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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Estimates suggest that only 20 % of HCV-infected patients have been identified and <10 % treated. However, baby boomers (1945-1965) are identified as having a higher prevalence of HCV which has led the Centers...

    Authors: Zobair M. Younossi, Louis L. LaLuna, John J. Santoro, Flavia Mendes, Victor Araya, Natarajan Ravendhran, Lisa Pedicone, Idania Lio, Fatema Nader, Sharon Hunt, Andrei Racila and Maria Stepanova

    Citation: BMC Gastroenterology 2016 16:45

    Content type: Research article

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  2. Hepatic artery pseudoaneurysm (HAP) and Hepatic artery dissection are rare vascular complications after living donor liver transplantation (LDLT), which may lead to graft loss and death of the recipients. Conv...

    Authors: Lin Ma, Kefei Chen, Qiang Lu, Wenwu Ling and Yan Luo

    Citation: BMC Gastroenterology 2016 16:44

    Content type: Case report

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  3. The routine use of preoperative biliary drainage before pancreaticoduodenectomy (PD) remains controversial. This observational retrospective study compared stented and non-stented patients undergoing PD to ass...

    Authors: Francesca Gavazzi, Cristina Ridolfi, Giovanni Capretti, Maria Rachele Angiolini, Paola Morelli, Erminia Casari, Marco Montorsi and Alessandro Zerbi

    Citation: BMC Gastroenterology 2016 16:43

    Content type: Research article

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  4. Off-treatment durability of nucleoside analogue (NA) therapy in patients with chronic hepatitis B has not been well investigated. In this study we monitored antiviral effect of NA therapy and evaluated off-tre...

    Authors: Naruhiko Nagata, Tatehiro Kagawa, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Kazuya Anzai, Koichi Shiraishi and Tetsuya Mine

    Citation: BMC Gastroenterology 2016 16:38

    Content type: Research article

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  5. Crigler-Najjar syndrome (CN) is a very rare genetic disorder characterized by an inability to conjugate bilirubin. Contrary to CN type I, patients with CN II exhibit residual capacity to conjugate bilirubin an...

    Authors: Samuel Raimundo Fernandes, Carlos Miguel Moura, Beatriz Rodrigues, Luís Araújo Correia, Helena Cortez-Pinto and José Velosa

    Citation: BMC Gastroenterology 2016 16:33

    Content type: Case report

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  6. Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increas...

    Authors: Yachana Kataria, Ryan J. Deaton, Erika Enk, Ming Jin, Milita Petrauskaite, Linlin Dong, Joseph R. Goldenberg, Scott J. Cotler, Donald M. Jensen, Richard B. van Breemen and Peter H. Gann

    Citation: BMC Gastroenterology 2016 16:30

    Content type: Research article

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  7. Actual differences of long term outcome of extrahepatic cholangiocarcinoma according to the location of the tumor have not yet been studied. The aim of this study was to evaluate the prognosis and optimal surg...

    Authors: Keun Soo Ahn, Koo Jeong Kang, Yu Na Kang, Yong Hoon Kim and Tae-Seok Kim

    Citation: BMC Gastroenterology 2016 16:21

    Content type: Research article

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  8. Optimal phosphorous control is an important aspect of the care of patients with end-stage renal disease, and phosphate binders are usually needed.

    Authors: Christina Tieu, Roger K. Moreira, Louis M. Wong Kee Song, Shounak Majumder, Konstantinos A. Papadakis and Marie C. Hogan

    Citation: BMC Gastroenterology 2016 16:20

    Content type: Case report

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  9. Improving prediction of treatment outcomes in chronic hepatitis C (CHC) genotype 4 (G4) is necessary to increase sustained viral response (SVR) rates. Vitamin D related and interferon stimulated genes are good...

    Authors: M. O. El-Derany, N. M. Hamdy, N. L. Al-Ansari and H. O. El-Mesallamy

    Citation: BMC Gastroenterology 2016 16:19

    Content type: Research article

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  10. Acute cholangitis is a life-threatening bacterial infection of the biliary tract. Main focus of this study was to create a useful risk prediction model that helps physicians to assign patients with acute chola...

    Authors: Jochen Schneider, Alexander Hapfelmeier, Sieglinde Thöres, Andreas Obermeier, Christoph Schulz, Dominik Pförringer, Simon Nennstiel, Christoph Spinner, Roland M. Schmid, Hana Algül, Wolfgang Huber and Andreas Weber

    Citation: BMC Gastroenterology 2016 16:15

    Content type: Research article

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  11. Liver fibrosis and its end-stage disease, cirrhosis, are major risk factors for hepatocellular carcinoma (HCC) and present in 80 to 90 % of patients with HCC. Current genetically engineered mouse models for HC...

