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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). We conducted a retrospective study to determine the incidence, clinical charac...

    Authors: Hui Xu, Hao Tang, Tao Xu, Meng Xiao, Ji Li, Bei Tan, Hong Yang, Hong Lv, Yue Li and Jiaming Qian

    Citation: BMC Gastroenterology 2019 19:3

    Content type: Research article

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  2. Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk facto...

    Authors: Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière and Benjamin Misselwitz

    Citation: BMC Gastroenterology 2019 19:2

    Content type: Research article

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  3. Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous ...

    Authors: Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Jin Ook Chung, Ji-Ho Seo, SunMin Kim, Dong Hyun Kim, Chang-Hwan Park, Jae-Kyun Ju, Young-Eun Joo, Jae-Hyuk Lee, Hyun-Soo Kim, Sung-Kyu Choi and Jong-Sun Rew

    Citation: BMC Gastroenterology 2018 18:188

    Content type: Research article

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  4. Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn’s disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopuri...

    Authors: Christina Ong, Poh Ting Lim, Veena Logarajah, Maria Janelle Liwanag, Bi Xia Ang, Yuqin Cher, Fang Kuan Chiou and Ajmal Kader

    Citation: BMC Gastroenterology 2018 18:185

    Content type: Research article

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  5. Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to loca...

    Authors: Yoichi Otomi, Hideki Otsuka, Kaori Terazawa, Moriaki Yamanaka, Yuki Obama, Maki Arase, Maki Otomo, Saho Irahara, Michiko Kubo, Naoto Uyama, Takashi Abe and Masafumi Harada

    Citation: BMC Gastroenterology 2018 18:183

    Content type: Research article

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  7. The adequacy of pre-procedure preparation is the principal determinant of the quality of colonoscopy in pediatric as in adult patients. There is a lack of consensus, among providers on a standard pre-procedure...

    Authors: Ashwath S. Kumar, Brooke L. Beutler and Thomas M. Attard

    Citation: BMC Gastroenterology 2018 18:170

    Content type: Research article

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  8. Alterations of the small-intestinal permeability (s-IP) might play an essential role in both diarrhoea-predominant IBS (D-IBS) and celiac disease (CD) patients. Our aims were to analyse in D-IBS patients the s...

    Authors: Michele Linsalata, Giuseppe Riezzo, Benedetta D’Attoma, Caterina Clemente, Antonella Orlando and Francesco Russo

    Citation: BMC Gastroenterology 2018 18:167

    Content type: Research article

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  9. Clinical severity and intestinal lesions of Crohn’s disease (CD) usually progress over time and require a step up adjustment of the therapy either to prevent or to treat complications. The aim of the study was...

    Authors: Nadia Pallotta, Giuseppina Vincoli, Patrizio Pezzotti, Maurizio Giovannone, Alessandro Gigliozzi, Danilo Badiali, Piero Vernia and Enrico Stefano Corazziari

    Citation: BMC Gastroenterology 2018 18:164

    Content type: Research article

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  10. The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite represe...

    Authors: Vito Domenico Corleto, Vincenza Patrizia Di Marino, Gloria Galli, Giulio Antonelli, Chiara Coluccio, Arcangelo Di Cerbo, Stefania Uccini and Bruno Annibale

    Citation: BMC Gastroenterology 2018 18:162

    Content type: Case report

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  13. Gastrointestinal complications are the main cause of death in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Available treatments often restore biochemical homeostasis, but fail t...

    Authors: Rana Yadak, Max V. Boot, Niek P. van Til, Dominique Cazals-Hatem, Armin Finkenstedt, Elly Bogaerts, Irenaeus F. de Coo and Marianna Bugiani

    Citation: BMC Gastroenterology 2018 18:149

    Content type: Research article

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  14. Vedolizumab is safe and effective in adult patients with Crohn’s disease (CD) and ulcerative colitis (UC); however, data in children with inflammatory bowel disease (IBD) are scarce. Therefore, we evaluated ve...

