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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The chronic nature of inflammatory bowel disease leads to considerable impairment on the health related quality of life (HRQOL). The aims of the present study are to validate the mainland Chinese translation o...

    Authors: Junjie Xu, Hui Lin, Xu Feng, Minyue Tang, Jun Shen and Zhihua Ran

    Citation: BMC Gastroenterology 2014 14:199

    Content type: Research article

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  2. Celiac disease is a multiform, challenging condition characterized by extremely variable features. Our goal was to define clinical, serological and histopathological findings in a large cohort of celiacs diagn...

    Authors: Umberto Volta, Giacomo Caio, Vincenzo Stanghellini and Roberto De Giorgio

    Citation: BMC Gastroenterology 2014 14:194

    Content type: Research article

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  3. Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of de...

    Authors: Stephan C Bischoff, Giovanni Barbara, Wim Buurman, Theo Ockhuizen, Jörg-Dieter Schulzke, Matteo Serino, Herbert Tilg, Alastair Watson and Jerry M Wells

    Citation: BMC Gastroenterology 2014 14:189

    Content type: Review

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  4. The serological diagnosis of celiac disease (CD) often relies on the presence of anti-tissue transglutaminase (tTG) IgA autoantibodies. Patients suffering from selective IgA deficiency (IgAD) are often not awa...

    Authors: Francoise Bienvenu, Silvia I Anghel, Cécile Besson Duvanel, Julien Guillemaud, Lorna Garnier, Florian Renosi, Alain Lachaux and Jacques Bienvenu

    Citation: BMC Gastroenterology 2014 14:186

    Content type: Research article

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  5. Fibromyalgia Syndrome (FMS) is a frequent comorbidity in Irritable Bowel Syndrome (IBS) patients with a higher functional bowel disorder severity index (FBDSI). We tested the possibility that mild to severe IB...

    Authors: Fabrizio Tremolaterra, Serena Gallotta, Yvonne Morra, Ennio Lubrano, Carolina Ciacci and Paola Iovino

    Citation: BMC Gastroenterology 2014 14:9002

    Content type: Research article

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  6. The treatment of iron deficiency anemia in children with inflammatory bowel disease is a particular challenge and often insufficient. Absorption of orally given iron may be impaired by intestinal inflammation ...

    Authors: Martin W Laass, Simon Straub, Suki Chainey, Garth Virgin and Timothy Cushway

    Citation: BMC Gastroenterology 2014 14:184

    Content type: Research article

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  7. Blood-based diagnostics has the potential to simplify the process of diagnosing celiac disease (CD). Although high levels of autoantibodies against tissue transglutaminase (anti-TG2) are strongly indicative of...

    Authors: Hanna Bragde, Ulf Jansson, Mats Fredrikson, Ewa Grodzinsky and Jan Söderman

    Citation: BMC Gastroenterology 2014 14:176

    Content type: Research article

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  8. Previous studies indicated that the micro integral membrane protein located within the media place of the integral membrane protein of Lactobacillus plantarum CGMCC 1258 had protective effects against the intesti...

    Authors: Zhihua Liu, Liang Kang, Chao Li, Chao Tong, Meijin Huang, Xingwei Zhang, Nanqi Huang, Mary Pat Moyer, Huanlong Qin and Jianping Wang

    Citation: BMC Gastroenterology 2014 14:171

    Content type: Research article

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  9. In up to 30 percent of small bowel capsule endoscopy procedures, the capsule does not reach the cecum within recording time. A prolonged gastric transit time has been recognized as a risk factor for incomplete...

    Authors: Jessie Westerhof, Rinse K Weersma, Reinier A Hoedemaker and Jan J Koornstra

    Citation: BMC Gastroenterology 2014 14:162

    Content type: Research article

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  10. Evaluation of pregnant women with known or suspected Crohn’s disease (CD) remains a challenge. Magnetic Resonance Enterography (MRE) is a promising diagnostic tool in these patients; however, the clinical data...

