We herein describe the first ca...

    Authors: Youkou Konno, Mikihiro Fujiya, Kazuyuki Tanaka, Aki Sakatani, Mizue Shimoda, Akihiro Hayashi, Momotaro Muto, Mitutaka Inoue, Jun Sakamoto, Kensuke Oikawa, Nobuhiro Ueno, Yuhei Inaba, Kentaro Moriichi and Yutaka Kohgo

    Citation: BMC Gastroenterology 2013 13:152

    Content type: Case report

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  16. To determine within one tertiary care center: 1) the variation between providers in testing for celiac disease in children with chronic abdominal pain; 2) the characteristics of those children who were more li...

    Authors: Bruno Pedro Chumpitazi, Krupa Mysore, Cynthia Man-Wai Tsai and Robert Jay Shulman

    Citation: BMC Gastroenterology 2013 13:150

    Content type: Research article

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  17. Gas-related symptoms represent very common complaints in children. The reduction of gas production can be considered as a valuable target in controlling symptoms. α-galactosidase has been shown to reduce gas p...

    Authors: Giovanni Di Nardo, Salvatore Oliva, Federica Ferrari, Saverio Mallardo, Giovanni Barbara, Cesare Cremon, Marina Aloi and Salvatore Cucchiara

    Citation: BMC Gastroenterology 2013 13:142

    Content type: Research article

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  18. Non-steroidal anti-inflammatory drugs (NSAIDs), the most widely prescribed drugs in the world, can cause gastrointestinal damage, including colitis. However, the prevalence of NSAID-induced colitis is unknown ...

    Authors: Hung-Ling Huang, Po-Liang Lu, Chun-Yu Lin, Yen-Hsu Chen, Chao-Hung Kuo and Wei-Ru Lin

    Citation: BMC Gastroenterology 2013 13:139

    Content type: Case report

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  19. Integrin-linked kinase (ILK) is a serine-threonine kinase that transduces extracellular matrix-related cues into intracellular signals, with fundamental roles in cell motility, development and cancer. Recently...

    Authors: Kiran Assi, Kirk Bergstrom, Bruce Vallance, David Owen and Baljinder Salh

    Citation: BMC Gastroenterology 2013 13:137

    Content type: Research article

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  20. Guanylate Cyclase C (GC-C) is an apically-oriented transmembrane receptor that is expressed on epithelial cells of the intestine. Activation of GC-C by the endogenous ligands guanylin or uroguanylin elevates i...

    Authors: Elizabeth A Mann, Eleana Harmel-Laws, Mitchell B Cohen and Kris A Steinbrecher

    Citation: BMC Gastroenterology 2013 13:135

    Content type: Research article

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  21. Ulcerative colitis is a chronic inflammatory disease and involves multiple etiological factors. Acetic acid (AA)-induced colitis is a reproducible and simple model, sharing many characteristics with human coli...

    Authors: Qingjing Wang, Yongqing Hou, Dan Yi, Lei Wang, Binying Ding, Xing Chen, Minhui Long, Yulan Liu and Guoyao Wu

    Citation: BMC Gastroenterology 2013 13:133

    Content type: Research article

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  22. The gut microbiome is altered in Crohn’s disease. Although individual taxa have been correlated with post-operative clinical course, global trends in microbial diversity have not been described in this context.

    Authors: Neelendu Dey, David AW Soergel, Susanna Repo and Steven E Brenner

    Citation: BMC Gastroenterology 2013 13:131

    Content type: Research article

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  23. Currently available drugs for the treatment of ulcerative colitis (UC) include salicylates, thiopurines, corticosteroids and new anti-tumour necrosis factor (TNF)-α biologics. Among these medications, corticos...

    Authors: Tomotaka Tanaka, Shinichiro Sugiyama, Hirokazu Goishi, Tsuyoshi Kajihara, Morihisa Akagi and Toshio Miura

    Citation: BMC Gastroenterology 2013 13:130

    Content type: Research article

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  24. The diagnosis of hereditary angioedema (HAE) is often delayed due to the low awareness of this condition. In patients with undiagnosed HAE, abdominal symptoms often create the risk of unnecessary surgical oper...

