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Intestinal disorders

Section edited by Peter Lakatos

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Tacrolimus (TAC) is a powerful remission-inducing drug for refractory ulcerative colitis (UC). However, it is unclear whether mucosal healing (MH) influences relapse after completion of TAC.We investigated whe...

    Authors: Ayumi Ito, Syun Murasugi, Teppei Omori, Shinichi Nakamura and Katsutoshi Tokushige

    Citation: BMC Gastroenterology 2020 20:203

    Content type: Research article

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  2. Studies have suggested that patients with inflammatory bowel disease (IBD) have an increased risk of rheumatoid arthritis (RA). However, the available data on this association are inconsistent. This meta-analy...

    Authors: Yi Chen, Lang Chen, Changsheng Xing, Guangtong Deng, Furong Zeng, Tingting Xie, Lei Gu and Huixiang Yang

    Citation: BMC Gastroenterology 2020 20:192

    Content type: Research article

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  3. Constipation is often self-managed by patients and guidelines are available to aid healthcare professionals in the counseling of patients for self-management. Therefore, we have explored the knowledge and atti...

    Authors: Marion Eberlin, Sabine Landes, Doerthe Biber-Feiter and Martin C. Michel

    Citation: BMC Gastroenterology 2020 20:191

    Content type: Research article

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  4. Gut microbiota alterations including small intestinal bacterial overgrowth (SIBO) might play a role in pathogenesis of irritable bowel syndrome (IBS). Rifaximin could effectively and safely improve IBS symptom...

    Authors: Xiaojun Zhuang, Zhenyi Tian, Mei Luo and Lishou Xiong

    Citation: BMC Gastroenterology 2020 20:187

    Content type: Research article

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  5. Intravenous iron replacement is recommended for iron-deficient patients with inflammatory bowel disease (IBD), but may be associated with hypophosphataemia, predisposing to osteomalacia and fractures. This stu...

    Authors: Wendy Fang, Rachel Kenny, Qurat-ul-Ain Rizvi, Lawrence P. McMahon and Mayur Garg

    Citation: BMC Gastroenterology 2020 20:183

    Content type: Research article

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  6. Small bowel (SB) bleeding accounts for 5% of all gastrointestinal (GI) bleeding cases and 80% of obscure GI bleeding cases. Although angioectasia is the common etiology of SB bleeding, nonsteroidal anti-inflam...

    Authors: Doo-Ho Lim, Kyoungwon Jung, Seung Bum Lee, In Kyu Park, Hee Jeong Cha, Jae Ho Park, Byung Gyu Kim, Seok Won Jung, In Du Jeong, Jae Hyun Kim, Sung Eun Kim, Won Moon, Moo In Park and Seun Ja Park

    Citation: BMC Gastroenterology 2020 20:178

    Content type: Research article

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  7. Indications and diagnostic yield of small-bowel video capsule endoscopy (SB-VCE) are communicated in recent clinical academic guidelines. However, guidelines are based mainly on relatively few, small, selectio...

    Authors: André Artan Kharazmi, Saeid Aslani, Malene Fey Kristiansen, Eva Efsen Dahl and Mark Berner-Hansen

    Citation: BMC Gastroenterology 2020 20:177

    Content type: Research article

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  8. Colitis is generally considered a risk factor for colon neoplasia. However, not all types of colitis seem to have equal neoplastic transformation potential.

    Authors: Hassan Ashktorab, Hassan Brim, Sally Hassan, Mehdi Nouraie, Agazi Gebreselassie, Adeyinka O. Laiyemo, Angesom Kibreab, Farshad Aduli, Giovanni Latella, Steven R. Brant, Zaki Sherif and Aida Habtezion

    Citation: BMC Gastroenterology 2020 20:170

    Content type: Research article

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  9. Colonoscopy is a routine procedure in diagnosis and treatment of colonic disease. While generally regarded as a safe procedure, potentially fatal complications can occur. Gas gangrene is one such complication,...

    Authors: Lachlan J. Fairley, Samuel L. Smith and Stephen K. Fairley

    Citation: BMC Gastroenterology 2020 20:163

    Content type: Case report

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  10. Intestinal perforation from peritoneal dialysis is rare, but the resulting complications are serious. Some patients do not necessarily have symptoms, and it can be difficult to differentiate their condition fr...

