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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The duodenum is a common site for diverticulum formation. Most of the duodenal diverticula are asymptomatic, incidental findings. Perforation is a rare but potentially lethal complication of duodenal diverticu...

    Authors: Moysis Moysidis, Daniel Paramythiotis, Anestis Karakatsanis, Evropi Amanatidou, Elisavet Psoma, Xanthippi Mavropoulou and Antonios Michalopoulos

    Citation: BMC Gastroenterology 2020 20:5

    Content type: Case report

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  2. The aim of this study was to investigate the efficacy and safety of the novel complex drug, consisting of released-active form of antibodies to S-100 protein, tumor necrosis factor-α and histamine, (Kolofort) ...

    Authors: Vladimir T. Ivashkin, Elena A. Poluektova, Alexey B. Glazunov, Mikhail A. Putilovskiy and Oleg I. Epstein

    Citation: BMC Gastroenterology 2019 20:2

    Content type: Research article

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  3. Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aime...

    Authors: Yun Cui, Shi-yuan Lu, Jie Xu, Yan-shen Peng, Qi Miao, Xiao-qing Wang, Xiao-yu Chen and Zhi-hua Ran

    Citation: BMC Gastroenterology 2019 19:232

    Content type: Research article

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  4. Conventional endoscopic treatments can’t control bleeding in as many as 20% of patients with non-variceal gastrointestinal (GI) bleeding. Recent studies have shown that over-the-scope-clip (OTSC) system allowe...

    Authors: Chunyu Zhong, Shali Tan, Yutang Ren, Muhan Lü, Yan Peng, Xiangsheng Fu and Xiaowei Tang

    Citation: BMC Gastroenterology 2019 19:225

    Content type: Research article

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  5. Various types of medical glues/adhesives/topical coagulants’ (referred to as MG hereinafter) have widespread application as surgical adhesives, and have been shown to be safe and effective for a broad range of...

    Authors: Wei Li, Mingming Xiao, Yujia Chen, Jiaxing Yang, Donghui Sun, Jian Suo and Daguang Wang

    Citation: BMC Gastroenterology 2019 19:224

    Content type: Case report

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  6. Capsule endoscopy (CE) is the preferred diagnostic test of choice in the investigation of obscure gastrointestinal bleeding (OGIB). Although, a conservative strategy is recommended in the short-term, for cases...

    Authors: Panu Wetwittayakhlang, Jirapat Wonglhow, Nisa Netinatsunton, Naichaya Chamroonkul and Teerha Piratvisuth

    Citation: BMC Gastroenterology 2019 19:216

    Content type: Research article

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  7. Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated...

    Authors: Alexander S. Somwaru, Vikesh Khanijow and Venkat S. Katabathina

    Citation: BMC Gastroenterology 2019 19:210

    Content type: Research article

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  9. Heparin bridging therapy (HBT) is indeed related to a high frequency of bleeding after endoscopic mucosal resection (EMR). In this study, our aim was to investigate clinical impact of management of oral antico...

    Authors: Shoko Ono, Marin Ishikawa, Kana Matsuda, Momoko Tsuda, Keiko Yamamoto, Yuichi Shimizu and Naoya Sakamoto

    Citation: BMC Gastroenterology 2019 19:206

    Content type: Research article

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  10. This case seeks to highlight to endoscopists a rare benign disorder that may be encountered during endoscopy. Clinicians may be tempted to biopsy, which could lead to a catastrophic gastrointestinal haemorrhage.

    Authors: Kushala W. M. Abeysekera, Daniel S. Pearl, Paul Burn and Andrew Lowe

    Citation: BMC Gastroenterology 2019 19:198

    Content type: Case report

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  11. The available information on granulocyte and monocyte adsorptive apheresis (GMA) in patients with inflammatory bowel disease (IBD) under special situations remains unclear. We conducted a retrospective, multic...

    Authors: Satoshi Motoya, Hiroki Tanaka, Tomoyoshi Shibuya, Taro Osada, Takayuki Yamamoto, Hitoshi Hongo, Chiemi Mizuno, Daisuke Saito, Nobuo Aoyama, Toshihisa Kobayashi, Hiroaki Ito, Satoshi Tanida, Masanori Nojima, Seiichiro Kokuma and Eiji Hosoi

    Citation: BMC Gastroenterology 2019 19:196

    Content type: Research article

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  12. Proton pump inhibitors (PPI) and histamine 2 receptor antagonists (H2RA) have been widely used as stress ulcer prophylaxis (SUP) in critically ill patients, however, its efficacy and safety remain unclear. Thi...

