Intestinal disorders

Section edited by Peter Lakatos

This section concerns all clinical and basic science aspects of intestinal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Research article

    Drug persistence and need for dose intensification to adalimumab therapy; the importance of therapeutic drug monitoring in inflammatory bowel diseases

    Therapeutic drug monitoring (TDM) aid therapeutic decision making in patients with inflammatory bowel disease (IBD) who lose response to anti-TNF therapy. Our aim was to evaluate the frequency and predictive f...

    Lorant Gonczi, Zsuzsanna Kurti, Mariann Rutka, Zsuzsanna Vegh, Klaudia Farkas, Barbara D. Lovasz, Petra A. Golovics, Krisztina B. Gecse, Balazs Szalay, Tamas Molnar and Peter L. Lakatos

    BMC Gastroenterology 2017 17:97

    Published on: 8 August 2017

  2. Case report

    Fetal death in utero and miscarriage in a patient with Crohn’s disease under therapy with ustekinumab: case-report and review of the literature

    Ustekinumab is a fully human monoclonal antibody against the p40 subunit of interleukin (IL) 12 and 23 which is involved in the pathogenesis of several inflammatory diseases. Ustekinumab is approved for psoria...

    C. Venturin, S. Nancey, P. Danion, M. Uzzan, M. Chauvenet, C. Bergoin, X. Roblin, B. Flourié and G. Boschetti

    BMC Gastroenterology 2017 17:80

    Published on: 19 June 2017

  3. Case report

    Incomplete ileus and hemafecia as the presenting features of multi-organ involved primary systemic AL amyloidosis: a rare case report

    AL Amyloidosis is known to be a systemic disease affecting multiple organs and tissue while it’s rare that patients present with gastrointestinal symptoms at first and later develop multiple-organ dysfuction. ...

    Li Tian, Anliu Tang, Xian Zhang, Zhen Mei, Fen Liu, Jingbo Li, Xiayu Li, Feiyan Ai, Xiaoyan Wang and Shourong Shen

    BMC Gastroenterology 2017 17:72

    Published on: 5 June 2017

  4. Research article

    Circulating cathelicidin levels correlate with mucosal disease activity in ulcerative colitis, risk of intestinal stricture in Crohn’s disease, and clinical prognosis in inflammatory bowel disease

    Cathelicidin (LL-37) is an antimicrobial peptide known to be associated with various autoimmune diseases. We attempt to determine if cathelicidin can accurately reflect IBD disease activity. We hypothesize tha...

    Diana Hoang-Ngoc Tran, Jiani Wang, Christina Ha, Wendy Ho, S. Anjani Mattai, Angelos Oikonomopoulos, Guy Weiss, Precious Lacey, Michelle Cheng, Christine Shieh, Caroline C. Mussatto, Samantha Ho, Daniel Hommes and Hon Wai Koon

    BMC Gastroenterology 2017 17:63

    Published on: 12 May 2017

  5. Research article

    Inflammatory Bowel Disease (IBD) pharmacotherapy and the risk of serious infection: a systematic review and network meta-analysis

    The magnitude of risk of serious infections due to available medical therapies of inflammatory bowel disease (IBD) remains controversial. We conducted a systematic review and network meta-analysis of the exist...

    Chelle L. Wheat, Cynthia W. Ko, Kindra Clark-Snustad, David Grembowski, Timothy A. Thornton and Beth Devine

    BMC Gastroenterology 2017 17:52

    Published on: 14 April 2017

  6. Research article

    Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome

    The evidence on the role of gut microbiota in post-infectious irritable bowel syndrome (PI-IBS) is convincing. Lactobacillus spp. positively affect IBS symptoms, although the mechanisms through which probiotic...

    Debora Compare, Alba Rocco, Pietro Coccoli, Debora Angrisani, Costantino Sgamato, Barbara Iovine, Umberto Salvatore and Gerardo Nardone

    BMC Gastroenterology 2017 17:53

    Published on: 14 April 2017

  7. Research article

    The utility of apoptosis inhibitor of macrophages as a possible diagnostic marker in patients with Crohn’s disease

    Apoptosis inhibitor of macrophages (AIM) was initially identified as an apoptosis inhibitor that supports the survival of macrophages against various apoptosis-inducing stimuli, and AIM produced by macrophages...

