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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Content type: Research article

    Liver failure (LF) is associated with prolonged hospital stay, increased cost and substantial mortality. Due to the limited number of donor organs, extracorporeal liver support is suggested as an appealing con...

    Authors: Wolfgang Huber, Benedikt Henschel, Roland Schmid and Ahmed Al-Chalabi

    Citation: BMC Gastroenterology 2017 17:32

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  2. Content type: Case report

    In patients with advanced hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only systemic treatment that has been shown to increase overall survival. However, similar to other tyrosine...

    Authors: Catherine Atkin, Philip Earwaker, Arvind Pallan, Shishir Shetty, Pankaj Punia and Yuk Ting Ma

    Citation: BMC Gastroenterology 2017 17:30

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  3. Content type: Research article

    Gastrointestinal fistula (GIF) in severe acute pancreatitis (SAP) is considered as a sparse episode and studied sporadically in the literature. There is paucity of data on the prediction of the effect on risk ...

    Authors: Zhipeng Hua, Yongjie Su, Xuefeng Huang, Kang Zhang, Zhengyu Yin, Xiaoming Wang and Pingguo Liu

    Citation: BMC Gastroenterology 2017 17:29

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  4. Content type: Research article

    A Phase 2a, open-label study (NCT01724086) was conducted to assess the efficacy and safety of a once-daily, 2-direct-acting-antiviral-agent (2-DAA) combination of simeprevir + TMC647055/ritonavir ± ribavirin a...

    Authors: Stefan Bourgeois, Hans Van Vlierberghe, Christophe Moreno, Hans Orlent, Frederik Nevens, Keikawus Arastéh, Yves Horsmans, Jörn M. Schattenberg, Peter Buggisch, Sven Francque, Leen Vijgen, Thomas N. Kakuda, Eva Hoeben, Donghan Luo, An Vandebosch, Bert Jacquemyn…

    Citation: BMC Gastroenterology 2017 17:26

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  5. Content type: Research article

    Little is known about the prognostic impact of cirrhosis on long-term survival of patients with combined hepatocellular-cholangiocarcinoma (cHCC-CC) after hepatic resection. The aim of this study was to elucid...

    Authors: Yan-Ming Zhou, Cheng-Jun Sui, Xiao-Feng Zhang, Bin Li and Jia-Mei Yang

    Citation: BMC Gastroenterology 2017 17:25

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  6. Content type: Research article

    The change of estimated glomerular filtration rate (eGFR) with off-treatment nucleos(t)ide analogues (NA) in chronic hepatitis B patients (CHB) is unclear. This study is aimed to evaluate the off-treatment eGF...

    Authors: Yang-Sheng Lin, Shou-Chuan Shih, Horng-Yuan Wang, Ching-Chung Lin, Chen-Wang Chang and Ming-Jen Chen

    Citation: BMC Gastroenterology 2017 17:22

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  7. Content type: Case report

    Histological confirmation is needed when the pancreatic lesions is uncertain for neoplastic or nonneoplastic. Current case with multicentric pancreatic carcinomas showing indefinite clinical images was success...

    Authors: Yoshihiro Kishida, Hiroyuki Matsubayashi, Keiko Sasaki, Shinsaku Honda, Sunao Uemura, Katsuhiko Uesaka, Akiko Todaka and Hiroyuki Ono

    Citation: BMC Gastroenterology 2017 17:20

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  8. Content type: Research article

    Delayed gastric emptying and bile reflux are common concerns in long-term survivors after Whipple surgery. The study was designed to assess modified retro colic retro gastric gastrojejunostomy in reducing macr...

    Authors: Rohan Chaminda Siriwardana, Rajapaksha Walimuni Mudiyanselage Anuradha Lokubandara, Shivanthi Janaki De Silva Hewavisenthi, Saumya Kumuduni Liyanage, Dona Subani Priyangika Jayatunge and Chandika Anuradha Habarakada Liyanage

    Citation: BMC Gastroenterology 2017 17:19

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  9. Content type: Research article

    The Egyptian government introduced the first directly acting antivirals (DAAs) into Egypt through the government funded National Treatment Program. As yet, there has been no investigation into the effects of t...

