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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 9 of 10

  1. Mini-Mental State Examination (MMSE) is one of the most commonly used methods in the assessment of cognitive mental status. MMSE has been used in hepatology but its usefulness in the evaluation of hepatic ence...

    Authors: Dorota Koziarska, Ewa Wunsch, Małgorzata Milkiewicz, Maciej Wójcicki, Przemysław Nowacki and Piotr Milkiewicz

    Citation: BMC Gastroenterology 2013 13:107

    Content type: Research article

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  2. Budd–Chiari syndrome (BCS) often leads to hepatocellular carcinoma (HCC). Transcatheter arterial chemoembolization (TACE) has been increasingly used to treat BCS patients with HCC. The purposes of this study w...

    Authors: Feng-Yong Liu, Mao-Qiang Wang, Feng Duan, Qing-Sheng Fan, Peng Song and Yan Wang

    Citation: BMC Gastroenterology 2013 13:105

    Content type: Research article

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  3. Cerebral edema is a well-recognized and potentially fatal complication of acute liver failure (ALF). The effectiveness of treatments that address intracranial hypertension is generally assessed by measuring in...

    Authors: Josef Prazak, Eva Laszikova, Tomas Pantoflicek, Ondrej Ryska, Eva Koblihova and Miroslav Ryska

    Citation: BMC Gastroenterology 2013 13:98

    Content type: Research article

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  4. Hemorrhagic complications during EUS-guided pseudocyst drainage can occur, because the vessels on the internal wall of the pseudocyst might be compressed by the fluid and thus not visible on color Doppler or e...

    Authors: Adrian Săftoiu, Lidia Ciobanu, Andrada Seicean and Marcel Tantău

    Citation: BMC Gastroenterology 2013 13:93

    Content type: Case report

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  5. Mortality of patients with acute liver failure (ALF) is still unacceptably high. Available liver support systems are still of limited success at improving survival. A new type of albumin dialysis, the Hepa Wash® ...

    Authors: Ahmed Al-Chalabi, Edouard Matevossian, Anne-K v Thaden, Peter Luppa, Albrecht Neiss, Tibor Schuster, Zejian Yang, Catherine Schreiber, Patrick Schimmel, Ewald Nairz, Aurel Perren, Peter Radermacher, Wolfgang Huber, Roland M Schmid and Bernhard Kreymann

    Citation: BMC Gastroenterology 2013 13:83

    Content type: Research article

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  6. Nowadays, treatments for cholestasis remain largely nonspecific and often ineffective. Recent studies showed that inflammatory injuries and oxidative stress occur in the liver with cholestasis. In this study, ...

    Authors: Feng Jin, Du Cheng, Jun-Yan Tao, Shu-Ling Zhang, Ran Pang, Yuan-Jin Guo, Pian Ye, Ji-Hua Dong and Lei Zhao

    Citation: BMC Gastroenterology 2013 13:79

    Content type: Research article

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  7. Two recent Italian studies suggested that Pegylated-interferon (PEG-IFN) alfa-2a achieves a higher sustained virological response (SVR) rate than PEG-IFN alfa-2b. We intended to compare the efficacy and safety...

    Authors: Young-Joo Jin, Jin-Woo Lee, Jung il Lee, Sang Hoon Park, Choong Kee Park, Young Seok Kim, Sook-Hyang Jeong, Yun Soo Kim, Ju Hyun Kim, Seong Gyu Hwang, Kyu Sung Rim, Hyung Joon Yim, Jae Youn Cheong, Sung Won Cho, June Sung Lee, Young Min Park…

    Citation: BMC Gastroenterology 2013 13:74

    Content type: Research article

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  8. Compared with biofluids, target tissues and organs more directly reflect the pathophysiological state of a disease process. In this study, a D-galactosamine (GalN) / lipopolysaccharide (LPS)-induced mouse mode...

    Authors: Bo Feng, Shengming Wu, Feng Liu, Yan Gao, Fangting Dong and Lai Wei

    Citation: BMC Gastroenterology 2013 13:73

    Content type: Research article

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  9. Iatrogenic biliary stricture (IBS) is a disastrous complication of cholecystectomy. Although the endoscopic treatments are well accepted as initial attempts for IBS, surgical hepaticojejunostomy (HJ) is often ...

