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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

Page 7 of 10

  1. Autochthonous hepatitis E has been observed with growing incidence in industrialized countries. Hepatitis E virus infection causes an acute hepatitis with spontaneous resolution in the majority of cases. Howev...

    Authors: Marcial Sebode, Sven Pischke, Marc Lütgehetmann, Susanne Polywka, Alexander Quaas, Ansgar W Lohse and Henning Wege

    Citation: BMC Gastroenterology 2014 14:191

    Content type: Case report

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  2. Hepatic encephalopathy (HE) represents a significant burden to the healthcare system. The aim of this study was to determine factors influencing the hospital length of stay among patients hospitalized with HE.

    Authors: Valérie Martel-Laferrière, Caitlin Homberger, Kian Bichoupan and Douglas T Dieterich

    Citation: BMC Gastroenterology 2014 14:185

    Content type: Research article

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  3. Type 1 autoimmune pancreatitis (AIP) often accompanies various systematic disorders such as sclerosing cholangitis, sialoadenitis, retroperitoneal fibrosis, interstitial pneumonitis and nephritis. Although rar...

    Authors: Hiroyuki Matsubayashi, Yoshihiro Kishida, Yukio Yoshida, Masao Yoshida, Yasuyuki Tanaka, Kimihiro Igarashi, Kenichiro Imai and Hiroyuki Ono

    Citation: BMC Gastroenterology 2014 14:173

    Content type: Case report

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  4. The question of whether the choice of preservation solution affects outcome after liver transplantation is still not satisfactorily answered. The purpose of this study is to examine the preservation solutions’...

    Authors: Alexander Kaltenborn, Jill Gwiasda, Volker Amelung, Christian Krauth, Frank Lehner, Felix Braun, Jürgen Klempnauer, Benedikt Reichert and Harald Schrem

    Citation: BMC Gastroenterology 2014 14:169

    Content type: Research article

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  5. Foreign body ingestion complicated by perforation of the digestive tract is a well-known occurrence. Contrary to this, perforation by fishbones has most often been described in South East Asian populations, an...

    Authors: Pierre-François Laterre and Carole Dangoisse

    Citation: BMC Gastroenterology 2014 14:167

    Content type: Case report

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    The Erratum to this article has been published in BMC Gastroenterology 2015 15:27

  6. Few studies have compared the prognosis and liver-related mortality in patients with NAFLD (nonalcoholic fatty liver disease) and AFLD (alcoholic fatty liver disease). We aimed to investigate the etiology and ...

    Authors: Svanhildur Haflidadottir, Jon G Jonasson, Helga Norland, Sylvia O Einarsdottir, David E Kleiner, Sigrun H Lund and Einar S Björnsson

    Citation: BMC Gastroenterology 2014 14:166

    Content type: Research article

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  7. Diagnosis of choledocholithiasis requires clinical manifestations and imaging examination findings suggesting a stone in the common bile duct (CBD), but these factors are not highly sensitive or specific. The ...

    Authors: Varayu Prachayakul, Pitulak Aswakul, Patommatat Bhunthumkomol and Morakod Deesomsak

    Citation: BMC Gastroenterology 2014 14:165

    Content type: Research article

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  8. The influence of size on the effectiveness of nasobiliary catheters has not yet been studied. We compared biliary drainage effectiveness and procedure-related discomfort and adverse events in 5 French (Fr) and...

    Authors: Toshio Fujisawa, Koichi Kagawa, Shunsuke Watanabe, Kantaro Hisatomi, Kensuke Kubota, Hajime Sato, Atsushi Nakajima and Nobuyuki Matsuhashi

    Citation: BMC Gastroenterology 2014 14:161

    Content type: Research article

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  9. Intrahepatic cholestasis of pregnancy (ICP) is a cholestasis condition caused by elevated levels of serum bile acids that mainly occurs in the third trimester of pregnancy. Maternal symptoms include pruritus; ...

    Authors: Kenya Kamimura, Hiroyuki Abe, Naomi Kamimura, Masayuki Yamaguchi, Maiko Mamizu, Kanna Ogi, Yoshifumi Takahashi, Ken-ichi Mizuno, Hiroteru Kamimura, Yuji Kobayashi, Manabu Takeuchi, Kunihiko Yoshida, Kyoko Yamada, Takayuki Enomoto, Koichi Takakuwa, Minoru Nomoto…

    Citation: BMC Gastroenterology 2014 14:160

    Content type: Case report

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  10. Numerous pathological processes that affect liver function in patients with liver failure have been identified. Among them, hyperammonia is one of the most common phenomena.The purpose of this study was to det...