    Authors: Naglaa F. A. Youssef, Mohamed El Kassas, Amany Farag and Ashley Shepherd

    Citation: BMC Gastroenterology 2017 17:18

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  10. Content type: Research article

    Activated hepatic stellate cell (HSC) is the main fibrogenic cell type in the injured liver. miRNA plays an important role in activation and proliferation of HSC.

    Authors: Bensong Duan, Jiangfeng Hu, Tongyangzi Zhang, Xu Luo, Yi Zhou, Shun Liu, Liang Zhu, Cheng Wu, Wenxiang Liu, Chao Chen and Hengjun Gao

    Citation: BMC Gastroenterology 2017 17:12

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  11. Content type: Research article

    Patients with biliary obstruction are at high risk to develop septic complications after endoscopic retrograde cholangiography (ERC). We evaluated the benefits of local application of antimicrobial agents into...

    Authors: Hella Wobser, Agnetha Gunesch and Frank Klebl

    Citation: BMC Gastroenterology 2017 17:10

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  12. Content type: Research article

    Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failu...

    Authors: Sanae Haga, Yimin and Michitaka Ozaki

    Citation: BMC Gastroenterology 2017 17:9

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  13. Content type: Research article

    Studies have revealed that resistin plays a role as an intrahepatic cytokine with proinflammatory activities. This study investigated the association between serum resistin and fibrosis severity and the possib...

    Authors: Zhongji Meng, Yonghong Zhang, Zhiqiang Wei, Ping Liu, Jian Kang, Yinhua Zhang, Deqiang Ma, Changzheng Ke, Yue Chen, Jie Luo and Zuojiong Gong

    Citation: BMC Gastroenterology 2017 17:6

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  14. Content type: Research article

    Risk adjustment is essential for valid comparison of patients’ health outcomes or performances of health care providers. Several risk adjustment methods for liver diseases are commonly used but the optimal app...

    Authors: Yuan Xu, Ning Li, Mingshan Lu, Elijah Dixon, Robert P. Myers, Rachel J. Jolley and Hude Quan

    Citation: BMC Gastroenterology 2017 17:5

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  15. Content type: Research article

    We aimed to examine the burden of intrahepatic cholangiocarcinoma (ICC) in Thailand and identify the prognostic factors for all-causes of death.

    Authors: Sombat Treeprasertsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Roongruedee Chaiteerakij, Kessarin Thanapirom, Pisaln Mairiang, Kookwan Sawadpanich, Kanokwan Sonsiri, Varocha Mahachai and Kamthorn Phaosawasdi

    Citation: BMC Gastroenterology 2017 17:3

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  16. Content type: Case report

    Lactobacilli are non-spore forming, lactic acid producing, gram-positive rods. They are a part of the normal gastrointestinal and genitourinary microbiota and have rarely been reported to be the cause of infec...

    Authors: Muhammed Sherid, Salih Samo, Samian Sulaiman, Husein Husein, Humberto Sifuentes and Subbaramiah Sridhar

    Citation: BMC Gastroenterology 2016 16:138

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  17. Content type: Research article

    The use of HCV-positive livers for HCV-positive recipients is becoming more common. Our aim is to evaluate long-term outcomes in liver transplant recipients transplanted with HCV antibody-positive organs.

    Authors: Maria Stepanova, Mehmet Sayiner, Leyla de Avila, Zahra Younoszai, Andrei Racila and Zobair M. Younossi

    Citation: BMC Gastroenterology 2016 16:137

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  18. Content type: Research article

    Toxic liver diseases are mainly caused by drug-induced liver injury (DILI). We assessed incidences and outcomes of DILI including associated factors for mortality.

