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Intestinal disorders

Section edited by Peter Lakatos

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Intestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) and gut microbiota.

    Authors: Xiao Wei, Shan Jiang, Yuye Chen, Xiangna Zhao, Huan Li, Weishi Lin, Boxing Li, Xuesong Wang, Jing Yuan and Yansong Sun

    Citation: BMC Gastroenterology 2016 16:121

    Content type: Research article

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  2. Ulcerative colitis (UC) is a chronic inflammatory disorder of still unknown pathogenesis. Increasing evidence indicates that alterations in mitochondrial respiration and thus adenosine triphosphate (ATP) produ...

    Authors: Theresa Dankowski, Torsten Schröder, Steffen Möller, Xinhua Yu, David Ellinghaus, Florian Bär, Klaus Fellermann, Hendrik Lehnert, Stefan Schreiber, Andre Franke, Christian Sina, Saleh M. Ibrahim and Inke R. König

    Citation: BMC Gastroenterology 2016 16:118

    Content type: Research article

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  3. International guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those tested positive to detect coeliac disease. However, pre-endoscopy serology is often unavailable, th...

    Authors: Michelle Shui Yee Lau, Peter D. Mooney, William L. White, Victoria Appleby, Sulleman Moreea, Ismail Haythem, Joshua E. Elias, Kiran Bundhoo, Gareth D. Corbett, Liam Wong, Her Hsin Tsai, Simon S. Cross, John M. Hebden, Sami Hoque and David S. Sanders

    Citation: BMC Gastroenterology 2016 16:115

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2016 16:122

  4. The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patie...

    Authors: David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez, María Julieta González, Daniela Simian, Marcela A. Hermoso and Rodrigo Quera

    Citation: BMC Gastroenterology 2016 16:103

    Content type: Research article

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  5. Little is known of the prevalence of hepatitis B virus (HBV) infection and its effect on choice of therapy and disease course in patients with inflammatory bowel disease (IBD). We assessed the prevalence of HB...

    Authors: Heyson C. H. Chan, Vincent W. S. Wong, Grace L. H. Wong, Whitney Tang, Justin C. Y. Wu and Siew C. Ng

    Citation: BMC Gastroenterology 2016 16:100

    Content type: Research article

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  6. The human gut is the habitat for diverse and dynamic microbial ecosystem. The human microbiota plays a critical role in functions that sustain health and is a positive asset in host defenses. Establishment of ...

    Authors: Erigene Rutayisire, Kun Huang, Yehao Liu and Fangbiao Tao

    Citation: BMC Gastroenterology 2016 16:86

    Content type: Research article

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  7. Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate i...

    Authors: Mingming Zhang, Qian Zhou, Robert G. Dorfman, Xiaoli Huang, Tingting Fan, Hao Zhang, Jun Zhang and Chenggong Yu

    Citation: BMC Gastroenterology 2016 16:84

    Content type: Research article

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  8. There are few reports of the efficacy of adalimumab (ADA) for clinical remission and preventing postoperative recurrence in Crohn's disease (CD) in Asian real practice settings. We conducted a Japanese multice...

    Authors: Fuminao Takeshima, Daisuke Yoshikawa, Syuntaro Higashi, Tomohito Morisaki, Hidetoshi Oda, Maho Ikeda, Haruhisa Machida, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Naoyuki Yamaguchi, Ken Ohnita, Hajime Isomoto, Masato Ueno and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2016 16:82

    Content type: Research article

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  9. Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adu...

    Authors: Antti Kylökäs, Katri Kaukinen, Heini Huhtala, Pekka Collin, Markku Mäki and Kalle Kurppa

    Citation: BMC Gastroenterology 2016 16:76

    Content type: Research article

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  10. Current knowledge suggests that small intestinal overgrowth participates in the pathogenesis of irritable bowel syndrome. It is questionable if this association is modulated by intake of proton pump inhibitors...

    Authors: Evangelos J. Giamarellos-Bourboulis, Emmanouel Pyleris, Charalambos Barbatzas, Aikaterini Pistiki and Mark Pimentel

    Citation: BMC Gastroenterology 2016 16:67

    Content type: Research article

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  11. Ulcerative colitis is a lifelong, immunologically mediated disease. Direct-acting antivirals (DAAs) are now available for the treatment of chronic hepatitis C virus (HCV) infection. An interferon-free regimen ...