    Yohei Ono, Shuji Kanmura, Yuko Morinaga, Kohei Oda, Katsuto Kawabata, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Hiroki Taguchi, Hirofumi Uto, Hirohito Tsubouchi and Akio Ido

    BMC Gastroenterology 2017 17:40

    Published on: 11 March 2017

  8. Research article

    Cytomegalovirus colitis in hospitalized inflammatory bowel disease patients in Taiwan: a referral center study

    Colitis is exacerbated in patients with concurrent cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). We assessed the prevalence and clinical features of CMV colitis in hospitalized IBD pati...

    Meng-Tzu Weng, Chien-Chih Tung, Yi-Shuan Lee, Yew-Loong Leong, Ming-Jium Shieh, Chia-Tung Shun, Cheng-Yi Wang, Jau-Min Wong and Shu-Chen Wei

    BMC Gastroenterology 2017 17:28

    Published on: 13 February 2017

  9. Research article

    Prevalence of paediatric inflammatory bowel disease in Sweden: a nationwide population-based register study

    We evaluated the impact of different case definition algorithms on the prevalence of paediatric inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) and to compare the occurrence ...

    J. F. Ludvigsson, K. Büsch, O. Olén, J. Askling, K. E. Smedby, A. Ekbom, E. Lindberg and M. Neovius

    BMC Gastroenterology 2017 17:23

    Published on: 31 January 2017

  10. Research article

    Dietary treatment of Crohn’s disease: perceptions of families with children treated by exclusive enteral nutrition, a questionnaire survey

    Diet is strongly associated with the aetiology of Crohn’s Disease (CD) and exclusive enteral nutrition (EEN) is the primary induction treatment in paediatric CD. This study explored opinions around the use of ...

    Vaios Svolos, Konstantinos Gerasimidis, Elaine Buchanan, Lee Curtis, Vikki Garrick, Jacqueline Hay, Susan Laird, Joanna Munro, Daniel R. Gaya, Richard K. Russell and Richard Hansen

    BMC Gastroenterology 2017 17:14

    Published on: 19 January 2017

  11. Research article

    Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study

    According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipatio...

    Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini and Gabrio Bassotti

    BMC Gastroenterology 2017 17:11

    Published on: 14 January 2017

  12. Research article

    Smoking influences the need for surgery in patients with the inflammatory bowel diseases: a systematic review and meta-analysis incorporating disease duration

    Studies examining the association between smoking and the need for surgery in patients with Crohn’s disease and ulcerative colitis have reached inconsistent conclusions. These studies often do not differentiat...

    M. Ellen Kuenzig, Sang Min Lee, Bertus Eksteen, Cynthia H. Seow, Cheryl Barnabe, Remo Panaccione and Gilaad G. Kaplan

    BMC Gastroenterology 2016 16:143

    Published on: 21 December 2016

  13. Research article

    Patients with longstanding ulcerative colitis in remission do not have more irritable bowel syndrome-like symptoms than controls

    Irritable bowel syndrome (IBS) is more common in patients with ulcerative colitis (UC) than expected. The prevalence of IBS in patients with UC with longstanding disease is not known. We investigated the preva...

    D. Lundgren, J. Rutegård, V. Eklöf, R. Palmqvist and P. Karling

    BMC Gastroenterology 2016 16:139

    Published on: 24 November 2016

  14. Research article

    Addition of Lubiprostone to polyethylene glycol(PEG) enhances the quality & efficacy of colonoscopy preparation: a randomized, double-blind, placebo controlled trial

    Adequate bowel preparation is an essential prerequisite for complete mucosal visualization during colonoscopy. Polyethylene glycol (PEG) solutions are commonly used. However the large volume of the solution is...

    Rupa Banerjee, Hrushikesh Chaudhari, Nirish Shah, Arjunan Saravanan, Manu Tandan and D. Nageshwar Reddy

    BMC Gastroenterology 2016 16:133

    Published on: 13 October 2016

  15. Research article

    The dual role of Escherichia coli in the course of ulcerative colitis

    This study examines the dual role of Escherichia coli in the course of ulcerative colitis (UC). The intestinal microbiota is considered to play an important role in UC pathogenesis, but how E. coli contributes to...

    Magdalena Pilarczyk-Zurek, Magdalena Strus, Pawel Adamski and Piotr B. Heczko

    BMC Gastroenterology 2016 16:128

    Published on: 10 October 2016

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