    Authors: Myriam D Stern, Uri Kopylov, Shomron Ben-Horin, Sarah Apter and Marianne Michal Amitai

    Citation: BMC Gastroenterology 2014 14:146

    Content type: Research article

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  11. Crohn’s disease (CD) is a lifelong, relapsing and remitting inflammatory condition of the intestine. Medical imaging is crucial for diagnosis, phenotyping, activity assessment and detecting complications. Dive...

    Authors: Stuart Taylor, Susan Mallett, Gauraang Bhatnagar, Stuart Bloom, Arun Gupta, Steve Halligan, John Hamlin, Ailsa Hart, Antony Higginson, Ilan Jacobs, Sara McCartney, Steve Morris, Nicola Muirhead, Charles Murray, Shonit Punwani, Manuel Rodriguez-Justo…

    Citation: BMC Gastroenterology 2014 14:142

    Content type: Study protocol

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  12. Coeliac disease is a common enteropathy characterized by an increased mortality mainly due to its complications. The natural history of complicated coeliac disease is characterised by two different types of co...

    Authors: Federico Biagi, Alessandra Marchese, Francesca Ferretti, Rachele Ciccocioppo, Annalisa Schiepatti, Umberto Volta, Giacomo Caio, Carolina Ciacci, Fabiana Zingone, Anna D’Odorico, Antonio Carroccio, Giuseppe Ambrosiano, Pasquale Mansueto, Antonio Gasbarrini, Anna Chiara Piscaglia, Alida Andrealli…

    Citation: BMC Gastroenterology 2014 14:139

    Content type: Research article

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  13. Hydroxyurea at a relatively low dose is frequently prescribed to induce hemoglobin F production in patients with sickle cell and β-thalassemia diseases because of its good efficacy and safety profiles. However...

    Authors: Kochawan Boonyawat, Sansanee Wongwaisayawan, Prawat Nitiyanant and Vichai Atichartakarn

    Citation: BMC Gastroenterology 2014 14:134

    Content type: Case report

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  14. Early induction with biologics can reduce complications in patients with Crohn’s disease (CD) and improve their quality of life. The safety of biologics, however, is uncertain. Granulocyte and monocyte adsorpt...

    Authors: Takumi Fukuchi, Hiroshi Nakase, Satoshi Ubukata, Minoru Matsuura, Takuya Yoshino, Takahiko Toyonaga, Keiji Shimazu, Hideaki Koga, Hiroshi Yamashita, Dai Ito and Kiyoshi Ashida

    Citation: BMC Gastroenterology 2014 14:124

    Content type: Research article

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  15. Hirschsprung’s disease (HSCR) is the most common congenital gut motility disorder. We aimed to investigate the roles of miR-195 in the pathogenesis of HSCR.

    Authors: Hao Lei, Junwei Tang, Hongxing Li, Hongwei Zhang, Changgui Lu, Huan Chen, Wei Li, Yankai Xia and Weibing Tang

    Citation: BMC Gastroenterology 2014 14:123

    Content type: Research article

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  16. Colonic lipomas (CL) are rare benign adipose tumours usually found incidentally during colonoscopy. Endoscopic resection of symptomatic large CL remains controversial, since significant rates of perforation ha...

    Authors: Hrvoje Ivekovic, Nadan Rustemovic, Tomislav Brkic, Rajko Ostojic and Klaus Monkemuller

    Citation: BMC Gastroenterology 2014 14:122

    Content type: Research article

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  17. To perform a meta-analysis evaluating the diagnostic ability of fecal lactoferrin (FL) to distinguish inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS).

    Authors: Xing-lu Zhou, Wen Xu, Xiao-xiao Tang, Lai-sheng Luo, Jiang-feng Tu, Chen-jing Zhang, Xiang Xu, Qin-dong Wu and Wen-sheng Pan

    Citation: BMC Gastroenterology 2014 14:121

    Content type: Research article

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  18. Irritable bowel syndrome (IBS) is among the most common gastrointestinal disorders worldwide. In selected patients with severe diarrhoea-predominant or mixed IBS subtypes sacral nerve stimulation (SNS) allevia...