    Authors: Zhu-lin Luo, Long Cheng, Jian-dong Ren, Li-jun Tang, Tao Wang and Fu-zhou Tian

    Citation: BMC Gastroenterology 2013 13:70

    Content type: Research article

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  10. FGF21 is a promising intervention therapy for metabolic diseases as fatty liver, obesity and diabetes. Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by star...

    Authors: Chaofeng Yang, Weiqin Lu, Tao Lin, Pan You, Min Ye, Yanqing Huang, Xianhan Jiang, Cong Wang, Fen Wang, Mong-Hong Lee, Sai-Ching J Yeung, Randy L Johnson, Chongjuan Wei, Robert Y Tsai, Marsha L Frazier, Wallace L McKeehan…

    Citation: BMC Gastroenterology 2013 13:67

    Content type: Research article

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  11. Colorectal cancer (CRC) is common, with surgery as the main curative treatment. The prevalence of chronic liver disease has increased, but knowledge is limited on postoperative mortality in patients with liver...

    Authors: Jonathan Montomoli, Rune Erichsen, Christian Fynbo Christiansen, Sinna Pilgaard Ulrichsen, Lars Pedersen, Tove Nilsson and Henrik Toft Sørensen

    Citation: BMC Gastroenterology 2013 13:66

    Content type: Research article

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  12. Endoscopic transpapillary pernasal gallbladder drainage and endoscopicgallbladder stenting (EGS) have recently been reported to be useful inpatients with acute cholecystitis for whom a percutaneous approach is...

    Authors: Satoshi Maekawa, Ryosuke Nomura, Takayuki Murase, Yasuyoshi Ann, Masayuki Oeholm and Masaru Harada

    Citation: BMC Gastroenterology 2013 13:65

    Content type: Research article

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  13. Primary biliary cirrhosis (PBC) is a liver specific chronic disease with unclear pathogenesis, especially for the early stage molecular events. The mitochondrion is a multi-functional organelle associated with...

    Authors: Guang Song, Chaojun Hu, Huishan Zhu, Xi Li, Liying Zhao, Renfang Zhou, Xuan Zhang, Fengchun Zhang, Lin Wu and Yongzhe Li

    Citation: BMC Gastroenterology 2013 13:64

    Content type: Research article

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  14. Metastases to the pancreas are rare, and usually mistaken for primary pancreatic cancers. This study aimed to describe the histology results of solid pancreatic tumours obtained by endoscopic ultrasound-guided...

    Authors: José Celso Ardengh, César Vivian Lopes, Rafael Kemp, Filadélfio Venco, Eder Rios de Lima-Filho and José Sebastião dos Santos

    Citation: BMC Gastroenterology 2013 13:63

    Content type: Research article

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  15. Only one case of santorinicele without pancreas divisum pathophysiology (SWOPP) was previously reported. The purpose of the study was to determine the gross prevalence of SWOPP and santorinicele with pancreas ...

    Authors: Wataru Gonoi, Hiroyuki Akai, Kazuchika Hagiwara, Masaaki Akahane, Naoto Hayashi, Eriko Maeda, Takeharu Yoshikawa, Shigeru Kiryu, Minoru Tada, Kansei Uno, Naoki Okura, Kazuhiko Koike and Kuni Ohtomo

    Citation: BMC Gastroenterology 2013 13:62

    Content type: Research article

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  16. Although transarterial chemoembolization (TACE) has been used extensively for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT), no consensus has been reached and an evidence base ...

    Authors: Tong-Chun Xue, Xiao-Ying Xie, Lan Zhang, Xin Yin, Bo-Heng Zhang and Zheng-Gang Ren

    Citation: BMC Gastroenterology 2013 13:60

    Content type: Research article

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  17. Acute liver failure (ALF) is a devastating clinical syndrome with a high mortality rate. The MELD score has been implied as a prognostic tool in ALF. Hyponatremia is associated with lethal outcome in ALF. Incl...

    Authors: Paul Manka, Lars P Bechmann, Frank Tacke, Jan-Peter Sowa, Martin Schlattjan, Julia Kälsch, Christoph Jochum, Andreas Paul, Fuat H Saner, Christian Trautwein, Guido Gerken and Ali Canbay

    Citation: BMC Gastroenterology 2013 13:58

    Content type: Research article

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  18. Patients with suspected alcoholic hepatitis and a Discriminant Function ≥32 underwent liver biopsy to confirm the diagnosis. Of these (n = 58), 43 had histological features of alcoholic hepatitis and 15 (25%) ...

