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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Dasatinib is a second-generation tyrosine kinase inhibitor (TKI) developed for treatment of patients with chronic myeloid leukemia (CML). The drug has been shown to act as a potent multikinase inhibitor by blo...

    Authors: Naoki Oshima, Yoshiyuki Mishima, Kotaro Shibagaki, Kousaku Kawashima, Norihisa Ishimura, Fumiyoshi Ikejiri, Chie Onishi, Takahiro Okada, Masaya Inoue, Ichiro Moriyama, Junji Suzumiya, Yoshikazu Kinoshita and Shunji Ishihara

    Citation: BMC Gastroenterology 2021 21:19

    Content type: Case report

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  2. Short-chain fatty acids (SCFAs) and serotonin (5-hydroxytryptamine, 5-HT) may be associated with the pathogenesis of irritable bowel syndrome (IBS). There are some reports of alterations in SCFAs and 5-HT in I...

    Authors: Mei Luo, Xiaojun Zhuang, Zhenyi Tian and Lishou Xiong

    Citation: BMC Gastroenterology 2021 21:14

    Content type: Research article

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  3. Many patients with ulcerative colitis (UC) in clinical remission frequently complain of bowel symptoms such as increased stool frequency (SF) and rectal bleeding (RB). However, studies on these patient-reporte...

    Authors: Kwangwoo Nam, Sang Hyoung Park, Jun Ho Oh, Ho-Su Lee, Soomin Noh, Jae Cheol Park, Jin Yong Kim, Eun Hye Oh, Jeongseok Kim, Nam Seok Ham, Sung Wook Hwang, Dong-Hoon Yang, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung and Suk-Kyun Yang

    Citation: BMC Gastroenterology 2021 21:13

    Content type: Research article

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  4. Chronic intestinal schistosomiasis has been reported to be associated with colonic polyps, colorectal cancer and ulcerative colitis. We aim to investigate the clinical characteristics of intestinal-related les...

    Authors: Xian Qin, Cai-Yuan Liu, Yi-Lin Xiong, Tao Bai, Lei Zhang, Xiao-Hua Hou and Jun Song

    Citation: BMC Gastroenterology 2021 21:12

    Content type: Research article

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  5. Colonic volvulus, a condition in which a colonic segment partially twists around its base, is the third leading cause of large bowel obstruction after colonic neoplasms and diverticular disease. However, volvu...

    Authors: Akihiro Yoshida, Yasutake Uchima, Naoki Hosaka, Kosuke Minaga and Masatoshi Kudo

    Citation: BMC Gastroenterology 2021 21:11

    Content type: Case report

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  6. Chronic active Epstein–Barr virus infection (CAEBV) is defined as Epstein–Barr virus (EBV)-positive T/NK cell-related neoplasia, and its major clinical symptom is systemic inflammation presenting as infectious...

    Authors: Yosuke Aihara, Kei Moriya, Naotaka Shimozato, Shinsaku Nagamatsu, Shinya Kobayashi, Masakazu Uejima, Hideki Matsuo, Eiwa Ishida, Hideo Yagi, Toshiya Nakatani, Hitoshi Yoshiji and Eiryo Kikuchi

    Citation: BMC Gastroenterology 2021 21:6

    Content type: Case report

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  7. Non-celiac gluten or wheat sensitivity (NCWS) is a “clinical entity induced by the ingestion of wheat leading to intestinal and/or extraintestinal symptoms that improve once the wheat-containing foodstuff is r...

    Authors: Consolato Sergi, Vincenzo Villanacci and Antonio Carroccio

    Citation: BMC Gastroenterology 2021 21:5

    Content type: Review

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  8. Quality of life (QOL) for patients with Peptic ulcer disease (PUD) is of interest worldwide and disease-specific instruments are needed for clinical research and practice. This paper focus on the development a...

    Authors: Chonghua Wan, Ying Chen, Li Gao, Qingqing Zhang, Peng Quan and Xiaoyuan Sun

    Citation: BMC Gastroenterology 2020 20:422

    Content type: Research article

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  9. Clinicians aim to prevent progression of Crohn’s disease (CD); however, many patients require surgical resection because of cumulative bowel damage. The aim of this study was to evaluate the impact of early in...