    Authors: Abhasnee Sobhonslidsuk, Kittiyod Poovorawan, Ngamphol Soonthornworasiri, Wirichada Pan-ngum and Kamthorn Phaosawasdi

    Citation: BMC Gastroenterology 2016 16:135

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  19. Content type: Research article

    Although elevated levels of lactoferrin provide a biomarker for inflammatory bowel diseases and colorectal cancer, the clinical significance of these elevated levels in ascitic fluid of patients with ascites c...

    Authors: Sang Soo Lee, Hyun Ju Min, Ja Yun Choi, Hyun Chin Cho, Jin Joo Kim, Jae Min Lee, Hong Jun Kim, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Jin Hyun Kim and Ok-Jae Lee

    Citation: BMC Gastroenterology 2016 16:132

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  20. Content type: Research article

    Alcoholic Hepatitis (AH) is major source of alcohol-related mortality and health care expenditures in the United States. There is insufficient information regarding the role of race and ethnicity on healthcare...

    Authors: Folasade P. May, Vineet S. Rolston, Elliot B. Tapper, Ashwini Lakshmanan, Sammy Saab and Vinay Sundaram

    Citation: BMC Gastroenterology 2016 16:129

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  21. Content type: Research article

    Cirrhosis patients are prescribed multiple medications for their liver disease and comorbidities. Discrepancies between medicines consumed by patients and those documented in the medical record may contribute ...

    Authors: Kelly L. Hayward, Patricia C. Valery, W. Neil Cottrell, Katharine M. Irvine, Leigh U. Horsfall, Caroline J. Tallis, Veronique S. Chachay, Brittany J Ruffin, Jennifer H. Martin and Elizabeth E. Powell

    Citation: BMC Gastroenterology 2016 16:114

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  22. Content type: Research article

    Previous studies have demonstrated that endoscopic ultrasound-fine needle aspiration (EUS-FNA) is a reliable tool for diagnosing pancreatic lesions; however, the reported sensitivity and specificity vary great...

    Authors: Omar Banafea, Fabian Pius Mghanga, Jinfang Zhao, Ruifeng Zhao and Liangru Zhu

    Citation: BMC Gastroenterology 2016 16:108

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  23. Content type: Research article

    Plastic and covered metal stents need to be removed or exchanged within appropriate time in case of undesirable complications. However, it is not uncommon that patients do not follow the recommendation for fur...

    Authors: Yong Gu, Limei Wang, Lina Zhao, Zhiguo Liu, Hui Luo, Qin Tao, Rongchun Zhang, Shuixiang He, Xiangping Wang, Rui Huang, Linhui Zhang, Yanglin Pan and Xuegang Guo

    Citation: BMC Gastroenterology 2016 16:105

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  24. Content type: Research article

    Sometimes, no definite filling defect could be found by cholangiogram (ERC) during the endoscopic retrograde cholangio-pancreatiographic (ERCP) exam; even prior images had evidence of common bile duct stones (...

    Authors: Po-Hung Chiang, Kwok-Hung Lai, Tzung-Jiun Tsai, Kung-Hung Lin, Kai-Ming Wang, Sung-Shuo Kao, Wei-Chih Sun, Jin-Shiung Cheng, Ping-I Hsu, Wei-Lun Tsai, Wen-Chi Chen, Yun-Da Li, E-Ming Wang, Huey-Shyan Lin and Hoi-Hung Chan

    Citation: BMC Gastroenterology 2016 16:102

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  25. Content type: Research article

    Recent data shows that patients with severe acute pancreatic might benefit from early intensive therapy, enteral nutrition and timely transfer to specialized centers. The early prophylactic use of antibiotics ...

    Authors: Andrius Karpavicius, Zilvinas Dambrauskas, Audrius Gradauskas, Arturas Samuilis, Kristina Zviniene, Juozas Kupcinskas, Gintautas Brimas, Artur Meckovski, Audrius Sileikis and Kestutis Strupas

    Citation: BMC Gastroenterology 2016 16:99

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  26. Content type: Research article

    Roux-en-Y reconstructive surgery excludes the biliopancreatic system from conventional endoscopic access. Balloon-assisted enteroscopy allows therapeutic endoscopic retrograde cholangiopancreatography (ERCP) i...