    Authors: Anna-Maria Schneider, Daniel Weghuber, Benjamin Hetzer, Andreas Entenmann, Thomas Müller, Georg Zimmermann, Sebastian Schütz, Wolf-Dietrich Huber and Judith Pichler

    Citation: BMC Gastroenterology 2018 18:140

    Content type: Research article

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  15. The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documen...

    Authors: Ryosuke Yamauchi, Toshihiro Araki, Keiichi Mitsuyama, Takaaki Tokito, Hidenobu Ishii, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Tetsuhiro Yoshimura, Osamu Tsuruta and Takuji Torimura

    Citation: BMC Gastroenterology 2018 18:135

    Content type: Case report

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  16. Alteration of the gut microbiota by repeated antibiotic treatment increases susceptibility to Clostridioides difficile infection. Faecal microbiota transplantation from donors with a normal microbiota effectively...

    Authors: Jillian R.-M. Brown, Burkhardt Flemer, Susan A. Joyce, Akbar Zulquernain, Donal Sheehan, Fergus Shanahan and Paul W. O’Toole

    Citation: BMC Gastroenterology 2018 18:131

    Content type: Research article

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  17. Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance o...

    Authors: Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae and Koichi Matsumoto

    Citation: BMC Gastroenterology 2018 18:120

    Content type: Research article

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  18. Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle s...

    Authors: Shi-Cheng Zheng, Hui Gong, Yi-Ping Wang, Qiang Zhang, Li-Li Wang, Xue-Fen Liao, Dai-Wen He and Jing Wu

    Citation: BMC Gastroenterology 2018 18:119

    Content type: Research article

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  19. Graft-versus-host disease (GVHD) is a common complication of allo-hematopoietic stem cell transplantation (allo-HSCT). Endoscopic biopsy can provide a definitive diagnosis, but the optimal endoscopic approach ...

    Authors: Yuusaku Sugihara, Sakiko Hiraoka, Nobuharu Fujii, Shiho Takashima, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Kenji Kuwaki, Keita Harada, Takehiro Tanaka and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:111

    Content type: Research article

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  20. Pneumatosis cystoides intestinalis (PCI) is characterized by gas-filled cysts in the intestinal submucosa and subserosa. There are few reports of PCI occurring in duodenum and rectum. Here we demonstrated four...

    Authors: Yong juan Wang, Yu ming Wang, Yan min Zheng, Hui qing Jiang and Jie Zhang

    Citation: BMC Gastroenterology 2018 18:100

    Content type: Case report

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  21. A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of t...

    Authors: Maria Magdalena Buijs, Morten Kobaek-Larsen, Lasse Kaalby and Gunnar Baatrup

    Citation: BMC Gastroenterology 2018 18:95

    Content type: Research article

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  22. Human rotavirus (HRV) is a major cause of viral gastroenteritis in infants; particularly in developing countries where malnutrition is prevalent. Malnutrition perturbs the infant gut microbiota leading to sub-...

    Authors: Anand Kumar, Anastasia N. Vlasova, Loic Deblais, Huang-Chi Huang, Asela Wijeratne, Sukumar Kandasamy, David D. Fischer, Stephanie N. Langel, Francine Chimelo Paim, Moyasar A. Alhamo, Lulu Shao, Linda J. Saif and Gireesh Rajashekara

    Citation: BMC Gastroenterology 2018 18:93

    Content type: Research article

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  23. Crohn’s Disease (CD) is typically characterized by abdominal symptoms, however, besides gastrointestinal symptoms, CD patients may suffer from extraintestinal manifestations which are far less common and medic...

    Authors: Arne Bokemeyer, Nicolas Tentrop, Peter J. Barth, Frank Lenze, Karin Hengst, Johannes Kleinheinz and Dominik Bettenworth

    Citation: BMC Gastroenterology 2018 18:88

    Content type: Case report

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  24. Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). The aim of this study was to evaluate the efficacy and safety of ESD for SES...

