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Intestinal disorders

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Cryptogenic multifocal ulcer stenosing enteritis (CMUSE) is a rare disease characterized by multiple superficial ulcers, stenosis, and obstruction of the small intestine of unknown origin, and the course can r...

    Authors: Cheng Chang, Chen Jiang, Yaoyao Miao, Bin Fang and Lili Zhang

    Citation: BMC Gastroenterology 2020 20:300

    Content type: Case report

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  2. Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell malignancy caused by human T-cell leukemia virus type 1. The clinical course of ATLL is very heterogeneous, and many organs, including the gastroint...

    Authors: Tadashi Miike, Hiroshi Kawakami, Takuro Kameda, Shojiro Yamamoto, Yoshihiro Tahara, Tomonori Hidaka, Yoko Kubuki, Kenji Yorita, Yutaka Akiyama, Yasuji Arimura, Yoshimasa Kubota, Hiroaki Kataoka and Kazuya Shimoda

    Citation: BMC Gastroenterology 2020 20:298

    Content type: Research article

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  3. Thioguanine (TG) is a thiopurine which has been used for patients with inflammatory bowel disease (IBD), who have failed azathioprine (AZA) or mercaptopurine (MP) due to adverse events or suboptimal response. ...

    Authors: Ahmed B. Bayoumy, Elsa L. S. A. van Liere, Melek Simsek, Ben Warner, Aathavan Loganayagam, Jeremy D. Sanderson, Simon Anderson, Jonathan Nolan, Nanne K. de Boer, Chris J. J. Mulder and Azhar Ansari

    Citation: BMC Gastroenterology 2020 20:296

    Content type: Research article

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  4. Cytomegalovirus (CMV) infection can significantly complicate and worsen the condition of acute severe ulcerative colitis (UC) patients. We aimed to explore the predictive risk factors to prevent and identify C...

    Authors: Hong Yang, Kaichun Wu, Hongjie Zhang, Qin Owyang, Yinglei Miao, Fang Gu, Naizhong Hu, Kaifang Zou, Jianqiu Sheng, Jin Li, Ping Zheng, Yulan Liu, Junxia Li, Xiaodi Wang, Yongdong Wu, Yaozong Yuan…

    Citation: BMC Gastroenterology 2020 20:294

    Content type: Research article

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  5. Pressure sores are sometimes refractory to treatment, often due to malnutrition. Small intestinal bacterial overgrowth (SIBO) obstructs absorption in the digestive tract and causes malnutrition. However, littl...

    Authors: Yoshitaka Kubota, Hidekazu Nagano, Kentaro Ishii, Takashi Kono, Satomi Kono, Shinsuke Akita, Nobuyuki Mitsukawa and Tomoaki Tanaka

    Citation: BMC Gastroenterology 2020 20:283

    Content type: Case report

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  6. While Helicobacter pylori (H. pylori) ulcers has declined recently, H. pylori-negative and/or gastrotoxic drug-negative peptic ulcers (HNGN-PU) has increased. This study aimed to analyze the etiology of peptic ul...

    Authors: Jung Yeon Joo, Jin Min Cho, In Hyuk Yoo and Hye Ran Yang

    Citation: BMC Gastroenterology 2020 20:280

    Content type: Research article

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  7. Although the etiology of pouchitis remains unknown, inflammatory cytokines are significantly associated with the pathogenesis of pouchitis. The cytokine responses that characterize inflammatory bowel diseases ...

    Authors: Takahito Kitajima, Yoshiki Okita, Mikio Kawamura, Satoru Kondo, Yuji Toiyama, Keiichi Uchida and Masato Kusunoki

    Citation: BMC Gastroenterology 2020 20:277

    Content type: Research article

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  8. Segmental absence of intestinal musculature (SAIM) is a rare cause of intestinal obstruction and perforation due to partial or complete defects in the intestinal muscularis propria in neonates and is occasiona...