    Authors: Janne Fassov, Lilli Lundby, Jonas Worsøe, Steen Buntzen, Søren Laurberg and Klaus Krogh

    Citation: BMC Gastroenterology 2014 14:111

    Content type: Research article

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  19. Several types of congenital lesions can cause complete or incomplete obstruction of the intestine. Our purpose is to present 3 neonates with dual intestinal type I atresia, i.e., simultaneous obstructive lesio...

    Authors: Hua-dong Chen, Hong Jiang, Anna Kan, Li-e Huang, Zhi-hai Zhong, Zhi-chong Zhang and Jun-cheng Liu

    Citation: BMC Gastroenterology 2014 14:108

    Content type: Case report

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  20. This study investigates the effect of glucose on the LPS-induced apoptosis of dendritic cells in the intestinal tract of mice and the dendritic cell line DC2.4.

    Authors: Mei Feng, Juan Li, Jun Wang, Chunyan Ma, Yulian Jiao, Yan Wang, Jie Zhang, Qiuying Sun, Ying Ju, Ling Gao and Yueran Zhao

    Citation: BMC Gastroenterology 2014 14:98

    Content type: Research article

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  21. Prevalence data is essential for planning of healthcare services. The prevalence of faecal incontinence (FI) varies worldwide, and in Malaysia is not known. We sought to estimate its prevalence among patients ...

    Authors: April C Roslani, Rajeshwary Ramakrishnan, Soraya Azmi, Daryl J Arapoc and Adrian Goh

    Citation: BMC Gastroenterology 2014 14:95

    Content type: Research article

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  22. Paneth cell metaplasia (PCM) is well described in adults but little is known about the distribution of colonic Paneth cells and the occurrence of PCM in a paediatric population. The aim of this study is to det...

    Authors: Naomi Simmonds, Mark Furman, Evi Karanika, Alan Phillips and Alan WH Bates

    Citation: BMC Gastroenterology 2014 14:93

    Content type: Research article

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  23. Adult intussusception is a rare clinical condition worldwide. It contributes to less than 5% of all cases of intussusception. Few studies have been conducted in low-income countries compared to high-income cou...

    Authors: Peter A Ongom, Christopher K Opio and Stephen C Kijjambu

    Citation: BMC Gastroenterology 2014 14:86

    Content type: Research article

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  24. The natural course of Crohn’s disease (CD), with continuing relapses and remissions, leads to irreversible intestinal damage. Early adoption of immunomodulator therapy has been proposed in order to address thi...

    Authors: Min Seob Kwak, Duk Hwan Kim, Soo Jung Park, Tae Il Kim, Sung Pil Hong, Won Ho Kim and Jae Hee Cheon

    Citation: BMC Gastroenterology 2014 14:85

    Content type: Research article

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  25. The long-term efficacy of infliximab (IFX) for patients with refractory ulcerative colitis (UC) is unclear. The aim of this study was to assess the long-term outcomes of IFX treatment in patients with refracto...

    Authors: Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Yoshihisa Tsuji and Hiroshi Nakase

    Citation: BMC Gastroenterology 2014 14:80

    Content type: Research article

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  26. Glucocorticoids (GCS) remain one of the mainstay treatments in the management of ulcerative colitis (UC) but up to a third of patients will ultimately fail to respond and progress to a more severe and difficul...

    Authors: Nikolai V Kuznetsov, Arezou Zargari, Alexander W Gielen, Oliver D von Stein, Eugen Musch, Ragnar Befrits, Robert Lofberg and Petra von Stein

    Citation: BMC Gastroenterology 2014 14:79

    Content type: Research article

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  27. To investigate whether anxiety and depression levels are associated with Heat Shock Protein 70 (HSP70) induction in the colon of patients with ulcerative colitis (UC).

    Authors: Ilias I Vlachos, Calypso Barbatis, Maria Tsopanomichalou, Lydia Abou-Assabeh, Konstantinos Goumas, Maria Ginieri-Coccossis, Marina Economou, George N Papadimitriou, Efstratios Patsouris and Polyxeni Nicolopoulou-Stamati

    Citation: BMC Gastroenterology 2014 14:77

    Content type: Research article

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  28. Hereditary angioedema (HAE) is characterized by unpredictable attacks of debilitating subcutaneous and mucosal edema. Gastrointestinal attacks are painful, of sudden onset and often mistaken for acute abdomen ...

