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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 9 of 9

  1. Content type: Research article

    Gallstone disease is associated with p.D19H of ABCG8 as well as alterations of cholesterol and bile acid metabolism. However, molecular mechanisms have not been fully elucidated. It is important to understand the...

    Authors: Olga Renner, Dieter Lütjohann, Dominique Richter, André Strohmeyer, Silke Schimmel, Oliver Müller, Eduard F Stange and Simone Harsch

    Citation: BMC Gastroenterology 2013 13:30

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  2. Content type: Research article

    Cirrhotic patients with ascites are prone to develop various infectious diseases. This study aimed to evaluate the occurrence and effect of major infectious diseases on the mortality of cirrhotic patients with...

    Authors: Tsung-Hsing Hung, Chih-Wei Tseng, Yu-Hsi Hsieh, Kuo-Chih Tseng, Chih-Chun Tsai and Chen-Chi Tsai

    Citation: BMC Gastroenterology 2013 13:25

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  3. Content type: Research article

    Overdosed acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) causes severe liver injury. We examined the effects of ozagrel, a selective thromboxane A2 (TXA2) synthase inhibitor, on liver injury induced by...

    Authors: Yoshiro Tomishima, Yoichi Ishitsuka, Naoya Matsunaga, Minako Nagatome, Hirokazu Furusho, Mitsuru Irikura, Shigehiro Ohdo and Tetsumi Irie

    Citation: BMC Gastroenterology 2013 13:21

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  4. Content type: Research article

    Studies have shown psychological distress in patients with cirrhosis, yet no studies have evaluated the laboratory and physiologic correlates of psychological symptoms in cirrhosis. This study therefore measur...

    Authors: Fang-Yuan Ko, Albert C Yang, Shih-Jen Tsai, Yang Zhou and Lie-Ming Xu

    Citation: BMC Gastroenterology 2013 13:18

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  5. Content type: Research article

    Many studies have suggested that the immune response may play a crucial role in the progression of hepatocellular carcinoma (HCC). Therefore, our aim was to establish a (i) functional culture of primary human ...

    Authors: Polyxeni P Doumba, Marilena Nikolopoulou, Ilias P Gomatos, Manousos M Konstadoulakis and John Koskinas

    Citation: BMC Gastroenterology 2013 13:17

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  6. Content type: Research article

    Few studies have examined the impact of Hepatitis C virus (HCV) infection on patient reported outcomes in Europe. This study was conducted to assess the burden of HCV infection in terms of work productivity lo...

    Authors: Jeffrey Vietri, Girish Prajapati and Antoine C El Khoury

    Citation: BMC Gastroenterology 2013 13:16

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  7. Content type: Research article

    Endoscopic sphincterotomy (EST) combined with large-balloon dilation (LBD) has been proposed as an alternative to manage large bile duct stones. However, recent reports indicate that LBD without EST may be saf...

    Authors: Jae Chul Hwang, Jin Hong Kim, Sun Gyo Lim, Soon Sun Kim, Sung Jae Shin, Kee Myung Lee and Byung Moo Yoo

    Citation: BMC Gastroenterology 2013 13:15

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  8. Content type: Research article

    The glycoprotein MFG-E8 mediates phagocytic clearance of apoptotic cells and influences the pathogenesis and progression of inflammatory diseases. MFG-E8 was shown to attenuate the progression of inflammation ...

    Authors: Jan G D’Haese, Ihsan Ekin Demir, Timo Kehl, Jannik Winckler, Nathalia A Giese, Frank Bergmann, Thomas Giese, Markus W Büchler, Helmut Friess, Mark Hartel and Güralp O Ceyhan

    Citation: BMC Gastroenterology 2013 13:14

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  9. Content type: Study protocol

    Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effect...

    Authors: Gabriele Fluhr, Julia Mayerle, Eckhard Weber, Ali Aghdassi, Peter Simon, Thomas Gress, Thomas Seufferlein, Joachim Mössner, Andreas Stallmach, Thomas Rösch, Martina Müller, Britta Siegmund, Petra Büchner-Steudel, Ina Zuber-Jerger, Marcus Kantowski, Albrecht Hoffmeister…

    Citation: BMC Gastroenterology 2013 13:11

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  10. Content type: Research article

    Four and one half LIM domain protein 2 (FHL2) has been reported to be a key regulator in many cellular processes being associated with fibrogenesis such as cell migration and contraction. Moreover, hepatic FHL...