    Authors: Jingjing Li, Zujiang Yu, Qiongye Wang, Duolu Li, Bin Jia, Yubing Zhou, Yanwei Ye, Shen Shen, Yanfang Wang, Shasha Li, Lu Bai and Quancheng Kan

    Citation: BMC Gastroenterology 2014 14:151

    Content type: Research article

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  11. Acetaminophen (APAP) is one of the most widely used analgesic and antipyretic pharmaceutical substances in the world and accounts for most cases of drug induced liver injury resulting in acute liver failure. A...

    Authors: Niels Steinebrunner, Carolin Mogler, Spiros Vittas, Birgit Hoyler, Catharina Sandig, Wolfgang Stremmel and Christoph Eisenbach

    Citation: BMC Gastroenterology 2014 14:148

    Content type: Research article

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  12. Hepatitis B virus (HBV) infection is a serious public health problem worldwide. This study aimed to investigate the relationship between serum alpha-fetoprotein (AFP) levels and pathological stages of liver bi...

    Authors: Yu-rui Liu, Bin-bin Lin, Da-wu Zeng, Yue-yong Zhu, Jing Chen, Qi Zheng, Jing Dong and Jia-ji Jiang

    Citation: BMC Gastroenterology 2014 14:145

    Content type: Research article

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  13. Gemcitabine/Cisplatin (Gem/CDDP) combination has demonstrated a clear survival advantage over gemcitabine alone and has become a new standard in advanced Biliary Tract Carcinoma (aBTC). However, Gemcitabine/Ox...

    Authors: Frédéric Fiteni, Marine Jary, Franck Monnien, Thierry Nguyen, Eric Beohou, Martin Demarchi, Erion Dobi, Francine Fein, Denis Cleau, Serge Fratté, Virginie Nerich, Franck Bonnetain, Xavier Pivot, Christophe Borg and Stefano Kim

    Citation: BMC Gastroenterology 2014 14:143

    Content type: Research article

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  14. Alkaline sphingomyelinase (NPP7) is an ecto-enzyme expressed in intestinal mucosa, which hydrolyses sphingomyelin (SM) to ceramide and inactivates platelet activating factor. It is also expressed in human live...

    Authors: Rui-Dong Duan, Ulf Hindorf, Yajun Cheng, Per Bergenzaun, Mats Hall, Erik Hertervig and Åke Nilsson

    Citation: BMC Gastroenterology 2014 14:138

    Content type: Research article

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  15. This study aimed to better understand the supporting role that mutational profiling (MP) of DNA from microdissected cytology slides and supernatant specimens may play in the diagnosis of malignancy in fine-nee...

    Authors: Nidhi Malhotra, Sara A Jackson, Lindsay L Freed, Mindi A Styn, Mary K Sidawy, Nadim G Haddad and Sydney D Finkelstein

    Citation: BMC Gastroenterology 2014 14:135

    Content type: Research article

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  16. Although pyogenic liver abscess (PPLA) fatalities are decreasing owing to early diagnosis and effective treatments, PPLA-associated complications still exist. The purpose of this study was to analyze the chara...

    Authors: Chang-Hua Chen, Shung-Sheng Wu, Hung-Chi Chang and Yu-Jun Chang

    Citation: BMC Gastroenterology 2014 14:133

    Content type: Research article

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  17. Hepatitis C virus (HCV) and Schistosoma mansoni are major causes of chronic liver disease (CLD) in which immune alteration is common. Recent studies suggested that certain platelets and lymphocytes activation mar...

    Authors: Mahmoud M Kamel, Shawky A Fouad and Maha MA Basyoni

    Citation: BMC Gastroenterology 2014 14:132

    Content type: Research article

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  18. The aim of this study was to assess whether two-years treatment with Pirfenidone influences necroinflammation, fibrosis and steatosis, serum levels of TGF-β1, IL-6, TNF-α and CB1 and CB2 gene expression, in pa...

    Authors: Lucia Flores-Contreras, Ana S Sandoval-Rodríguez, Mayra G Mena-Enriquez, Silvia Lucano-Landeros, Inmaculada Arellano-Olivera, Arnulfo Álvarez-Álvarez, M Guadalupe Sanchez-Parada and Juan Armendáriz-Borunda

    Citation: BMC Gastroenterology 2014 14:131

    Content type: Research article

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  19. Statins can modify bile cholesterol and, thus, the formation of gallstones. We examined whether statin use also modifies the severity of symptomatic gallstone disease and its treatment.

