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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Underlying causes in Chinese children with recurrent acute liver failure (RALF), including liver crises less than full acute liver failure, are incompletely understood. We sought to address this by searching f...

    Authors: Jia-Qi Li, Yi-Ling Qiu, Jing-Yu Gong, Li-Min Dou, Yi Lu, A. S. Knisely, Mei-Hong Zhang, Wei-Sha Luan and Jian-She Wang

    Citation: BMC Gastroenterology 2017 17:77

    Content type: Research article

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  2. The gut microbiome exerts extensive roles in metabolism of nutrients, pharmaceuticals, organic chemicals. Little has been known for the role of gut microbiota in regulating cholesterol and bile acids in associ...

    Authors: Qihan Wang, Long Jiao, Chuanqi He, Haidong Sun, Qu Cai, Tianquan Han and Hai Hu

    Citation: BMC Gastroenterology 2017 17:74

    Content type: Research article

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  3. The Tokyo guideline for acute cholecystitis recommended percutaneous transhepatic gallbladder drainage followed by cholecystectomy for severe acute cholecystitis, but the optimal timing for the subsequent chol...

    Authors: Koetsu Inoue, Tatsuya Ueno, Orie Nishina, Daisuke Douchi, Kentaro Shima, Shinji Goto, Michinaga Takahashi, Chikashi Shibata and Hiroo Naito

    Citation: BMC Gastroenterology 2017 17:71

    Content type: Research article

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  4. Endoscopic papillectomy (EP) is reported to be a relatively safe and reliable procedure for complete resection of ampullary neoplasms. The aim of this study was to evaluate the therapeutic outcomes and complic...

    Authors: Sung Hoon Kang, Kook Hyun Kim, Tae Nyeun Kim, Min Kyu Jung, Chang Min Cho, Kwang Bum Cho, Ji Min Han, Ho Gak Kim and Hyun Soo Kim

    Citation: BMC Gastroenterology 2017 17:69

    Content type: Research article

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  5. The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patient...

    Authors: Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Nobuaki Azemoto, Aki Hasebe, Hirotaka Seike, Mari Nishiyama, Nobu Inada, Naozumi Shibata, Hideki Miyata, Tomoe Kawamura, Yusuke Imai, Akiko Ueno-Toshimori, Yoshinori Tanaka, Takashi Terao, Yoshiki Imamura…

    Citation: BMC Gastroenterology 2017 17:66

    Content type: Research article

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  6. Mac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis st...

    Authors: Hongqin Xu, Wenli Kong, Lei Liu, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Xiuzhu Gao, Huan Wang, Limei Qu, Yue Qi, Yu Pan and Junqi Niu

    Citation: BMC Gastroenterology 2017 17:62

    Content type: Research article

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  7. To assess the clinical validity of controlled attenuation parameter (CAP) in the diagnosis of hepatic steatosis in a series of overweight or obese children by using the imperfect gold standard methodology.

    Authors: Giovanna Ferraioli, Valeria Calcaterra, Raffaella Lissandrin, Marinella Guazzotti, Laura Maiocchi, Carmine Tinelli, Annalisa De Silvestri, Corrado Regalbuto, Gloria Pelizzo, Daniela Larizza and Carlo Filice

    Citation: BMC Gastroenterology 2017 17:61

    Content type: Research article

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  8. Chronic kidney disease is a significant complication after liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains unclear among LT recipients receiving sirolimus.

    Authors: Lung-Chih Li, Chien-Ning Hsu, Chih-Che Lin, Yu-Fan Cheng, Tsung-Hui Hu, Ding-Wei Chen, Chih-Hsiung Lee, Toshiaki Nakano and Chao-Long Chen

    Citation: BMC Gastroenterology 2017 17:58

    Content type: Research article

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  9. Advanced stages of liver cirrhosis lead to a dramatically increased mortality. For valid identification of these patients suitable biomarkers are essential. The most important biomarkers for liver function are...