    Authors: Sebastian Huss, Christian Stellmacher, Diane Goltz, Inna Khlistunova, Alexander C Adam, Jonel Trebicka, Jutta Kirfel, Reinhard Büttner and Ralf Weiskirchen

    Citation: BMC Gastroenterology 2013 13:8

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  11. Content type: Research article

    A novel in vitro system was employed to investigate liver tissue respiration (mitochondrial O2 consumption) in mice treated with concanavalin A (Con A). This study aimed to investigate hepatocyte bioenergetics in...

    Authors: Mariam Al-Shamsi, Allen Shahin, Eric PK Mensah-Brown and Abdul-Kader Souid

    Citation: BMC Gastroenterology 2013 13:6

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  12. Content type: Research article

    Second-generation intravenous blood-pool ultrasound contrast agents are increasingly used in endoscopic ultrasound (EUS) for characterization of microvascularization, differential diagnosis of benign and malig...

    Authors: Dan Ionuţ Gheonea, Costin Teodor Streba, Tudorel Ciurea and Adrian Săftoiu

    Citation: BMC Gastroenterology 2013 13:2

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  13. Content type: Research article

    Septic acute liver and intestinal failure is associated with a high mortality. We therefore investigated the influence of volume resuscitation with different crystalloid or colloid solutions on liver and intes...

    Authors: Martin Alexander Schick, Jobst Tobias Isbary, Tanja Stueber, Juergen Brugger, Jan Stumpner, Nicolas Schlegel, Norbert Roewer, Otto Eichelbroenner and Christian Wunder

    Citation: BMC Gastroenterology 2012 12:179

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  14. Content type: Research article

    The aim of this study was to evaluate whether polymorphisms in the guanine nucleotide binding (G protein), beta polypeptide 1 (GNB1) gene are associated with a rapid virological response (RVR) among HCV genotype ...

    Authors: Yun-Ping Lim, Fuu-Jen Tsai, Wen-Ling Liao, Ni Tien, Dong-Zong Hung, Cheng-Yuan Peng and Lei Wan

    Citation: BMC Gastroenterology 2012 12:167

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  15. Content type: Research article

    The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively inve...

    Authors: Adriano M Pellicelli, Mario Romano, Tommaso Stroffolini, Ettore Mazzoni, Fabrizio Mecenate, Roberto Monarca, Antonio Picardi, Maria Elena Bonaventura, Cristina Mastropietro, Pascal Vignally, Arnaldo Andreoli, Massimo Marignani, Cecilia D’Ambrosio, Lucia Miglioresi, Lorenzo Nosotti, Olga Mitidieri…

    Citation: BMC Gastroenterology 2012 12:162

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  16. Content type: Research article

    The Breast Cancer Resistance Protein (BCRP/ABCG2) is one member of ABC transporters proteins super family responsible of drug resistance. Since data on ABCG2 expression in liver malignances are scanty, here we...

    Authors: Caecilia HC Sukowati, Natalia Rosso, Devis Pascut, Beatrice Anfuso, Giuliano Torre, Paola Francalanci, Lory S Crocè and Claudio Tiribelli

    Citation: BMC Gastroenterology 2012 12:160

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  17. Content type: Research article

    IL28B and ITPA genetic variants are associated with the outcome of pegylated-interferon and ribavirin (PEG-IFN/RBV) therapy. However, the significance of these genetic variants in cirrhotic patients following ...

    Authors: Takashi Motomura, Ken Shirabe, Norihiro Furusyo, Tomoharu Yoshizumi, Toru Ikegami, Yuji Soejima, Tomohiko Akahoshi, Morimasa Tomikawa, Takasuke Fukuhara, Jun Hayashi and Yoshihiko Maehara

    Citation: BMC Gastroenterology 2012 12:158

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  18. Content type: Research article

    Oral lichen planus (OLP) is seen frequently in patients with hepatitis C virus (HCV) infection. The aim of this study was to evaluate the occurrence of oral candidiasis, other mucosal lesions, and xerostomia d...

    Authors: Yumiko Nagao, Kouji Hashimoto and Michio Sata

    Citation: BMC Gastroenterology 2012 12:155

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  19. Content type: Research article

    In a recent study we showed that in patients with primary biliary cirrhosis (PBC) being positive or negative for anti-M2 antibodies reacting with the 2-oxoacid-dehydrogenase complex (ODC) also antibodies to th...