    Authors: Isao Ohsawa, Seiji Nagamachi, Hiyori Suzuki, Daisuke Honda, Nobuyuki Sato, Hiroyuki Ohi, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Gastroenterology 2013 13:123

    Content type: Research article

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  25. Endovascular revascularization has recently been established as a less invasive treatment method for chronic mesenteric ischemia. However, intestinal necrosis caused by distal embolization following this proce...

    Authors: Takuro Shirasu, Akihiro Hosaka, Hiroyuki Okamoto, Kunihiro Shigematsu, Yasushi Takeda, Tetsuro Miyata and Toshiaki Watanabe

    Citation: BMC Gastroenterology 2013 13:118

    Content type: Case report

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  26. Oral immunization with vaccines may be an effective strategy for prevention of Clostridium difficile infection (CDI). However, application of previously developed vaccines for preventing CDI has been limited due ...

    Authors: Xiao-qiang Yang, Ya-gang Zhao, Xue-qing Chen, Bo Jiang and Da-yong Sun

    Citation: BMC Gastroenterology 2013 13:117

    Content type: Research article

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  27. Coeliac disease (CD), due to its protean clinical manifestation, is still very under diagnosed in adults and delays in diagnosis may take years and even decades. Simple tools to find cases in primary care may ...

    Authors: Alina Popp, Mariana Jinga, Ciprian Jurcut, Vasile Balaban, Catalina Bardas, Kaija Laurila, Florina Vasilescu, Adina Ene, Ioana Anca and Markku Mäki

    Citation: BMC Gastroenterology 2013 13:115

    Content type: Research article

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  28. Celiac disease (CD) is an autoimmune disorder of the small intestine which is triggered by dietary gluten in genetically predisposed (HLA-DQ2/DQ8 positive) individuals. Only a fraction of HLA-DQ2/DQ8 positive ...

    Authors: Jing Cheng, Marko Kalliomäki, Hans GHJ Heilig, Airi Palva, Hannu Lähteenoja, Willem M de Vos, Jarkko Salojärvi and Reetta Satokari

    Citation: BMC Gastroenterology 2013 13:113

    Content type: Research article

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  29. The intestinal microbiota has been proposed to play a pathogenic role in coeliac disease (CD). Although antibiotics are common environmental factors with a profound impact on intestinal microbiota, data on ant...

    Authors: Karl Mårild, Weimin Ye, Benjamin Lebwohl, Peter HR Green, Martin J Blaser, Tim Card and Jonas F Ludvigsson

    Citation: BMC Gastroenterology 2013 13:109

    Content type: Research article

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  30. Treatment of low-dose aspirin (LDA)-induced small-bowel injury has not been established. Polaprezinc, a chelate of zinc and L-carnosine, may be efficacious for such injury. We conducted a pilot randomized cont...

    Authors: Ikue Watari, Shiro Oka, Shinji Tanaka, Taiki Aoyama, Hiroki Imagawa, Takayoshi Shishido, Shigeto Yoshida and Kazuaki Chayama

    Citation: BMC Gastroenterology 2013 13:108

    Content type: Research article

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  31. Complications of chronic anal fissure (CAF) treatments are prompting interest in lower-risk therapies. This study was conducted to compare nitroglycerin (NTG) 0.4% ointment with placebo for pain associated wit...

    Authors: Scott M Berry, Charles F Barish, Raj Bhandari, Gemma Clark, Gregory V Collins, Julian Howell, John E Pappas, Dennis S Riff, Michael Safdi and Ann Yellowlees

    Citation: BMC Gastroenterology 2013 13:106

    Content type: Research article

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  32. The advent of double-balloon enteroscopy has enabled more accurate diagnosis and treatment of small bowel disorders. Single-balloon enteroscopy permits visualization of the entire small intestine less often th...