    Authors: Kosuke Kashiwagi, Keisuke Jimbo, Kenji Hosoi, Go Miyano, Takahiro Kudo, Atsuyuki Yamataka and Toshiaki Shimizu

    Citation: BMC Gastroenterology 2020 20:272

    Content type: Case report

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  9. Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genot...

    Authors: Masoud Keikha, Mohammad Ali-Hassanzadeh and Mohsen Karbalaei

    Citation: BMC Gastroenterology 2020 20:266

    Content type: Research article

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  10. Delayed bowel obstruction due to seat belt injury is extremely rare. The delayed onset of nonspecific symptoms makes a timely diagnosis difficult. A deep understanding of the characteristics of this condition ...

    Authors: Xing-Bin Ma, Bao-Guang Hu, Wei Wang, Xian-Yong Cheng, Chun-Di Guan and Cheng-Xia Liu

    Citation: BMC Gastroenterology 2020 20:262

    Content type: Case report

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  11. The incidence of gluten-related disorders (GRDs) continues to increase and its global prevalence is estimated at approximately 5% of the population. Celiac disease (CD), dermatitis herpetiformis (DH), gluten a...

    Authors: Nazanin Taraghikhah, Sara Ashtari, Nastaran Asri, Bijan Shahbazkhani, David Al-Dulaimi, Mohammad Rostami-Nejad, Mostafa Rezaei-Tavirani, Mohammad Reza Razzaghi and Mohammad Reza Zali

    Citation: BMC Gastroenterology 2020 20:258

    Content type: Review

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  12. Rapid and accurate diagnostic tools are needed for appropriate management of infectious diarrhea.

    Authors: Daisy Torres-Miranda, Hana Akselrod, Ryan Karsner, Alessandra Secco, Diana Silva-Cantillo, Marc O. Siegel, Afsoon D. Roberts and Gary L. Simon

    Citation: BMC Gastroenterology 2020 20:246

    Content type: Research article

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  13. Chronic active Epstein-Barr virus infection (CAEBV) is a rare disease, which is difficult to be differentiated from inflammatory bowel disease (IBD). To cause the attention, we present twelve cases of CAEBV in...

    Authors: Weijia Xu, Xiaoyun Jiang, Jiajie Chen, Qiqi Mao, Xianguang Zhao, Xu Sun, Liang Zhong and Lan Rong

    Citation: BMC Gastroenterology 2020 20:257

    Content type: Research article

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  14. Crystal storing histiocytosis is a rare disorder associated with monoclonal gammopathy. In this disease, monoclonal heavy and light chains accumulate in the lysosome of macrophages, leading to histiocytic reac...

    Authors: Adrien Contejean, Frédérique Larousserie, Didier Bouscary, Anthony Dohan, Bénédicte Deau-Fischer, Tali-Anne Szwebel, Marion Dhooge, Benoit Terris and Marguerite Vignon

    Citation: BMC Gastroenterology 2020 20:239

    Content type: Case report

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  15. A gluten-free diet (GFD) is the only effective treatment for celiac patients and assessing adherence to this diet is important. Celiac disease Adherence Test (CDAT) is a valid English-language questionnaire th...

    Authors: Zeinab Nikniaz, Mohammad Asghari Jafarabadi, Saeideh Ghaffarifar, Zahra Saeedi, Zahra Akbari Namvar and Masood Shirmohammadi

    Citation: BMC Gastroenterology 2020 20:247

    Content type: Research article

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  16. Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neutrophilic inflammation and nuclear debris in post capillary venules. LCV is a rare dermatologic manifestation of C...

    Authors: Meredith Buck, Igor Dumic, Wendy McDermott, Charles Nordstrom, Samarth Dawan, Andrew Virata, Scott Martin, Ann Hudson, Tamara Milovanovic and Terri Nordin

    Citation: BMC Gastroenterology 2020 20:240

    Content type: Case report

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  17. Pigmented bile salts darken the small-bowel lumen and are present with bile acid, which is involved in the development of bowel habits. The small-bowel water content (SBWC) in the ileum could represent the col...