    Authors: Mingming Zhu, Qi Feng, Xitao Xu, Yuqi Qiao, Zhe Cui, Yunqi Yan and Zhihua Ran

    Citation: BMC Gastroenterology 2020 20:421

    Content type: Research article

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  10. Pediatric Crohn’s disease is characterized by a higher incidence of complicated phenotypes. Murine models help to better understand the dynamic process of intestinal fibrosis and test therapeutic interventions...

    Authors: Claire Dupont-Lucas, Rachel Marion-Letellier, Mathilde Pala, Charlène Guerin, Asma Amamou, Marine Jarbeau, Christine Bôle-Feysot, Lionel Nicol, Amelyne David, Moutaz Aziz, Elodie Colasse, Céline Savoye-Collet and Guillaume Savoye

    Citation: BMC Gastroenterology 2020 20:416

    Content type: Research article

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  11. In contrast to the well-characterized Celiac Disease (CD), the clinical scenarios encompassed by the non-celiac self-reported wheat sensitivity (NCSRWS) might be related to different antigens that trigger dist...

    Authors: Antonia Isabel Castillo-Rodal, Janette Furuzawa-Carballeda, Mario Peláez-Luna, José Castro-Gómez, Yolanda López-Vidal and Luis Uscanga

    Citation: BMC Gastroenterology 2020 20:414

    Content type: Research article

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  12. Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), the pathogenesis of which is complicated, and it is difficult to treat. In recent years, the emerging fecal microbiota transplantation (F...

    Authors: Xiao-Fei Dang, Qing-Xi Wang, Zhao Yin, Lin Sun and Wei-Hua Yang

    Citation: BMC Gastroenterology 2020 20:401

    Content type: Research article

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  13. Gastrointestinal endoscopy may be associated with pain and anxiety. Predictors for high pain scores after endoscopies in children are not known. The aim of our study was to identify risk factors for prolonged ...

    Authors: Tut Galai, Anat Yerushalmy-Feler, Nathan P. Heller, Amir Ben-Tov, Yael Weintraub, Achiya Amir, Hadar Moran-Lev, Lilach Zac and Shlomi Cohen

    Citation: BMC Gastroenterology 2020 20:400

    Content type: Research article

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  14. We aimed to characterize the trends of prognosis in ulcerative colitis (UC) and Crohn’s disease (CD) in a Chinese tertiary hospital.

    Authors: Hong Lv, Meng Jin, Huimin Zhang, Xuanfu Chen, Meixu Wu, Mingyue Guo, Runing Zhou, Zheng Wang, Hong Yang and Jiaming Qian

    Citation: BMC Gastroenterology 2020 20:377

    Content type: Research article

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  15. Inflammatory bowel disease (IBD) is a debilitating chronic disease with limited treatment options. Resistant starches may represent a novel treatment for IBD. However, its efficacy and safety remain unclear. O...

    Authors: Joshua Montroy, Rania Berjawi, Manoj M. Lalu, Eyal Podolsky, Cayden Peixoto, Levent Sahin, Alain Stintzi, David Mack and Dean A. Fergusson

    Citation: BMC Gastroenterology 2020 20:372

    Content type: Research article

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  16. A full spectrum of video capsule endoscopy (VCE) adverse events over the past two decades has not been evaluated. We aimed to determine pooled rates, predictors and temporal-trend of VCE adverse events over th...

    Authors: Yuan-Chen Wang, Jun Pan, Ya-Wei Liu, Feng-Yuan Sun, Yang-Yang Qian, Xi Jiang, Wen-Bin Zou, Ji Xia, Bin Jiang, Nan Ru, Jia-Hui Zhu, En-Qiang Linghu, Zhao-Shen Li and Zhuan Liao

    Citation: BMC Gastroenterology 2020 20:364

    Content type: Research article

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  17. Thymic carcinoma is a rare mediastinal neoplasm with a high malignant potential. It often shows pleural invasion and distant metastasis. The metastasis of thymic carcinoma to the small intestine is rarely repo...

    Authors: Yi Yuan, Hong Pu, Ming-hui Pang, Yi-sha Liu and Hang Li

    Citation: BMC Gastroenterology 2020 20:358

    Content type: Case report

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  18. Tunneled peritoneal drainage catheters are described as an effective and relatively safe method in the management of malignant and non-malignant refractory ascites. Therapeutic advantages, linked to their use,...

