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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Up to 30% of patients with ulcerative colitis will undergo surgery resulting in an ileal pouch-anal anastomosis (IPAA) or permanent end ileostomy (EI). We aimed to understand how patients decide between these ...

    Authors: Jessica N. Cohan, Elissa M. Ozanne, Rebecca K. Hofer, Yvonne M. Kelly, Anna Kata, Craig Larsen and Emily Finlayson

    Citation: BMC Gastroenterology 2021 21:347

    Content type: Research article

    Published on:

  2. There is rising utilization of immune checkpoint inhibitors (ICI) for a growing number of metastatic malignancies. While gastrointestinal side effects of ICI are common, isolated ICI-induced enteritis leading ...

    Authors: Kellie Young, Emery Lin, Emerson Chen, Brian Brinkerhoff, Gregory Scott and Jessica Yu

    Citation: BMC Gastroenterology 2021 21:345

    Content type: Case report

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  4. SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is ...

    Authors: Albert Martin-Cardona, Josep Lloreta Trull, Raquel Albero-González, Marta Paraira Beser, Xavier Andújar, Pablo Ruiz-Ramirez, Jaume Tur-Martínez, Carme Ferrer, José Angel De Marcos Izquierdo, Anna Pérez-Madrigal, Laura Goiburú González, Jorge Espinós Perez and Maria Esteve

    Citation: BMC Gastroenterology 2021 21:334

    Content type: Case report

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  5. Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respec...

    Authors: Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S. Mandavdhare, Jayanta Samanta, Kaushal K. Prasad, Usha Dutta and Vishal Sharma

    Citation: BMC Gastroenterology 2021 21:327

    Content type: Research article

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  6. Serum anti-proteinase 3 antineutrophil cytoplasmic antibody (PR3-ANCA) is a disease-specific antibody against granulomatosis with polyangiitis. PR3-ANCA is a useful serological marker for disease severity in u...

    Authors: Yuki Aoyama, Tomoki Inaba, Sakuma Takahashi, Hisae Yasuhara, Sakiko Hiraoka, Takeshi Morimoto, Hugh Shunsuke Colvin, Masaki Wato, Midori Ando, Satoko Nakamura, Koichi Mizobuchi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2021 21:325

    Content type: Research article

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  7. Prevalence of chronic gastrointestinal diseases has been rising amongst ethnic minority populations in Western countries, despite the first-generation migrants originating from countries of low prevalence. Dif...

    Authors: Salina Ahmed, Paul D. Newton, Omorogieva Ojo and Lesley Dibley

    Citation: BMC Gastroenterology 2021 21:322

    Content type: Research

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  9. Deep remission (DR) is a treatment target in IBD associated with reduced hospitalization and improved outcome. Randomized control trial (RCT) data demonstrates efficacy of anti-TNFα agents in achieving DR; how...

    Authors: Omeed Alipour, Alakh Gualti, Ling Shao and Bing Zhang

    Citation: BMC Gastroenterology 2021 21:312

    Content type: Research article

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  10. Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome tha...

    Authors: Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl and Isabelle Frey-Wagner

    Citation: BMC Gastroenterology 2021 21:310

    Content type: Research article

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  11. Irritable bowel syndrome (IBS) appears to have a bidirectional interaction with both depressive and anxiety-related complaints. However, it remains unclear how exactly the psychological complaints, at the indi...

    Authors: Felicitas Engel, Tatjana Stadnitski, Esther Stroe-Kunold, Sabrina Berens, Rainer Schaefert and Beate Wild

    Citation: BMC Gastroenterology 2021 21:309

    Content type: Case report

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  12. Epidemiological studies suggest an inverse association between H. pylori infection/exposure and inflammatory bowel disease prevalence/incidence, however, there are no reports of individual patients who developed ...

    Authors: J. Homolak, M. Nikolić, D. Potoč, M. Živković, D. Bakula, I. Budimir, I. Pavić, D. Hrabar, N. Ljubičić and D. Vražić

    Citation: BMC Gastroenterology 2021 21:303

    Content type: Case report

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  13. Research has indicated a lack of disease-specific reproductive knowledge among patients with Inflammatory Bowel Disease (IBD) and this has been associated with increased “voluntary childlessness”. Furthermore,...

    Authors: Astrid-Jane Williams, Neda Karimi, Radha Chari, Susan Connor, Mary A. De Vera, Levinus A. Dieleman, Tawnya Hansen, Kathleen Ismond, Rshmi Khurana, Dawn Kingston, Katie O’Connor, Daniel C. Sadowski, Flora Fang-Hwa, Eytan Wine, Yvette Leung and Vivian Huang

    Citation: BMC Gastroenterology 2021 21:302

    Content type: Research

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  14. Intestinal perforations and fistulas are common complications of Crohn’s disease. However, chronic perforation with peritoneal space to rectal and vaginal fistulas have not been previously reported.