    Authors: Taiki Aoyama, Akira Fukumoto, Kenjiro Shigita, Naoki Asayama, Shinichi Mukai and Shinji Nagata

    Citation: BMC Gastroenterology 2020 20:237

    Content type: Research article

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  18. The induction of chronic inflammation, perforation, and abscess by foreign bodies (FBs) in adults is uncommon. We present a delayed diagnosis case for a patient who had a fishbone stuck in the duodenal bulb, r...

    Authors: Zhihui Wang, Zhiqiang Du, Xiangrong Zhou, Tianming Chen and Chunyan Li

    Citation: BMC Gastroenterology 2020 20:236

    Content type: Case report

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  19. Studies of microbiota composition of infants with small intestinal ostomy due to various etiologies are limited. Here, we characterized the intestinal microbiota of neonates with ileostomy resulting from disti...

    Authors: Tian Qian, Haitao Zhu, Li Zhu, Chao Chen, Chun Shen and Rong Zhang

    Citation: BMC Gastroenterology 2020 20:224

    Content type: Research article

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  20. Real-world comparisons of biologic treatment outcomes for ulcerative colitis (UC) or Crohn’s disease (CD) patients are limited. We sought to evaluate the real-world effectiveness of vedolizumab (VDZ) and anti-...

    Authors: Ulf Helwig, Michael Mross, Stefan Schubert, Heinz Hartmann, Alina Brandes, Dara Stein, Christian Kempf, Jana Knop, Sarah Campbell-Hill and Robert Ehehalt

    Citation: BMC Gastroenterology 2020 20:211

    Content type: Research article

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  21. Functional dyspepsia (FD), belching disorders (BD) and functional heartburn (FH) are the three most common upper functional gastrointestinal disorders (FGID) in IBS patients. FD is known to exert deleterious e...

    Authors: Xin Yao, Yunsheng Yang, Shutian Zhang, Yu Shi, Qian Zhang and Yongjun Wang

    Citation: BMC Gastroenterology 2020 20:209

    Content type: Research article

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  22. Tacrolimus (TAC) is a powerful remission-inducing drug for refractory ulcerative colitis (UC). However, it is unclear whether mucosal healing (MH) influences relapse after completion of TAC.We investigated whe...

    Authors: Ayumi Ito, Syun Murasugi, Teppei Omori, Shinichi Nakamura and Katsutoshi Tokushige

    Citation: BMC Gastroenterology 2020 20:203

    Content type: Research article

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  23. Studies have suggested that patients with inflammatory bowel disease (IBD) have an increased risk of rheumatoid arthritis (RA). However, the available data on this association are inconsistent. This meta-analy...

    Authors: Yi Chen, Lang Chen, Changsheng Xing, Guangtong Deng, Furong Zeng, Tingting Xie, Lei Gu and Huixiang Yang

    Citation: BMC Gastroenterology 2020 20:192

    Content type: Research article

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  24. Constipation is often self-managed by patients and guidelines are available to aid healthcare professionals in the counseling of patients for self-management. Therefore, we have explored the knowledge and atti...

    Authors: Marion Eberlin, Sabine Landes, Doerthe Biber-Feiter and Martin C. Michel

    Citation: BMC Gastroenterology 2020 20:191

    Content type: Research article

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  25. Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptom...

    Authors: Xiaojun Zhuang, Zhenyi Tian, Mei Luo and Lishou Xiong

    Citation: BMC Gastroenterology 2020 20:187

    Content type: Research article

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  26. Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This stu...

    Authors: Wendy Fang, Rachel Kenny, Qurat-ul-Ain Rizvi, Lawrence P. McMahon and Mayur Garg

    Citation: BMC Gastroenterology 2020 20:183

    Content type: Research article

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  27. Small bowel (SB) bleeding accounts for 5% of all gastrointestinal (GI) bleeding cases and 80% of obscure GI bleeding cases. Although angioectasia is the common etiology of SB bleeding, nonsteroidal anti-inflam...