    Authors: Byeong Geun Song, Yang Won Min, Ra Ri Cha, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee and Jae J. Kim

    Citation: BMC Gastroenterology 2018 18:80

    Content type: Research article

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  25. Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a ge...

    Authors: A. Quaas, D. Waldschmidt, H. Alakus, T. Zander, C. Heydt, T. Goeser, M. Daheim, P. Kasper, P. Plum, C. Bruns, A. Brunn, W. Roth, N. Hartmann, A. Bunck, M. Schmidt, H. Göbel…

    Citation: BMC Gastroenterology 2018 18:75

    Content type: Case report

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  26. Due to finite resources, the clinical decision to subject a patient to colonoscopy needs to be based on the evidence, regardless of its availability, affordability and safety. This study assessed the appropria...

    Authors: Yasara Samarakoon, Nalika Gunawardena, Aloka Pathirana and Sumudu Hewage

    Citation: BMC Gastroenterology 2018 18:72

    Content type: Research article

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  27. Accumulating evidence supports the view that an imbalance of gut bacteria contributes to IBS, and that increasing the mass of beneficial species may reduce the numbers of pathogenic bacteria and help alleviate...

    Authors: Shamsuddin M. Ishaque, S. M. Khosruzzaman, Dewan Saifuddin Ahmed and Mukesh Prasad Sah

    Citation: BMC Gastroenterology 2018 18:71

    Content type: Research article

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  28. Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ ge...

    Authors: Hossam Murad, Batoul Jazairi, Issam Khansaa, Doaa Olabi and Lina Khouri

    Citation: BMC Gastroenterology 2018 18:70

    Content type: Research article

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  29. It is not clear why some patients with coeliac disease (CD) present with severe symptoms and small intestinal mucosal damages while others present with milder symptoms and no frank enteropathy. There is no stu...

    Authors: Mohammad Rostami-Nejad, Seyed Hossein Hejazi, Amado Salvador Peña, Hamid Asadzadeh-Aghdaei, Kamran Rostami, Umberto Volta and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2018 18:66

    Content type: Research article

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  30. A relationship between IgA nephropathy (IgAN) and celiac disease (CD) has been reported. We show the pathogenetic link for the first time.

    Authors: Stefano Costa, Giovanni Currò, Salvatore Pellegrino, Maria Cristina Lucanto, Giovanni Tuccari, Antonio Ieni, Giuseppina Visalli, Giuseppe Magazzù and Domenico Santoro

    Citation: BMC Gastroenterology 2018 18:64

    Content type: Case report

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  32. Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-...

    Authors: Francesco Strati, Antonio Calabrò, Claudio Donati, Claudio De Felice, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Lisa Rizzetto, Carlotta De Filippo and Duccio Cavalieri

    Citation: BMC Gastroenterology 2018 18:57

    Content type: Research article

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  33. Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-th...

    Authors: Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro and Gunadi

    Citation: BMC Gastroenterology 2018 18:56

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Gastroenterology 2018 18:110

  34. Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with...

    Authors: Richelle J. F. Felt-Bersma, Maarten S. Vlietstra, Paul F. Vollebregt, Ingrid J. M. Han-Geurts, Vera Rempe-Sorm, Grietje J. H. Vander Mijnsbrugge and Charlotte B. H. Molenaar

    Citation: BMC Gastroenterology 2018 18:44

    Content type: Research article

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  36. The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by asse...

    Authors: Trent Edwards, Craig Friesen and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2018 18:41

    Content type: Research article

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  38. The primary function of the intestines is the absorption of water and nutrients. Although our knowledge about these processes on the cellular level is extensive, a number of important intracellular elements re...

    Authors: Satu Oltedal, Ivar Skaland, Jodi Maple-Grødem, Kjersti Tjensvoll, Emiel A. M. Janssen, Bjørnar Gilje, Rune Smaaland, Reino Heikkilä and Oddmund Nordgård

    Citation: BMC Gastroenterology 2018 18:26

    Content type: Research article

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  40. Mesenteric inflammatory veno-occlusive disease (MIVOD) is difficult to diagnose because of its rarity, nonspecific clinical findings, and frequent confusion with other diseases including inflammatory bowel dis...