    Authors: Eitan Rubinstein, Leslie E Stolz, Albert L Sheffer, Chris Stevens and Athos Bousvaros

    Citation: BMC Gastroenterology 2014 14:71

    Content type: Research article

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  29. Therapeutic gene transfer is currently being evaluated as a potential therapy for inflammatory bowel disease. This study investigates the safety and therapeutic benefit of a locally administered lentiviral vec...

    Authors: Hiroshi Matsumoto, Kazunori Haga, Izumi Ohno, Kei Hiraoka, Takahiro Kimura, Kip Hermann, Noriyuki Kasahara, Peter Anton and Ian McGowan

    Citation: BMC Gastroenterology 2014 14:68

    Content type: Research article

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  30. Some patients with Prader-Willi Syndrome (PWS) have symptoms of constipation, but bowel function in PWS has never been systematically evaluated. The aim of the present study was to describe colorectal function...

    Authors: Louise Kuhlmann, Iben Moeller Joensson, Jens Broendum Froekjaer, Klaus Krogh and Stense Farholt

    Citation: BMC Gastroenterology 2014 14:63

    Content type: Research article

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  31. In recent years, the gut microbiota has been found to provide an important link to the development of inflammatory bowel diseases (IBD) like ulcerative colitis (UC). Accordingly, inter-individual variation in ...

    Authors: Katsuyuki Fukuda and Yoshiyuki Fujita

    Citation: BMC Gastroenterology 2014 14:49

    Content type: Research article

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  32. Mutations in the NOD2 gene are a significant risk factor to acquire intestinal failure requiring home parenteral nutrition. Tuberculous lymphadenitis is the main manifestation of extrapulmonary tuberculosis. Defe...

    Authors: Holger Schäffler, Matthias Teufel, Sabrina Fleischer, Chih-Jen Hsieh, Julia-Stefanie Frick and Georg Lamprecht

    Citation: BMC Gastroenterology 2014 14:43

    Content type: Case report

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  33. Celiac disease is present in ~1% of the general population in the United States and Europe. Despite the availability of inexpensive serologic screening tests, ~85% of individuals with celiac disease remain und...

    Authors: Erika M Barbero, Shawna L McNally, Michael C Donohue and Martin F Kagnoff

    Citation: BMC Gastroenterology 2014 14:42

    Content type: Research article

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  34. Although it is known that first degree relatives of celiac patients have an increased risk for celiac disease few studies are available on its incidence. We investigated the incidence of serologic conversion a...

    Authors: Rosa H Uenishi, Lenora Gandolfi, Lucas M Almeida, Patrícia M Fritsch, Fernanda C Almeida, Yanna K M Nóbrega and Riccardo Pratesi

    Citation: BMC Gastroenterology 2014 14:36

    Content type: Research article

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  35. Crohn’s disease is a relapsing, systemic inflammatory disease affecting the gastrointestinal tract with associated extraintestinal manifestations and immune disorders. Among the few cases reported, the associa...

    Authors: Vipula R Bataduwaarachchi, Nilesh Fenandopulle, Upul Liyanage and Champa Jayasundara

    Citation: BMC Gastroenterology 2014 14:35

    Content type: Case report

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  36. Celiac disease can present in children and adults with a variety of manifestations including a rare complication known as ulcerative jejunitis. The latter has been associated with refractory celiac disease in ...

    Authors: Terry Sigman, Van-Hung Nguyen, Florin Costea, Ana Sant’Anna and Ernest G Seidman

    Citation: BMC Gastroenterology 2014 14:29

    Content type: Case report

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  37. In diagnosing celiac disease (CD), serological tests are highly valuable. However, their role in following up children with CD after prescription of a gluten-free diet is unclear. This study aimed to compare t...

    Authors: Edith Vécsei, Stephanie Steinwendner, Hubert Kogler, Albina Innerhofer, Karin Hammer, Oskar A Haas, Gabriele Amann, Andreas Chott, Harald Vogelsang, Regine Schoenlechner, Wolfgang Huf and Andreas Vécsei

    Citation: BMC Gastroenterology 2014 14:28

    Content type: Research article

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  38. The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describ...