    Authors: Doo-Ho Lim, Kyoungwon Jung, Seung Bum Lee, In Kyu Park, Hee Jeong Cha, Jae Ho Park, Byung Gyu Kim, Seok Won Jung, In Du Jeong, Jae Hyun Kim, Sung Eun Kim, Won Moon, Moo In Park and Seun Ja Park

    Citation: BMC Gastroenterology 2020 20:178

    Content type: Research article

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  28. Indications and diagnostic yield of small-bowel video capsule endoscopy (SB-VCE) are communicated in recent clinical academic guidelines. However, guidelines are based mainly on relatively few, small, selectio...

    Authors: André Artan Kharazmi, Saeid Aslani, Malene Fey Kristiansen, Eva Efsen Dahl and Mark Berner-Hansen

    Citation: BMC Gastroenterology 2020 20:177

    Content type: Research article

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  29. Colitis is generally considered a risk factor for colon neoplasia. However, not all types of colitis seem to have equal neoplastic transformation potential.

    Authors: Hassan Ashktorab, Hassan Brim, Sally Hassan, Mehdi Nouraie, Agazi Gebreselassie, Adeyinka O. Laiyemo, Angesom Kibreab, Farshad Aduli, Giovanni Latella, Steven R. Brant, Zaki Sherif and Aida Habtezion

    Citation: BMC Gastroenterology 2020 20:170

    Content type: Research article

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  30. Colonoscopy is a routine procedure in diagnosis and treatment of colonic disease. While generally regarded as a safe procedure, potentially fatal complications can occur. Gas gangrene is one such complication,...

    Authors: Lachlan J. Fairley, Samuel L. Smith and Stephen K. Fairley

    Citation: BMC Gastroenterology 2020 20:163

    Content type: Case report

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  31. Intestinal perforation from peritoneal dialysis is rare, but the resulting complications are serious. Some patients do not necessarily have symptoms, and it can be difficult to differentiate their condition fr...

    Authors: Qiuyuan Shao, Yangyang Xia, Qingyan Zhang and Miao Zhang

    Citation: BMC Gastroenterology 2020 20:157

    Content type: Case report

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  32. Indigo naturalis is a Chinese herbal medicine that has currently been used to treat various inflammatory diseases, including ulcerative colitis. Recently, there are several reports concerning severe adverse ev...

    Authors: Byungha Cho, Soon Man Yoon, Seung-Myoung Son, Hyoung Woo Kim, Ki Bae Kim and Sei Jin Youn

    Citation: BMC Gastroenterology 2020 20:154

    Content type: Case report

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  33. Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes ...

    Authors: Zong Hao, Lifeng Gong, Qiang Shen, Huipeng Wang, Shaowen Feng, Xin Wang, Yuankun Cai and Jun Chen

    Citation: BMC Gastroenterology 2020 20:150

    Content type: Research article

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  34. Colonic transendoscopic enteral tubing (TET) refers to colonic transendoscopic tube-delivered enteral therapy. Colonic TET has been successfully used for frequent colonic administration of drugs or multiple fe...

    Authors: Ting Zhang, Chuyan Long, Bota Cui, Heena Buch, Quan Wen, Qianqian Li, Xiao Ding, Guozhong Ji and Faming Zhang

    Citation: BMC Gastroenterology 2020 20:135

    Content type: Research article

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  35. The role of the fecal microbiota composition for the postoperative disease course of patients with Crohn’s disease (CD) who have undergone ileocecal resection remains to be established. In this study, we inves...

    Authors: Anna Strömbeck, Anders Lasson, Hans Strid, Johanna Sundin, Per-Ove Stotzer, Magnus Simrén, Maria K. Magnusson and Lena Öhman

    Citation: BMC Gastroenterology 2020 20:130

    Content type: Research article

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  36. Management of diarrhoea-predominant irritable bowel syndrome (IBS-D) is generally based on patient-reported symptoms; however, limited information on symptom severity exists. The objective of the study was to ...

    Authors: Anton Emmanuel, Richard William Goosey, Gwen Wiseman, Stephen Baker and Hans Törnblom

    Citation: BMC Gastroenterology 2020 20:127

    Content type: Research article

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  37. The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) ins...