    Authors: Meng-Wu Chung, Chien-Ming Chen, Jun-Te Hsu, Ren-Chin Wu, Cheng-Tang Chiu, Chia-Jung Kuo, Ming-Yao Su and Puo-Hsien Le

    Citation: BMC Gastroenterology 2021 21:299

    Content type: Case report

    Published on:

  15. The chronic and progressive evolution of Inflammatory Bowel Diseases (IBD), with its prototypical fluctuating trend, creates a condition of psycho-social discomfort, impacting the quality of life in terms of p...

    Authors: E. Volpato, C. Bosio, E. Previtali, S. Leone, A. Armuzzi, F. Pagnini and G. Graffigna

    Citation: BMC Gastroenterology 2021 21:293

    Content type: Research

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  16. Fecal microbiota transplantation (FMT) is a promising new strategy in the treatment of Inflammatory Bowel Disease, but long-term delivery systems are lacking. This randomized study was designed as a safety and...

    Authors: Jessica W. Crothers, Nathaniel D. Chu, Le Thanh Tu Nguyen, Magen Phillips, Cheryl Collins, Karen Fortner, Roxana Del Rio-Guerra, Brigitte Lavoie, Peter Callas, Mario Velez, Aaron Cohn, Ryan J. Elliott, Wing Fei Wong, Elaine Vo, Rebecca Wilcox, Mark Smith…

    Citation: BMC Gastroenterology 2021 21:281

    Content type: Research

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  17. Eosinophilic gastrointestinal disorders, also known as eosinophilic gastroenteritis, are rare inflammatory conditions characterized by eosinophilic infiltration of different parts of the gastrointestinal tract...

    Authors: Emran A. El-Alali, Ibrahim M. Abukhiran and Tarik Z. Alhmoud

    Citation: BMC Gastroenterology 2021 21:279

    Content type: Case report

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  18. Haemolymphangioma arising from the small bowel and its mesentery is extremely rare in the clinical setting. To date, only 8 cases of small bowel haemolymphangioma have been reported, and there have been no pre...

    Authors: Yao Du, Jiang Nan Zhang, Lu Lu Zhu, Yi Wang and Wei Ping Li

    Citation: BMC Gastroenterology 2021 21:273

    Content type: Case report

    Published on:

  19. γδT cells play an important role in the mucosa inflammation and immunity-associated disorders. Our previous study reported that γδ T cells producing IL-17 were involved in the pathogenesis of post-infectious i...

    Authors: L. W. Dong, X. N. Sun, Z. C. Ma, J. Fu, F. J. Liu, B. L. Huang, D. C. Liang, D. M. Sun and Cheng Lan

    Citation: BMC Gastroenterology 2021 21:271

    Content type: Research article

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  21. Wilson’s disease (WD) is a rare autosomal recessive disease associated with defective biliary excretion of copper. The simultaneous occurrence of WD and systemic lupus erythematosus (SLE) has seldom been repor...

    Authors: Lishan Xu, Bin Liu, Zhaoyang Liu, Ning Tang, Chunhui She, Jing Wang, Bo Zang and Yifei Yang

    Citation: BMC Gastroenterology 2021 21:229

    Content type: Case report

    Published on:

  22. Immune checkpoint inhibitors (ICPIs) have changed the way advanced malignancies are currently confronted, improving cancer patients’ outcomes but also generating distinct immune-related (ir) adverse events. IC...

    Authors: Stratigoula Sakellariou, Dionysia N. Zouki, Dimitrios C. Ziogas, Despoina Pouloudi, Helen Gogas and Ioanna Delladetsima

    Citation: BMC Gastroenterology 2021 21:227

    Content type: Case report

    Published on:

  25. Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease, and few cases combine with Crohn’s disease. We present the first SLE patient concurrent with Crohn’s disease and rectovaginal fistula. ...

    Authors: Heng Yeh, Ren-Chin Wu, Wen-Sy Tsai, Chia-Jung Kuo, Ming-Yao Su, Cheng-Tang Chiu and Puo-Hsien Le

    Citation: BMC Gastroenterology 2021 21:206

    Content type: Case report

    Published on:

  27. Extracorporeal shock wave lithotripsy (ESWL) is a relatively safe and convenient mode of treatment for ureteral and renal stones, despite its relative safety; ESWL is not without its complications. We present ...