    Authors: Francesca Tucci, Luca Astarita, Abdelhak Abkari, Mona Abu-Zekry, Thomas Attard, Mongi Ben Hariz, José Ramon Bilbao, Ghazalia Boudraa, Samir Boukthir, Stefano Costa, Veselinka Djurisic, Jean-Pierre Hugot, Iñaki Irastorza, Aydan Kansu, Sanja Kolaček, Giuseppe Magazzù…

    Citation: BMC Gastroenterology 2014 14:24

    Content type: Research article

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  39. The results of previous studies assessing the association between the 5-HTTLPR polymorphism of serotonin transporter gene and irritable bowel syndrome (IBS) are inconsistent. The aim of this study was to clari...

    Authors: Zhi-Feng Zhang, Zhi-Jun Duan, Li-Xia Wang, Dong Yang, Gang Zhao and Lin Zhang

    Citation: BMC Gastroenterology 2014 14:23

    Content type: Research article

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  40. Splenic abscesses in children are rare. In recent years aseptic abscesses have been recognized as a new disease entity, especially in adults.

    Authors: Alexander J Jordan, Klaus-Peter Becker, Metin Sertemir, K Wolfgang Neff, Rüdiger Adam, Horst Schroten and Tobias Tenenbaum

    Citation: BMC Gastroenterology 2014 14:20

    Content type: Case report

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  41. Environmental enteropathy (EE) is an asymptomatic abnormality of small bowel structure and function, which may underlie vaccine inefficacy in the developing world. HIV infection co-exists in many of these popu...

    Authors: John Louis-Auguste, Stephen Greenwald, Michelo Simuyandi, Rose Soko, Rose Banda and Paul Kelly

    Citation: BMC Gastroenterology 2014 14:15

    Content type: Research article

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  42. Brunner’s gland hamartoma is a rare tumor, predominantly found in the fifth to sixth decades of life. Generally, it is a single pedunculated polyp, rarely larger than 5 cm. Asymptomatic cases are found inciden...

    Authors: Mayumi Akaki, Shoji Taniguchi, Kinta Hatakeyama, Ryoji Kushima and Hiroaki Kataoka

    Citation: BMC Gastroenterology 2014 14:14

    Content type: Case report

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  43. Ulcerative colitis (UC) is a chronic, inflammatory bowel disease which may lead to dysplasia and adenocarcinoma in patients when long-lasting. Short telomeres have been reported in mucosal cells of UC patients...

    Authors: Mariann Friis-Ottessen, Laila Bendix, Steen Kølvraa, Solveig Norheim-Andersen, Paula M De Angelis and Ole Petter F Clausen

    Citation: BMC Gastroenterology 2014 14:8

    Content type: Research article

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  44. Bisphosphonates have a widespread indication for osteoporosis and are also applied in cancer patients with skeletal-related conditions. Bisphosphonate-associated osteonecrosis of the jaw (BRONJ) is a feared si...

    Authors: Raimund HM Preidl, Tobias Ebker, Martin Raithel, Falk Wehrhan, Friedrich W Neukam and Philipp Stockmann

    Citation: BMC Gastroenterology 2014 14:6

    Content type: Case report

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  45. Allopurinol is a frequently prescribed drug. In inflammatory bowel disease patients who shunt thiopurine metabolism towards more toxic and less desirable pathways, allopurinol is proving to be an effective add...

    Authors: Muhammad W Fazal, Matt P Doogue, Rupert W Leong, Peter A Bampton and Jane M Andrews

    Citation: BMC Gastroenterology 2013 13:172

    Content type: Case report

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  46. We sought to define the sensitivity and specificity of intraperitoneal (IP) and intraluminal (IL) microdialysate metabolites in depicting ex vivo small intestinal total ischemia during GI-tract surgery. We hyp...

    Authors: Lauri Pynnönen, Minna Minkkinen, Anders Perner, Sari Räty, Isto Nordback, Juhani Sand and Jyrki Tenhunen

    Citation: BMC Gastroenterology 2013 13:170

    Content type: Research article

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