    Authors: Yuki Ohta, Tatsuo Kanda, Tatsuro Katsuno, Shin Yasui, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Shingo Nakamoto, Makoto Arai and Osamu Yokosuka

    Citation: BMC Gastroenterology 2016 16:66

    Content type: Case report

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  12. Irritable bowel syndrome (IBS) is one of the most common functional gastroenterological diseases, affecting 11.2 % of people worldwide. Previous studies have shown that probiotic treatment may benefit IBS pati...

    Authors: Yan Zhang, Lixiang Li, Chuanguo Guo, Dan Mu, Bingcheng Feng, Xiuli Zuo and Yanqing Li

    Citation: BMC Gastroenterology 2016 16:62

    Content type: Research article

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  13. Clinical practice guidelines (CPGs) are formally developed statements that assist users to provide proper health care for a kind of disease and play a significant contribution in healthcare system. This study ...

    Authors: Hongliang Tian, Chao Ding, Jianfeng Gong, Xiaolong Ge, Lynne V. McFarland, Lili Gu, Qiyi Chen, Chunlian Ma, Weiming Zhu, Jieshou Li and Ning Li

    Citation: BMC Gastroenterology 2016 16:52

    Content type: Research article

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  14. The relationship between fecal calprotectin (FC) and disease extent in ulcerative colitis (UC) has not been fully elucidated. The aim of this study was to clarify the correlation of FC with disease extent and ...

    Authors: Kousaku Kawashima, Shunji Ishihara, Takafumi Yuki, Nobuhiko Fukuba, Naoki Oshima, Hideaki Kazumori, Hiroki Sonoyama, Noritsugu Yamashita, Yasumasa Tada, Ryusaku Kusunoki, Akihiko Oka, Yoshiyuki Mishima, Ichiro Moriyama and Yoshikazu Kinoshita

    Citation: BMC Gastroenterology 2016 16:47

    Content type: Research article

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  15. Polyethylene glycol is commonly used to manage constipation and is available with or without electrolytes. The addition of electrolytes dates back to its initial development as lavage solutions in preparation ...

    Authors: Peter Katelaris, Vasi Naganathan, Ken Liu, George Krassas and John Gullotta

    Citation: BMC Gastroenterology 2016 16:42

    Content type: Research article

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  16. Breastfeeding is associated with a variety of positive health outcomes in children and is recommended exclusively for the first 6 months of life; however, 50–70 % of infants in the US are formula-fed. To test ...

    Authors: Laxmi Yeruva, Nicole E. Spencer, Manish K. Saraf, Leah Hennings, Anne K. Bowlin, Mario A. Cleves, Kelly Mercer, Sree V. Chintapalli, Kartik Shankar, Roger G. Rank, Thomas M. Badger and Martin J. J. Ronis

    Citation: BMC Gastroenterology 2016 16:40

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2016 16:55

  17. Studies have shown an increased prevalence of irritable bowel syndrome (IBS) after acute gastroenteritis. Food as a precipitating and perpetuating factor in IBS has gained recent interest, but food intolerance...

    Authors: Sverre Litleskare, Knut-Arne Wensaas, Geir Egil Eide, Kurt Hanevik, Gudrun Elise Kahrs, Nina Langeland and Guri Rortveit

    Citation: BMC Gastroenterology 2015 15:164

    Content type: Research article

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  18. Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active Crohn’s disease (CD). However, with routine weekly therapy, it may take several weeks to achieve remission. This s...

    Authors: Naoki Yoshimura, Yoko Yokoyama, Katsuyoshi Matsuoka, Hiroki Takahashi, Ryuichi Iwakiri, Takayuki Yamamoto, Tomoo Nakagawa, Takumi Fukuchi, Satoshi Motoya, Reiko Kunisaki, Shingo Kato, Fumihito Hirai, Yoh Ishiguro, Satoshi Tanida, Sakiko Hiraoka, Keiichi Mitsuyama…

    Citation: BMC Gastroenterology 2015 15:163

    Content type: Research article

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  19. Trans-anal irrigation (TAI) is used widely to treat bowel dysfunction, although evidence for its use in adult chronic functional constipation remains unclear. Long-term outcome data are lacking, and the effect...

