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Hepatobiliary and pancreatic disorders

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.


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  1. Low 25-Hydroxy-vitamin-D; “25(OH)-D3” serum and vitamin D receptor (VDR) levels were recently correlated to advanced fibrosis. However, VDR mechanism in liver fibrosis modulations is not well understood. In th...

    Authors: Ahmad Salhab, Johnny Amer, Lu Yinying and Rifaat Safadi

    Citation: BMC Gastroenterology 2020 20:102

    Content type: Research article

    Published on:

  2. Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofreq...

    Authors: Chih-Wen Lin, Yaw-Sen Chen, Gin-Ho Lo, Yao-Chun Hsu, Chia-Chang Hsu, Tsung-Chin Wu, Jen-Hao Yeh, Pojen Hsiao, Pei-Min Hsieh, Hung-Yu Lin, Chih-Wen Shu and Chao-Ming Hung

    Citation: BMC Gastroenterology 2020 20:99

    Content type: Research article

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  3. Statin may confer anticancer effect. However, the association between statin and risk of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) or hepatitis C (HCV) virus infection remains inc...

    Authors: Xiaofei Li, Lina Sheng, Liwen Liu, Yongtao Hu, Yongxin Chen and Lianqing Lou

    Citation: BMC Gastroenterology 2020 20:98

    Content type: Research article

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  4. Aceruloplasminaemia is a very rare autosomal recessive disorder caused by a mutation in the ceruloplasmin gene, which is clinically manifested by damage to the nervous system and retinal degeneration. This cla...

    Authors: Mária Ondrejkovičová, Sylvia Dražilová, Monika Drakulová, Juan López Siles, Renáta Zemjarová Mezenská, Petra Jungová, Martin Fabián, Boris Rychlý and Miroslav Žigrai

    Citation: BMC Gastroenterology 2020 20:95

    Content type: Case report

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  5. There are conflicting data regarding the risk of hepatocellular carcinoma (HCC) after direct-acting antiviral agent (DAA) treatment. Risk of HCC in HCV genotype-3 infected persons after DAA therapy is not well...

    Authors: Ghias Un Nabi Tayyab, Shafqat Rasool, Bilal Nasir, Ghazala Rubi, Abdul-Badi Abou-Samra and Adeel A. Butt

    Citation: BMC Gastroenterology 2020 20:93

    Content type: Research article

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  6. Endoscopic balloon dilation and/or plastic stent placement has been a standard method for treating biliary strictures complicated post living donor liver transplantation (LDLT). The strictures may be refractor...

    Authors: Mitsuhito Koizumi, Teru Kumagi, Taira Kuroda, Yoshiki Imamura, Kozue Kanemitsu, Kohei Ogawa, Yasutsugu Takada and Yoichi Hiasa

    Citation: BMC Gastroenterology 2020 20:92

    Content type: Research article

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  7. Liver disease is a leading cause of morbidity and mortality among Human Immunodeficiency virus (HIV) infected patients; however no consensus exists on HIV-related risk factors for it. The aim of this study was...

    Authors: Theodoros Androutsakos, Maria Schina, Abraham Pouliakis, Athanasios Kontos, Nikolaos Sipsas and Gregorios Hatzis

    Citation: BMC Gastroenterology 2020 20:91

    Content type: Research article

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  8. Gastroesophageal variceal hemorrhage is the most severe complication of portal hypertension, with a high mortality rate. The current recommendations for gastroesophageal varices include pharmacological treatme...

    Authors: Yujen Tseng, Lili Ma, Minzhi Lv, Tiancheng Luo, Chengfeng Liu, Yichao Wei, Chu Liu, Ji Zhou, Zhiping Yan, Pengju Xu, Guohua Hu, Hong Ding, Yuan Ji, Shiyao Chen and Jian Wang

    Citation: BMC Gastroenterology 2020 20:83

    Content type: Research article

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  9. Vascular invasion is an important criterion for resectability and deciding the therapeutic strategy for pancreatic ductal adenocarcinoma (PDAC), but imaging diagnosis is currently difficult. Endoscopic ultraso...