    Authors: Elaine N. Gitonga and Haitao Shen

    Citation: BMC Gastroenterology 2021 21:176

    Content type: Case report

    Published on:

  29. Physical activity may affect disease activity in patients with inflammatory bowel disease. We used a survey to investigate this association and performed interviews to get a better understanding of patient exp...

    Authors: Carlijn R. Lamers, Nicole M. de Roos, Lola J. M. Koppelman, Maria T. E. Hopman and Ben J. M. Witteman

    Citation: BMC Gastroenterology 2021 21:172

    Content type: Research article

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  30. Defects in interleukin 10 (IL10) and its receptors are particularly involved in very early onset inflammatory bowel disease (VEOIBD). However, large fragment deletions of IL10 receptor A (IL10RA) are rare.

    Authors: Zifei Tang, Ping Zhang, Min Ji, Chunlan Yin, Ruiqin Zhao, Zhiheng Huang and Ying Huang

    Citation: BMC Gastroenterology 2021 21:167

    Content type: Research article

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  31. Amyand’s hernia was an unusual condition defined by the presence of an appendix located in the inguinal hernia sac. Its prevalence was 1% of all inguinal hernia in children. The clinical manifestation of Amyan...

    Authors: Supangat, Henggar Allest Pratama, Nanda Eka Sri Sejati, Brenda Desy Romadhon and Ina Sulistyani

    Citation: BMC Gastroenterology 2021 21:165

    Content type: Case report

    Published on:

  32. Systemic vasculitis associated with antineutrophil cytoplasmic autoantibodies (ANCA) have an extremely wide variety of symptoms, therefore the fast and proper diagnosis is difficult to establish even for exper...

    Authors: Nóra Ledó and Ákos Géza Pethő

    Citation: BMC Gastroenterology 2021 21:158

    Content type: Case report

    Published on:

  33. Antiphospholipid syndrome (APS) is an acquired pre-thrombotic autoimmune condition, which produces autoantibodies called antiphospholipid antibodies (APL) against phospholipid-binding plasma proteins. The diag...

    Authors: Xiaojuan Zou, Zhongqi Fan, Ling Zhao, Weiling Xu, Jin Zhang and Zhenyu Jiang

    Citation: BMC Gastroenterology 2021 21:148

    Content type: Case report

    Published on:

  34. Fibromuscular dysplasia (FMD) is a type of unexplained nonatherosclerotic vascular disease that usually involves the renal and internal carotid arteries and rarely involves the mesenteric artery. Mesenteric ar...

    Authors: Shuwen Du, Shanbing Yang, Kangmei Jia, Peng Du, Limin Zhang and Jiheng Wang

    Citation: BMC Gastroenterology 2021 21:133

    Content type: Case report

    Published on:

  35. The SCCAI was designed to facilitate assessment of disease activity in ulcerative colitis (UC). We aimed to interrogate the metric properties of individual items of the SCCAI using item response theory (IRT) a...

    Authors: Alissa Walsh, Rena Cao, Darren Wong, Ramona Kantschuster, Lawrence Matini, Jean Wilson, Andrey Kormilitzin, Matthew South, Simon Travis and Sarah Bauermeister

    Citation: BMC Gastroenterology 2021 21:132

    Content type: Research article

    Published on:

  36. Cysteine-rich angiogenic inducer 61 (Cyr61) is emerging as an important regulator of tissue homeostasis and wound repair. We aim to explore the colonic mucosal expression of Cyr61 and analyze the association b...

    Authors: Su-Mi Lee, Kyung-Hwa Lee, Seon-Young Park, Dong Hyun Kim, Jin Ook Chung, Jae Kyun Ju, Jae-Hyuk Lee and Hyun Soo Kim

    Citation: BMC Gastroenterology 2021 21:129

    Content type: Research article

    Published on:

  37. Whipple's disease is a chronic infectious disease that primarily affects the small intestine, but several organs can simultaneously be involved. The disease is caused by a gram-positive bacterium called Tropherym...

    Authors: Nikolaos Melas, Rasjan Amin, Paula Gyllemark, Amil Haji Younes and Sven Almer

    Citation: BMC Gastroenterology 2021 21:128

    Content type: Case report

    Published on:

  38. Irritable bowel syndrome (IBS) is common and difficult to treat and its pathogenesis is closely related to gut microbiota. However, differences in gut microbiota of patients in different regions make it more d...

    Authors: Lijun Mei, Jiaoli Zhou, Yimo Su, Kunhong Mao, Jing Wu, Caicai Zhu, Ling He and Ying Cui

    Citation: BMC Gastroenterology 2021 21:105

    Content type: Research article

    Published on:

  39. Several modifications of the Kimura procedure for congenital duodenal obstruction (CDO) have been reported, however, their effects on the outcomes show conflicting results.