    Authors: Christopher D. Emmett, Helen J. Close, Yan Yiannakou and James M. Mason

    Citation: BMC Gastroenterology 2015 15:139

    Content type: Research article

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  20. Pyogenic granuloma (PG) is a polypoid lobular capillary hemangioma rarely observed in the gastrointestinal tract. Only a few cases in the small bowel have been described in the literature.

    Authors: Shun-ichi Misawa, Hiroto Sakamoto, Akira Kurogochi, Yasushi Kirii, Shinichiro Nakamura, Tomoko Misawa, Suguru Yoneda, Mari Hirano, Osamu Owa, Hiroyuki Takagi and Hiroyoshi Ota

    Citation: BMC Gastroenterology 2015 15:126

    Content type: Case report

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  21. Although sarcoidosis and celiac disease are both chronic immunologic disorders involving multiple organ systems, reports about association of diseases in individual patients are sparse. While sarcoidosis is a ...

    Authors: Tassilo Kruis, Korinna Jöhrens, Verena Moos, Imke Puls, Britta Siegmund, Severin Daum and Michael Schumann

    Citation: BMC Gastroenterology 2015 15:62

    Content type: Case report

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  22. Studies have demonstrated usefulness of cognitive-behavioural therapy (CBT) in managing distress in inflammatory bowel disease (IBD); however, few have focused on IBD course. The present trial aimed to investi...

    Authors: Antonina Mikocka-Walus, Peter Bampton, David Hetzel, Patrick Hughes, Adrian Esterman and Jane M Andrews

    Citation: BMC Gastroenterology 2015 15:54

    Content type: Research article

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  23. Oral tacrolimus therapy is effective for refractory ulcerative colitis (UC), but dose adjustment according to the trough concentrations which varies largely among individuals, is required. This study aimed to ...

    Authors: Sakiko Hiraoka, Jun Kato, Yuki Moritou, Daisuke Takei, Toshihiro Inokuchi, Asuka Nakarai, Sakuma Takahashi, Keita Harada, Hiroyuki Okada and Kazuhide Yamamoto

    Citation: BMC Gastroenterology 2015 15:53

    Content type: Research article

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  24. Several systematic reviews (SRs) of randomised controlled trials (RCTs) comparing laparoscopic versus open appendectomy have been published, but there has been no overview of SRs of these two interventions. Th...

    Authors: Thomas Jaschinski, Christoph Mosch, Michaela Eikermann and Edmund AM Neugebauer

    Citation: BMC Gastroenterology 2015 15:48

    Content type: Research article

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  25. In the chronically inflamed rabbit small intestine, brush border membrane (BBM) Na-glutamine co-transport is inhibited in villus cells (mediated by B0AT1), while it is stimulated in crypt cells (mediated by SN...

    Authors: Soudamani Singh, Subha Arthur, Jamilur Talukder, Balasubramanian Palaniappan, Steven Coon and Uma Sundaram

    Citation: BMC Gastroenterology 2015 15:47

    Content type: Research article

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  26. Many factors have been found to affect the difficulty of colonoscope insertion, such as age, gender, body mass index (BMI), history of abdominal surgery and operator etc. However, a scoring system may be more ...

    Authors: Hui Jia, Limei Wang, Hui Luo, Shaowei Yao, Xiangping Wang, Linhui Zhang, Rui Huang, Zhiguo Liu, Xiaoyu Kang, Yanglin Pan and Xuegang Guo

    Citation: BMC Gastroenterology 2015 15:46

    Content type: Research article

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  27. Inflammatory bowel disease (IBD)-like conditions in glycogen storage disease (GSD) type Ib have been predominantly described in children. Signs and symptoms of GSD type Ib are hypoglycemia, pancytopenia and he...

    Authors: Magdalena Sarah Volz, Mani Nassir, Christoph Treese, Moritz von Winterfeld, Ursula Plöckinger, Hans-Jörg Epple and Britta Siegmund

    Citation: BMC Gastroenterology 2015 15:45

    Content type: Case report

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  28. Free perforation is the most severe and debilitating complication associated with Crohn’s disease (CD), and it usually requires emergency surgery. The aim of this study was to evaluate the incidence of free pe...

