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Intestinal disorders

Section edited by Peter Lakatos

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohn...

    Authors: Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Åsa V. Keita, Awen M. Gallimore and Andrew Godkin

    Citation: BMC Gastroenterology 2019 19:98

    Content type: Technical advance

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  2. Currently, WeChat is widely used in disease education for patients with Crohn’s disease (CD) in China. It is beneficial for the patients to actively engage in their disease management.

    Authors: Qiao Yu, Liyi Xu, Lili Li, Min Zhi, Yubei Gu, Xinying Wang, Hong Guo, Yue Li, Yihong Fan, Bolin Yang, Meng Xue, Minfang Lv, Dingting Xu, Hanyun Zhang, Yan Li, Yongmao Song…

    Citation: BMC Gastroenterology 2019 19:97

    Content type: Research article

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  3. Celiac disease (CD) is triggered by gluten and related prolamines in genetically susceptible individuals. We aimed to investigate the influence of HLA-DQ genotypes in clinical, serological and histological fea...

    Authors: Eva Martínez-Ojinaga, Marta Fernández-Prieto, Manuel Molina, Isabel Polanco, Elena Urcelay and Concepción Núñez

    Citation: BMC Gastroenterology 2019 19:91

    Content type: Research article

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  4. Patients with inflammatory bowel disease (IBD) present with reduced serum insulin-like growth factor I (IGF-I). Anti-inflammatory treatment with prednisolone or infliximab ameliorates symptoms and increases ci...

    Authors: Rikke Hjortebjerg, Karen L. Thomsen, Jørgen Agnholt and Jan Frystyk

    Citation: BMC Gastroenterology 2019 19:83

    Content type: Research article

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  5. Intestinal inflammation in Crohn’s disease (CD) is caused by mucosal immune system reactivity to luminal antigen and results in debilitating symptoms, reduced quality of life, impaired work productivity and si...

    Authors: John A. Snowden, Chris Hawkey, Daniel Hind, Lizzie Swaby, Katie Mellor, Richard Emsley, Laura Mandefield, Ellen Lee, Manuela Badoglio, Emmanuelle Polge, Myriam Labopin, John Gribben, A. Graham Pockley, Gemma A. Foulds, Alan Lobo, Simon Travis…

    Citation: BMC Gastroenterology 2019 19:82

    Content type: Study protocol

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  6. Ambulatory surgery maintains the advantages of a more rapid return to work and overall reduced hospital costs. The specific impact of ambulatory surgery for anal fistula using the LIFT procedure (ligation of t...

    Authors: Jian-ming Qiu, Guan-gen Yang, Hong-tao Wang, Chao Fu, Dong Wang and Tingting Mei

    Citation: BMC Gastroenterology 2019 19:81

    Content type: Research article

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  8. Colonoscopy requires colon cleansing. For this, many polyethylene glycol (PEG)-based preparations still require a high preparation-volume intake. Using an increased osmotic load with ascorbate (Asc), five new ...

    Authors: Lucy B. Clayton, Bola Tayo, Marc Halphen and Rüdiger Kornberger

    Citation: BMC Gastroenterology 2019 19:79

    Content type: Research article

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  10. Peutz-Jeghers syndrome (PJS) is a Mendelian disease, whose causative gene is STK11, mainly characterized by gastrointestinal polyposis and increased cancer risk. Clinical observation reveals intussusception in ch...

    Authors: Yu-Liang Jiang, Zi-Ye Zhao, Bai-Rong Li, Jing Li, Xiao-Wei Jin, En-Da Yu, Xiao-Dong Xu and Shou-Bin Ning

    Citation: BMC Gastroenterology 2019 19:70

    Content type: Case report

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  11. Irritable bowel syndrome with predominant constipation (IBS-C) is a complex disorder with gastrointestinal and nervous system components. The study aim was to assess the economic burden of moderate to severe I...

