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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Several pull-through procedures have been described for Hirschsprung disease (HSCR) with varying functional outcomes. The voluntary bowel movement (VBM) and the absence of soiling or constipation after pull-th...

    Authors: Amira Widyasari, Winona Alda Pravitasari, Andi Dwihantoro and Gunadi

    Citation: BMC Gastroenterology 2018 18:56

    Content type: Research article

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    The Correction to this article has been published in BMC Gastroenterology 2018 18:110

  2. Perianal fistula surgery can damage the anal sphincters which may cause faecal incontinence. By measuring regional pressures, 3D-HRAM potentially provides better guidance for surgical strategy in patients with...

    Authors: Richelle J. F. Felt-Bersma, Maarten S. Vlietstra, Paul F. Vollebregt, Ingrid J. M. Han-Geurts, Vera Rempe-Sorm, Grietje J. H. Vander Mijnsbrugge and Charlotte B. H. Molenaar

    Citation: BMC Gastroenterology 2018 18:44

    Content type: Research article

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  3. The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by asse...

    Authors: Trent Edwards, Craig Friesen and Jennifer V. Schurman

    Citation: BMC Gastroenterology 2018 18:41

    Content type: Research article

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  4. The primary function of the intestines is the absorption of water and nutrients. Although our knowledge about these processes on the cellular level is extensive, a number of important intracellular elements re...

    Authors: Satu Oltedal, Ivar Skaland, Jodi Maple-Grødem, Kjersti Tjensvoll, Emiel A. M. Janssen, Bjørnar Gilje, Rune Smaaland, Reino Heikkilä and Oddmund Nordgård

    Citation: BMC Gastroenterology 2018 18:26

    Content type: Research article

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  5. Mesenteric inflammatory veno-occlusive disease (MIVOD) is difficult to diagnose because of its rarity, nonspecific clinical findings, and frequent confusion with other diseases including inflammatory bowel dis...

    Authors: Yosuke Yamada, Ken Sugimoto, Yashiro Yoshizawa, Yoshifumi Arai, Yoshiro Otsuki, Tomio Arai, Yasuyuki Kobayashi, Yoshihiko Sato and Yoshisuke Hosoda

    Citation: BMC Gastroenterology 2018 18:9

    Content type: Case report

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  6. Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and there...

    Authors: Anita Bálint, Klaudia Farkas, Zoltán Szepes, Ferenc Nagy, Mónika Szűcs, László Tiszlavicz, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián and Tamás Molnár

    Citation: BMC Gastroenterology 2018 18:7

    Content type: Research article

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  7. Elevation of the transcription factor HIF-1 is a prominent mediator of not only processes that accompany hypoxia, but also the tumor microenvironment and tissue regeneration. This study uses mediators of “chem...

    Authors: K. M. DiGuilio, M. C. Valenzano, E. Rybakovsky and J. M. Mullin

    Citation: BMC Gastroenterology 2018 18:2

    Content type: Research article

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  8. The only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD). The restrictive nature of the GFD makes adherence a challenge. As an integral part of CeD management, multiple professional org...

    Authors: Jacob J. Hughey, Bonnie K. Ray, Anne R. Lee, Kristin N. Voorhees, Ciaran P. Kelly and Detlef Schuppan

    Citation: BMC Gastroenterology 2017 17:156

    Content type: Research article

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  9. Irritable bowel syndrome (IBS) is a common functional disease of the gastrointestinal tract. The current study aimed to examine the association between visceral hypersensitivity in IBS and cortical activation ...

    Authors: Danping Wang, Xie Zhang, Xuesong Zhang, Zhigang Huang and Yufei Song

    Citation: BMC Gastroenterology 2017 17:148

    Content type: Research article

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  10. Currently, a suitable questionnaire in German language is not available to monitor the progression and evaluate the severity of irritable bowel syndrome (IBS). Therefore, this study aimed to translate the Gast...

    Authors: Sarah K. Schäfer, Kathrin Julia Weidner, Jorge Hoppner, Nicolas Becker, Dana Friedrich, Caroline S. Stokes, Frank Lammert and Volker Köllner

    Citation: BMC Gastroenterology 2017 17:139

    Content type: Research article

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  11. Post-transplant tuberculosis (PTTB) is a serious opportunistic infection in renal graft recipients with a 30-70 fold higher incidence compared to the general population. PTTB occurs most frequently within the ...