    Authors: Qiuyuan Shao, Yangyang Xia, Qingyan Zhang and Miao Zhang

    Citation: BMC Gastroenterology 2020 20:157

    Content type: Case report

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  11. Indigo naturalis is a Chinese herbal medicine that has currently been used to treat various inflammatory diseases, including ulcerative colitis. Recently, there are several reports concerning severe adverse ev...

    Authors: Byungha Cho, Soon Man Yoon, Seung-Myoung Son, Hyoung Woo Kim, Ki Bae Kim and Sei Jin Youn

    Citation: BMC Gastroenterology 2020 20:154

    Content type: Case report

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  12. Polyethylene glycol solution (PEG) is widely used for bowel preparation prior to colonoscopies. However, patients often exhibited adverse events as nausea, vomit and distention due to its uncomfortable tastes ...

    Authors: Zong Hao, Lifeng Gong, Qiang Shen, Huipeng Wang, Shaowen Feng, Xin Wang, Yuankun Cai and Jun Chen

    Citation: BMC Gastroenterology 2020 20:150

    Content type: Research article

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  13. Colonic transendoscopic enteral tubing (TET) refers to colonic transendoscopic tube-delivered enteral therapy. Colonic TET has been successfully used for frequent colonic administration of drugs or multiple fe...

    Authors: Ting Zhang, Chuyan Long, Bota Cui, Heena Buch, Quan Wen, Qianqian Li, Xiao Ding, Guozhong Ji and Faming Zhang

    Citation: BMC Gastroenterology 2020 20:135

    Content type: Research article

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  14. The role of the fecal microbiota composition for the postoperative disease course of patients with Crohn’s disease (CD) who have undergone ileocecal resection remains to be established. In this study, we inves...

    Authors: Anna Strömbeck, Anders Lasson, Hans Strid, Johanna Sundin, Per-Ove Stotzer, Magnus Simrén, Maria K. Magnusson and Lena Öhman

    Citation: BMC Gastroenterology 2020 20:130

    Content type: Research article

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  15. Management of diarrhoea-predominant irritable bowel syndrome (IBS-D) is generally based on patient-reported symptoms; however, limited information on symptom severity exists. The objective of the study was to ...

    Authors: Anton Emmanuel, Richard William Goosey, Gwen Wiseman, Stephen Baker and Hans Törnblom

    Citation: BMC Gastroenterology 2020 20:127

    Content type: Research article

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  16. The majority of colonic obstructions result from colorectal cancer. However, malignancies of extra-colonic origin can also disrupt colorectal patency, and the efficacy of self-expanding metal stents (SEMS) ins...

    Authors: Eui Joo Kim, Sang Hoon Han, Kyoung Oh Kim, Jun-Won Chung, Dong Kyun Park, Kwang An Kwon and Jung Ho Kim

    Citation: BMC Gastroenterology 2020 20:117

    Content type: Research article

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  17. Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blo...

    Authors: Natsuki Ishida, Takahiro Miyazu, Ryosuke Takano, Satoshi Tamura, Shinya Tani, Takuma Kagami, Mihoko Yamade, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima and Ken Sugimoto

    Citation: BMC Gastroenterology 2020 20:114

    Content type: Research article

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  18. Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocol...

    Authors: Qiwei Li, Tao Chen, Hexi Cui, Xiao Xiao, Chunqiu Chen, Zhenyu Shen, Fu Ji and Lu Yin

    Citation: BMC Gastroenterology 2020 20:112

    Content type: Case report

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  19. Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients’ life, leading to disability which is essential to quantify as part of Patient-Reported Outcomes (...

    Authors: C. Le Berre, A. Bourreille, M. Flamant, G. Bouguen, L. Siproudhis, M. Dewitte, N. Dib, E. Cesbron-Metivier, T. Goronflot, M. Hanf, P.-A. Gourraud, E. Kerdreux, A. Poinas and C. Trang-Poisson

    Citation: BMC Gastroenterology 2020 20:110

    Content type: Study protocol

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  20. Capicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological,...

    Authors: Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor and Naohiro Sata

    Citation: BMC Gastroenterology 2020 20:105

    Content type: Case report

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  21. While the number of therapeutic options for treating inflammatory bowel diseases (IBD) is increasing, evidence for rational treatment decisions is scarce in many cases. In particular, appropriate biomarkers to...

    Authors: Clarissa Allner, Michaela Melde, Emily Becker, Friederike Fuchs, Laura Mühl, Entcho Klenske, Lisa Müller, Nadine Morgenstern, Konstantin Fietkau, Simon Hirschmann, Raja Atreya, Imke Atreya, Markus F. Neurath and Sebastian Zundler

    Citation: BMC Gastroenterology 2020 20:103

    Content type: Research article

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  22. A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed for Crohn’s disease (CD) patients. Hence, we evaluated, for the fir...