    Authors: Jan Tack, Vincenzo Stanghellini, Fermín Mearin, Yan Yiannakou, Peter Layer, Benoit Coffin, Magnus Simren, Jonathan Mackinnon, Gwen Wiseman and Anne Marciniak

    Citation: BMC Gastroenterology 2019 19:69

    Content type: Research article

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  12. Before diagnosis, people with coeliac disease suffer reduced quality of life, which improves substantially after the disease has been diagnosed. Delayed diagnosis is common. The aim of this study was to assess...

    Authors: Mara Violato and Alastair Gray

    Citation: BMC Gastroenterology 2019 19:68

    Content type: Research article

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  13. Ulcerative colitis (UC)-related post-colectomy enteritis is a very rare condition that is characterized by diffuse small-bowel mucosal inflammation following colectomy and could be very dangerous. In previousl...

    Authors: Yingyun Yang, Yuan Liu, Weiyang Zheng, Weixun Zhou, Bin Wu, Xiyu Sun, Wei Chen, Tao Guo, Xiaoqing Li, Hong Yang, Jiaming Qian and Yue Li

    Citation: BMC Gastroenterology 2019 19:61

    Content type: Case report

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  14. Severe haemorrhage is an uncommon but life-threatening complication of ulcerative colitis (UC). Superselective transcatheter embolization has shown to be an effective and safe therapeutic modality in patients ...

    Authors: Jose Miranda-Bautista, Lucía Diéguez, Gracia Rodríguez-Rosales, Ignacio Marín-Jiménez and Luis Menchén

    Citation: BMC Gastroenterology 2019 19:55

    Content type: Case report

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  15. CMUSE is a rare disease whose diagnosis remains difficult because the lesion is confined to the small bowel.

    Authors: En-Wei Tao, Tian-Hui Zou, Yong-Feng Wang, Jie-Ting Tang, Ying-Xuan Chen and Qin-Yan Gao

    Citation: BMC Gastroenterology 2019 19:49

    Content type: Case report

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:64

  17. Small bowel adenocarcinoma (SBA) is a rare neoplasm, which can occur in a sporadic form or can be associated with a number of predisposing conditions such as hereditary syndromes and immune-mediated intestinal...

    Authors: Giacomo Caio, Umberto Volta, Francesco Ursini, Roberto Manfredini and Roberto De Giorgio

    Citation: BMC Gastroenterology 2019 19:45

    Content type: Research article

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  18. Cronkhite-Canada syndrome is a rare disease of unknown etiology and the optimal treatment for this syndrome is unknown.

    Authors: Sigrid Schulte, Fabian Kütting, Jessica Mertens, Thomas Kaufmann, Uta Drebber, Dirk Nierhoff, Ulrich Töx and Hans-Michael Steffen

    Citation: BMC Gastroenterology 2019 19:36

    Content type: Case report

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  19. Inflammatory Bowel Disease (IBD) with its high incidence and prevalence rates in Canada generates a heavy burden of tests and procedures. The purpose of this study is to gain a better understanding of the tran...

    Authors: Isabelle Noiseux, Sophie Veilleux, Alain Bitton, Rita Kohen, Luc Vachon, Brian White Guay and John D. Rioux

    Citation: BMC Gastroenterology 2019 19:30

    Content type: Research article

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  20. Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. We aimed to determine if a program of aerobic and resistance exercise could safely achieve body c...

    Authors: Owen Cronin, Wiley Barton, Carthage Moran, Donal Sheehan, Ronan Whiston, Helena Nugent, Yvonne McCarthy, Catherine B. Molloy, Orla O’Sullivan, Paul D. Cotter, Michael G. Molloy and Fergus Shanahan

    Citation: BMC Gastroenterology 2019 19:29

    Content type: Research article

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  21. Superior mesenteric artery (SMA) syndrome, also known as Wilkie’s syndrome or Benign duodenal stasis, is a rare benign disease. It could threaten the life if the manifestation is severe and the treatment is in...

    Authors: Ying Shi, Guangya Shi, Zhenyu Li, Yanfang Chen, Shaohui Tang and Wei Huang

    Citation: BMC Gastroenterology 2019 19:15

    Content type: Case report

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  22. Health administrative data is increasingly used to conduct population-based health services research. A major limitation of these data for the study of inflammatory bowel diseases is the absence of detailed cl...