    Authors: Sook In Chung, Hyuk Moon, Dae Yeong Kim, Kyung Joo Cho, Hye-Lim Ju, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han and Simon Weonsang Ro

    Citation: BMC Gastroenterology 2016 16:13

    Content type: Research article

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  12. Hepatocellular carcinoma (HCC) with biliary tumor thrombus (BTT) is rare and its impact on postoperative prognosis remains controversial. The aim of this study was to evaluate the published evidence concerning...

    Authors: Wenhui Qiao, Feng Yu, Lupeng Wu, Bin Li and Yanming Zhou

    Citation: BMC Gastroenterology 2016 16:11

    Content type: Research article

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  13. Laparoscopic cholecystectomy (LC) has become the ‘gold standard’ for the treatment of symptomatic gallstones. Innovative methods are being introduced, and these procedures include transgastric or transcolonic ...

    Authors: Nan Ge, Siyu Sun, Shiwei Sun, Sheng Wang, Xiang Liu and Guoxin Wang

    Citation: BMC Gastroenterology 2016 16:9

    Content type: Research article

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  14. In pancreaticobiliary maljunction (PBM), the sphincter of Oddi can not control bile and pancreatic juice flow, which may lead to two-way reflux of bile and pancreatic juice, thus causing chronic inflammation, ...

    Authors: Shun-gen Huang, Wan-liang Guo, Zhi-cheng Zhou, Jun-jie Li, Fu-bin Yang and Jian Wang

    Citation: BMC Gastroenterology 2016 16:7

    Content type: Research article

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  15. The surveillance of subjects at risk of pancreatic cancer is restricted to clinical research; the incidence of familial pancreatic cancer needs to be better established. Thus, we aimed to evaluate the frequenc...

    Authors: Martina Mughetti, Lucia Calculli, Anna Maria Chiesa, Federica Ciccarese, Odeta Rrusho and Raffaele Pezzilli

    Citation: BMC Gastroenterology 2016 16:6

    Content type: Research article

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  16. Hemorrhage from the pancreatic duct, or hemosuccus pancreaticus (HP), is an unusual cause of intermittent gastrointestinal bleeding. HP is most often diagnosed in patients with chronic pancreatitis, and is usu...

    Authors: Hye Ryoung Sul, Hyun Woong Lee, Jeong Wook Kim, Sung Jae Cha, Yoo Shin Choi, Gi Hyeon Kim and Byung Kook Kwak

    Citation: BMC Gastroenterology 2016 16:5

    Content type: Case report

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  17. Pancreatic hamartoma is an extremely rare benign disease of the pancreas. Only 30 cases have been reported to date.

    Authors: Daisuke Matsushita, Hiroshi Kurahara, Yuko Mataki, Kosei Maemura, Michiyo Higashi, Satoshi Iino, Masahiko Sakoda, Hiroyuki Shinchi, Shinichi Ueno and Shoji Natsugoe

    Citation: BMC Gastroenterology 2016 16:3

    Content type: Case report

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  18. To assess correlation between liver or spleen stiffness measurement by transient elastography (TE) and hepatic venous pressure gradient (HVPG) in patients with chronic liver disease as well find optimal and ru...

    Authors: Romanas Zykus, Laimas Jonaitis, Vitalija Petrenkienė, Andrius Pranculis and Limas Kupčinskas

    Citation: BMC Gastroenterology 2015 15:183

    Content type: Research article

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    The Erratum to this article has been published in BMC Gastroenterology 2016 16:53

  19. Malignant bile duct obstruction is a common problem among cancer patients with hepatic or lymphatic metastases. Endoscopic retrograde cholangiography (ERC) with the placement of a stent is the method of choice...

    Authors: Georg-Martin Haag, Thomas Herrmann, Dirk Jaeger, Wolfgang Stremmel, Peter Schemmer, Peter Sauer and Daniel Nils Gotthardt

    Citation: BMC Gastroenterology 2015 15:171

    Content type: Research article

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  20. In cases of difficult bile duct cannulation, the use of wire-guided cannulation over a pancreatic stent (WGC-PS) or the double guidewire technique (DGT) may facilitate biliary cannulation. The aim of this stud...

    Authors: Min Jae Yang, Jae Chul Hwang, Byung Moo Yoo, Jin Hong Kim, Hyoung-Kyu Ryu, Soon Sun Kim, Joon Koo Kang and Min Kyeong Kim

    Citation: BMC Gastroenterology 2015 15:150

    Content type: Research article

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  21. Pyoderma Gangrenosum (PG) is a cutaneous condition, its diagnosis suggested by the presence of a painful cutaneous ulcer showing rapid progression. Pyoderma gangrenosum is associated with a concomitant systemi...