    Authors: Varayu Prachayakul, Morakod Deesomsak, Pitulak Aswakul and Somchai Leelakusolvong

    Citation: BMC Gastroenterology 2013 13:103

    Content type: Research article

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  33. The objective is to compare primary repair vs intestinal resection in cases of intestinal typhoid perforations. In addition, we hypothesised the usefulness of laparostomy for the early diagnosis and treatment ...

    Authors: Roberto Caronna, Alassan Kadiri Boukari, Dieudonnè Zaongo, Thierry Hessou, Rènè Castro Gayito, Cesar Ahononga, Sosten Adeniran and Giambattista Priuli

    Citation: BMC Gastroenterology 2013 13:102

    Content type: Research article

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  34. How to maintain “gut health” is a goal for scientists throughout the world. Therefore, microbiota management models for testing probiotics, prebiotics, and synbiotics have been developed.

    Authors: Katia Sivieri, Martha L Villarreal Morales, Maria A Tallarico Adorno, Isabel Kimiko Sakamoto, Susana M Isay Saad and Elizeu A Rossi

    Citation: BMC Gastroenterology 2013 13:100

    Content type: Research article

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  35. An association between eosinophilic esophagitis (EoE) and celiac disease (CD) has been suggested in the literature. Our aim was to confirm and quantify the association between these two diseases.

    Authors: Michael J Stewart, Eldon Shaffer, Stephan J Urbanski, Paul L Beck and Martin A Storr

    Citation: BMC Gastroenterology 2013 13:96

    Content type: Research article

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  36. Intussusception (IS) is a form of acute intestinal obstruction that occurs mainly in infants and is usually of unknown cause. An association between IS and the first licensed rotavirus vaccine, a reassortant-t...

    Authors: Xavier Sáez-Llorens, F Raúl Velázquez, Pio Lopez, Felix Espinoza, Alexandre C Linhares, Hector Abate, Ernesto Nuñez, Guillermo Venegas, Rodrigo Vergara, Ana L Jimenez, Maribel Rivera, Carlos Aranza, Vesta Richardson, Mercedes Macias-Parra, Guillermo Ruiz Palacios, Luis Rivera…

    Citation: BMC Gastroenterology 2013 13:95

    Content type: Research article

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  37. Cereals of baking quality with absent or reduced toxicity are actively sought as alternative therapy to a gluten-free diet (GFD) for patients with coeliac disease (CD). Triticum monococcum, an ancient wheat, is a...

    Authors: Barbara Zanini, Beatrice Petroboni, Tarcisio Not, Nicola Di Toro, Vincenzo Villanacci, Francesco Lanzarotto, Norberto Pogna, Chiara Ricci and Alberto Lanzini

    Citation: BMC Gastroenterology 2013 13:92

    Content type: Research article

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  38. Measurements of CFTR function in rectal biopsies ex vivo have been used for diagnosis and prognosis of Cystic Fibrosis (CF) disease. Here, we aimed to evaluate this procedure regarding: i) viability of the rectal...

    Authors: Maria F Servidoni, Marisa Sousa, Adriana M Vinagre, Silvia R Cardoso, Maria A Ribeiro, Luciana R Meirelles, Rita B de Carvalho, Karl Kunzelmann, Antônio F Ribeiro, José D Ribeiro and Margarida D Amaral

    Citation: BMC Gastroenterology 2013 13:91

    Content type: Research article

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  39. There is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine the prevalence of microscopic colitis and inflammation in Malaysian IBS patients with diarrhoea (...

    Authors: Ida Hilmi, Juanda Leo Hartono, Jayalakshmi Pailoor, Sanjiv Mahadeva and Khean-Lee Goh

    Citation: BMC Gastroenterology 2013 13:80

    Content type: Research article

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  40. Some studies have shown that endoscopist specialty is associated with colorectal cancers missed by colonoscopy. We sought to examine the relationship between endoscopist specialty and polypectomy rate, a colon...