    Authors: Gian Eugenio Tontini, Fernando Rizzello, Flaminia Cavallaro, Gianluca Bonitta, Dania Gelli, Luca Pastorelli, Marco Salice, Maurizio Vecchi, Paolo Gionchetti and Carlo Calabrese

    Citation: BMC Gastroenterology 2020 20:97

    Content type: Research article

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  23. Endoscopic placement of intestinal decompression tubes is a feasible technique for treatment of acute intestinal dilation. Given the heterogeneity of the underlying diseases leading to intestinal obstruction d...

    Authors: Thorsten Book, Martha M. Kirstein, Andrea Schneider, Michael P. Manns and Torsten Voigtländer

    Citation: BMC Gastroenterology 2020 20:87

    Content type: Research article

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  24. Rome IV criteria for functional gastrointestinal disorders state that children suspected of having Irritable Bowel Syndrome (IBS) with Constipation (IBS-C) should be preliminarily treated for constipation. We ...

    Authors: Monica Tosto, Paola D’Andrea, Ignazio Salamone, Salvatore Pellegrino, Stefano Costa, Maria Cristina Lucanto, Socrate Pallio, Giuseppe Magazzu’ and Stefano Guandalini

    Citation: BMC Gastroenterology 2020 20:86

    Content type: Research article

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  25. Many studies have revealed that mucosal healing improves the long-term prognosis of ulcerative colitis. Frequent colonoscopy is difficult because of its invasiveness and cost. Therefore, in diagnosing and trea...

    Authors: Masaki Wakai, Ryohei Hayashi, Shinji Tanaka, Toshikatsu Naito, Junko Kumada, Motonobu Nomura, Hidehiko Takigawa, Shiro Oka, Yoshitaka Ueno, Masanori Ito and Kazuaki Chayama

    Citation: BMC Gastroenterology 2020 20:85

    Content type: Research article

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  26. Kaposi’s sarcoma (KS) is a rare vascular tumor associated with human herpesvirus (HHV)-8 infection. One of the variants of KS is defined iatrogenic and is overall reported in transplanted patient but also, alt...

    Authors: Valerio Papa, Maria Cristina Giustiniani, Loris Riccardo Lopetuso and Alfredo Papa

    Citation: BMC Gastroenterology 2020 20:76

    Content type: Case report

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  27. Short-chain fatty acids (SCFAs) alteration have been reported in irritable bowel syndrome (IBS), but the results are conflicting. Our study aims to explore the alteration of SCFAs in patients with diarrhea-pre...

    Authors: Zhenyi Tian, Xiaojun Zhuang, Mei Luo, Wei Yin and Lishou Xiong

    Citation: BMC Gastroenterology 2020 20:73

    Content type: Research article

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  28. Loeys-Dietz syndrome (LDS) is a systemic connective tissue disease (CTD) associated with a predisposition for intestinal inflammation, food allergy, and failure to thrive, often necessitating nutritional suppl...

    Authors: Pamela A. Frischmeyer-Guerrerio, Gretchen MacCarrick, Harry C. Dietz, F. Dylan Stewart and Anthony L. Guerrerio

    Citation: BMC Gastroenterology 2020 20:71

    Content type: Research article

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  29. Meckel’s diverticulum is a remnant of the omphalomesenteric duct. It can lead to intestinal perforation, obstruction and gastrointestinal bleeding. While the internal hernia caused by Meckel’s diverticulum is ...

    Authors: Yang Zhang, Yuchen Guo, Yuanlin Sun and Yuechao Xu

    Citation: BMC Gastroenterology 2020 20:69

    Content type: Case report

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  30. Although prophylactic clip application before polypectomy may prevent postpolypectomy bleeding (PPB), the usefulness of prophylactic clipping in the treatment of large pedunculated polyps is controversial in s...

    Authors: Jae Seung Soh, Myeongsook Seo and Kyung-Jo Kim

    Citation: BMC Gastroenterology 2020 20:68

    Content type: Research article

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  31. Mucormycosis is rare, life-threatening fungal infection. Frequently observed in those patients having underlying immunosuppression such as, diabetes, organ transplantation, Human immunodeficiency virus (HIV) i...