    Authors: Young Seok Doh, You Sun Kim, Song I Bae, Jong Pil Im, Jae Hee Cheon, Byong Duk Ye, Ji Won Kim, Young Sook Park, Ji Hyun Lee, Young-Ho Kim, Joo Sung Kim, Dong Soo Han and Won Ho Kim

    Citation: BMC Gastroenterology 2015 15:31

    Content type: Research article

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  29. To observe and compare the short term results and functional recovery of laparoscopic subtotal colectomy with antiperistaltic cecorectal anastomosis (LSCACRA) in the treatment of Adult slow transit constipatio...

    Authors: Dong Wei, Jian Cai, Yang Yang, Ting Zhao, Hui Zhang, Changshan Zhang, Yuanyao Zhang, Jianfeng Zhang and Fengbo Cai

    Citation: BMC Gastroenterology 2015 15:30

    Content type: Research article

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  30. Gastrointestinal endoscopy plays a crucial role in the diagnosis and management of gastrointestinal disorders. When endoscopy is indicated during pregnancy, concerns about the effects on pregnancy outcome ofte...

    Authors: Alison De Lima, Boris Galjart, Pieter HA Wisse, Wichor M Bramer and C Janneke van der Woude

    Citation: BMC Gastroenterology 2015 15:15

    Content type: Research article

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  31. Tofacitinib, a novel, oral Janus kinase inhibitor, demonstrated a dose-dependent efficacy for induction of clinical response and remission in patients with active ulcerative colitis (UC). The objective of the ...

    Authors: Julián Panés, Chinyu Su, Andrew G Bushmakin, Joseph C Cappelleri, Carla Mamolo and Paul Healey

    Citation: BMC Gastroenterology 2015 15:14

    Content type: Research article

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  32. Cross-sectional imaging techniques as magnetic resonance enterography (MRE) may offer additional information on transmural inflammation, stricturing and fistulising complications in Crohn’s disease (CD). The p...

    Authors: Feng Qi, Shen Jun, Qiao Yu Qi, Peng Jiang Chen, Geng Xiao Chuan, Zhu Jiong and Xu Jian Rong

    Citation: BMC Gastroenterology 2015 15:12

    Content type: Research article

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  33. Environmental and genetic factors contribute to variation in irritable bowel syndrome (IBS), anxiety and depression. Comorbidity between these disorders is high. A previous investigation of our population-base...

    Authors: May-Bente Bengtson, Geir Aamodt, Morten H Vatn and Jennifer R Harris

    Citation: BMC Gastroenterology 2015 15:9

    Content type: Research article

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  34. Celiac disease (CD) is a global health problem and its prevalence is underestimated, especially in Latin American populations. Our aim was to evaluate the clinical features, psychological factors, and health-r...

    Authors: Karen Lizzete Ramírez-Cervantes, José María Remes-Troche, María del Pilar Milke-García, Viridiana Romero and Luis F Uscanga

    Citation: BMC Gastroenterology 2015 15:4

    Content type: Research article

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  35. Precise diagnostics of inflammatory bowel disease (IBD) and identification of potentially more aggressive phenotypes of Crohn’s disease (CD) is urgently needed. The aim of our prospective study was to assess t...

    Authors: Darina Kohoutova, Marcela Drahosova, Paula Moravkova, Stanislav Rejchrt and Jan Bures

    Citation: BMC Gastroenterology 2014 14:190

    Content type: Research article

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  36. Non-adherence to aminosalicylates is observed among 30% to 45% of patients with ulcerative colitis and increases the risk of relapse. The Health Belief Model is a theoretical model that could offer a broader p...

    Authors: Aki Kawakami, Makoto Tanaka, Masakazu Nishigaki, Naoki Yoshimura, Ryoichi Suzuki, Shin Maeda, Reiko Kunisaki and Noriko Yamamoto-Mitani

    Citation: BMC Gastroenterology 2014 14:220

    Content type: Research article

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  37. Early life exposures may modify risk of inflammatory bowel diseases (IBD; Crohn’s disease (CD), ulcerative colitis (UC)). However, the relationship between early life exposures and natural history of IBD has n...