    Authors: Xiaoyang Zhou, Hanyuan Fang, Jianfei Xu, Peifu Chen, Xujun Hu, Bixin Chen, Hua Wang, Caibao Hu and Zhaojun Xu

    Citation: BMC Gastroenterology 2019 19:193

    Content type: Research article

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  13. There is an unmet need for novel treatments, such as drugs or vaccines, adjunctive to or replacing a burdensome life-long gluten-free diet for coeliac disease. The gold standard for successful treatment is a h...

    Authors: Juha Taavela, Keijo Viiri, Alina Popp, Mikko Oittinen, Valeriia Dotsenko, Markku Peräaho, Synnöve Staff, Jani Sarin, Francisco Leon, Markku Mäki and Jorma Isola

    Citation: BMC Gastroenterology 2019 19:189

    Content type: Research article

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  14. Bile acid malabsorption (BAM) and bile acid-related diarrhea represent an under-recognized cause of chronic diarrhea mainly because of limited guidance on appropriate diagnostic and laboratory tests. We aimed ...

    Authors: Ivan Lyutakov, Francesco Ursini, Plamen Penchev, Giacomo Caio, Antonio Carroccio, Umberto Volta and Roberto De Giorgio

    Citation: BMC Gastroenterology 2019 19:185

    Content type: Research article

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  15. Patients using opioids to treat chronic non-cancer pain often experience side effects that may affect health-related quality of life (HRQOL). These side effects include opioid-induced constipation (OIC), sedat...

    Authors: Michelle S. Keller, Alma Jusufagic and Brennan M. R. Spiegel

    Citation: BMC Gastroenterology 2019 19:182

    Content type: Research article

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  16. A validated histopathological tool to precisely evaluate bowel fibrosis in patients with Crohn’s disease is lacking. We attempted to establish a new index to quantify the severity of bowel fibrosis in patients...

    Authors: Xue-hua Li, Zhuang-nian Fang, Tian-ming Guan, Jin-jiang Lin, Can-hui Sun, Si-yun Huang, Ren Mao, Bao-lan Lu, Qing-hua Cao, Shi-ting Feng and Zi-ping Li

    Citation: BMC Gastroenterology 2019 19:180

    Content type: Research article

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  19. Colonoscopy is associated with a risk of peritonitis in patients on peritoneal dialysis. However, no study has yet described the risk factors in play.

    Authors: Tae-Geun Gweon, Sung Hoon Jung, Sang Woo Kim, Kang-Moon Lee, Dae Young Cheung, Bo-In Lee and Hwang Choi

    Citation: BMC Gastroenterology 2019 19:175

    Content type: Research article

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  20. The extra-intestinal manifestation of tracheobronchitis is a rare complication of ulcerative colitis (UC). Here, we present a case of UC-related tracheobronchitis wherein the positive clinical effects of infli...

    Authors: Lisa Horgan, Siobhain Mulrennan, Lloyd D’Orsogna and Andrew McLean-Tooke

    Citation: BMC Gastroenterology 2019 19:171

    Content type: Case report

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  21. A nested qualitative interview study within the CONSTRUCT trial was conducted to explore experiences and perceptions of patients with acute severe ulcerative colitis following treatment with infliximab or cicl...

    Authors: Frances Rapport, Clare Clement, Anne C. Seagrove, Laith Alrubaiy, Hayley A. Hutchings and John G. Williams

    Citation: BMC Gastroenterology 2019 19:166

    Content type: Research article

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  22. Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review...

    Authors: Shiwei Zhu, Ben Wang, Qiong Jia and Liping Duan

    Citation: BMC Gastroenterology 2019 19:165

    Content type: Research article

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  23. Plaque psoriasis and inflammatory bowel disease (IBD) are both chronic immune-mediated inflammatory diseases with an overlapping genetic profile and have been linked in epidemiological studies. Psoriasis and I...

    Authors: Matthew K. Smith, Jay Pai, Remo Panaccione, Paul Beck, Jose G. Ferraz and Humberto Jijon

    Citation: BMC Gastroenterology 2019 19:162

    Content type: Case report

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  25. An intestinal stoma, though a life-saving procedure on the care of many gastrointestinal conditions, carries significant number of complications. This study describes the common indications, complications, and...