    Authors: Dominik Nann, Christoph P Berg, Beate E Preuß and Reinhild Klein

    Citation: BMC Gastroenterology 2012 12:152

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  20. Content type: Research article

    We previously reported that immune activation in the spinal dorsal horn contributes to pain induced by chronic pancreatitis (CP). Targeting immune response in the CNS may provide effective treatments for CP-in...

    Authors: Feng Quan-Xin, Feng Fan, Feng Xiang-Ying, Li Shu-Jun, Wang Shi-Qi, Liu Zhao-Xu, Zhang Xu-Jie, Zhao Qing-Chuan and Wang Wei

    Citation: BMC Gastroenterology 2012 12:148

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  21. Content type: Research article

    Liver function tests (LFTs) can be affected by many factors and the proposed effects of coffee on LFT require a comprehensive evaluation. The aim of this study was to elucidate whether drinking coffee, smoking...

    Authors: Eun Sun Jang, Sook-Hyang Jeong, Sung Ho Hwang, Hyun Young Kim, So Yeon Ahn, Jaebong Lee, Sang Hyub Lee, Young Soo Park, Jin Hyeok Hwang, Jin-Wook Kim, Nayoung Kim and Dong Ho Lee

    Citation: BMC Gastroenterology 2012 12:145

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  22. Content type: Research article

    The most common causes of cholestatic jaundice are biliary atresia and idiopathic neonatal hepatitis (INH). Specific disorders underlying INH, such as various infectious and metabolic causes, including neonata...

    Authors: Suporn Treepongkaruna, Suttiruk Jitraruch, Porawee Kodcharin, Dussadee Charoenpipop, Pim Suwannarat, Paneeya Pienvichit, Keiko Kobayashi and Duangrurdee Wattanasirichaigoon

    Citation: BMC Gastroenterology 2012 12:141

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  23. Content type: Research article

    No study has compared the long-term prognoses of hepatitis C patients with hepatitis C virus (HCV) antibody-negative individuals and investigated the effects of interferon (IFN) treatment. To clarify the long-...

    Authors: Kazumi Yamasaki, Mayumi Tomohiro, Yumiko Nagao, Michio Sata, Toshiaki Shimoda, Kazuhiro Hirase and Satoshi Shirahama

    Citation: BMC Gastroenterology 2012 12:139

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  24. Content type: Research article

    There is no standard therapeutic procedure for the hepatocellular carcinoma (HCC) in patients with poor hepatic reserve function. With the approval of newly developed chemotherapeutic agent of miriplatin, we h...

    Authors: Kenya Kamimura, Takeshi Suda, Yasushi Tamura, Masaaki Takamura, Takeshi Yokoo, Masato Igarashi, Hirokazu Kawai, Satoshi Yamagiwa, Minoru Nomoto and Yutaka Aoyagi

    Citation: BMC Gastroenterology 2012 12:127

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  25. Content type: Research article

    Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in Asians. However, data on prevalence and factors associated with NAFLD in Asians are lacking. The aim of this study i...

    Authors: Xiaona Hu, Yiqin Huang, Zhijun Bao, Yiqian Wang, Dongmei Shi, Fang Liu, Zhanjuan Gao and Xiaofeng Yu

    Citation: BMC Gastroenterology 2012 12:123

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  26. Content type: Case report

    MCAD-deficiency is the most common inborn error of fatty acid oxidation now included in many newborn screening programms using MS/MS. During prolonged catabolic episodes, patients may suffer from metabolic dec...

    Authors: Anibh M Das, Sabine Drache, Nils Janzen and Andreas Franke

    Citation: BMC Gastroenterology 2012 12:119

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  27. Content type: Research article

    Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease (CLD). About 80% of those exposed to the virus develop a chronic infection. Hyperhomocysteinemia, which is an independent...

    Authors: Mubin Mustafa, Sofia Hussain, Saleem Qureshi, Salman Akbar Malik, Ali Raza Kazmi and Muhammad Naeem

    Citation: BMC Gastroenterology 2012 12:117

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  28. Content type: Research article

    Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addi...