    Authors: Maria Paparoupa, Henning Wege, Anna Creutzfeldt, Marcial Sebode, Faik G. Uzunoglu, Olaf Boenisch, Axel Nierhaus, Jakob R. Izbicki and Stefan Kluge

    Citation: BMC Gastroenterology 2020 20:345

    Content type: Case report

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  19. Population-based analysis for the liver metastases of small bowel cancer is currently lacking. This study aimed to analyze the frequency, prognosis and treatment modalities for newly diagnosed small bowel canc...

    Authors: Xiaorong Ye, Lifu Wang, Yongjun Xing and Chengjun Song

    Citation: BMC Gastroenterology 2020 20:342

    Content type: Research article

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  20. As with isolated ileitis the findings of nonspecific small bowel enteritis (NSE) on capsule endoscopy (CE) poses a clinical challenge. There is lack of available evidence to help clinicians to predict signific...

    Authors: Sandeep Sihag, Brandon Tan, Serhiy Semenov, Mohd Syafiq Ismail, Barbara Ryan, Anthony O’Connor, Niall Breslin, Rita Douglas and Deirdre McNamara

    Citation: BMC Gastroenterology 2020 20:341

    Content type: Research article

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  21. Previous studied revealed that psoriasis and Inflammatory bowel disease (IBD) have highly overlapping epidemiological characteristics, genetic susceptibility loci, disease risk factors, immune mechanisms, and ...

    Authors: Jingyi Ju, Yuanyuan Dai, Jiaolan Yang, Changqin Liu, Li Fan, Lijin Feng, Binghui Zhao, Meiying Zeng, Zhanju Liu and Xiaomin Sun

    Citation: BMC Gastroenterology 2020 20:340

    Content type: Case report

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  22. A defecation disorder (DD) is a difficulty in evacuation documented by physiological exams. However, this physiological evaluation can be cumbersome, inaccessible and costly. Three “low-cost” tools to evaluate...

    Authors: A. C. Caetano, D. Costa, R. Gonçalves, J. Correia-Pinto and C. Rolanda

    Citation: BMC Gastroenterology 2020 20:338

    Content type: Research article

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  25. Foreign body ingestion is a common clinical problem. The upper esophagus is the most common site of foreign body, accounting for more than 75% of all cases, but cases with a foreign body in the duodenal papill...

    Authors: Lizhi Yi, Zhengyu Cheng, Yafei Zhou, Qin Wang, Yangyang Liu, Ke Liu, Tao Wang and Xianfei Zhong

    Citation: BMC Gastroenterology 2020 20:323

    Content type: Case report

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  26. There are no accurate markers that can predict clinical outcome in ulcerative colitis at time of diagnosis. The aim of this study was to explore a comprehensive data set to identify and validate predictors of ...

    Authors: Jon R. Florholmen, Kay-Martin Johnsen, Renate Meyer, Trine Olsen, Øystein K. Moe, Petter Tandberg, Mona D. Gundersen, Jan-Magnus Kvamme, Knut Johnsen, Terje Løitegård, Gabriele Raschpichler, Cecilia Vold, Sveinung W. Sørbye and Rasmus Goll

    Citation: BMC Gastroenterology 2020 20:321

    Content type: Research article

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  27. SARS-CoV-2 is highly infectious and has been a significant public health threat. Despite typical manifestations of illness are dominated by respiratory symptom, some patients have concurrent gastrointestinal m...

    Authors: Taojiang Chen, Qin Yang and Hongyu Duan

    Citation: BMC Gastroenterology 2020 20:318

    Content type: Case report

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  28. Diet may play a role in disease status in patients with inflammatory bowel disease. We tested whether the inflammatory potential of diet, based on a summation of pro- and anti-inflammatory nutrients, is associ...

    Authors: Carlijn R. Lamers, Nicole M. de Roos and Ben J. M. Witteman

    Citation: BMC Gastroenterology 2020 20:316

    Content type: Research article

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  29. Cryptogenic multifocal ulcer stenosing enteritis (CMUSE) is a rare disease characterized by multiple superficial ulcers, stenosis, and obstruction of the small intestine of unknown origin, and the course can r...