    Authors: Sanjay K. Murthy, Tushar Shukla, Lilia Antonova, Marc-Andre Belair, Tim Ramsay, Zane Gallinger, Geoffrey C. Nguyen and Eric I. Benchimol

    Citation: BMC Gastroenterology 2019 19:13

    Content type: Research article

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  23. Encapsulating peritoneal sclerosis (EPS) is a chronic clinical syndrome of acute or subacute gastrointestinal obstruction seen mainly in patients undergoing peritoneal dialysis. Although there are a few report...

    Authors: Yoshimitsu Shimomura, Shinsuke Sakai, Hiroyuki Ueda, Kohei Fujikura, Yukihiro Imai and Takayuki Ishikawa

    Citation: BMC Gastroenterology 2019 19:12

    Content type: Case report

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  24. Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn’s disease based upon clinical, imaging...

    Authors: Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery and Oscar Swift

    Citation: BMC Gastroenterology 2019 19:11

    Content type: Case report

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  25. Recent studies have found gut microbiota to be closely associated with onset and perpetuation of UC. Currently, studies about gut microbiota have mainly covered samples collected from the intestinal lumen. How...

    Authors: Ling-yan Pei, Yu-shi Ke, Huan-hu Zhao, Lin Wang, Chao Jia, Wei-zhi Liu, Qian-hui Fu, Meng-ni Shi, Jian Cui and Shu-chun Li

    Citation: BMC Gastroenterology 2019 19:10

    Content type: Research article

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  26. Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten geneti...

    Authors: Jun Ishihara, Tatsuki Mizuochi, Takashi Uchida, Yugo Takaki, Ken-ichiro Konishi, Masahiko Joo, Yasuhiko Takahashi, Shinichiro Yoshioka, Hironori Kusano, Yoji Sasahara and Yushiro Yamashita

    Citation: BMC Gastroenterology 2019 19:9

    Content type: Case report

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  27. The incidence of Ulcerative colitis (UC) in Asia is increasing but reports on its long-term course are few. The aim of this study was to identify risk factors predictive of extent progression in Asian patients...

    Authors: Yun Qiu, Baili Chen, Yufei Li, Shanshan Xiong, Shenghong Zhang, Yao He, Zhirong Zeng, Shomron Ben-Horin, Minhu Chen and Ren Mao

    Citation: BMC Gastroenterology 2019 19:7

    Content type: Research article

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  28. Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these in...

    Authors: Floris Imhann, K. J. Van der Velde, R. Barbieri, R. Alberts, M. D. Voskuil, A. Vich Vila, V. Collij, L. M. Spekhorst, K. W. J. Van der Sloot, V. Peters, H. M. Van Dullemen, M. C. Visschedijk, E. A. M. Festen, M. A. Swertz, G. Dijkstra and R. K. Weersma

    Citation: BMC Gastroenterology 2019 19:5

    Content type: Database

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    The Correction to this article has been published in BMC Gastroenterology 2019 19:44

  29. We aimed to investigate how high-dose ecabet sodium affects low-dose aspirin-induced small intestinal mucosal injury in healthy volunteers.

    Authors: Kazuhiro Ota, Toshihisa Takeuchi, Yuichi Kojima, Satoshi Harada, Yuki Hirata, Noriaki Sugawara, Sadaharu Nouda, Kazuki Kakimoto, Takanori Kuramoto and Kazuhide Higuchi

    Citation: BMC Gastroenterology 2019 19:4

    Content type: Research article

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  30. Many reports have documented the increasing impact of Clostridium difficile infection (CDI) in patients with ulcerative colitis (UC). We conducted a retrospective study to determine the incidence, clinical charac...

    Authors: Hui Xu, Hao Tang, Tao Xu, Meng Xiao, Ji Li, Bei Tan, Hong Yang, Hong Lv, Yue Li and Jiaming Qian

    Citation: BMC Gastroenterology 2019 19:3

    Content type: Research article

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  31. Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk facto...