    Authors: Eui Joo Kim, Sang Hoon Han, Kyoung Oh Kim, Jun-Won Chung, Dong Kyun Park, Kwang An Kwon and Jung Ho Kim

    Citation: BMC Gastroenterology 2020 20:117

    Content type: Research article

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  38. Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blo...

    Authors: Natsuki Ishida, Takahiro Miyazu, Ryosuke Takano, Satoshi Tamura, Shinya Tani, Takuma Kagami, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima and Ken Sugimoto

    Citation: BMC Gastroenterology 2020 20:114

    Content type: Research article

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  39. Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocol...

    Authors: Qiwei Li, Tao Chen, Hexi Cui, Xiao Xiao, Chunqiu Chen, Zhenyu Shen, Fu Ji and Lu Yin

    Citation: BMC Gastroenterology 2020 20:112

    Content type: Case report

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  40. Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients’ life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (...

    Authors: C. Le Berre, A. Bourreille, M. Flamant, G. Bouguen, L. Siproudhis, M. Dewitte, N. Dib, E. Cesbron-Metivier, T. Goronflot, M. Hanf, P.-A. Gourraud, E. Kerdreux, A. Poinas and C. Trang-Poisson

    Citation: BMC Gastroenterology 2020 20:110

    Content type: Study protocol

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  41. Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological,...

    Authors: Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor and Naohiro Sata

    Citation: BMC Gastroenterology 2020 20:105

    Content type: Case report

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  42. While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to...

    Authors: Clarissa Allner, Michaela Melde, Emily Becker, Friederike Fuchs, Laura Mühl, Entcho Klenske, Lisa Müller, Nadine Morgenstern, Konstantin Fietkau, Simon Hirschmann, Raja Atreya, Imke Atreya, Markus F. Neurath and Sebastian Zundler

    Citation: BMC Gastroenterology 2020 20:103

    Content type: Research article

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  43. A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn’s disease (CD) patients. Hence, we evaluated, for the fir...

    Authors: Gian Eugenio Tontini, Fernando Rizzello, Flaminia Cavallaro, Gianluca Bonitta, Dania Gelli, Luca Pastorelli, Marco Salice, Maurizio Vecchi, Paolo Gionchetti and Carlo Calabrese

    Citation: BMC Gastroenterology 2020 20:97

    Content type: Research article

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  44. Endoscopic placement of intestinal decompression tubes is a feasible technique for treatment of acute intestinal dilation. Given the heterogeneity of the underlying diseases leading to intestinal obstruction d...

    Authors: Thorsten Book, Martha M. Kirstein, Andrea Schneider, Michael P. Manns and Torsten Voigtländer

    Citation: BMC Gastroenterology 2020 20:87

    Content type: Research article

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  45. Rome IV criteria for functional gastrointestinal disorders state that children suspected of having Irritable Bowel Syndrome (IBS) with Constipation (IBS-C) should be preliminarily treated for constipation. We ...

    Authors: Monica Tosto, Paola D’Andrea, Ignazio Salamone, Salvatore Pellegrino, Stefano Costa, Maria Cristina Lucanto, Socrate Pallio, Giuseppe Magazzu’ and Stefano Guandalini

    Citation: BMC Gastroenterology 2020 20:86

    Content type: Research article

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  46. Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and trea...

    Authors: Masaki Wakai, Ryohei Hayashi, Shinji Tanaka, Toshikatsu Naito, Junko Kumada, Motonobu Nomura, Hidehiko Takigawa, Shiro Oka, Yoshitaka Ueno, Masanori Ito and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:85

    Content type: Research article

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  47. Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, alt...

    Authors: Valerio Papa, Maria Cristina Giustiniani, Loris Riccardo Lopetuso and Alfredo Papa

    Citation: BMC Gastroenterology 2020 20:76

    Content type: Case report

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  48. Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-pre...

    Authors: Zhenyi Tian, Xiaojun Zhuang, Mei Luo, Wei Yin and Lishou Xiong

    Citation: BMC Gastroenterology 2020 20:73

    Content type: Research article

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