    Authors: Michael De Koning and Tom G. Moreels

    Citation: BMC Gastroenterology 2016 16:98

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  27. Content type: Research article

    This study analyzes the clinicopathologic and radiologic characteristics of malignant serous cystic neoplasm (SCN) of the pancreas through systematic review and an institutional case report.

    Authors: Jimi Huh, Jae Ho Byun, Seung-Mo Hong, Kyung Won Kim, Jin Hee Kim, Seung Soo Lee, Hyoung Jung Kim and Moon-Gyu Lee

    Citation: BMC Gastroenterology 2016 16:97

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  28. Content type: Research article

    Portal hypertensive gastropathy (PHG) is a frequently overlooked complication of liver cirrhosis (LC). The clinical implications of PHG as a prognostic factor of LC or a predictive factor for the development o...

    Authors: Chang Seok Bang, Hyo Sun Kim, Ki Tae Suk, Sung Eun Kim, Ji Won Park, Seung Ha Park, Hyoung Su Kim, Myoung Kuk Jang, Sang Hoon Park, Myung Seok Lee, Choong Kee Park and Dong Joon Kim

    Citation: BMC Gastroenterology 2016 16:93

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  29. Content type: Case report

    Fibrinogen storage disease (FSD) is a rare autosomal-dominant disorder caused by mutation in FGG, encoding the fibrinogen gamma chain. Here we report the first Han Chinese patient with FSD, caused by de novo fibr...

    Authors: Mei-Hong Zhang, A. S. Knisely, Neng-li Wang, Jing-Yu Gong and Jian-She Wang

    Citation: BMC Gastroenterology 2016 16:92

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  30. Content type: Research article

    Pegylated interferon alpha 2a, alpha 2b and ribavirin have been included to the National List of Essential Medicines (NLEM) for treatment of only chronic hepatitis C genotypes 2 and 3 in Thailand. This reimbur...

    Authors: Nattiya Kapol, Surasit Lochid-amnuay and Yot Teerawattananon

    Citation: BMC Gastroenterology 2016 16:91

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  31. Content type: Case report

    Hepatic inflammatory pseudotumor (IPT) is a rare disease which often mimics a malignant tumor and is therefore often misdiagnosed and surgically resected. Recently, a concept of IgG4-related diseases (IgG4-RD)...

    Authors: Masayuki Shibata, Hiroyuki Matsubayashi, Tsuyoshi Aramaki, Katsuhiko Uesaka, Naoyuki Tsutsumi, Keiko Sasaki and Hiroyuki Ono

    Citation: BMC Gastroenterology 2016 16:89

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  32. Content type: Research article

    Poly(ADP-ribose) polymerase (PARP) participates in multi-organ failure in various inflammatory diseases including acute necrotizing pancreatitis (ANP). Since pancreatitis-associated adrenal insufficiency is pa...

    Authors: Jia Yu, Teng Zuo, Wenhong Deng, Qiao Shi, Peng Ma, Chen Chen, Liang Zhao, Kailiang Zhao and Weixing Wang

    Citation: BMC Gastroenterology 2016 16:81

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  33. Content type: Research article

    Epilepsy is associated with an increased mortality among cirrhosis patients, but the reasons are unknown. We aimed to determine whether epilepsy is a risk factor for developing hepatic encephalopathy (HE), whi...

    Authors: Peter Jepsen, Jakob Christensen, Karin Weissenborn, Hugh Watson and Hendrik Vilstrup

    Citation: BMC Gastroenterology 2016 16:77

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  34. Content type: Research article

    Toll-like receptors (TLRs) are effectors of the innate immune system that are able to recognize hepatitis C virus (HCV) and give rise to an immune response. Failure of interferon (IFN)-α-based treatment is rel...