    Authors: Irina V. Tcymbarevich, Jyrki J. Eloranta, Jean-Benoît Rossel, Nicole Obialo, Marianne Spalinger, Jesus Cosin-Roger, Silvia Lang, Gerd A. Kullak-Ublick, Carsten A. Wagner, Michael Scharl, Klaus Seuwen, Pedro A. Ruiz, Gerhard Rogler, Cheryl de Vallière and Benjamin Misselwitz

    Citation: BMC Gastroenterology 2019 19:2

    Content type: Research article

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  32. Intestinal alkaline phosphatase (IAP) plays important role in gut homeostasis. We aimed to evaluate the expression of endogenous IAP and to assess the clinical course according to the expression of endogenous ...

    Authors: Seon-Young Park, Ji-Young Kim, Su-Mi Lee, Jin Ook Chung, Ji-Ho Seo, SunMin Kim, Dong Hyun Kim, Chang-Hwan Park, Jae-Kyun Ju, Young-Eun Joo, Jae-Hyuk Lee, Hyun-Soo Kim, Sung-Kyu Choi and Jong-Sun Rew

    Citation: BMC Gastroenterology 2018 18:188

    Content type: Research article

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  33. Exclusive enteral nutrition (EEN) is as effective as corticosteroids in inducing remission in children with Crohn’s disease (CD). However, over 50% of these children relapse by 12 months of diagnosis. Thiopuri...

    Authors: Christina Ong, Poh Ting Lim, Veena Logarajah, Maria Janelle Liwanag, Bi Xia Ang, Yuqin Cher, Fang Kuan Chiou and Ajmal Kader

    Citation: BMC Gastroenterology 2018 18:185

    Content type: Research article

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  34. Blood loss from the gastrointestinal tract can be an acute and life-threatening event. For the treatment of gastrointestinal bleeding, it is important to accurately detect gastrointestinal bleeding and to loca...

    Authors: Yoichi Otomi, Hideki Otsuka, Kaori Terazawa, Moriaki Yamanaka, Yuki Obama, Maki Arase, Maki Otomo, Saho Irahara, Michiko Kubo, Naoto Uyama, Takashi Abe and Masafumi Harada

    Citation: BMC Gastroenterology 2018 18:183

    Content type: Research article

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  36. The adequacy of pre-procedure preparation is the principal determinant of the quality of colonoscopy in pediatric as in adult patients. There is a lack of consensus, among providers on a standard pre-procedure...

    Authors: Ashwath S. Kumar, Brooke L. Beutler and Thomas M. Attard

    Citation: BMC Gastroenterology 2018 18:170

    Content type: Research article

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  37. Alterations of the small-intestinal permeability (s-IP) might play an essential role in both diarrhoea-predominant IBS (D-IBS) and celiac disease (CD) patients. Our aims were to analyse in D-IBS patients the s...

    Authors: Michele Linsalata, Giuseppe Riezzo, Benedetta D’Attoma, Caterina Clemente, Antonella Orlando and Francesco Russo

    Citation: BMC Gastroenterology 2018 18:167

    Content type: Research article

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  38. Clinical severity and intestinal lesions of Crohn’s disease (CD) usually progress over time and require a step up adjustment of the therapy either to prevent or to treat complications. The aim of the study was...

    Authors: Nadia Pallotta, Giuseppina Vincoli, Patrizio Pezzotti, Maurizio Giovannone, Alessandro Gigliozzi, Danilo Badiali, Piero Vernia and Enrico Stefano Corazziari

    Citation: BMC Gastroenterology 2018 18:164

    Content type: Research article

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  39. The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite represe...

    Authors: Vito Domenico Corleto, Vincenza Patrizia Di Marino, Gloria Galli, Giulio Antonelli, Chiara Coluccio, Arcangelo Di Cerbo, Stefania Uccini and Bruno Annibale

    Citation: BMC Gastroenterology 2018 18:162

    Content type: Case report

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  42. Gastrointestinal complications are the main cause of death in patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Available treatments often restore biochemical homeostasis, but fail t...