    Authors: Thorsten Kaiser, Benedict Kinny-Köster, Michael Bartels, Thomas Berg, Markus Scholz, Cornelius Engelmann, Daniel Seehofer, Susen Becker, Uta Ceglarek and Joachim Thiery

    Citation: BMC Gastroenterology 2017 17:57

    Content type: Research article

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  10. Patients with chronic hepatitis C (HCV) infection have high prevalence of vitamin D deficiency. Genome-wide association study data has showed that several genetic variants within vitamin D cascade affect vitam...

    Authors: Kessarin Thanapirom, Sirinporn Suksawatamnuay, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Sombat Treeprasertsuk, Panarat Thaimai, Rujipat Wasitthankasem, Yong Poovorawan and Piyawat Komolmit

    Citation: BMC Gastroenterology 2017 17:54

    Content type: Research article

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  11. Controlled attenuation parameter (CAP) and liver stiffness (LS) measured by transient elastography (TE, Fibroscan®) have been used for steatosis and fibrosis assessment. We evaluated the effect of meal intake ...

    Authors: Kanittha Ratchatasettakul, Sasivimol Rattanasiri, Kwannapa Promson, Pranee Sringam and Abhasnee Sobhonslidsuk

    Citation: BMC Gastroenterology 2017 17:50

    Content type: Research article

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  12. Few studies have investigated the relationship between carotid-femoral pulse wave velocity (cfPWV) and serum alanine aminotransferase (ALT) normal-range levels across the world. The current analysis was design...

    Authors: Shihui Fu, Ying Lin, Leiming Luo and Ping Ye

    Citation: BMC Gastroenterology 2017 17:49

    Content type: Research article

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  13. Health care providers need solid evidence based data on cost differences between alternative surgical procedures for common surgical disorders. We aimed to compare small-incision open cholecystectomy (SIOC) an...

    Authors: Mats H. Rosenmüller, Erik Nilsson, Fredrik Lindberg, Sten-Olof Åberg and Markku M. Haapamäki

    Citation: BMC Gastroenterology 2017 17:48

    Content type: Research article

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  14. The long-term clinical outcomes of antiviral therapy for patients with chronic hepatitis C are uncertain in terms of hepatitis C virus (HCV)-related morbidity and mortality according to the response to antivir...

    Authors: Chang Seok Bang and Il Han Song

    Citation: BMC Gastroenterology 2017 17:46

    Content type: Research article

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  15. It has been shown that the proportion of natural killer T cells is markedly elevated during liver regeneration and their activation under different conditions can modulate this process. As natural killer T cel...

    Authors: Ami Ben Ya’acov, Hadar Meir, Lydia Zolotaryova, Yaron Ilan and Eyal Shteyer

    Citation: BMC Gastroenterology 2017 17:44

    Content type: Research article

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  16. Acute pancreatitis is a severe complication of endoscopic retrograde cholangiopancreatography (ERCP). Previous meta-analyses have shown that indomethacin effectively prevents this complication; however, the da...

    Authors: Jianhua Wan, Yuping Ren, Zhenhua Zhu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2017 17:43

    Content type: Research article

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  17. European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infectio...

    Authors: Jian-Hua Lei, Xu Yang, Xin-Qiang Xiao, Zi Chen and Feng Peng

    Citation: BMC Gastroenterology 2017 17:42

    Content type: Research article

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  18. There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare the long-term efficacy between them in...

    Authors: Ji Won Park, Kyeong Min Kwak, Sung Eun Kim, Myoung Kuk Jang, Ki Tae Suk, Dong Joon Kim, Sang Hoon Park, Myung Seok Lee, Hyoung Su Kim and Choong Kee Park

    Citation: BMC Gastroenterology 2017 17:39

    Content type: Research article

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  19. Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging endoscopic procedure, harboring a wide range of complexities within every single investigation. Classifications of the complex...

    Authors: Greger Olsson, Urban Arnelo, Fredrik Swahn, Björn Törnqvist, Lars Lundell and Lars Enochsson

    Citation: BMC Gastroenterology 2017 17:38

    Content type: Research article

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  20. Acute pancreatitis is a potentially lethal disease, with a rising incidence in the Western world. Yet, no pharmacological prevention or specific treatment for acute pancreatitis exists. Also, the connection wi...