    Authors: Theodoros Androutsakos, Paraskevas Stamopoulos, Kiriaki Aroni and Gregorios Hatzis

    Citation: BMC Gastroenterology 2015 15:149

    Content type: Case report

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  22. Continuous use of anabolic androgenic steroid in high-doses is associated with substantial health risks, including hepatocellular adenoma. Malignant transformation from hepatocellular adenoma to hepatocellular...

    Authors: Philipp Solbach, Andrej Potthoff, Hans-Jürgen Raatschen, Bisharah Soudah, Ulrich Lehmann, Andrea Schneider, Michael J. Gebel, Michael P. Manns and Arndt Vogel

    Citation: BMC Gastroenterology 2015 15:60

    Content type: Case report

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  23. Endoscopic sphincterotomy (EST) is currently recognized as the primary endoscopic treatment for common bile duct stones. However, it is difficult to remove multiple (≥3) or large (≥15 mm) common bile duct ston...

    Authors: Kouhei Tsuchida, Mari Iwasaki, Misako Tsubouchi, Tsunehiro Suzuki, Chieko Tsuchida, Naoto Yoshitake, Takako Sasai and Hideyuki Hiraishi

    Citation: BMC Gastroenterology 2015 15:59

    Content type: Research article

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  24. Several association studies with small sample sizes of two SNPs in IL28BB (rs12979860 and rs8099917) showed inconsistent results, so in this study, we aim to evaluate the association between the two SNPs and i...

    Authors: Jing Chen, Wei Wang, Xiaoguang Li and Jie Xu

    Citation: BMC Gastroenterology 2015 15:58

    Content type: Research article

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  25. Biologic activities of functional mediators activate downstream transducers regulating inflammation and carcinogenesis. Correlation among mediators (IL-6, IL-27, TNF-α, and VEGF) with STAT proteins at diverse ...

    Authors: Jung-Ta Kao, Chun-Lung Feng, Cheng-Ju Yu, Shu-Mei Tsai, Ping-Ning Hsu, Yao-Li Chen and Yi-Ying Wu

    Citation: BMC Gastroenterology 2015 15:50

    Content type: Research article

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  26. Surgical resection is the only curative treatment for pancreatic and periampullary cancer, but many patients undergo unnecessary laparotomy because tumours can be understaged by computerised tomography (CT). A...

    Authors: Stephen Morris, Kurinchi S Gurusamy, Jessica Sheringham and Brian R Davidson

    Citation: BMC Gastroenterology 2015 15:44

    Content type: Research article

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  27. Although many of the factors and molecules closely associated with non-alcoholic steatohepatitis (NASH) have been reported, the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) on the p...

    Authors: Yuichi Nozaki, Koji Fujita, Koichiro Wada, Masato Yoneda, Takaomi Kessoku, Yoshiyasu Shinohara, Kento Imajo, Yuji Ogawa, Makoto Nakamuta, Satoru Saito, Naohiko Masaki, Yoji Nagashima, Yasuo Terauchi and Atsushi Nakajima

    Citation: BMC Gastroenterology 2015 15:42

    Content type: Research article

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  28. Recurrent hepatitis C virus infection after liver transplantation is associated with reduced graft and patient survival. Re-transplantation for graft failure due to recurrent hepatitis C is controversial and n...

    Authors: Julien Vionnet, Manuel Pascual, Haithem Chtioui, Emiliano Giostra, Pietro E Majno, Laurent A Decosterd and Darius Moradpour

    Citation: BMC Gastroenterology 2015 15:38

    Content type: Case report

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  29. Ischemic pancreatitis is a rare medical entity. The pancreatic tissue is susceptible to ischemia with the possibility of developing acute pancreatitis. The abdominal aortic aneurysm can be one possible cause o...

    Authors: Ileana Cocota, Radu Badea, Traian Scridon and Dan L Dumitrascu

    Citation: BMC Gastroenterology 2015 15:35

    Content type: Case report

    Published on:

  30. Colorectal liver metastases (CLM) occur frequently and postoperative intestinal infection is a common complication. Our previous study showed that probiotics could decrease the rate of infectious complications...