    Authors: Andrea Cikova, Diana Vavrincova-Yaghi, Peter Vavrinec, Anna Dobisova, Andrea Gebhardtova, Zora Flassikova, Mark A. Seelen, Robert H. Henning and Aktham Yaghi

    Citation: BMC Gastroenterology 2017 17:131

    Content type: Case report

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  12. Tumor suppressor gene p53 expression has been reported in patients with ulcerative colitis (UC). However, the correlation between p53 expression and UC remains controversial. The aim of this meta-analysis was ...

    Authors: Xiaohong Lu, Yuanjie Yu and Shiyun Tan

    Citation: BMC Gastroenterology 2017 17:111

    Content type: Research article

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  13. We aimed to evaluate the role of fecal calprotectin (FC) as a noninvasive marker for the disease activity of ulcerative colitis (UC) in a Korean cohort.

    Authors: Sun-Ho Lee, Min-Ju Kim, Kiju Chang, Eun Mi Song, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang and Byong Duk Ye

    Citation: BMC Gastroenterology 2017 17:110

    Content type: Research article

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  14. Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive f...

    Authors: Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D. Lovasz, Petra A. Golovics, Krisztina B. Gecse, Balazs Szalay, Tamas Molnar and Peter L. Lakatos

    Citation: BMC Gastroenterology 2017 17:97

    Content type: Research article

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  15. During weaning, babies and young animal often experience diarrhea from food intolerance and/or decreasing levels of maternal antibodies, and diarrhea tends to be particularly severe during the early-weaned per...

    Authors: Yulan Dong, Yanan Han, Zixu Wang, Zhuoming Qin, Chenyu Yang, Jing Cao and Yaoxing Chen

    Citation: BMC Gastroenterology 2017 17:82

    Content type: Research article

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  16. Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoria...

    Authors: C. Venturin, S. Nancey, P. Danion, M. Uzzan, M. Chauvenet, C. Bergoin, X. Roblin, B. Flourié and G. Boschetti

    Citation: BMC Gastroenterology 2017 17:80

    Content type: Case report

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  17. Sclerosing mesenteritis (SM) is sometimes used as an umbrella-term for idiopathic inflammatory conditions in the mesentery. Mesenteric panniculitis (MP) is a radiological finding and its relation to clinical S...

    Authors: Lisa Nyberg, Jan Björk, Peter Björkdahl, Olle Ekberg, Klas Sjöberg and Lina Vigren

    Citation: BMC Gastroenterology 2017 17:75

    Content type: Research article

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  18. AL Amyloidosis is known to be a systemic disease affecting multiple organs and tissue while it’s rare that patients present with gastrointestinal symptoms at first and later develop multiple-organ dysfuction. ...

    Authors: Li Tian, Anliu Tang, Xian Zhang, Zhen Mei, Fen Liu, Jingbo Li, Xiayu Li, Feiyan Ai, Xiaoyan Wang and Shourong Shen

    Citation: BMC Gastroenterology 2017 17:72

    Content type: Case report

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  19. Inflammatory bowel disease (IBD) is associated with increased intestinal permeability, which involves paracellular passage regulated through tight junctions (TJ). The aim of the study was to investigate single...

    Authors: Elisabeth Norén, Sven Almer and Jan Söderman

    Citation: BMC Gastroenterology 2017 17:68

    Content type: Research article

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  20. Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity. We hypothesize tha...

    Authors: Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes and Hon Wai Koon

    Citation: BMC Gastroenterology 2017 17:63

    Content type: Research article

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  21. The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotic...

    Authors: Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore and Gerardo Nardone

    Citation: BMC Gastroenterology 2017 17:53

    Content type: Research article

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  22. The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We conducted a systematic review and network meta-analysis of the exist...

    Authors: Chelle L. Wheat, Cynthia W. Ko, Kindra Clark-Snustad, David Grembowski, Timothy A. Thornton and Beth Devine

    Citation: BMC Gastroenterology 2017 17:52

    Content type: Research article

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  23. Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages...

    Authors: Yohei Ono, Shuji Kanmura, Yuko Morinaga, Kohei Oda, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Hiroki Taguchi, Hirofumi Uto, Hirohito Tsubouchi and Akio Ido

    Citation: BMC Gastroenterology 2017 17:40

    Content type: Research article

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  24. Polyethylene glycosylated (PEGylated) porcine glucagon-like peptide-2 (pGLP-2) considerably increases half-life and stability compared with the native pGLP-2, but the effective dose for intestinal damage is st...