    Authors: Chuan-Mo Lee, Tsung-Hui Hu, Sheng-Nan Lu, Jing-Houng Wang, Chao-Hung Hung, Chien-Hung Chen and Yi-Hao Yen

    Citation: BMC Gastroenterology 2016 16:73

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  35. Content type: Study protocol

    Pruritus (itch) is a symptom commonly experienced by patients with cholestatic liver diseases such as primary biliary cholangitis (PBC, previously referred to as primary biliary cirrhosis). Bile acids (BAs) ha...

    Authors: Vinod S. Hegade, Stuart F. W. Kendrick, Robert L. Dobbins, Sam R. Miller, Duncan Richards, James Storey, George Dukes, Kim Gilchrist, Susan Vallow, Graeme J. Alexander, Margaret Corrigan, Gideon M. Hirschfield and David E. J. Jones

    Citation: BMC Gastroenterology 2016 16:71

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  36. Content type: Research article

    Difficult biliary cannulation in endoscopic retrograde cholangiopancreatography (ERCP) can result in failure of common bile duct (CBD) stone removal and pancreatitis. The present study aimed to report the effi...

    Authors: Chung-Mou Kuo, Yi-Chun Chiu, Chih-Ming Liang, Lung-Sheng Lu, Wei-Chen Tai, Yuan-Hung Kuo, Cheng-Kun Wu, Seng-Kee Chuah, Chi-Sin Changchien and Chung-Huang Kuo

    Citation: BMC Gastroenterology 2016 16:70

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  37. Content type: Research article

    Most complications after pancreaticoduodenectomy (PD) were relation to pancreaticoenterostomy. We improved a new method of pancreaticoenterostomy that included the continuous suturing of the jejunum and the st...

    Authors: Guoliang Yao, Yonggang Fan and Jingming Zhai

    Citation: BMC Gastroenterology 2016 16:69

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  38. Content type: Research article

    Obstructive jaundice has been reported to influence liver elasticity, independent of liver fibrosis. The aim of our prospective study was to evaluate the changes in liver elasticity, before and after biliary d...

    Authors: Kimitoshi Kubo, Hiroshi Kawakami, Masaki Kuwatani, Mutsumi Nishida, Kazumichi Kawakubo, Shuhei Kawahata, Yoko Taya, Yoshimasa Kubota, Toraji Amano, Hiroki Shirato and Naoya Sakamoto

    Citation: BMC Gastroenterology 2016 16:65

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    The Erratum to this article has been published in BMC Gastroenterology 2016 16:116

  39. Content type: Research article

    The incidence of hepatocellular carcinoma with nonalcoholic steatohepatitis is increasing, and its clinicopathological features are well established. Several animal models of nonalcoholic steatohepatitis have ...

    Authors: Norihiro Kishida, Sachiko Matsuda, Osamu Itano, Masahiro Shinoda, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Yohei Masugi, Koichi Aiura, Michiie Sakamoto and Yuko Kitagawa

    Citation: BMC Gastroenterology 2016 16:61

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  40. Content type: Research article

    Hexokinase-2 (HK2) and Beta2-adrenergic receptor (Beta2AR) are overexpressed in hepatocellular carcinoma (HCC) tissues and associated with poor prognosis. However, the synergistic effect of HK2 and Beta2AR in ...

    Authors: Zhi-Feng Zhang, Xiao-Sha Feng, He Chen, Zhi-Jun Duan, Li-Xia Wang, Dong Yang, Pi-Xu Liu, Qiu-Ping Zhang, Yan-Ling Jin, Zhi-Gang Sun and Han Liu

    Citation: BMC Gastroenterology 2016 16:57

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  41. Content type: Technical advance

    Anastomotic stricture is a complex and substantial complication following Roux-en-Y hepaticojejunostomy. Initially, endoscopic and percutaneous approaches are often attempted, but the gold standard remains sur...

    Authors: Yu-long Yang, Cheng Zhang, Ping Wu, Yue-feng Ma, Jing-yi Li, Hong-wei Zhang, Li-jun Shi, Mei-ju Lin and Ying Yu

    Citation: BMC Gastroenterology 2016 16:54

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  42. Content type: Research article

    Transarterial chemoembolization (TACE) and sorafenib are the therapeutic standard for intermediate and advanced stage hepatocellular carcinoma (HCC) patients respectively. High costs with adverse events (AE) o...