    Authors: Rana Yadak, Max V. Boot, Niek P. van Til, Dominique Cazals-Hatem, Armin Finkenstedt, Elly Bogaerts, Irenaeus F. de Coo and Marianna Bugiani

    Citation: BMC Gastroenterology 2018 18:149

    Content type: Research article

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  43. Vedolizumab is safe and effective in adult patients with Crohn’s disease (CD) and ulcerative colitis (UC); however, data in children with inflammatory bowel disease (IBD) are scarce. Therefore, we evaluated ve...

    Authors: Anna-Maria Schneider, Daniel Weghuber, Benjamin Hetzer, Andreas Entenmann, Thomas Müller, Georg Zimmermann, Sebastian Schütz, Wolf-Dietrich Huber and Judith Pichler

    Citation: BMC Gastroenterology 2018 18:140

    Content type: Research article

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  44. The use of immune-checkpoint inhibitors in cancer treatment has become increasingly common, resulting in an increase in the incidence of related side effects. Diarrhoea and colitis have been previously documen...

    Authors: Ryosuke Yamauchi, Toshihiro Araki, Keiichi Mitsuyama, Takaaki Tokito, Hidenobu Ishii, Shinichiro Yoshioka, Kotaro Kuwaki, Atsushi Mori, Tetsuhiro Yoshimura, Osamu Tsuruta and Takuji Torimura

    Citation: BMC Gastroenterology 2018 18:135

    Content type: Case report

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  45. Alteration of the gut microbiota by repeated antibiotic treatment increases susceptibility to Clostridioides difficile infection. Faecal microbiota transplantation from donors with a normal microbiota effectively...

    Authors: Jillian R.-M. Brown, Burkhardt Flemer, Susan A. Joyce, Akbar Zulquernain, Donal Sheehan, Fergus Shanahan and Paul W. O’Toole

    Citation: BMC Gastroenterology 2018 18:131

    Content type: Research article

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  46. Calprotectin is a stable neutrophil protein, which can be measured in faecal samples. The faecal level of calprotectin increases during disease activity in ulcerative colitis (UC). Nonetheless, the relevance o...

    Authors: Takahiro Shimoyama, Takayuki Yamamoto, Satoru Umegae and Koichi Matsumoto

    Citation: BMC Gastroenterology 2018 18:120

    Content type: Research article

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  47. Stress is a common contributing factor for irritable bowel syndrome (IBS). This study was to evaluate the efficacy of the centralized health education program in improving the quality of life (QOL) of middle s...

    Authors: Shi-Cheng Zheng, Hui Gong, Yi-Ping Wang, Qiang Zhang, Li-Li Wang, Xue-Fen Liao, Dai-Wen He and Jing Wu

    Citation: BMC Gastroenterology 2018 18:119

    Content type: Research article

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  48. Graft-versus-host disease (GVHD) is a common complication of allo-hematopoietic stem cell transplantation (allo-HSCT). Endoscopic biopsy can provide a definitive diagnosis, but the optimal endoscopic approach ...

    Authors: Yuusaku Sugihara, Sakiko Hiraoka, Nobuharu Fujii, Shiho Takashima, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Kenji Kuwaki, Keita Harada, Takehiro Tanaka and Hiroyuki Okada

    Citation: BMC Gastroenterology 2018 18:111

    Content type: Research article

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  49. Pneumatosis cystoides intestinalis (PCI) is characterized by gas-filled cysts in the intestinal submucosa and subserosa. There are few reports of PCI occurring in duodenum and rectum. Here we demonstrated four...

    Authors: Yong juan Wang, Yu ming Wang, Yan min Zheng, Hui qing Jiang and Jie Zhang

    Citation: BMC Gastroenterology 2018 18:100

    Content type: Case report

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  50. A high rate of complete colon capsule endoscopy (CCE) investigations is required for a more widespread use of CCE. The objective of this study was to assess if coffee or chewing gum can increase excretion of t...

    Authors: Maria Magdalena Buijs, Morten Kobaek-Larsen, Lasse Kaalby and Gunnar Baatrup

    Citation: BMC Gastroenterology 2018 18:95

    Content type: Research article

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