    Authors: Ke-ke Qi, Jia-jia Lv, Jie Wu and Zi-wei Xu

    Citation: BMC Gastroenterology 2017 17:34

    Content type: Research article

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  25. Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD pati...

    Authors: Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong and Shu-Chen Wei

    Citation: BMC Gastroenterology 2017 17:28

    Content type: Research article

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  26. We evaluated the impact of different case definition algorithms on the prevalence of paediatric inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) and to compare the occurrence ...

    Authors: J. F. Ludvigsson, K. Büsch, O. Olén, J. Askling, K. E. Smedby, A. Ekbom, E. Lindberg and M. Neovius

    Citation: BMC Gastroenterology 2017 17:23

    Content type: Research article

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  27. Diet is strongly associated with the aetiology of Crohn’s Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of ...

    Authors: Vaios Svolos, Konstantinos Gerasimidis, Elaine Buchanan, Lee Curtis, Vikki Garrick, Jacqueline Hay, Susan Laird, Joanna Munro, Daniel R. Gaya, Richard K. Russell and Richard Hansen

    Citation: BMC Gastroenterology 2017 17:14

    Content type: Research article

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  28. According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipatio...

    Authors: Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini and Gabrio Bassotti

    Citation: BMC Gastroenterology 2017 17:11

    Content type: Research article

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  29. Studies examining the association between smoking and the need for surgery in patients with Crohn’s disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiat...

    Authors: M. Ellen Kuenzig, Sang Min Lee, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Remo Panaccione and Gilaad G. Kaplan

    Citation: BMC Gastroenterology 2016 16:143

    Content type: Research article

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  30. Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the preva...

    Authors: D. Lundgren, J. Rutegård, V. Eklöf, R. Palmqvist and P. Karling

    Citation: BMC Gastroenterology 2016 16:139

    Content type: Research article

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  31. Adequate bowel preparation is an essential prerequisite for complete mucosal visualization during colonoscopy. Polyethylene glycol (PEG) solutions are commonly used. However the large volume of the solution is...

    Authors: Rupa Banerjee, Hrushikesh Chaudhari, Nirish Shah, Arjunan Saravanan, Manu Tandan and D. Nageshwar Reddy

    Citation: BMC Gastroenterology 2016 16:133

    Content type: Research article

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  32. This study examines the dual role of Escherichia coli in the course of ulcerative colitis (UC). The intestinal microbiota is considered to play an important role in UC pathogenesis, but how E. coli contributes to...

    Authors: Magdalena Pilarczyk-Zurek, Magdalena Strus, Pawel Adamski and Piotr B. Heczko

    Citation: BMC Gastroenterology 2016 16:128

    Content type: Research article

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  33. Faecal calprotectin (FC) is one of the most widely used non-invasive tests for the diagnosis and assessment of Crohn’s disease (CD) activity. Despite this, factors other than disease activity which affect leve...

    Authors: Michael A. Mendall, Derek Chan, Roshani Patel and Devinder Kumar

    Citation: BMC Gastroenterology 2016 16:126

    Content type: Debate

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  34. Cronkhite-Canada syndrome (CCS) is a rare non-inherited disorder, characterized by gastrointestinal polyposis and ectodermal changes. The pathophysiology remains unclear. Treatment with corticosteroids is cons...

    Authors: Kohei Yamakawa, Takuya Yoshino, Kotaro Watanabe, Koichiro Kawano, Akira Kurita, Naomi Matsuzaki, Yoshiaki Yuba and Shujiro Yazumi

    Citation: BMC Gastroenterology 2016 16:123

    Content type: Case report

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  35. Intestinal microbiota operated as a whole and was closely related with human health. Previous studies had suggested close relationship between liver cirrhosis (LC) and gut microbiota.

    Authors: Xiao Wei, Shan Jiang, Yuye Chen, Xiangna Zhao, Huan Li, Weishi Lin, Boxing Li, Xuesong Wang, Jing Yuan and Yansong Sun

    Citation: BMC Gastroenterology 2016 16:121

    Content type: Research article

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  36. Ulcerative colitis (UC) is a chronic inflammatory disorder of still unknown pathogenesis. Increasing evidence indicates that alterations in mitochondrial respiration and thus adenosine triphosphate (ATP) produ...