    Authors: Timothy Hardy, Christopher Wells, Stuart Kendrick, Mark Hudson, Christopher P Day, Alastair D Burt, Steven Masson and Stephen F Stewart

    Citation: BMC Gastroenterology 2013 13:55

    Content type: Research article

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  19. Three-dimensional (3D) whole-liver perfusion magnetic resonance(MR) imaging with parallel imaging, a novel imaging method to characterize tumor vascularization in vivo, has recently been applied to comprehensivel...

    Authors: Sheng-Xiang Rao, Cai-Zhong Chen, Hao Liu, Meng-Su Zeng and Xu-Dong Qu

    Citation: BMC Gastroenterology 2013 13:53

    Content type: Research article

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  20. Long-term outcomes of partial liver resection of hepatocellular carcinoma (HCC) remain satisfactory due to high incidences of recurrence. This study was intended to see whether preoperative transcatheter arter...

    Authors: Yanming Zhou, Xiaofeng Zhang, Lupeng Wu, Feng Ye, Xu Su, Lehua Shi and Bin Li

    Citation: BMC Gastroenterology 2013 13:51

    Content type: Research article

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  21. Chronic hepatitis C virus (HCV) infection is frequently associated with extrahepatic autoimmune disorders while interferon (IFN) and ribavirin treatment may exacerbate these conditions. Autoantibodies from HCV...

    Authors: Laura M Stinton, Robert P Myers, Carla S Coffin and Marvin J Fritzler

    Citation: BMC Gastroenterology 2013 13:50

    Content type: Research article

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  22. In current practice, patients with chronic pancreatitis undergo surgical intervention in a late stage of the disease, when conservative treatment and endoscopic interventions have failed. Recent evidence sugge...

    Authors: Usama Ahmed Ali, Yama Issa, Marco J Bruno, Harry van Goor, Hjalmar van Santvoort, Olivier RC Busch, Cornelis HC Dejong, Vincent B Nieuwenhuijs, Casper H van Eijck, Hendrik M van Dullemen, Paul Fockens, Peter D Siersema, Dirk J Gouma, Jeanin E van Hooft, Yolande Keulemans, Jan W Poley…

    Citation: BMC Gastroenterology 2013 13:49

    Content type: Study protocol

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  23. Less than 67% of patients with intermediate risk for common bile duct (CBD) stones require therapeutic intervention. It is important to have an accurate, safe, and reliable method for the definitive diagnosis ...

    Authors: Hoi-Hung Chan, E-Ming Wang, Meng-Shun Sun, Ping-I Hsu, Wei-Lun Tsai, Tzung-Jiun Tsai, Kai-Ming Wang, Wen-Chi Chen, Huay-Min Wang, Huei-Lung Liang, Kwok-Hung Lai and William Robert Brugge

    Citation: BMC Gastroenterology 2013 13:44

    Content type: Research article

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  24. Haemobilia usually occurs secondary to accidental or iatrogenic hepatobiliary trauma. It can occasionally present with cataclysmal upper gastrointestinal haemorrhage posing as a life threatening emergency. Hae...

    Authors: Hazrah Priya, Gupta Anshul, Tiwari Alok, Kale Saurabh, Nath Ranjit, Lal Romesh and Sharma Deborshi

    Citation: BMC Gastroenterology 2013 13:43

    Content type: Case report

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  25. Advanced liver disease predisposes to bacterial translocation and endotoxaemia which can contribute to elevated circulating levels of IL-10 and down-regulation of MHC class II on antigen-presenting cells. We s...

    Authors: Jack Peter, Oliver Frey, Andreas Stallmach and Tony Bruns

    Citation: BMC Gastroenterology 2013 13:37

    Content type: Research article

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  26. A reliable and accurate estimation of liver size by physical examination is an important aspect of the clinical assessment of a patient. The scratch test uses auscultation to detect the lower liver edge by usi...

    Authors: Krishan Gupta, Akash Dhawan, Christian Abel, Nicholas Talley and John Attia

    Citation: BMC Gastroenterology 2013 13:35

    Content type: Research article

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  27. Earlier, we reported a highly statistically significant association between T-helper 1 (Th1) and Th2 cytokine genotypes and hepatocellular carcinoma (HCC) risk among natives of southern Guangxi, China, a hyper...