    Authors: Munawir Makkadafi, Aditya Rifqi Fauzi, Setya Wandita, Akhmad Makhmudi and Gunadi

    Citation: BMC Gastroenterology 2021 21:100

    Content type: Research article

    Published on:

  40. Coeliac disease (CD) is characterised by diverse clinical symptoms, which may cause diagnostic problems and reduce the patients’ quality of life. A study conducted in the United Kingdom (UK) revealed that the ...

    Authors: Emilia Majsiak, Magdalena Choina, Dominik Golicki, Alastair M. Gray and Bożena Cukrowska

    Citation: BMC Gastroenterology 2021 21:99

    Content type: Research article

    Published on:

  42. Inpatient colonoscopy bowel preparation (ICBP) is frequently inadequate and can lead to adverse events, delayed or repeated procedures, and negative patient outcomes. Guidelines to overcome the complex factors...

    Authors: Alexandra T. Strauss, Jennifer Yeh, Diego A. Martinez, Gayane Yenokyan, Janet Yoder, Ravi Nehra, Tara Feller, Kathy Bull-Henry, Ellen Stein, Lawrence C. H. Hsu, Haitham Al-Grain, Candice Zabko and Christopher Fain

    Citation: BMC Gastroenterology 2021 21:89

    Content type: Research article

    Published on:

  43. The threshold concentration of infliximab during maintenance therapy has not been well-defined in relation to histologic remission. The aim of the study is to dentify the maintenance-phase infliximab concentra...

    Authors: Aze Wilson, Bethany Choi, Michael Sey, Terry Ponich, Melanie Beaton and Richard B. Kim

    Citation: BMC Gastroenterology 2021 21:77

    Content type: Research article

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  44. NER1006 (Plenvu®, Salix Pharmaceuticals, Bridgewater, NJ) is a 1 L polyethylene glycol bowel preparation indicated for colonoscopy in adults. A US online survey assessed real-world ease of use and treatment satis...

    Authors: Brooks D. Cash, Mary Beth C. Moncrief, Michael S. Epstein and David M. Poppers

    Citation: BMC Gastroenterology 2021 21:70

    Content type: Research article

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  45. Endoscopic submucosal dissection (ESD) and endoscopic submucosal excavation (ESE) have been widely used and have gradually become the main endoscopic treatment for gastrointestinal mucosal and submucosal lesio...

    Authors: Yongkang Lai, Qian Zhang, Xiaolin Pan, Zhenhua Zhu, Shunhua Long, Xiaojiang Zhou, Guohua Li, Yin Zhu, Youxiang Chen and Xu Shu

    Citation: BMC Gastroenterology 2021 21:64

    Content type: Research article

    Published on:

  46. Bile acid malabsorption occurs in up to one third of patients with chronic diarrhoea of functional characteristics. The gold standard test for its diagnosis is the 75Selenium homocholic acid taurine (75SeHCAT) te...

    Authors: Virginia Flores, Helena Martínez-Lozano, Federico Bighelli, Javier Orcajo, Javier García-Lledó, Juan Carlos Alonso-Farto and Luis Menchén

    Citation: BMC Gastroenterology 2021 21:56

    Content type: Research article

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  47. Small intestinal bacterial overgrowth (SIBO) is characterized by the condition that bacteria overgrowth in the small intestine. Fecal microbiota transplantation (FMT) has been applied as an effective tool for ...

    Authors: Fenghua Xu, Ning Li, Chun Wang, Hanyang Xing, Dongfeng Chen and Yanling Wei

    Citation: BMC Gastroenterology 2021 21:54

    Content type: Research article

    Published on:

  48. Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disord...

    Authors: Martina Ledergerber, Brian M. Lang, Henriette Heinrich, Luc Biedermann, Stefan Begré, Jonas Zeitz, Niklas Krupka, Andreas Rickenbacher, Matthias Turina, Thomas Greuter, Philipp Schreiner, René Roth, Alexander Siebenhüner, Stephan R. Vavricka, Gerhard Rogler, Niko Beerenwinkel…

    Citation: BMC Gastroenterology 2021 21:53

    Content type: Research article

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  49. Aortoenteric fistula (AEF) is a rare cause of gastrointestinal bleeding and is often misdiagnosed in clinical practice. Herein, a case series of AEFs are presented and the clinical characteristics, diagnosis, ...

    Authors: Jia Luo, Wen Tang, Mengran Wang, Yao Xiao, Manhong Tan and Chunyan Jiang

    Citation: BMC Gastroenterology 2021 21:49

    Content type: Research article

    Published on:

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