    Authors: Kenta Yamada, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroyuki Tanaka, Masanao Nakamura, Ryoji Miyahara, Masatoshi Ishigami, Yoshiki Hirooka and Mitsuhiro Fujishiro

    Citation: BMC Gastroenterology 2020 20:81

    Content type: Research article

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  10. This study aimed to develop prognostic models for predicting 28- and 90-day mortality rates of hepatitis B virus (HBV)-associated acute-on-chronic liver failure (HBV-ACLF) through artificial neural network (AN...

    Authors: Yixin Hou, Qianqian Zhang, Fangyuan Gao, Dewen Mao, Jun Li, Zuojiong Gong, Xinla Luo, Guoliang Chen, Yong Li, Zhiyun Yang, Kewei Sun and Xianbo Wang

    Citation: BMC Gastroenterology 2020 20:75

    Content type: Research article

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  11. Non-alcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease nowadays. Changes in diet and lifestyle have led to a dramatic increase in the prevalence of NAFLD around t...

    Authors: Shu-ting Wang, Jing Zheng, He-wei Peng, Xiao-lin Cai, Xin-ting Pan, Hui-quan Li, Qi-zhu Hong and Xian-E Peng

    Citation: BMC Gastroenterology 2020 20:66

    Content type: Research article

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  12. Ineffective antibiotic therapy increases mortality of acute cholangitis. The choice of antibiotics should reflect local resistance patterns and avoid the overuse of broad-spectrum agents. In this study, we ana...

    Authors: Tassilo Kruis, Sarah Güse-Jaschuck, Britta Siegmund, Thomas Adam and Hans-Jörg Epple

    Citation: BMC Gastroenterology 2020 20:65

    Content type: Research article

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  13. Endoscopic retrograde cholangio-pancreatography (ERCP) is commonly performed in the management of pancreatic and biliary disease. Duodenoscopes are specialized endoscopes used to perform ERCP, and inherent to ...

    Authors: Nauzer Forbes, B. Joseph Elmunzer, Thibault Allain, Millie Chau, Hannah F. Koury, Sydney Bass, Paul J. Belletrutti, Martin J. Cole, Emmanuel Gonzalez-Moreno, Ahmed Kayal, Puja Kumar, Rachid Mohamed, Christian Turbide, Andre G. Buret and Steven J. Heitman

    Citation: BMC Gastroenterology 2020 20:64

    Content type: Study protocol

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  14. Crigler Najjar type 1 is a rare autosomal recessive condition caused by the absence of UDPGT enzyme due to mutations in the UGT1A1 gene. This enzyme is responsible for elimination of unconjugated bilirubin fro...

    Authors: Sailaja Valmiki, Kiran Kumar Mandapati, Leela Krishna Vamsee Miriyala, Chayarani Chandrashekhar Kelgeri, Mohamed Rela, Naresh P. Shanmugam and Durga Rao Vegulada

    Citation: BMC Gastroenterology 2020 20:62

    Content type: Case report

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  15. Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hypon...

    Authors: Shunsuke Shiba, Po-sung Chu, Nobuhiro Nakamoto, Karin Yamataka, Nobuhito Taniki, Keisuke Ojiro, Akihiro Yamaguchi, Rei Morikawa, Aya Yoshida, Akihiko Ikura, Hirotoshi Ebinuma, Hidetsugu Saito and Takanori Kanai

    Citation: BMC Gastroenterology 2020 20:53

    Content type: Research article

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  16. We investigated real-world effectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of patients infected with hepatitis C virus (HCV) genotypes 1, 2, 3, 4, or 6.

    Authors: Phunchai Charatcharoenwitthaya, Virasak Wongpaitoon, Piyawat Komolmit, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Teerha Piratvisuth, Theeranun Sanpajit, Chinnavat Sutthivana, Chalermrat Bunchorntavakul, Abhasnee Sobhonslidsuk, Soonthorn Chonprasertsuk, Chotipong Siripipattanamongkol, Supatsri Sethasine and Tawesak Tanwandee

    Citation: BMC Gastroenterology 2020 20:47

    Content type: Research article

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  17. Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Within the spectrum of NAFLD, non-alcoholic steatohepatitis (NASH) in combination with hepatic inflammation and fibro...