    Authors: Tomas S. Bexelius, Rickard Ljung, Fredrik Mattsson, Yunxia Lu and Mats Lindblad

    Citation: BMC Gastroenterology 2017 17:36

    Content type: Research article

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  21. NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental model...

    Authors: Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo and Carmine Vecchione

    Citation: BMC Gastroenterology 2017 17:35

    Content type: Research article

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    The Correction to this article has been published in BMC Gastroenterology 2017 17:116

  22. Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Authors: Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    Citation: BMC Gastroenterology 2017 17:32

    Content type: Research article

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  23. In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Authors: Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    Citation: BMC Gastroenterology 2017 17:30

    Content type: Case report

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  24. Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Authors: Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    Citation: BMC Gastroenterology 2017 17:29

    Content type: Research article

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  25. A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Authors: Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    Citation: BMC Gastroenterology 2017 17:26

    Content type: Research article

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  26. Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucid...

    Authors: Yan-Ming Zhou, Cheng-Jun Sui, Xiao-Feng Zhang, Bin Li and Jia-Mei Yang

    Citation: BMC Gastroenterology 2017 17:25

    Content type: Research article

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  27. The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGF...

    Authors: Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang and Ming-Jen Chen

    Citation: BMC Gastroenterology 2017 17:22

    Content type: Research article

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  28. Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was success...

    Authors: Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka and Hiroyuki Ono

    Citation: BMC Gastroenterology 2017 17:20

    Content type: Case report

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  29. Delayed gastric emptying and bile reflux are common concerns in long-term survivors after Whipple surgery. The study was designed to assess modified retro colic retro gastric gastrojejunostomy in reducing macr...

    Authors: Rohan Chaminda Siriwardana, Rajapaksha Walimuni Mudiyanselage Anuradha Lokubandara, Shivanthi Janaki De Silva Hewavisenthi, Saumya Kumuduni Liyanage, Dona Subani Priyangika Jayatunge and Chandika Anuradha Habarakada Liyanage

    Citation: BMC Gastroenterology 2017 17:19

    Content type: Research article

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  30. The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of t...

    Authors: Naglaa F. A. Youssef, Mohamed El Kassas, Amany Farag and Ashley Shepherd

    Citation: BMC Gastroenterology 2017 17:18

    Content type: Research article

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  31. Activated hepatic stellate cell (HSC) is the main fibrogenic cell type in the injured liver. miRNA plays an important role in activation and proliferation of HSC.

    Authors: Bensong Duan, Jiangfeng Hu, Tongyangzi Zhang, Xu Luo, Yi Zhou, Shun Liu, Liang Zhu, Cheng Wu, Wenxiang Liu, Chao Chen and Hengjun Gao

    Citation: BMC Gastroenterology 2017 17:12

    Content type: Research article

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  32. Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into...

    Authors: Hella Wobser, Agnetha Gunesch and Frank Klebl

    Citation: BMC Gastroenterology 2017 17:10

    Content type: Research article

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  33. Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failu...

    Authors: Sanae Haga, Yimin and Michitaka Ozaki

    Citation: BMC Gastroenterology 2017 17:9

    Content type: Research article

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  34. Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possib...

    Authors: Zhongji Meng, Yonghong Zhang, Zhiqiang Wei, Ping Liu, Jian Kang, Yinhua Zhang, Deqiang Ma, Changzheng Ke, Yue Chen, Jie Luo and Zuojiong Gong

    Citation: BMC Gastroenterology 2017 17:6

    Content type: Research article

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  35. Risk adjustment is essential for valid comparison of patients’ health outcomes or performances of health care providers. Several risk adjustment methods for liver diseases are commonly used but the optimal app...

    Authors: Yuan Xu, Ning Li, Mingshan Lu, Elijah Dixon, Robert P. Myers, Rachel J. Jolley and Hude Quan

    Citation: BMC Gastroenterology 2017 17:5

    Content type: Research article

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  36. We aimed to examine the burden of intrahepatic cholangiocarcinoma (ICC) in Thailand and identify the prognostic factors for all-causes of death.