    Authors: Cheng Chang, Chen Jiang, Yaoyao Miao, Bin Fang and Lili Zhang

    Citation: BMC Gastroenterology 2020 20:300

    Content type: Case report

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  30. Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastroint...

    Authors: Tadashi Miike, Hiroshi Kawakami, Takuro Kameda, Shojiro Yamamoto, Yoshihiro Tahara, Tomonori Hidaka, Yoko Kubuki, Kenji Yorita, Yutaka Akiyama, Yasuji Arimura, Yoshimasa Kubota, Hiroaki Kataoka and Kazuya Shimoda

    Citation: BMC Gastroenterology 2020 20:298

    Content type: Research article

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  31. Thioguanine (TG) is a thiopurine which has been used for patients with inflammatory bowel disease (IBD), who have failed azathioprine (AZA) or mercaptopurine (MP) due to adverse events or suboptimal response. ...

    Authors: Ahmed B. Bayoumy, Elsa L. S. A. van Liere, Melek Simsek, Ben Warner, Aathavan Loganayagam, Jeremy D. Sanderson, Simon Anderson, Jonathan Nolan, Nanne K. de Boer, Chris J. J. Mulder and Azhar Ansari

    Citation: BMC Gastroenterology 2020 20:296

    Content type: Research article

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  32. Cytomegalovirus (CMV) infection can significantly complicate and worsen the condition of acute severe ulcerative colitis (UC) patients. We aimed to explore the predictive risk factors to prevent and identify C...

    Authors: Hong Yang, Kaichun Wu, Hongjie Zhang, Qin Owyang, Yinglei Miao, Fang Gu, Naizhong Hu, Kaifang Zou, Jianqiu Sheng, Jin Li, Ping Zheng, Yulan Liu, Junxia Li, Xiaodi Wang, Yongdong Wu, Yaozong Yuan…

    Citation: BMC Gastroenterology 2020 20:294

    Content type: Research article

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  33. Pressure sores are sometimes refractory to treatment, often due to malnutrition. Small intestinal bacterial overgrowth (SIBO) obstructs absorption in the digestive tract and causes malnutrition. However, littl...

    Authors: Yoshitaka Kubota, Hidekazu Nagano, Kentaro Ishii, Takashi Kono, Satomi Kono, Shinsuke Akita, Nobuyuki Mitsukawa and Tomoaki Tanaka

    Citation: BMC Gastroenterology 2020 20:283

    Content type: Case report

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  34. While Helicobacter pylori (H. pylori) ulcers has declined recently, H. pylori-negative and/or gastrotoxic drug-negative peptic ulcers (HNGN-PU) has increased. This study aimed to analyze the etiology of peptic ul...

    Authors: Jung Yeon Joo, Jin Min Cho, In Hyuk Yoo and Hye Ran Yang

    Citation: BMC Gastroenterology 2020 20:280

    Content type: Research article

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  35. Although the etiology of pouchitis remains unknown, inflammatory cytokines are significantly associated with the pathogenesis of pouchitis. The cytokine responses that characterize inflammatory bowel diseases ...

    Authors: Takahito Kitajima, Yoshiki Okita, Mikio Kawamura, Satoru Kondo, Yuji Toiyama, Keiichi Uchida and Masato Kusunoki

    Citation: BMC Gastroenterology 2020 20:277

    Content type: Research article

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  36. Segmental absence of intestinal musculature (SAIM) is a rare cause of intestinal obstruction and perforation due to partial or complete defects in the intestinal muscularis propria in neonates and is occasiona...

    Authors: Kosuke Kashiwagi, Keisuke Jimbo, Kenji Hosoi, Go Miyano, Takahiro Kudo, Atsuyuki Yamataka and Toshiaki Shimizu

    Citation: BMC Gastroenterology 2020 20:272

    Content type: Case report

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  37. Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genot...

    Authors: Masoud Keikha, Mohammad Ali-Hassanzadeh and Mohsen Karbalaei

    Citation: BMC Gastroenterology 2020 20:266

    Content type: Research article

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  38. Delayed bowel obstruction due to seat belt injury is extremely rare. The delayed onset of nonspecific symptoms makes a timely diagnosis difficult. A deep understanding of the characteristics of this condition ...