    Authors: Jian-Min Yuan, Yunhua Fan, Simona Ognjanovic, Renwei Wang, David Van Den Berg, Sugantha Govindarajan and Mimi C Yu

    Citation: BMC Gastroenterology 2013 13:32

    Content type: Research article

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  28. Although endoscopic biliary stents have been accepted as part of palliative therapy for cases of malignant hilar obstruction, the optimal endoscopic management regime remains controversial. In this study, we e...

    Authors: Osamu Inatomi, Shigeki Bamba, Makoto Shioya, Yosuke Mochizuki, Hiromitsu Ban, Tomoyuki Tsujikawa, Yasuharu Saito, Akira Andoh and Yoshihide Fujiyama

    Citation: BMC Gastroenterology 2013 13:31

    Content type: Research article

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  29. Gallstone disease is associated with p.D19H of ABCG8 as well as alterations of cholesterol and bile acid metabolism. However, molecular mechanisms have not been fully elucidated. It is important to understand the...

    Authors: Olga Renner, Dieter Lütjohann, Dominique Richter, André Strohmeyer, Silke Schimmel, Oliver Müller, Eduard F Stange and Simone Harsch

    Citation: BMC Gastroenterology 2013 13:30

    Content type: Research article

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  30. Cirrhotic patients with ascites are prone to develop various infectious diseases. This study aimed to evaluate the occurrence and effect of major infectious diseases on the mortality of cirrhotic patients with...

    Authors: Tsung-Hsing Hung, Chih-Wei Tseng, Yu-Hsi Hsieh, Kuo-Chih Tseng, Chih-Chun Tsai and Chen-Chi Tsai

    Citation: BMC Gastroenterology 2013 13:25

    Content type: Research article

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  31. Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor, on liver injury induced by...

    Authors: Yoshiro Tomishima, Yoichi Ishitsuka, Naoya Matsunaga, Minako Nagatome, Hirokazu Furusho, Mitsuru Irikura, Shigehiro Ohdo and Tetsumi Irie

    Citation: BMC Gastroenterology 2013 13:21

    Content type: Research article

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  32. Studies have shown psychological distress in patients with cirrhosis, yet no studies have evaluated the laboratory and physiologic correlates of psychological symptoms in cirrhosis. This study therefore measur...

    Authors: Fang-Yuan Ko, Albert C Yang, Shih-Jen Tsai, Yang Zhou and Lie-Ming Xu

    Citation: BMC Gastroenterology 2013 13:18

    Content type: Research article

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  33. Many studies have suggested that the immune response may play a crucial role in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a (i) functional culture of primary human ...

    Authors: Polyxeni P Doumba, Marilena Nikolopoulou, Ilias P Gomatos, Manousos M Konstadoulakis and John Koskinas

    Citation: BMC Gastroenterology 2013 13:17

    Content type: Research article

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  34. Few studies have examined the impact of Hepatitis C virus (HCV) infection on patient reported outcomes in Europe. This study was conducted to assess the burden of HCV infection in terms of work productivity lo...

    Authors: Jeffrey Vietri, Girish Prajapati and Antoine C El Khoury

    Citation: BMC Gastroenterology 2013 13:16

    Content type: Research article

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  35. Endoscopic sphincterotomy (EST) combined with large-balloon dilation (LBD) has been proposed as an alternative to manage large bile duct stones. However, recent reports indicate that LBD without EST may be saf...

    Authors: Jae Chul Hwang, Jin Hong Kim, Sun Gyo Lim, Soon Sun Kim, Sung Jae Shin, Kee Myung Lee and Byung Moo Yoo

    Citation: BMC Gastroenterology 2013 13:15

    Content type: Research article

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  36. The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation ...

    Authors: Jan G D’Haese, Ihsan Ekin Demir, Timo Kehl, Jannik Winckler, Nathalia A Giese, Frank Bergmann, Thomas Giese, Markus W Büchler, Helmut Friess, Mark Hartel and Güralp O Ceyhan

    Citation: BMC Gastroenterology 2013 13:14

    Content type: Research article

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  37. Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effect...