    Authors: Zhihua Liu, Chao Li, Meijin Huang, Chao Tong, Xingwei Zhang, Lei Wang, Hui Peng, Ping Lan, Peng Zhang, Nanqi Huang, Junsheng Peng, Xiaojian Wu, Yanxing Luo, Huanlong Qin, Liang Kang and Jianping Wang

    Citation: BMC Gastroenterology 2015 15:34

    Content type: Research article

    Published on:

  31. Percutaneous liver biopsy (PLB) is the “gold standard” in the diagnosis of liver diseases. A pilot trial has shown pethidine may reduce anxiety and the need for post-procedural pain relief. The aim of this stu...

    Authors: Antony Pan, Mohammed Alansari, Ralf Lubcke, Martin Schlup, Merrilee Williams, Margaret Fraser, Sarah Buckingham and Michael Schultz

    Citation: BMC Gastroenterology 2015 15:33

    Content type: Research article

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  32. Although most patients with autoimmune pancreatitis (AIP) respond favorably to prednisolone therapy, some individuals who later suffer from pancreatic calculi may require additional extracorporeal shock wave l...

    Authors: Masahiro Maruyama, Takayuki Watanabe, Keita Kanai, Takaya Oguchi, Jumpei Asano, Tetsuya Ito, Takashi Muraki, Hideaki Hamano, Norikazu Arakura, Takeshi Uehara and Shigeyuki Kawa

    Citation: BMC Gastroenterology 2015 15:28

    Content type: Research article

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  33. Non-alcoholic steatohepatitis (NASH) is associated with hepatic fibrogenesis. Despite well-known cholesterol-lowering action of statins, their mechanisms against NASH-mediated fibrogenesis remain unclear. This...

    Authors: Lee-Won Chong, Yi-Chao Hsu, Ting-Fang Lee, Yun Lin, Yung-Tsung Chiu, Kuo-Ching Yang, Jaw-Ching Wu and Yi-Tsau Huang

    Citation: BMC Gastroenterology 2015 15:22

    Content type: Research article

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  34. Liver surgery in perihilar cholangiocarcinoma (PHC) is associated with high postoperative morbidity because the tumor typically causes biliary obstruction. Preoperative biliary drainage is used to create a saf...

    Authors: Jimme K Wiggers, Robert JS Coelen, Erik AJ Rauws, Otto M van Delden, Casper HJ van Eijck, Jeroen de Jonge, Robert J Porte, Carlijn I Buis, Cornelis HC Dejong, I Quintus Molenaar, Marc GH Besselink, Olivier RC Busch, Marcel GW Dijkgraaf and Thomas M van Gulik

    Citation: BMC Gastroenterology 2015 15:20

    Content type: Study protocol

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  35. Pancreatitis induced by hypertriglyceridemia (HTG) has gained much attention. However, very limited numbers of studies have focused on the clinical significance of TG elevation in non-HTG induced pancreatitis,...

    Authors: Long Cheng, Zhulin Luo, Ke Xiang, Jiandong Ren, Zhu Huang, Lijun Tang and Fuzhou Tian

    Citation: BMC Gastroenterology 2015 15:19

    Content type: Research article

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  36. Alpha-fetoprotein (AFP)-producing pancreatic neuroendocrine tumors (pNETs) are rare, and the few reported cases usually coexisted with other malignant components such as adenocarcinoma or hepatoid carcinoma. W...

    Authors: Xiang Zhu, Huijuan Yong, Li Zhang, Yonghui Huang, Jie Zheng, Cuiling Liu, Dianrong Xiu and Pan Zhang

    Citation: BMC Gastroenterology 2015 15:16

    Content type: Case report

    Published on:

  37. Endoscopic biliary stenting (EBS) is one of the most important palliative treatments for biliary tract cancer. However, reflux cholangitis arising from bacterial adherence to the inner wall of the stent must b...

    Authors: Noritoshi Kobayashi, Seitaro Watanabe, Kunihiro Hosono, Kensuke Kubota, Atsushi Nakajima, Takashi Kaneko, Kazuya Sugimori, Motohiko Tokuhisa, Ayumu Goto, Ryutaro Mori, Koichi Taniguchi, Ryusei Matsuyama, Itaru Endo, Shin Maeda and Yasushi Ichikawa

    Citation: BMC Gastroenterology 2015 15:8

    Content type: Technical advance

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  38. Activated hepatic stellate cells are the main source of excessive collagen deposition in liver fibrosis. Here we report the inhibitory effects of the combinational treatment of two natural products, astragalus...

    Authors: Jin Zheng, Li-tian Ma, Qin-you Ren, Lu Li, Yi Zhang, Heng-jun Shi, Yi Liu, Cheng-hua Li, Yong-qi Dou, Shao-dan Li, Hui Zhang and Ming-hui Yang

    Citation: BMC Gastroenterology 2014 14:224

    Content type: Research article

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  39. Non-invasive models and methods to substitute liver biopsy in chronic hepatitis B (CHB) patients were investigated but their roles as predictors of significant liver histology for diagnosis of HBeAg-negative C...