    Authors: Mengzhu Jiang, Maida J Sewitch, Alan N Barkun, Lawrence Joseph and Robert J Hilsden

    Citation: BMC Gastroenterology 2013 13:78

    Content type: Research article

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  41. Influence of genetic variants in the NOD2 gene may play a more important role in disease activity, behaviour and treatment of pediatric- than adult-onset Crohn’s disease (CD).

    Authors: Carsten Posovszky, Veronika Pfalzer, Georgia Lahr, Jan Hendrik Niess, Jochen Klaus, Benjamin Mayer, Klaus-Michael Debatin and Georg BT von Boyen

    Citation: BMC Gastroenterology 2013 13:77

    Content type: Research article

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  42. Intra-abdominal infections are one of the most common infections encountered by a general surgeon. However, despite this prevalence, standardized guidelines outlining the proper use of antibiotic therapy are p...

    Authors: Fausto Catena, Carlo Vallicelli, Luca Ansaloni, Massimo Sartelli, Salomone Di Saverio, Riccardo Schiavina, Eddi Pasqualini, Annalisa Amaduzzi, Federico Coccolini, Michele Cucchi, Daniel Lazzareschi, Gian Luca Baiocchi and Antonio D Pinna

    Citation: BMC Gastroenterology 2013 13:76

    Content type: Research article

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  43. Evidence suggests that many coeliac disease patients suffer from persistent clinical symptoms and reduced health-related quality of life despite a strict gluten-free diet. We aimed to find predictors for these...

    Authors: Pilvi Paarlahti, Kalle Kurppa, Anniina Ukkola, Pekka Collin, Heini Huhtala, Markku Mäki and Katri Kaukinen

    Citation: BMC Gastroenterology 2013 13:75

    Content type: Research article

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  44. Chronic diarrhea in adults is a common symptom with a wide range of underlying etiologies. Although various strategies have been proposed for evaluation, there are still cases with undetermined origins even af...

    Authors: Chen Wang, Yue Li, Yali Jin, Weixun Zhou, Yanlin Zhu, Fang Yao and Jiaming Qian

    Citation: BMC Gastroenterology 2013 13:71

    Content type: Case report

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  45. Intestinal ischemia-reperfusion injury (IRI) can occur in clinical scenarios such as organ transplantation, trauma and cardio-pulmonary bypass, as well as in neonatal necrotizing enterocolitis or persistent du...

    Authors: Steven SC Cho, Ina Rudloff, Philip J Berger, Michael G Irwin, Marcel F Nold, Wei Cheng and Claudia A Nold-Petry

    Citation: BMC Gastroenterology 2013 13:69

    Content type: Research article

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  46. Many patients with IBS suffer on-going symptoms. The evidence base is poor for IBS drugs but they are widely prescribed and advised in Guidelines. Cognitive Behavioural Therapy (CBT) can be helpful, but availa...

    Authors: Hazel Everitt, Rona Moss-Morris, Alice Sibelli, Laura Tapp, Nicholas Coleman, Lucy Yardley, Peter Smith and Paul Little

    Citation: BMC Gastroenterology 2013 13:68

    Content type: Research article

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  47. This study investigated a possible role of Escherichia coli in propagation and perpetuation of the chronic inflammation in ulcerative colitis (UC). The lesions of UC are located superficially on the rectal and/or...

    Authors: Magdalena Pilarczyk-Zurek, Agnieszka Chmielarczyk, Tomasz Gosiewski, Anna Tomusiak, Pawel Adamski, Malgorzata Zwolinska-Wcislo, Tomasz Mach, Piotr B Heczko and Magdalena Strus

    Citation: BMC Gastroenterology 2013 13:61

    Content type: Research article

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  48. Orbital myositis is a rare extra-intestinal manifestation of inflammatory bowel disease. Seventeen cases of Crohn’s disease associated orbital myositis and 3 cases of ulcerative colitis associated orbital myos...

    Authors: Sanam Verma, Karen I Kroeker and Richard N Fedorak

    Citation: BMC Gastroenterology 2013 13:59

    Content type: Case report

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