    Authors: Jukka Pulkkinen, Matti Eskelinen, Vesa Kiviniemi, Tuukka Kotilainen, Markus Pöyhönen, Lasse Kilpeläinen, Pirjo Käkelä, Helena Kastarinen and Hannu Paajanen

    Citation: BMC Gastroenterology 2014 14:119

    Content type: Research article

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  20. Noninvasive markers of liver fibrosis have not been extensively studied in patients with chronic hepatitis B virus (HBV) infection. Our aim was to evaluate the capacity of FibroSURE, one of the two noninvasive...

    Authors: Marija Zeremski, Rositsa B Dimova, Samantha Benjamin, Jessy Makeyeva, Rhonda K Yantiss, Maya Gambarin-Gelwan and Andrew H Talal

    Citation: BMC Gastroenterology 2014 14:118

    Content type: Research article

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  21. HCC predominantly develops in the condition of chronic inflammation that has led to liver cirrhosis. A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with...

    Authors: Kerstin Schütte, Christian Schulz, Janine Poranzke, Kai Antweiler, Jan Bornschein, Tina Bretschneider, Jörg Arend, Jens Ricke and Peter Malfertheiner

    Citation: BMC Gastroenterology 2014 14:117

    Content type: Research article

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  22. Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characteri...

    Authors: Juan Li, Xian-lin Zhao, Yi-xia Liu, Xiao-hang Peng, Shi-feng Zhu, Hui Guo, Yi-Ling Liu, Mei-hua Wan and Wen-fu Tang

    Citation: BMC Gastroenterology 2014 14:115

    Content type: Research article

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  23. The aim of the study was to construct a new scoring system for more accurate diagnostics of acute appendicitis. Applying the new score into clinical practice could reduce the need of potentially harmful diagno...

    Authors: Henna E Sammalkorpi, Panu Mentula and Ari Leppäniemi

    Citation: BMC Gastroenterology 2014 14:114

    Content type: Research article

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  24. The aim of this study was to evaluate whether polymorphisms of the mannose receptor C type 1 (MRC-1) and interleukin 28B (IL-28B) genes are associated with the treatment outcome of patients infected with hepatiti...

    Authors: Cheng-Yuan Peng, Ter-Hsin Chen, Yun-Ping Lim, Fuu-Jen Tsai, Wei-Yong Lin, Wen-Ling Liao and Lei Wan

    Citation: BMC Gastroenterology 2014 14:113

    Content type: Research article

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  25. Gastroenteropancreatic neuroendocrine tumors have occasionally been described in association with neurofibromatosis type 1, whereas an association with neurofibromatosis type 2 has never been reported.

    Authors: Sara Massironi, Alessandra Zilli, Roberta Elisa Rossi, Federica Cavalcoli, Dario Conte and Maddalena Peracchi

    Citation: BMC Gastroenterology 2014 14:110

    Content type: Case report

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  26. Hepatobiliary cystadenocarcinoma is a rare epithelial malignant neoplasm of the liver or extrahepatic bile ducts. Early diagnosis of hepatobiliary cystadenocarcinoma is difficult because of its asymptomatic fe...

    Authors: Yang-Hong Dai, Yee Hui Yeo, Yao-Feng Li, Chung-Bao Hsieh and Yu-Lueng Shih

    Citation: BMC Gastroenterology 2014 14:109

    Content type: Case report

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  27. Prolonged stress leads over time to allostatic load on the body and is likely to exacerbate a disease process. Long-term of stress exposure is one of a risk factor for metabolism-related diseases such as obesi...

    Authors: Yun-Zi Liu, Ji-Kuai Chen, Yi Zhang, Xia Wang, Shen Qu and Chun-Lei Jiang

    Citation: BMC Gastroenterology 2014 14:106

    Content type: Research article

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  28. The aim of this study was to evaluate the association between obesity and infected bile or bacteremia in patients with acute calculous cholecystitis.

    Authors: Chang Seok Bang, Jai Hoon Yoon, Youn Jeong Kim, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Yeon Soo Kim and Dong Joon Kim

    Citation: BMC Gastroenterology 2014 14:104

    Content type: Research article

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  29. The intravenous use of protease inhibitors in patients with acute pancreatitis is still controversial. The purpose of this study was to evaluate the effectiveness of protease inhibitors intravenously administe...