    Authors: Alicia Massenga, Alfred Chibwae, Aloyce A. Nuri, Merchades Bugimbi, Yasin K. Munisi, Ramadhani Mfinanga and Phillipo L. Chalya

    Citation: BMC Gastroenterology 2019 19:157

    Content type: Research article

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  26. Haemolytic uraemic syndrome is a rarely seen in adults often leading to critical illness. This case highlights how difficult it can be to establish a diagnosis and treat when a patient presents with bloody dia...

    Authors: Shiva Thambiah Radhakrishnan, Aruchuna Ruban, Aarthy Kanmany Uthayakumar, Patrizia Cohen, Jeremy Levy and Julian Teare

    Citation: BMC Gastroenterology 2019 19:156

    Content type: Case report

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  27. Systemic lupus erythematosus is an autoimmune disease which can affect multiple organs, resulting in significant mortality and morbidity. Lupus enteritis is one of the rare complications of SLE, defined as vas...

    Authors: Xiu-Li Zhu, Xue-Mei Xu, Si Chen, Qiao-Min Wang and Kai-Guang Zhang

    Citation: BMC Gastroenterology 2019 19:154

    Content type: Case report

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  28. With the development and application of endoscopic technology, most pedunculated polyps can be absolutely resected with a complete specimen by hot snare polypectomy (HSP). Brunner’s gland hamartoma (BGH) is a ...

    Authors: Lizhi Yi, Zhengyu Cheng, Huarong Qiu, Jianjun Yang, Tao Wang and Ke Liu

    Citation: BMC Gastroenterology 2019 19:151

    Content type: Case report

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  29. To evaluate the role of colonoscopy in infants and young children and clarify the distribution of colonoscopy-requiring diseases in this age group.

    Authors: Ryusuke Nambu, Shin-ichiro Hagiwara, Fumihiko Kakuta, Tomoko Hara, Hirotaka Shimizu, Daiki Abukawa, Itaru Iwama, Seiichi Kagimoto and Katsuhiro Arai

    Citation: BMC Gastroenterology 2019 19:149

    Content type: Research article

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  30. Splenic nodules are uncommon entities that occur rarely in the general population. Although an infectious etiology (primarily bacteria, followed by mycobacteria) is usually found, noninfectious diseases, inclu...

    Authors: D. F. Bavaro, G. Ingravallo, F. Signorile, F. Fortarezza, F. Di Gennaro, G. Angarano and A. Saracino

    Citation: BMC Gastroenterology 2019 19:144

    Content type: Case report

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  33. Bone mesenchymal stromal cells (BMSC) showed protective potential against intestinal ischemia. Oxygenase-1(HO-1) could alleviate oxidative stress. In the present study, we constructed HO-1-expressing BMSC and ...

    Authors: Xue-Tao Yan, Xiao-Li Cheng, Xiang-Hu He, Wen-Zhong Zheng, Yuan Xiao-Fang and Chen Hu

    Citation: BMC Gastroenterology 2019 19:124

    Content type: Research article

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  34. Fecal microbiota transplantation may contribute to disease remission in ulcerative colitis; however, the factors that determine the effects of treatment remain unknown. The aim of the present study was to pros...

    Authors: Yan Tian, Yan Zhou, Sisi Huang, Jun Li, Kui Zhao, Xiaohui Li, Xiangchen Wen and Xiao-an Li

    Citation: BMC Gastroenterology 2019 19:116

    Content type: Research article

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  35. Patients with Inflammatory Bowel Disease (IBD) also suffer from a wide range of additional disorders, which may be caused by the disease, the side effect of the medication, or a lack of physical activity (PA)....

    Authors: Katharina G. Eckert, Isabelle Abbasi-Neureither, Maximilian Köppel and Gerhard Huber

    Citation: BMC Gastroenterology 2019 19:115

    Content type: Research article

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  36. Microcirculatory disturbance is an important factor in the pathogenesis of Inflammatory Bowel Disease (IBD) but there have been few studies in this field. Confocal Laser Endomicroscopy (CLE) has been used over...

    Authors: Yu Tian, Yue Zheng, Guigen Teng, Junxia Li and Huahong Wang

    Citation: BMC Gastroenterology 2019 19:114

    Content type: Research article

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  37. Irritable bowel syndrome (IBS) can be responsible for alteration in quality of life and economic burden. The aim of this study was to evaluate healthcare use related to this disorder in France.