    Authors: Weifeng Shi, Chaodong Zhu, Wei Zheng, Michael J Carr, Desmond G Higgins and Zhong Zhang

    Citation: BMC Gastroenterology 2012 12:116

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  29. Content type: Research article

    Chronic pancreatitis is characterized by progressive fibrosis, pain and loss of exocrine and endocrine functions. The long-standing chronic pancreatitis and its associated pancreatic fibrosis are the most comm...

    Authors: Han Bai, Xiaokai Chen, Lin Zhang and Xiaoguang Dou

    Citation: BMC Gastroenterology 2012 12:115

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  30. Content type: Research article

    Previous research has shown variation in the effects of patient factors, including hepatic necroinflammatory activity, on liver stiffness measurement (LSM). This prospective study attempts to identify explanat...

    Authors: Sheng-Hung Chen, Yu-Fen Li, Hsueh-Chou Lai, Jung-Ta Kao, Cheng-Yuan Peng, Po-Heng Chuang, Wen-Pang Su and I-Ping Chiang

    Citation: BMC Gastroenterology 2012 12:105

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  31. Content type: Research article

    Endoscopic biliary drainage of hilar cholangiocarcinoma is controversial with respect to the optimal types of stents and the extent of drainage. This study evaluated endoscopic palliation in patients with hila...

    Authors: Manuel José Antunes Liberato and Jorge Manuel Tavares Canena

    Citation: BMC Gastroenterology 2012 12:103

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  32. Content type: Research article

    Non alcoholic fatty liver disease (NAFLD) is associated with increased risk of type 2 diabetes and chronic liver disease but identifying patients who have NAFLD without resorting to expensive imaging tests is ...

    Authors: Ki-Chul Sung, Bum-Soo Kim, Yong-Kyun Cho, Dong-il Park, Sookyoung Woo, Seonwoo Kim, Sarah H Wild and Christopher D Byrne

    Citation: BMC Gastroenterology 2012 12:84

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  33. Content type: Research article

    Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome that is closely associated with multiple factors such as obesity, hyperlipidemia and type 2 diabetes mellitus. However...

    Authors: Masato Yoneda, Shuhei Naka, Kazuhiko Nakano, Koichiro Wada, Hiroki Endo, Hironori Mawatari, Kento Imajo, Ryota Nomura, Kazuya Hokamura, Masafumi Ono, Shogo Murata, Iwai Tohnai, Yoshio Sumida, Toshihide Shima, Masae Kuboniwa, Kazuo Umemura…

    Citation: BMC Gastroenterology 2012 12:16

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  34. Content type: Research article

    Accurate tests to diagnose adenocarcinoma and high-grade dysplasia among mucinous pancreatic cysts are clinically needed. This study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst...

    Authors: May T Tun, Reetesh K Pai, Shirley Kwok, Aiwen Dong, Aparna Gupta, Brendan C Visser, Jeff A Norton, George A Poultsides, Subhas Banerjee, Jacques Van Dam, Ann M Chen, Shai Friedland, Brennan A Scott, Rahul Verma, Anson W Lowe and Walter G Park

    Citation: BMC Gastroenterology 2012 12:15

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  35. Content type: Research article

    The aspartate aminotransferase-to-platelet ratio index (APRI), a tool with limited expense and widespread availability, is a promising noninvasive alternative to liver biopsy for detecting hepatic fibrosis. Th...

    Authors: Wenwen Jin, Zhonghua Lin, Yongning Xin, Xiangjun Jiang, Quanjiang Dong and Shiying Xuan

    Citation: BMC Gastroenterology 2012 12:14

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  36. Content type: Research article

    Up to now, few data are available regarding the clinical characteristics of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome. The study was to investigate and analyze the prevalent and clini...

    Authors: Pan Zhao and Yukun Han

    Citation: BMC Gastroenterology 2012 12:1

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  37. Content type: Research article

    Responsiveness of the "jaundiced heart" to propofol is not completely understood. The purpose of this study was to evaluate the effect of propofol on myocardial performance in rats with obstructive jaundice.

    Authors: Hong-Mei Ren, Li-Qun Yang, Zhi-Qiang Liu, Cai-Yang Chen, Chi-Wai Cheung, Kun-Ming Tao, Jian-Gang Song, Wu-Rong Chen and Wei-Feng Yu

    Citation: BMC Gastroenterology 2011 11:144

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  38. Content type: Research article

    The purpose of this investigation was to compare the outcome of percutaneous radiofrequency thermal ablation therapy (PRFA) with surgical resection (SR) in the treatment of single and small hepatocellular carc...