    Authors: Wang-De Hsiao, Cheng-Yuan Peng, Po-Heng Chuang, Hsueh-Chou Lai, Ken-Sheng Cheng, Jen-Wei Chou, Yang-Yuan Chen, Cheng-Ju Yu, Chun-Lung Feng, Wen-Pang Su, Sheng-Hung Chen and Jung-Ta Kao

    Citation: BMC Gastroenterology 2016 16:50

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  43. Content type: Research article

    Estimates suggest that only 20 % of HCV-infected patients have been identified and <10 % treated. However, baby boomers (1945-1965) are identified as having a higher prevalence of HCV which has led the Centers...

    Authors: Zobair M. Younossi, Louis L. LaLuna, John J. Santoro, Flavia Mendes, Victor Araya, Natarajan Ravendhran, Lisa Pedicone, Idania Lio, Fatema Nader, Sharon Hunt, Andrei Racila and Maria Stepanova

    Citation: BMC Gastroenterology 2016 16:45

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  44. Content type: Case report

    Hepatic artery pseudoaneurysm (HAP) and Hepatic artery dissection are rare vascular complications after living donor liver transplantation (LDLT), which may lead to graft loss and death of the recipients. Conv...

    Authors: Lin Ma, Kefei Chen, Qiang Lu, Wenwu Ling and Yan Luo

    Citation: BMC Gastroenterology 2016 16:44

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  45. Content type: Research article

    The routine use of preoperative biliary drainage before pancreaticoduodenectomy (PD) remains controversial. This observational retrospective study compared stented and non-stented patients undergoing PD to ass...

    Authors: Francesca Gavazzi, Cristina Ridolfi, Giovanni Capretti, Maria Rachele Angiolini, Paola Morelli, Erminia Casari, Marco Montorsi and Alessandro Zerbi

    Citation: BMC Gastroenterology 2016 16:43

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  46. Content type: Research article

    Off-treatment durability of nucleoside analogue (NA) therapy in patients with chronic hepatitis B has not been well investigated. In this study we monitored antiviral effect of NA therapy and evaluated off-tre...

    Authors: Naruhiko Nagata, Tatehiro Kagawa, Shunji Hirose, Yoshitaka Arase, Kota Tsuruya, Kazuya Anzai, Koichi Shiraishi and Tetsuya Mine

    Citation: BMC Gastroenterology 2016 16:38

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  47. Content type: Case report

    Crigler-Najjar syndrome (CN) is a very rare genetic disorder characterized by an inability to conjugate bilirubin. Contrary to CN type I, patients with CN II exhibit residual capacity to conjugate bilirubin an...

    Authors: Samuel Raimundo Fernandes, Carlos Miguel Moura, Beatriz Rodrigues, Luís Araújo Correia, Helena Cortez-Pinto and José Velosa

    Citation: BMC Gastroenterology 2016 16:33

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  48. Content type: Research article

    Approximately 2.7 million Americans are chronically infected with hepatitis C virus (HCV). HCV patients with cirrhosis form the largest group of persons at high risk for hepatocellular carcinoma (HCC). Increas...

    Authors: Yachana Kataria, Ryan J. Deaton, Erika Enk, Ming Jin, Milita Petrauskaite, Linlin Dong, Joseph R. Goldenberg, Scott J. Cotler, Donald M. Jensen, Richard B. van Breemen and Peter H. Gann

    Citation: BMC Gastroenterology 2016 16:30

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  49. Content type: Case report

    Optimal phosphorous control is an important aspect of the care of patients with end-stage renal disease, and phosphate binders are usually needed.

    Authors: Christina Tieu, Roger K. Moreira, Louis M. Wong Kee Song, Shounak Majumder, Konstantinos A. Papadakis and Marie C. Hogan

    Citation: BMC Gastroenterology 2016 16:20

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