    Authors: Atsuko Takai, Kentaro Kikuchi, Mayuko Ichimura, Koichi Tsuneyama, Yuki Moritoki, Kotaro Matsumoto, Hiromichi Tsunashima, Takeshi Onda, Noriyuki Kuniyoshi, Tomoyuki Nariyama, Sho Ohyatsu, Juri Kubota, Kozue Nagumo, Shinpei Sato, Masumi Hara and Hiroshi Miyakawa

    Citation: BMC Gastroenterology 2020 20:46

    Content type: Research article

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  18. The level and profiles of blood free carnitine and acylcarnitines, obtained by acylcarnitine analysis using tandem mass spectrometry, reflect various metabolic conditions. We aimed to examine the level of free...

    Authors: Hisamitsu Miyaaki, Hironori Kobayashi, Satoshi Miuma, Masanori Fukusima, Ryu Sasaki, Masafumi Haraguchi and Kazuhiko Nakao

    Citation: BMC Gastroenterology 2020 20:41

    Content type: Research article

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  19. One major etiology of hepatic sinusoidal obstruction syndrome (HSOS) in China is the intake of pyrrolizidine alkaloids (PAs). Since PAs-induced HSOS is a rare disease that has not been clearly characterized un...

    Authors: Fang Liu, Xinxin Rong, Hui Guo, Dong Xu, Chang Liu, Lingling Meng, Xiaoqian Yang, Tingting Guo, Xuefeng Kan and Yuhu Song

    Citation: BMC Gastroenterology 2020 20:30

    Content type: Research article

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  20. Chronic hepatitis delta virus (HDV) infection causes severe liver disease which often leads to cirrhosis and hepatocellular carcinoma (HCC). Aim of this study was to establish the disease severity and prognost...

    Authors: Jan-Hendrik Bockmann, Marcel Grube, Vanessa Hamed, Johann von Felden, Johanna Landahl, Malte Wehmeyer, Katja Giersch, Michaela T. Hall, John M. Murray, Maura Dandri, Stefan Lüth, Ansgar W. Lohse, Marc Lütgehetmann and Julian Schulze Zur Wiesch

    Citation: BMC Gastroenterology 2020 20:24

    Content type: Research article

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  21. Biliary tract cancers (BTC) have a poor prognosis even after curative resection because of frequent local and distant recurrences. Therefore, the importance of adjuvant therapy in BTC has been advocated to imp...

    Authors: Hyera Kim, Mi Hwa Heo and Jin Young Kim

    Citation: BMC Gastroenterology 2020 20:20

    Content type: Research article

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    The Correction to this article has been published in BMC Gastroenterology 2020 20:207

  22. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has high accuracy and a low complication rate; therefore, it has been widely used as a useful tool for diagnosis of and to determine treatment stra...

    Authors: Nami Sato, Shigetsugu Takano, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Takashi Mishima, Eri Nakadai, Rintaro Mikata, Naoya Kato and Masayuki Ohtsuka

    Citation: BMC Gastroenterology 2020 20:13

    Content type: Case report

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  23. ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the s...

    Authors: Xuefeng Ma, Shousheng Liu, Jie Zhang, Mengzhen Dong, Yifen Wang, Mengke Wang and Yongning Xin

    Citation: BMC Gastroenterology 2020 20:10

    Content type: Research article

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  24. The anti-immunological rejection therapy for small-for-size syndrome (SFSS) after live donor liver transplantation (LDLT) play a central role in keeping graft survival. The hepatocyte number and grafts functio...

    Authors: Yanhu Feng, Zhijian Han, Zedong Feng, Bofang Wang, Huijuan Cheng, Luxi Yang, Yangbing Li, Baohong Gu, Xuemei Li, Yahao Li, Yumin Li, Chen Wang and Hao Chen

    Citation: BMC Gastroenterology 2020 20:7

    Content type: Research article

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  25. Aspirin has been found to lower the occurrence rates of some cancers through the inhibition of the cyclooxygenase enzyme. For example, there is a well-known association between aspirin use and the occurrence o...