    Authors: Hiroki Nishikawa, Tadashi Inuzuka, Haruhiko Takeda, Jun Nakajima, Fumihiro Matsuda, Azusa Sakamoto, Shinichiro Henmi, Keiichi Hatamaru, Tetsuro Ishikawa, Sumio Saito, Akihiro Nasu, Ryuichi Kita, Toru Kimura, Akira Arimoto and Yukio Osaki

    Citation: BMC Gastroenterology 2011 11:143

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  39. Content type: Research article

    Hepatic angiosarcoma (HAS) is a rare type of liver cancer that is often fatal, and arsenic and vinyl chloride monomer (VCM) are two major causal agents. Whereas Taiwan is an endemic area of liver cancer, epide...

    Authors: Neng-Chyan Huang, Shue-Ren Wann, Hong-Tai Chang, Shoa-Lin Lin, Jyh-Seng Wang and How-Ran Guo

    Citation: BMC Gastroenterology 2011 11:142

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  40. Content type: Research article

    Hepatic encephalopathy (HE) is a frequent and severe complication of cirrhosis. A single determination of ammonia in venous blood correlates poorly with neurological symptoms. Thus, a better biological marker ...

    Authors: Saskia Ditisheim, Emiliano Giostra, Pierre R Burkhard, Nicolas Goossens, Gilles Mentha, Antoine Hadengue and Laurent Spahr

    Citation: BMC Gastroenterology 2011 11:134

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  41. Content type: Research article

    Vascular complications, such as HAT, are an important cause of graft loss and recipient mortality. We aimed to characterize post-transplant thrombotic events in a cohort of liver transplant recipients, and ide...

    Authors: Rosa Ayala, Joaquín Martínez-López, Teresa Cedena, Rosalía Bustelos, Carlos Jimenez, Enrique Moreno and Carmen Ribera

    Citation: BMC Gastroenterology 2011 11:130

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  42. Content type: Research article

    We aimed to study the predictive value of combined 18F-fluoro-deoxy-D-glucose positron emission tomography and computerized tomography (FDG-PET-CT), on outcomes in locally advanced pancreatic carcinoma (LAPC) ...

    Authors: Erkan Topkan, Cem Parlak, Ayşe Kotek, Ali Fuat Yapar and Berrin Pehlivan

    Citation: BMC Gastroenterology 2011 11:123

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  43. Content type: Research article

    Alcoholic steatohepatitis (ASH) is a serious complication of alcoholic liver disease. The diagnosis of ASH requires the association of steatosis, evidence of hepatocellular injury with ballooning degeneration,...

    Authors: Laurent Spahr, Laura Rubbia-Brandt, Muriel Genevay, Antoine Hadengue and Emiliano Giostra

    Citation: BMC Gastroenterology 2011 11:115

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  44. Content type: Research article

    Cholelithiasis has become a major health problem in Taiwan. The predominant type of gallstone found in Asian populations differs from that in the West, indicating possible differences in the etiology and risk ...

    Authors: Shih-Chang Hung, Kuan-Fu Liao, Shih-Wei Lai, Chia-Ing Li and Wen-Chi Chen

    Citation: BMC Gastroenterology 2011 11:111

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  45. Content type: Research article

    Translocation of gut-derived bacterial products such as endotoxin is a major problem in liver cirrhosis.

    Authors: Daniel Benten, Julian Schulze zur Wiesch, Karsten Sydow, Andreas Koops, Peter Buggisch, Rainer H Böger, Charlotte A Gaydos, Helen Won, Veronica Franco, Ansgar W Lohse, Stuart C Ray and Ashwin Balagopal

    Citation: BMC Gastroenterology 2011 11:107

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  46. Content type: Case report

    Gallbladder adenomyomatosis is a benign condition characterized by hyperplastic change in the gallbladder wall and overgrowth of the mucosa because of an unknown cause. Patients with gallbladder adenomyomatosi...

    Authors: Sheng-Hong Lin, Feng-Yee Chang, Ya-Sung Yang, Jong-Shiaw Jin and Teng-Wei Chen

    Citation: BMC Gastroenterology 2011 11:106

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