    Authors: Abdi Bati Wotiye, Poornachandra KS and Biniyam Alemayehu Ayele

    Citation: BMC Gastroenterology 2020 20:61

    Content type: Case report

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  32. Endoscopic mucosal resection (EMR) is a minimally invasive procedure used for the treatment of lesions in the gastrointestinal (GI) tract. There is increased usage of hemoclips during EMR for the prevention of...

    Authors: Karen Chang, Brian S. Lee, Timnit Tekeste, Andrew Nguyen, Mopelola Adeyemo, Agathon Girgis, Karl K. Kwok, H. Michael Crowson, Alicia O. Burris, Rajeev Attam, Charles T. Chaya, Theodore E. Durbin, Andrew Q. Giap, Gordon C. Hunt, John Iskander, Kevin T. Kao…

    Citation: BMC Gastroenterology 2020 20:60

    Content type: Research article

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  33. The gut microbiota participates in the metabolism of substances and energy, promotes the development and maturation of the immune system, forms the mucosal barrier, and protects the host from pathogen attacks....

    Authors: Qiang Wang, Chenjun Hao, Wenchao Yao, Defu Zhu, Haifeng Lu, Long Li, Biao Ma, Bei Sun, Dongbo Xue and Weihui Zhang

    Citation: BMC Gastroenterology 2020 20:59

    Content type: Research article

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  34. The implication of microscopic ileitis finding in patients referred for ileocolonoscopy for clinically suspected inflammatory bowel disease (IBD) is not well defined, and its correlation with clinical outcome ...

    Authors: Fadi Abu Baker, Jesus Alonso Z’cruz De La Garza, Smadar Nafrin, Amir Mari, Muhammed Suki, Baruch Ovadia, Oren Gal and Yael Kopelamn

    Citation: BMC Gastroenterology 2020 20:52

    Content type: Research article

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  35. Owing to the development of double-balloon enteroscopy (DBE) and video capsule endoscopy (VCE) in recent years, direct visualization of the entire small intestinal mucosa has become possible. Because of the no...

    Authors: Zihan Huang, Xiang Liu, Fei Yang, Guoxin Wang, Nan Ge, Sheng Wang, Jintao Guo and Siyu Sun

    Citation: BMC Gastroenterology 2020 20:42

    Content type: Research article

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  36. Effective control of the inflammatory process in Crohn’s disease (CD) is reflected in intestinal mucosal healing. The performances of faecal calprotectin (fcal), clinical and serologic parameters in the inflam...

    Authors: Francisco Guilherme Cancela e Penna, Rodrigo Macedo Rosa, Pedro Ferrari Sales da Cunha, Stella Cristina Silva de Souza and Maria de Lourdes de Abreu Ferrari

    Citation: BMC Gastroenterology 2020 20:35

    Content type: Research article

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  37. Irritable bowel syndrome (IBS) is a common disease that affects the quality of life (QOL) and social functioning of sufferers. Visceral anxiety is currently considered a key factor in the onset and exacerbatio...

    Authors: Shino Kikuchi, Yuki Oe, Yohei Sasaki, Hirono Ishii, Yuri Ito, Masaru Horikoshi, Takashi Sozu, Hiroshi Seno and Toshi A. Furukawa

    Citation: BMC Gastroenterology 2020 20:29

    Content type: Study protocol

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  38. Patients with inflammatory bowel disease (IBD) tend to avoid dairy products to minimize abdominal pain and diarrhea. The aim of this study was to estimate the proportion of protein from dairy sources (PPDS) in...

    Authors: May-Bente Bengtson, Margaretha Haugen, Anne Lise Brantsæter, Geir Aamodt and Morten H. Vatn

    Citation: BMC Gastroenterology 2020 20:28

    Content type: Research article

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  39. Monopolar instruments are generally used in colorectal endoscopic mucosal resection (EMR). Bipolar instruments have previously been reported to be as safe as monopolar instruments. We sought to compare the saf...

    Authors: Kensuke Shinmura, Hiroaki Ikematsu, Motohiro Kojima, Hiroshi Nakamura, Shozo Osera, Yusuke Yoda, Keisuke Hori, Yasuhiro Oono, Atsushi Ochiai and Tomonori Yano

    Citation: BMC Gastroenterology 2020 20:27

    Content type: Research article

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  40. Hemodialysis patients are prone to constipation, which can adversely affect their quality of life (QOL). Elobixibat, a highly selective inhibitor of the ileal bile acid transporter, can increase the bile acid ...