    Authors: Yen-Hsiang Liao, Ren-Jun Hsu, Tzu-Hwei Wang, Chen-Ta Wu, Sheng-Yao Huang, Chung-Y. Hsu, Yuan-Chih Su, Wen-Lin Hsu and Dai-Wei Liu

    Citation: BMC Gastroenterology 2020 20:6

    Content type: Research article

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  26. Recent evidence cautions against the use of non-selective beta-blockers (NSBB) in patients with refractory ascites or spontaneous bacterial peritonitis while other data suggests a survival benefit in patients ...

    Authors: Taiwo Ngwa, Eric Orman, Eduardo Vilar Gomez, Raj Vuppalanchi, Chandrashekhar Kubal, Naga Chalasani and Marwan Ghabril

    Citation: BMC Gastroenterology 2020 20:4

    Content type: Research article

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  27. The multifactorial mechanisms driving negative health outcomes among risky drinkers with HIV may include immunosenescence. Immunosenescence, aging of the immune system, may be accentuated in HIV and leads to p...

    Authors: Kaku So-Armah, Matthew Freiberg, Debbie Cheng, Joseph K. Lim, Natalia Gnatienko, Gregory Patts, Margaret Doyle, Daniel Fuster, Dmitry Lioznov, Evgeny Krupitsky and Jeffrey Samet

    Citation: BMC Gastroenterology 2019 20:1

    Content type: Research article

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  28. Statin has been more and more widely used in chronic liver disease, however, existed studies have attained contradictory results. According to the present study, we aimed to test the efficacy and safety of sta...

    Authors: Yue Gu, Xueqin Yang, Hang Liang and Deli Li

    Citation: BMC Gastroenterology 2019 19:231

    Content type: Research article

    Published on:

  29. Hepatocellular carcinoma (HCC) is a common human malignant cancer due to a high metastatic capacity and the recurrence rate is also high. This study is aim to investigate the role of musashi1 as a potential bi...

    Authors: Qiuhua Liu, Cuijie Zhou and Bo Zhang

    Citation: BMC Gastroenterology 2019 19:230

    Content type: Research article

    Published on:

  30. A large-scale Japanese study showed that low skeletal muscle index (SMI) and intramuscular fat (IMF) deposition are associated with hepatocellular carcinoma (HCC) survival. Here, we evaluated the effects of SM...

    Authors: Yan Mardian, Yoshihiko Yano, Neneng Ratnasari, Lina Choridah, Widya Wasityastuti, Nurhuda Hendra Setyawan and Yoshitake Hayashi

    Citation: BMC Gastroenterology 2019 19:229

    Content type: Research article

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  31. Endoscopic nasobiliary drainage (ENBD) is widely used for biliary decompression in patients with biliary disease. However, it is difficult to reposition a nasobiliary catheter from the mouth to nostril. We dev...

    Authors: Seong Ji Choi, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Soon Ho Um, Chang Duck Kim and Chi Hyuk Oh

    Citation: BMC Gastroenterology 2019 19:222

    Content type: Research article

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  32. Endoscopic ultrasound is useful for obtaining high-resolution images of pancreaticobiliary diseases, but is not readily available for physical checkups. In this study, we evaluated the safety and efficacy of s...

    Authors: Daisuke Uchida, Hironari Kato, Kazuyuki Matsumoto, Yuki Ishihara, Akihiro Matsumi, Yosuke Saragai, Saimon Takada, Shuntaro Yabe, Shinichiro Muro, Takeshi Tomoda, Shigeru Horiguchi and Hiroyuki Okada

    Citation: BMC Gastroenterology 2019 19:220

    Content type: Research article

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  33. Portal vein thrombosis (PVT) is a common complication of cirrhosis. However, in patients with PVT and cirrhosis, there is no clear evidence supporting effective treatment modalities. In this study, we examined...