    Authors: Gabriele Fluhr, Julia Mayerle, Eckhard Weber, Ali Aghdassi, Peter Simon, Thomas Gress, Thomas Seufferlein, Joachim Mössner, Andreas Stallmach, Thomas Rösch, Martina Müller, Britta Siegmund, Petra Büchner-Steudel, Ina Zuber-Jerger, Marcus Kantowski, Albrecht Hoffmeister…

    Citation: BMC Gastroenterology 2013 13:11

    Content type: Study protocol

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  38. Four and one half LIM domain protein 2 (FHL2) has been reported to be a key regulator in many cellular processes being associated with fibrogenesis such as cell migration and contraction. Moreover, hepatic FHL...

    Authors: Sebastian Huss, Christian Stellmacher, Diane Goltz, Inna Khlistunova, Alexander C Adam, Jonel Trebicka, Jutta Kirfel, Reinhard Büttner and Ralf Weiskirchen

    Citation: BMC Gastroenterology 2013 13:8

    Content type: Research article

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  39. A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in...

    Authors: Mariam Al-Shamsi, Allen Shahin, Eric PK Mensah-Brown and Abdul-Kader Souid

    Citation: BMC Gastroenterology 2013 13:6

    Content type: Research article

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  40. Second-generation intravenous blood-pool ultrasound contrast agents are increasingly used in endoscopic ultrasound (EUS) for characterization of microvascularization, differential diagnosis of benign and malig...

    Authors: Dan Ionuţ Gheonea, Costin Teodor Streba, Tudorel Ciurea and Adrian Săftoiu

    Citation: BMC Gastroenterology 2013 13:2

    Content type: Research article

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  41. Septic acute liver and intestinal failure is associated with a high mortality. We therefore investigated the influence of volume resuscitation with different crystalloid or colloid solutions on liver and intes...

    Authors: Martin Alexander Schick, Jobst Tobias Isbary, Tanja Stueber, Juergen Brugger, Jan Stumpner, Nicolas Schlegel, Norbert Roewer, Otto Eichelbroenner and Christian Wunder

    Citation: BMC Gastroenterology 2012 12:179

    Content type: Research article

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  42. The aim of this study was to evaluate whether polymorphisms in the guanine nucleotide binding (G protein), beta polypeptide 1 (GNB1) gene are associated with a rapid virological response (RVR) among HCV genotype ...

    Authors: Yun-Ping Lim, Fuu-Jen Tsai, Wen-Ling Liao, Ni Tien, Dong-Zong Hung, Cheng-Yuan Peng and Lei Wan

    Citation: BMC Gastroenterology 2012 12:167

    Content type: Research article

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  43. The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively inve...

    Authors: Adriano M Pellicelli, Mario Romano, Tommaso Stroffolini, Ettore Mazzoni, Fabrizio Mecenate, Roberto Monarca, Antonio Picardi, Maria Elena Bonaventura, Cristina Mastropietro, Pascal Vignally, Arnaldo Andreoli, Massimo Marignani, Cecilia D’Ambrosio, Lucia Miglioresi, Lorenzo Nosotti, Olga Mitidieri…

    Citation: BMC Gastroenterology 2012 12:162

    Content type: Research article

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  44. The Breast Cancer Resistance Protein (BCRP/ABCG2) is one member of ABC transporters proteins super family responsible of drug resistance. Since data on ABCG2 expression in liver malignances are scanty, here we...

    Authors: Caecilia HC Sukowati, Natalia Rosso, Devis Pascut, Beatrice Anfuso, Giuliano Torre, Paola Francalanci, Lory S Crocè and Claudio Tiribelli

    Citation: BMC Gastroenterology 2012 12:160

    Content type: Research article

    Published on:

  45. IL28B and ITPA genetic variants are associated with the outcome of pegylated-interferon and ribavirin (PEG-IFN/RBV) therapy. However, the significance of these genetic variants in cirrhotic patients following ...

    Authors: Takashi Motomura, Ken Shirabe, Norihiro Furusyo, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Tomohiko Akahoshi, Morimasa Tomikawa, Takasuke Fukuhara, Jun Hayashi and Yoshihiko Maehara

    Citation: BMC Gastroenterology 2012 12:158

    Content type: Research article

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  46. Oral lichen planus (OLP) is seen frequently in patients with hepatitis C virus (HCV) infection. The aim of this study was to evaluate the occurrence of oral candidiasis, other mucosal lesions, and xerostomia d...

    Authors: Yumiko Nagao, Kouji Hashimoto and Michio Sata

    Citation: BMC Gastroenterology 2012 12:155

    Content type: Research article

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