    Authors: Yosuke Yamada, Ken Sugimoto, Yashiro Yoshizawa, Yoshifumi Arai, Yoshiro Otsuki, Tomio Arai, Yasuyuki Kobayashi, Yoshihiko Sato and Yoshisuke Hosoda

    Citation: BMC Gastroenterology 2018 18:9

    Content type: Case report

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  41. Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and there...

    Authors: Anita Bálint, Klaudia Farkas, Zoltán Szepes, Ferenc Nagy, Mónika Szűcs, László Tiszlavicz, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián and Tamás Molnár

    Citation: BMC Gastroenterology 2018 18:7

    Content type: Research article

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  42. Elevation of the transcription factor HIF-1 is a prominent mediator of not only processes that accompany hypoxia, but also the tumor microenvironment and tissue regeneration. This study uses mediators of “chem...

    Authors: K. M. DiGuilio, M. C. Valenzano, E. Rybakovsky and J. M. Mullin

    Citation: BMC Gastroenterology 2018 18:2

    Content type: Research article

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  43. The only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD). The restrictive nature of the GFD makes adherence a challenge. As an integral part of CeD management, multiple professional org...

    Authors: Jacob J. Hughey, Bonnie K. Ray, Anne R. Lee, Kristin N. Voorhees, Ciaran P. Kelly and Detlef Schuppan

    Citation: BMC Gastroenterology 2017 17:156

    Content type: Research article

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  44. Irritable bowel syndrome (IBS) is a common functional disease of the gastrointestinal tract. The current study aimed to examine the association between visceral hypersensitivity in IBS and cortical activation ...

    Authors: Danping Wang, Xie Zhang, Xuesong Zhang, Zhigang Huang and Yufei Song

    Citation: BMC Gastroenterology 2017 17:148

    Content type: Research article

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  45. Currently, a suitable questionnaire in German language is not available to monitor the progression and evaluate the severity of irritable bowel syndrome (IBS). Therefore, this study aimed to translate the Gast...

    Authors: Sarah K. Schäfer, Kathrin Julia Weidner, Jorge Hoppner, Nicolas Becker, Dana Friedrich, Caroline S. Stokes, Frank Lammert and Volker Köllner

    Citation: BMC Gastroenterology 2017 17:139

    Content type: Research article

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  46. Post-transplant tuberculosis (PTTB) is a serious opportunistic infection in renal graft recipients with a 30-70 fold higher incidence compared to the general population. PTTB occurs most frequently within the ...

    Authors: Andrea Cikova, Diana Vavrincova-Yaghi, Peter Vavrinec, Anna Dobisova, Andrea Gebhardtova, Zora Flassikova, Mark A. Seelen, Robert H. Henning and Aktham Yaghi

    Citation: BMC Gastroenterology 2017 17:131

    Content type: Case report

    Published on:

  48. Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was ...

    Authors: Xiaohong Lu, Yuanjie Yu and Shiyun Tan

    Citation: BMC Gastroenterology 2017 17:111

    Content type: Research article

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  49. We aimed to evaluate the role of fecal calprotectin (FC) as a noninvasive marker for the disease activity of ulcerative colitis (UC) in a Korean cohort.

    Authors: Sun-Ho Lee, Min-Ju Kim, Kiju Chang, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang and Byong Duk Ye

    Citation: BMC Gastroenterology 2017 17:110

    Content type: Research article

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  50. Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive f...

    Authors: Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D. Lovasz, Petra A. Golovics, Krisztina B. Gecse, Balazs Szalay, Tamas Molnar and Peter L. Lakatos

    Citation: BMC Gastroenterology 2017 17:97

    Content type: Research article

    Published on:

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BMC Gastroenterology

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