    Authors: Takehiro Hayashi, Hajime Takatori, Rika Horii, Kouki Nio, Takeshi Terashima, Noriho Iida, Masaaki Kitahara, Tetsuro Shimakami, Kuniaki Arai, Kazuya Kitamura, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda…

    Citation: BMC Gastroenterology 2019 19:217

    Content type: Research article

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  34. Endoscopic treatment of post-cholecystectomy biliary strictures (PCBS) with multiple plastic biliary stents placed sequentially is a minimally invasive alternative to surgery but requires multiple intervention...

    Authors: Andrea Tringali, D. Nageshwar Reddy, Thierry Ponchon, Horst Neuhaus, Ferrán González-Huix Lladó, Claudio Navarrete, Marco J. Bruno, Paul P. Kortan, Sundeep Lakhtakia, Joyce Peetermans, Matthew Rousseau, David Carr-Locke, Jacques Devière and Guido Costamagna

    Citation: BMC Gastroenterology 2019 19:214

    Content type: Research article

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  35. The clinical value of the controlling nutritional status (CONUT) score in hepatocellular carcinoma (HCC) has increased. The aim of this meta-analysis was to systematically review the association between the CO...

    Authors: Kosei Takagi, Piotr Domagala, Wojciech G. Polak, Stefan Buettner and Jan N. M. Ijzermans

    Citation: BMC Gastroenterology 2019 19:211

    Content type: Research article

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  36. Drug induced liver injury (DILI) is an important cause of acute liver injury and accounts for approximately 10% of all cases of acute hepatitis. Both prescription and natural health products (NHPs) have been i...

    Authors: Tyler Pitre, Jasmine Mah, Jaclyn Vertes, Rosario Rebello and Julie Zhu

    Citation: BMC Gastroenterology 2019 19:199

    Content type: Case report

    Published on:

  37. Pancreatic cavernous hemangioma is an extremely rare benign tumor that is difficult to diagnose on an imaging examination, and its histopathological examination has rarely been reported.

    Authors: Tao Lianyuan, Wang Yafeng, Yu Haibo, Dong Yadong, Ma Jiahao, Lu Yuanxiang and Li Deyu

    Citation: BMC Gastroenterology 2019 19:197

    Content type: Case report

    Published on:

  38. Although isolating Glissonean pedicles and hepatic veins are critical procedures during anatomical hepatectomy, there is no standardized approach. We propose the novel Laennec’s approach for laparoscopic anato...

    Authors: Yue Hu, Jiong Shi, Shaohe Wang, Wenjie Zhang, Xitai Sun, Beicheng Sun and Decai Yu

    Citation: BMC Gastroenterology 2019 19:194

    Content type: Research article

    Published on:

  39. Syphilis is a common disease that has been researched and focused on for many years, however, syphilitic hepatitis has not been well-recognized. We report this case of syphilitic hepatitis with intrahepatic chole...

    Authors: Jiaofeng Huang, Su Lin, Mingfang Wang, Bo Wan and Yueyong Zhu

    Citation: BMC Gastroenterology 2019 19:191

    Content type: Case report

    Published on:

    The Correspondence to this article has been published in BMC Gastroenterology 2020 20:379

  40. Hepatic epithelioid hemangioendothelioma (HEH) is rare; it is reported in < 1 person in 1,000,000 individuals. For accurate diagnosis, information regarding multiple graphic modalities in HEH is required. Howe...

    Authors: Jun Arai, Yuu Shimozuma, Yumi Otoyama, Ikuya Sugiura, Yoko Nakajima, Eiichi Hayashi, Atsushi Kajiwara, Risa Omori, Shojiro Uozumi, Miyuki Miyashita, Manabu Uchikoshi, Hiroyoshi Doi, Masashi Sakaki, Tianpeng Wang, Junichi Eguchi, Takayoshi Ito…

    Citation: BMC Gastroenterology 2019 19:187

    Content type: Case report

    Published on:

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    60 days to first decision for all manuscripts
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    3.441 - 5-year Impact Factor
    1.128 - SNIP (Source-Normalized Impact per Paper)
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