    Authors: Takeshi Seta, Yoshinori Noguchi, Satoru Shikata and Takeo Nakayama

    Citation: BMC Gastroenterology 2014 14:102

    Content type: Research article

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  30. Carbohydrate deficient transferrin (CDT) is the most specific serum biomarker of heavy alcohol consumption, defined as ≥ 350–420 g alcohol/week. Despite introduction of a standardized reference measurement tec...

    Authors: Kevin J Fagan, Katharine M Irvine, Brett C McWhinney, Linda M Fletcher, Leigh U Horsfall, Lambro Johnson, Peter O’Rourke, Jennifer Martin, Ian Scott, Carel J Pretorius, Jacobus PJ Ungerer and Elizabeth E Powell

    Citation: BMC Gastroenterology 2014 14:97

    Content type: Research article

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  31. Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitution...

    Authors: Giovanni Galati, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Paolo Gallo, Donatella Vincenti, Maria Carmela Solmone, Chiara Dell’Unto and Antonio Picardi

    Citation: BMC Gastroenterology 2014 14:94

    Content type: Case report

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  32. Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of e...

    Authors: Tarak K Chheda, Pratibha Shivakumar, Satish Kumar Sadasivan, Harish Chanderasekharan, Yogananda Moolemath, Anup M Oommen, Jagannath R Madanahalli and Venkataranganna V Marikunte

    Citation: BMC Gastroenterology 2014 14:89

    Content type: Research article

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  33. Pathogenesis of gallstones (GS) is multifactorial and multiple genetic and environmental factors have been identified in different populations for different types of GS with varying prevalence. However the rol...

    Authors: Harshi TW Weerakoon, Jamburagoda GS Ranasinghe, Ayanthi Navaratna, Ramaiah Sivakanesan, Kuda B Galketiya and Shanthini Rosairo

    Citation: BMC Gastroenterology 2014 14:88

    Content type: Research article

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  34. The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological re...

    Authors: Malte H Wehmeyer, Friederike Eißing, Sabine Jordan, Claudia Röder, Annette Hennigs, Olaf Degen, Anja Hüfner, Sandra Hertling, Stefan Schmiedel, Martina Sterneck, Jan van Lunzen, Ansgar W Lohse, Julian Schulze zur Wiesch and Stefan Lüth

    Citation: BMC Gastroenterology 2014 14:87

    Content type: Research article

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  35. This study investigated the survival benefits of sorafenib vs. radiotherapy (RT) in patients with unresectable hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) in the main trunk or the fi...

    Authors: Takahide Nakazawa, Hisashi Hidaka, Akitaka Shibuya, Yusuke Okuwaki, Yoshiaki Tanaka, Juichi Takada, Tsutomu Minamino, Masaaki Watanabe, Shigehiro Kokubu and Wasaburo Koizumi

    Citation: BMC Gastroenterology 2014 14:84

    Content type: Research article

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  36. Chronic oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. However, so far, few studies reported increased circulating levels of oxidative s...

    Authors: Maria Del Ben, Licia Polimeni, Roberto Carnevale, Simona Bartimoccia, Cristina Nocella, Francesco Baratta, Lorenzo Loffredo, Pasquale Pignatelli, Francesco Violi and Francesco Angelico

    Citation: BMC Gastroenterology 2014 14:81

    Content type: Research article

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  37. Stomach is an integral part of the energy balance regulating circuit. Studies exploring the effects of cross-system changes in the energy homeostasis in stomach tissue are scarce. The proximity of the stomach ...

    Authors: Rohini Mehta, Aybike Birerdinc, Lei Wang, Zahra Younoszai, Amir Moazzez, Hazem Elariny, Zachary Goodman, Vikas Chandhoke, Ancha Baranova and Zobair M Younossi

    Citation: BMC Gastroenterology 2014 14:72

    Content type: Research article

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  38. Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte nec...

    Authors: Runkuan Yang, Xiaoping Zou, Jyrki Tenhunen, Shengtao Zhu, Henri Kajander, Marja-Leena Koskinen and Tor Inge Tonnessen

    Citation: BMC Gastroenterology 2014 14:66

    Content type: Research article

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  39. Although cardiovascular disease is thouht to be common in cirrhosis, there are no systematic investigations on the prevalence of electrocardiographic (ECG) abnormalities in these patients and data on the occur...