    Authors: Theresa Dankowski, Torsten Schröder, Steffen Möller, Xinhua Yu, David Ellinghaus, Florian Bär, Klaus Fellermann, Hendrik Lehnert, Stefan Schreiber, Andre Franke, Christian Sina, Saleh M. Ibrahim and Inke R. König

    Citation: BMC Gastroenterology 2016 16:118

    Content type: Research article

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  37. International guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those tested positive to detect coeliac disease. However, pre-endoscopy serology is often unavailable, th...

    Authors: Michelle Shui Yee Lau, Peter D. Mooney, William L. White, Victoria Appleby, Sulleman Moreea, Ismail Haythem, Joshua E. Elias, Kiran Bundhoo, Gareth D. Corbett, Liam Wong, Her Hsin Tsai, Simon S. Cross, John M. Hebden, Sami Hoque and David S. Sanders

    Citation: BMC Gastroenterology 2016 16:115

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2016 16:122

  38. The ST2/IL-33 pathway has been related to ulcerative colitis (UC), and soluble ST2 (sST2), to disease severity. We tested the potential usefulness of sST2 as a predictive marker of treatment response and patie...

    Authors: David Díaz-Jiménez, Marjorie De la Fuente, Karen Dubois-Camacho, Glauben Landskron, Janitza Fuentes, Tamara Pérez, María Julieta González, Daniela Simian, Marcela A. Hermoso and Rodrigo Quera

    Citation: BMC Gastroenterology 2016 16:103

    Content type: Research article

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  39. Little is known of the prevalence of hepatitis B virus (HBV) infection and its effect on choice of therapy and disease course in patients with inflammatory bowel disease (IBD). We assessed the prevalence of HB...

    Authors: Heyson C. H. Chan, Vincent W. S. Wong, Grace L. H. Wong, Whitney Tang, Justin C. Y. Wu and Siew C. Ng

    Citation: BMC Gastroenterology 2016 16:100

    Content type: Research article

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  40. The human gut is the habitat for diverse and dynamic microbial ecosystem. The human microbiota plays a critical role in functions that sustain health and is a positive asset in host defenses. Establishment of ...

    Authors: Erigene Rutayisire, Kun Huang, Yehao Liu and Fangbiao Tao

    Citation: BMC Gastroenterology 2016 16:86

    Content type: Research article

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  41. Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate i...

    Authors: Mingming Zhang, Qian Zhou, Robert G. Dorfman, Xiaoli Huang, Tingting Fan, Hao Zhang, Jun Zhang and Chenggong Yu

    Citation: BMC Gastroenterology 2016 16:84

    Content type: Research article

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  42. There are few reports of the efficacy of adalimumab (ADA) for clinical remission and preventing postoperative recurrence in Crohn's disease (CD) in Asian real practice settings. We conducted a Japanese multice...

    Authors: Fuminao Takeshima, Daisuke Yoshikawa, Syuntaro Higashi, Tomohito Morisaki, Hidetoshi Oda, Maho Ikeda, Haruhisa Machida, Kayoko Matsushima, Hitomi Minami, Yuko Akazawa, Naoyuki Yamaguchi, Ken Ohnita, Hajime Isomoto, Masato Ueno and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2016 16:82

    Content type: Research article

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  43. Association between celiac disease and type 1 diabetes in adults is still somewhat unclear, and that between celiac disease and type 2 diabetes even less known. We studied these issues in a large cohort of adu...

    Authors: Antti Kylökäs, Katri Kaukinen, Heini Huhtala, Pekka Collin, Markku Mäki and Kalle Kurppa

    Citation: BMC Gastroenterology 2016 16:76

    Content type: Research article

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  44. Ulcerative colitis is a lifelong, immunologically mediated disease. Direct-acting antivirals (DAAs) are now available for the treatment of chronic hepatitis C virus (HCV) infection. An interferon-free regimen ...

    Authors: Yuki Ohta, Tatsuo Kanda, Tatsuro Katsuno, Shin Yasui, Yuki Haga, Reina Sasaki, Masato Nakamura, Shuang Wu, Shingo Nakamoto, Makoto Arai and Osamu Yokosuka

    Citation: BMC Gastroenterology 2016 16:66

    Content type: Case report

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