    Authors: Abra Y Guo, Betsy W Stevens, Robin G Wilson, Caitlin N Russell, Melissa A Cohen, Holly C Sturgeon, Anna Thornton, Cosmas Giallourakis, Hamed Khalili, Deanna D Nguyen, Jenny Sauk, Vijay Yajnik, Ramnik J Xavier and Ashwin N Ananthakrishnan

    Citation: BMC Gastroenterology 2014 14:216

    Content type: Research article

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  38. Women treated with gonadotropin-releasing hormone (GnRH) analogs may develop enteric neuropathy and dysmotility. Administration of a GnRH analog to rats leads to similar degenerative neuropathy and ganglioneur...

    Authors: Elin Sand, Bodil Roth, Björn Weström, Peter Bonn, Eva Ekblad and Bodil Ohlsson

    Citation: BMC Gastroenterology 2014 14:209

    Content type: Research article

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  39. Intestinal capillariasis is one of the common causes of malabsorption in the East. Reports emphasizing the roles of clinical, endoscopic and radiologic findings of intestinal capillariasis are limited.

    Authors: Julajak Limsrivilai, Supot Pongprasobchai, Piyaporn Apisarnthanarak and Sathaporn Manatsathit

    Citation: BMC Gastroenterology 2014 14:207

    Content type: Research article

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  40. The pathogenesis of inflammatory bowel disease (IBD) involves interactions between the host genetic susceptibility, intestinal microflora and mucosal immune responses through the pattern recognition receptor. ...

    Authors: Nezha Senhaji, Brehima Diakité, Nadia Serbati, Younes Zaid, Wafaa Badre and Sellama Nadifi

    Citation: BMC Gastroenterology 2014 14:206

    Content type: Research article

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  41. Small bowel angioectasia is reported as the most common cause of bleeding in patients with obscure gastrointestinal bleeding. Although the safety and efficacy of endoscopic treatment have been demonstrated, re...

    Authors: Eiji Sakai, Hiroki Endo, Masataka Taguri, Harunobu Kawamura, Leo Taniguchi, Yasuo Hata, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Ken Ishii, Jun Arimoto, Eiji Yamada, Hidenori Ohkubo, Takuma Higurashi, Tomoko Koide, Takashi Nonaka…

    Citation: BMC Gastroenterology 2014 14:200

    Content type: Research article

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  42. Gastrointestinal graft–versus-host disease (GvHD) is a potentially life-threatening complication after allogeneic stem cell transplantation (SCT). Since therapeutic options are still limited, a prophylactic ap...

    Authors: Renate Schmelz, Martin Bornhäuser, Johannes Schetelig, Alexander Kiani, Uwe Platzbecker, Uta Schwanebeck, Xina Grählert, Lutz Uharek, Daniela Aust, Gustavo Baretton, Rainer Schwerdtfeger, Jochen Hampe, Roland Greinwald, Ralph Mueller, Gerhard Ehninger and Stephan Miehlke

    Citation: BMC Gastroenterology 2014 14:197

    Content type: Research article

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  43. The chronic nature of inflammatory bowel disease leads to considerable impairment on the health related quality of life (HRQOL). The aims of the present study are to validate the mainland Chinese translation o...

    Authors: Junjie Xu, Hui Lin, Xu Feng, Minyue Tang, Jun Shen and Zhihua Ran

    Citation: BMC Gastroenterology 2014 14:199

    Content type: Research article

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  44. Celiac disease is a multiform, challenging condition characterized by extremely variable features. Our goal was to define clinical, serological and histopathological findings in a large cohort of celiacs diagn...

    Authors: Umberto Volta, Giacomo Caio, Vincenzo Stanghellini and Roberto De Giorgio

    Citation: BMC Gastroenterology 2014 14:194

    Content type: Research article

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  45. Data are accumulating that emphasize the important role of the intestinal barrier and intestinal permeability for health and disease. However, these terms are poorly defined, their assessment is a matter of de...

    Authors: Stephan C Bischoff, Giovanni Barbara, Wim Buurman, Theo Ockhuizen, Jörg-Dieter Schulzke, Matteo Serino, Herbert Tilg, Alastair Watson and Jerry M Wells

    Citation: BMC Gastroenterology 2014 14:189

    Content type: Review

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