    Authors: Surat Praneenararat, Naichaya Chamroonkul, Pimsiri Sripongpun, Samornmas Kanngurn, Roongrueng Jarumanokul and Teerha Piratvisuth

    Citation: BMC Gastroenterology 2014 14:218

    Content type: Research article

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  40. HBV and HCV reactivation have been widely reported in patients undergoing immunosuppressive therapy (IT); however, few data are available on the risk of reactivation in patients with psoriasis receiving IT. Th...

    Authors: Filomena Morisco, Maria Guarino, Serena La Bella, Luisa Di Costanzo, Nicola Caporaso, Fabio Ayala and Nicola Balato

    Citation: BMC Gastroenterology 2014 14:214

    Content type: Research article

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  41. Visceral obesity is often accompanied by non-alcoholic fatty liver disease (NAFLD). Activation of NACHT, LRR and PYD domains-containing proteins (NALPs) may contribute to the release of pro-inflammatory cytoki...

    Authors: Rohini Mehta, Arpan Neupane, Lei Wang, Zachary Goodman, Ancha Baranova and Zobair M Younossi

    Citation: BMC Gastroenterology 2014 14:208

    Content type: Research article

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  42. Whether non-alcoholic fatty liver disease (NAFLD) is a risk factor for gallstones remains uncertain. Few longitudinal or cohort studies have been used to identify this relationship. The aim of this study was t...

    Authors: Jia Liu, Haiyan Lin, Chengqi Zhang, Lu Wang, Shuo Wu, Dongzhi Zhang, Fang Tang, Fuzhong Xue and Yanxun Liu

    Citation: BMC Gastroenterology 2014 14:213

    Content type: Research article

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  43. Efforts to identify cell sources and approaches for cell therapy of liver diseases are ongoing, taking into consideration the limits recognized for adult liver tissue and for other forms of stem cells. In the ...

    Authors: Vincenzo Cardinale, Guido Carpino, Raffaele Gentile, Chiara Napoletano, Hassan Rahimi, Antonio Franchitto, Rossella Semeraro, Marianna Nuti, Paolo Onori, Pasquale Bartolomeo Berloco, Massimo Rossi, Daniela Bosco, Roberto Brunelli, Alice Fraveto, Cristina Napoli, Alessia Torrice…

    Citation: BMC Gastroenterology 2014 14:204

    Content type: Research article

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  44. Serotonin exhibits a vast repertoire of actions including cell proliferation and differentiation. The effect of serotonin, as an incomplete mitogen, on liver regeneration has recently been unveiled and is medi...

    Authors: Konstantinos N Tzirogiannis, Kalliopi T Kourentzi, Sofia Zyga, Vassiliki Papalimneou, Maria Tsironi, Agni D Grypioti, Ioannis Protopsaltis, Dimitrios Panidis and Georgios I Panoutsopoulos

    Citation: BMC Gastroenterology 2014 14:201

    Content type: Research article

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  45. We examined the intrinsic hepatic innervation after partial hepatectomy (PH) in rats and the presence and pattern of neural sprouting in regenerating liver.

    Authors: Apostolos N Kandilis, John Koskinas, Ioannis Vlachos, Spyridon Skaltsas, Despina Karandrea, Petros Karakitsos, Alkistis Pantopoulou, Marina Palaiologou, Nikolaos Nikiteas, Dina G Tiniakos and Despina N Perrea

    Citation: BMC Gastroenterology 2014 14:202

    Content type: Research article

    Published on:

  46. Cirrhosis is a long-term consequence of chronic hepatic injury with fibrosis. No effective therapy is currently available for decompensated cirrhosis except liver transplantation. Hence, we investigated the ef...

    Authors: Yoon Ok Jang, Moon Young Kim, Mee Yon Cho, Soon Koo Baik, Youn Zoo Cho and Sang Ok Kwon

    Citation: BMC Gastroenterology 2014 14:198

    Content type: Research article

    Published on:

  47. Nonalcoholic fatty liver disease (NAFLD) is a risk factor for hepatocellular carcinoma (HCC), but the association between a high-fat diet (HFD) and HCC is not fully understood. In this study, we investigated w...

    Authors: Xiao-Yan Duan, Qin Pan, Shi-Yan Yan, Wen-Jin Ding, Jian-Gao Fan and Liang Qiao

    Citation: BMC Gastroenterology 2014 14:195

    Content type: Research article

    Published on:

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