    Authors: Sombat Treeprasertsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Roongruedee Chaiteerakij, Kessarin Thanapirom, Pisaln Mairiang, Kookwan Sawadpanich, Kanokwan Sonsiri, Varocha Mahachai and Kamthorn Phaosawasdi

    Citation: BMC Gastroenterology 2017 17:3

    Content type: Research article

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  37. Lactobacilli are non-spore forming, lactic acid producing, gram-positive rods. They are a part of the normal gastrointestinal and genitourinary microbiota and have rarely been reported to be the cause of infec...

    Authors: Muhammed Sherid, Salih Samo, Samian Sulaiman, Husein Husein, Humberto Sifuentes and Subbaramiah Sridhar

    Citation: BMC Gastroenterology 2016 16:138

    Content type: Case report

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  38. The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs.

    Authors: Maria Stepanova, Mehmet Sayiner, Leyla de Avila, Zahra Younoszai, Andrei Racila and Zobair M. Younossi

    Citation: BMC Gastroenterology 2016 16:137

    Content type: Research article

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  39. Toxic liver diseases are mainly caused by drug-induced liver injury (DILI). We assessed incidences and outcomes of DILI including associated factors for mortality.

    Authors: Abhasnee Sobhonslidsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Wirichada Pan-ngum and Kamthorn Phaosawasdi

    Citation: BMC Gastroenterology 2016 16:135

    Content type: Research article

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  40. Although elevated levels of lactoferrin provide a biomarker for inflammatory bowel diseases and colorectal cancer, the clinical significance of these elevated levels in ascitic fluid of patients with ascites c...

    Authors: Sang Soo Lee, Hyun Ju Min, Ja Yun Choi, Hyun Chin Cho, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Jin Hyun Kim and Ok-Jae Lee

    Citation: BMC Gastroenterology 2016 16:132

    Content type: Research article

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  41. Alcoholic Hepatitis (AH) is major source of alcohol-related mortality and health care expenditures in the United States. There is insufficient information regarding the role of race and ethnicity on healthcare...

    Authors: Folasade P. May, Vineet S. Rolston, Elliot B. Tapper, Ashwini Lakshmanan, Sammy Saab and Vinay Sundaram

    Citation: BMC Gastroenterology 2016 16:129

    Content type: Research article

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  42. Cirrhosis patients are prescribed multiple medications for their liver disease and comorbidities. Discrepancies between medicines consumed by patients and those documented in the medical record may contribute ...

    Authors: Kelly L. Hayward, Patricia C. Valery, W. Neil Cottrell, Katharine M. Irvine, Leigh U. Horsfall, Caroline J. Tallis, Veronique S. Chachay, Brittany J Ruffin, Jennifer H. Martin and Elizabeth E. Powell

    Citation: BMC Gastroenterology 2016 16:114

    Content type: Research article

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  43. Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary great...

    Authors: Omar Banafea, Fabian Pius Mghanga, Jinfang Zhao, Ruifeng Zhao and Liangru Zhu

    Citation: BMC Gastroenterology 2016 16:108

    Content type: Research article

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  44. Plastic and covered metal stents need to be removed or exchanged within appropriate time in case of undesirable complications. However, it is not uncommon that patients do not follow the recommendation for fur...

    Authors: Yong Gu, Limei Wang, Lina Zhao, Zhiguo Liu, Hui Luo, Qin Tao, Rongchun Zhang, Shuixiang He, Xiangping Wang, Rui Huang, Linhui Zhang, Yanglin Pan and Xuegang Guo

    Citation: BMC Gastroenterology 2016 16:105

    Content type: Research article

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  45. Sometimes, no definite filling defect could be found by cholangiogram (ERC) during the endoscopic retrograde cholangio-pancreatiographic (ERCP) exam; even prior images had evidence of common bile duct stones (...

    Authors: Po-Hung Chiang, Kwok-Hung Lai, Tzung-Jiun Tsai, Kung-Hung Lin, Kai-Ming Wang, Sung-Shuo Kao, Wei-Chih Sun, Jin-Shiung Cheng, Ping-I Hsu, Wei-Lun Tsai, Wen-Chi Chen, Yun-Da Li, E-Ming Wang, Huey-Shyan Lin and Hoi-Hung Chan

    Citation: BMC Gastroenterology 2016 16:102

    Content type: Research article

    Published on:

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