    Authors: Daigo Kamei, Yuiko Kamei, Masashi Nagano, Michio Mineshima, Kosaku Nitta and Ken Tsuchiya

    Citation: BMC Gastroenterology 2020 20:26

    Content type: Research article

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  41. Naldemedine, a novel peripherally-acting mu-opioid receptor antagonist, has improved opioid-induced constipation in randomized controlled trials. The most frequent adverse event of naldemedine is diarrhea, whi...

    Authors: Yusuke Takagi, Gakuji Osawa, Yoriko Kato, Eri Ikezawa, Chika Kobayashi and Etsuko Aruga

    Citation: BMC Gastroenterology 2020 20:25

    Content type: Research article

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  42. Gastrointestinal (GI) cytomegaloviral (CMV) infection is common among patients with immunocompromised status; however, data specific to GI-CMV infection in immunocompetent patients are comparatively limited.

    Authors: Thanaboon Chaemsupaphan, Julajak Limsrivilai, Chenchira Thongdee, Asawin Sudcharoen, Ananya Pongpaibul, Nonthalee Pausawasdi and Phunchai Charatcharoenwitthaya

    Citation: BMC Gastroenterology 2020 20:22

    Content type: Research article

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  43. Patients with ulcerative colitis (UC) experience periods of recurring and episodic clinical signs and symptoms. This study sought to establish the association between disease activity and health-related qualit...

    Authors: Alessandro Armuzzi, Miriam Tarallo, James Lucas, Daniel Bluff, Benjamin Hoskin, Danielle Bargo, Joseph C. Cappelleri, Leonardo Salese and Marco daCosta DiBonaventura

    Citation: BMC Gastroenterology 2020 20:18

    Content type: Research article

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  44. Gankyrin (GK) is an oncoprotein which regulates inflammatory responses and its inhibition is considered as a possible anti-inflammatory therapy for inflammatory bowel disease (IBD).

    Authors: Toshiharu Sakurai, Hiroki Nishiyama, Tomoyuki Nagai, Susumu Goto, Hiroyuki Ogata and Masatoshi Kudo

    Citation: BMC Gastroenterology 2020 20:12

    Content type: Research article

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  45. Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU) is a new category of mature B-cell neoplasms. Ulcers occur in the oropharyngeal mucosa, skin, and gastrointestinal tract. The onset of EBV-MCU is sugge...

    Authors: Nozomi Morita, Chiaki Okuse, Keigo Suetani, Hiroyasu Nakano, Tetsuya Hiraishi, Shinya Ishigooka, Shuzo Mori, Tsukasa Shimamura, Takeshi Asakura, Junki Koike, Fumio Itoh and Michihiro Suzuki

    Citation: BMC Gastroenterology 2020 20:9

    Content type: Case report

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  46. Interleukin-10 (IL10) signalling pathway deficiency results in severe very early onset inflammatory bowel disease (VEOIBD), and enterostomy is often inevitable. However, studies in these surgical populations a...

    Authors: Zifei Tang, Zhiheng Huang, Weili Yan, Yi Zhang, Peng Shi, Kuiran Dong, Ying Gong, Min Ji, Yuhuan Wang, Zhuowe Yu and Ying Huang

    Citation: BMC Gastroenterology 2020 20:8

    Content type: Research article

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  47. The duodenum is a common site for diverticulum formation. Most of the duodenal diverticula are asymptomatic, incidental findings. Perforation is a rare but potentially lethal complication of duodenal diverticu...

    Authors: Moysis Moysidis, Daniel Paramythiotis, Anestis Karakatsanis, Evropi Amanatidou, Elisavet Psoma, Xanthippi Mavropoulou and Antonios Michalopoulos

    Citation: BMC Gastroenterology 2020 20:5

    Content type: Case report

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  48. The aim of this study was to investigate the efficacy and safety of the novel complex drug, consisting of released-active form of antibodies to S-100 protein, tumor necrosis factor-α and histamine, (Kolofort) ...

    Authors: Vladimir T. Ivashkin, Elena A. Poluektova, Alexey B. Glazunov, Mikhail A. Putilovskiy and Oleg I. Epstein

    Citation: BMC Gastroenterology 2019 20:2

    Content type: Research article

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  49. Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn’s disease are non-specific characteristics. We aime...

    Authors: Yun Cui, Shi-yuan Lu, Jie Xu, Yan-shen Peng, Qi Miao, Xiao-qing Wang, Xiao-yu Chen and Zhi-hua Ran

    Citation: BMC Gastroenterology 2019 19:232

    Content type: Research article

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