    Authors: Jean-Marc Sabaté, Sébastien Rivière, Pauline Jouet, Christelle Gastaldi-Menager, Anne Fagot-Campagna and Philippe Tuppin

    Citation: BMC Gastroenterology 2019 19:111

    Content type: Research article

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  38. Accurate evaluation of anti-tubercular therapy (ATT) responses is crucial for both diagnosis and treatment of intestinal tuberculosis (ITB). Little is known about the role of cross-sectional imaging techniques...

    Authors: Li Ma, Qingli Zhu, Yue Li, Wenbo Li, Xuan Wang, Wei Liu, Jianchu Li and Yuxin Jiang

    Citation: BMC Gastroenterology 2019 19:106

    Content type: Research article

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  39. Daily cannabis assumption is currently associated with several physical and mental health problems, however in the past it was prescribed for a multitude of symptoms, including vomiting, abdominal pain and dia...

    Authors: Lanfranco Pellesi, Maria Chiara Verga, Nicola De Maria, Erica Villa, Luigi Alberto Pini and Simona Guerzoni

    Citation: BMC Gastroenterology 2019 19:105

    Content type: Case report

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  40. The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn...

    Authors: Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore and Andrew Godkin

    Citation: BMC Gastroenterology 2019 19:98

    Content type: Technical advance

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  41. Currently, WeChat is widely used in disease education for patients with Crohn’s disease (CD) in China. It is beneficial for the patients to actively engage in their disease management.

    Authors: Qiao Yu, Liyi Xu, Lili Li, Min Zhi, Yubei Gu, Xinying Wang, Hong Guo, Yue Li, Yihong Fan, Bolin Yang, Meng Xue, Minfang Lv, Dingting Xu, Hanyun Zhang, Yan Li, Yongmao Song…

    Citation: BMC Gastroenterology 2019 19:97

    Content type: Research article

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  42. Celiac disease (CD) is triggered by gluten and related prolamines in genetically susceptible individuals. We aimed to investigate the influence of HLA-DQ genotypes in clinical, serological and histological fea...

    Authors: Eva Martínez-Ojinaga, Marta Fernández-Prieto, Manuel Molina, Isabel Polanco, Elena Urcelay and Concepción Núñez

    Citation: BMC Gastroenterology 2019 19:91

    Content type: Research article

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  43. Patients with inflammatory bowel disease (IBD) present with reduced serum insulin-like growth factor I (IGF-I). Anti-inflammatory treatment with prednisolone or infliximab ameliorates symptoms and increases ci...

    Authors: Rikke Hjortebjerg, Karen L. Thomsen, Jørgen Agnholt and Jan Frystyk

    Citation: BMC Gastroenterology 2019 19:83

    Content type: Research article

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  44. Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and si...

    Authors: John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis…

    Citation: BMC Gastroenterology 2019 19:82

    Content type: Study protocol

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  45. Ambulatory surgery maintains the advantages of a more rapid return to work and overall reduced hospital costs. The specific impact of ambulatory surgery for anal fistula using the LIFT procedure (ligation of t...

    Authors: Jian-ming Qiu, Guan-gen Yang, Hong-tao Wang, Chao Fu, Dong Wang and Tingting Mei

    Citation: BMC Gastroenterology 2019 19:81

    Content type: Research article

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  47. Colonoscopy requires colon cleansing. For this, many polyethylene glycol (PEG)-based preparations still require a high preparation-volume intake. Using an increased osmotic load with ascorbate (Asc), five new ...

    Authors: Lucy B. Clayton, Bola Tayo, Marc Halphen and Rüdiger Kornberger

    Citation: BMC Gastroenterology 2019 19:79

    Content type: Research article

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  49. Peutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in ch...

    Authors: Yu-Liang Jiang, Zi-Ye Zhao, Bai-Rong Li, Jing Li, Xiao-Wei Jin, En-Da Yu, Xiao-Dong Xu and Shou-Bin Ning

    Citation: BMC Gastroenterology 2019 19:70

    Content type: Case report

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  50. Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe I...

    Authors: Jan Tack, Vincenzo Stanghellini, Fermín Mearin, Yan Yiannakou, Peter Layer, Benoit Coffin, Magnus Simren, Jonathan Mackinnon, Gwen Wiseman and Anne Marciniak

    Citation: BMC Gastroenterology 2019 19:69

    Content type: Research article

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