    Authors: Axel Josefsson, Michael Fu, Einar Björnsson and Evangelos Kalaitzakis

    Citation: BMC Gastroenterology 2014 14:65

    Content type: Research article

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  40. Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in human population. The 6-fluoro-3-formylchromone (FCC) has been shown to have anti-tumor activity against various tumor cells. H...

    Authors: Yijie Zhang, Kailian Zheng, Hongli Yan, Gang Jin, Chenghao Shao, Xuyu Zhou, Yingqi Zhou and Tianlin He

    Citation: BMC Gastroenterology 2014 14:62

    Content type: Research article

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    The Retraction Note to this article has been published in BMC Gastroenterology 2015 15:39

  41. Ajmaline is a pharmaceutical agent now administered globally for a variety of indications, particularly investigation of suspected Brugada syndrome. There have been previous reports suggesting that repetitive ...

    Authors: Benjamin H Mullish, Rishi K Fofaria, Belinda C Smith, Kirsty Lloyd, Josephine Lloyd, Robert D Goldin and Ameet Dhar

    Citation: BMC Gastroenterology 2014 14:60

    Content type: Case report

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  42. Earlier kinetics of serum HCV core antigen (HCVcAg) and its predictive value on sustained virological response (SVR) were investigated in patients with genotype 1 HCV infection during antiviral treatment.

    Authors: Bo Feng, Rui-Feng Yang, Qing Xie, Jia Shang, Fan-Yun Kong, Hai-Ying Zhang, Hui-Ying Rao, Qian Jin, Xu Cong, Yun-Ye Liu, Yi Kang and Lai Wei

    Citation: BMC Gastroenterology 2014 14:47

    Content type: Research article

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  43. Situs inversus is a rare congenital anomaly characterized by the complete inversion of thoracic and abdominal organs. Liver transplantation in such patients or from donors in situs inversus is technically chal...

    Authors: Songfeng Yu, Hua Guo, Wu Zhang, Jun Yu, Sheng Yan, Jian Wu, Min Zhang and Shusen Zheng

    Citation: BMC Gastroenterology 2014 14:46

    Content type: Case report

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  44. FABP1 has been reported to possess strong antioxidant properties. Upon successful transfection of the Chang cell line, which has undetectable FABP1 mRNA levels, with human FABP1 cDNA, the Chang cells were show...

    Authors: Yu Gong, Guqi Wang, Yuewen Gong, Jing Yan, Yufei Chen and Frank J Burczynski

    Citation: BMC Gastroenterology 2014 14:44

    Content type: Research article

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  45. The liver is the first line of defence against continuously occurring influx of microbial-derived products and bacteria from the gut. Intestinal bacteria have been implicated in the pathogenesis of alcoholic l...

    Authors: Sari Tuomisto, Tanja Pessi, Pekka Collin, Risto Vuento, Janne Aittoniemi and Pekka J Karhunen

    Citation: BMC Gastroenterology 2014 14:40

    Content type: Research article

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  46. The relationship between resistin and non-alcoholic steatohepatitis (NASH) is not clear, some studies claimed that serum resistin levels were associated with neither the presence of NASH nor its severity, othe...

    Authors: Chuan Shen, Cai-Yan Zhao, Wei Wang, Ya-Dong Wang, Hui Sun, Wei Cao, Wei-Yan Yu, Li Zhang, Ru Ji, Meng Li and Jian Gao

    Citation: BMC Gastroenterology 2014 14:39

    Content type: Research article

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  47. Zinc is necessary for normal liver function; and vice versa, the liver plays a central role in zinc homeostasis. The aim of present study is to assess the effects of repeated psychological stress (PS) on the z...

    Authors: Xue Tian, Yuanyuan Zheng, Yingjie Li, Zhilei Shen, Liping Tao, Xiao Dou, Jianxin Qian and Hui Shen

    Citation: BMC Gastroenterology 2014 14:32

    Content type: Research article

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  48. Occult HBV infection (OBI) is defined by the persistence of HBV in the liver without serum HBsAg and HBVDNA. It represents a life-threatening event during immunosuppressive chemotherapies. An OBI occurs in app...

    Authors: Mario Masarone, Amalia De Renzo, Vincenzo La Mura, Ferdinando Carlo Sasso, Marco Romano, Giuseppe Signoriello, Valerio Rosato, Fabiana Perna, Fabrizio Pane and Marcello Persico

    Citation: BMC Gastroenterology 2014 14:31

    Content type: Research article

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