    Authors: Xing-Bin Ma, Bao-Guang Hu, Wei Wang, Xian-Yong Cheng, Chun-Di Guan and Cheng-Xia Liu

    Citation: BMC Gastroenterology 2020 20:262

    Content type: Case report

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  39. The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten a...

    Authors: Nazanin Taraghikhah, Sara Ashtari, Nastaran Asri, Bijan Shahbazkhani, David Al-Dulaimi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Razzaghi and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2020 20:258

    Content type: Review

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  40. Rapid and accurate diagnostic tools are needed for appropriate management of infectious diarrhea.

    Authors: Daisy Torres-Miranda, Hana Akselrod, Ryan Karsner, Alessandra Secco, Diana Silva-Cantillo, Marc O. Siegel, Afsoon D. Roberts and Gary L. Simon

    Citation: BMC Gastroenterology 2020 20:246

    Content type: Research article

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  41. Chronic active Epstein-Barr virus infection (CAEBV) is a rare disease, which is difficult to be differentiated from inflammatory bowel disease (IBD). To cause the attention, we present twelve cases of CAEBV in...

    Authors: Weijia Xu, Xiaoyun Jiang, Jiajie Chen, Qiqi Mao, Xianguang Zhao, Xu Sun, Liang Zhong and Lan Rong

    Citation: BMC Gastroenterology 2020 20:257

    Content type: Research article

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  43. Crystal storing histiocytosis is a rare disorder associated with monoclonal gammopathy. In this disease, monoclonal heavy and light chains accumulate in the lysosome of macrophages, leading to histiocytic reac...

    Authors: Adrien Contejean, Frédérique Larousserie, Didier Bouscary, Anthony Dohan, Bénédicte Deau-Fischer, Tali-Anne Szwebel, Marion Dhooge, Benoit Terris and Marguerite Vignon

    Citation: BMC Gastroenterology 2020 20:239

    Content type: Case report

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  44. A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire th...

    Authors: Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Saeideh Ghaffarifar, Zahra Saeedi, Zahra Akbari Namvar and Masood Shirmohammadi

    Citation: BMC Gastroenterology 2020 20:247

    Content type: Research article

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  45. Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of C...

    Authors: Meredith Buck, Igor Dumic, Wendy McDermott, Charles Nordstrom, Samarth Dawan, Andrew Virata, Scott Martin, Ann Hudson, Tamara Milovanovic and Terri Nordin

    Citation: BMC Gastroenterology 2020 20:240

    Content type: Case report

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  46. Pigmented bile salts darken the small-bowel lumen and are present with bile acid, which is involved in the development of bowel habits. The small-bowel water content (SBWC) in the ileum could represent the col...

    Authors: Taiki Aoyama, Akira Fukumoto, Kenjiro Shigita, Naoki Asayama, Shinichi Mukai and Shinji Nagata

    Citation: BMC Gastroenterology 2020 20:237

    Content type: Research article

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  47. The induction of chronic inflammation, perforation, and abscess by foreign bodies (FBs) in adults is uncommon. We present a delayed diagnosis case for a patient who had a fishbone stuck in the duodenal bulb, r...

    Authors: Zhihui Wang, Zhiqiang Du, Xiangrong Zhou, Tianming Chen and Chunyan Li

    Citation: BMC Gastroenterology 2020 20:236

    Content type: Case report

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  49. Studies of microbiota composition of infants with small intestinal ostomy due to various etiologies are limited. Here, we characterized the intestinal microbiota of neonates with ileostomy resulting from disti...

    Authors: Tian Qian, Haitao Zhu, Li Zhu, Chao Chen, Chun Shen and Rong Zhang

    Citation: BMC Gastroenterology 2020 20:224

    Content type: Research article

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  50. Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn’s disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-...

    Authors: Ulf Helwig, Michael Mross, Stefan Schubert, Heinz Hartmann, Alina Brandes, Dara Stein, Christian Kempf, Jana Knop, Sarah Campbell-Hill and Robert Ehehalt

    Citation: BMC Gastroenterology 2020 20:211

    Content type: Research article

    Published on:

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