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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. Content type: Research article

    The gut microbiota plays crucial roles in the development of non-alcoholic steatohepatitis (NASH). However, the precise mechanisms by which alterations of the gut microbiota and its metabolism contributing to ...

    Authors: Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai and Hidetsugu Saito

    Citation: BMC Gastroenterology 2017 17:136

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  2. Content type: Research article

    Nonalcoholic fatty liver disease (NAFLD) is a common problem across the world. We aimed to determine the prevalence of NAFLD and its associations in Sri Lankan adolescents living in an urban Sri Lankan community.

    Authors: Shaman Rajindrajith, Arunasalam Pathmeswaran, Chamilka Jayasinghe, Dulani Kottahachchi, Anuradhani Kasturiratne, Shamila T. de Silva, Madunil A. Niriella, Anuradha S. Dassanayake, Arjuna P. de Silva and H. Janaka de Silva

    Citation: BMC Gastroenterology 2017 17:135

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  3. Content type: Research article

    Liver stiffness measurement (LSM) has recently become available for assessment of liver fibrosis. We aimed to develop a prediction model for liver fibrosis using clinical variables, including LSM.

    Authors: Yusuke Mitsuka, Yutaka Midorikawa, Hayato Abe, Naoki Matsumoto, Mitsuhiko Moriyama, Hiroki Haradome, Masahiko Sugitani, Shingo Tsuji and Tadatoshi Takayama

    Citation: BMC Gastroenterology 2017 17:133

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  4. Content type: Research article

    Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect. Th...

    Authors: A. Drori, D. Rotnemer-Golinkin, S. Avni, A. Drori, O. Danay, D. Levanon, J. Tam, L. Zolotarev and Y. Ilan

    Citation: BMC Gastroenterology 2017 17:130

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  5. Content type: Case report

    Hepatobiliary tuberculosis includes miliary, tuberculous hepatitis or localized forms. The localised form is extremely uncommon and can mimic malignancy. Still rarer is its presentation as sclerosing cholangitis.

    Authors: Aleena Jain, Rachana Chaturvedi, Chetan Kantharia, Amita Joshi, Mangesh Londhe and Mayura Kekan

    Citation: BMC Gastroenterology 2017 17:126

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  6. Content type: Research article

    Gut microbiota may be altered in patients with cirrhosis, and may further change after administration of lactulose. We studied the composition of gut microbiota in patients with cirrhosis and assessed the effe...

    Authors: Aditya Narayan Sarangi, Amit Goel, Ankur Singh, Avani Sasi and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2017 17:125

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  7. Content type: Research article

    Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induc...

    Authors: Tae Hyung Kim, Dahee Choi, Joo Young Kim, Jeong Hyeon Lee and Seung-Hoi Koo

    Citation: BMC Gastroenterology 2017 17:124

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  8. Content type: Research article

    Chronic hepatitis C virus (HCV) infection is associated with impairment of cognitive function and mood disorders. Our aim was to evaluate the impact of sustained virological response (SVR) on cognitive functio...

    Authors: Mary Ellen Dias Barbosa, Ana Luiza Zaninotto, Daniel Ferraz de Campos Mazo, Mario Guimarães Pessoa, Cláudia Pinto Marques Souza de Oliveira, Flair José Carrilho and Alberto Queiroz Farias

    Citation: BMC Gastroenterology 2017 17:122

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  9. Content type: Research article

    Minimally invasive pancreatoduodenectomy (MIPD) has been gradually attempted. However, whether MIPD is superior, equal or inferior to its conventional open pancreatoduodenectomy (OPD) is not clear.

    Authors: Ke Chen, Yu Pan, Xiao-long Liu, Guang-yi Jiang, Di Wu, Hendi Maher and Xiu-jun Cai

    Citation: BMC Gastroenterology 2017 17:120

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  10. Content type: Research article

    Eradication of hepatitis C virus (HCV) using direct-acting agents (DAA) has been associated with a financial burden to health authorities worldwide. We aimed to evaluate the guideline-based treatment costs by ...

    Authors: Hugo Perazzo, Marcelino Jose Jorge, Julio Castro Silva, Alexandre Monken Avellar, Patrícia Santos Silva, Carmen Romero, Valdilea Gonçalves Veloso, Ruben Mujica-Mota, Rob Anderson, Chris Hyde and Rodolfo Castro

    Citation: BMC Gastroenterology 2017 17:119

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  11. Content type: Research article

    Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate th...

    Authors: Jianfeng Tu, Jingzhu Zhang, Lu Ke, Yue Yang, Qi Yang, Guotao Lu, Baiqiang Li, Zhihui Tong, Weiqin Li and Jieshou Li

    Citation: BMC Gastroenterology 2017 17:114

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  12. Content type: Research article

    Portal vein thrombosis (PVT) is a serious complication in liver cirrhosis with portal hypertension. We examined the treatment, recurrence and prognosis of PVT in cirrhotic patients.

    Authors: Shunichiro Fujiyama, Satoshi Saitoh, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Yasuji Arase, Kenji Ikeda and Hiromitsu Kumada

    Citation: BMC Gastroenterology 2017 17:112

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  13. Content type: Technical advance

    Prophylactic pancreatic stents after endoscopic retrograde cholangiopancreatography (ERCP) can help prevent post-ERCP pancreatitis. However most of the pancreatic stents need to be removed by another ERCP. The...

    Authors: Cheng Zhang, Yu-long Yang, Yue-feng Ma, Hong-wei Zhang, Jing-yi Li, Mei-ju Lin, Li-jun Shi and Chun-chun Qi

    Citation: BMC Gastroenterology 2017 17:108

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  14. Content type: Research article

    Spontaneous bacterial peritonitis (SBP) is often difficult to diagnose because bacteria in ascites cannot be detected accurately by conventional culture. In situ hybridization (ISH) was previously developed fo...

    Authors: Shingo Usui, Hirotoshi Ebinuma, Po-Sung Chu, Nobuhiro Nakamoto, Yoshiyuki Yamagishi, Hidetsugu Saito and Takanori Kanai

    Citation: BMC Gastroenterology 2017 17:106

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  15. Content type: Research article

    Self-expandable metal stents (SEMSs) are widely used for malignant biliary obstructions. Nitinol-covered SEMSs have been developed to improve stent patency. Currently, SEMSs may be uncovered, partially covered...

    Authors: Yudai Yokota, Mitsuharu Fukasawa, Shinichi Takano, Makoto Kadokura, Hiroko Shindo, Ei Takahashi, Sumio Hirose, Satoshi Kawakami, Yoshimitsu Fukasawa, Tadashi Sato and Nobuyuki Enomoto

    Citation: BMC Gastroenterology 2017 17:105

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  16. Content type: Research article

    Current treatments for chronic hepatitis B (CHB) include pegylated interferon alpha (PEG-IFN-α) which is an immune modulator, and nucleos(t)ide analogs (NAs) which directly inhibit HBV DNA polymerase. With the...

    Authors: Yan Xu, Xu Wang, Zhenhua Liu, Changyu Zhou, Wenqian Qi, Jian Jiao, Fan Yu, Honghua Guo, Ping Zhao and Jiangbin Wang

    Citation: BMC Gastroenterology 2017 17:102

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  17. Content type: Research article

    We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) f...

    Authors: Faisal M. Sanai, Taha Farah, Khalid Albeladi, Faisal Batwa, Yaser Dahlan, Mohammed A. Babatin, Hamad Al-Ashgar, Hadeel AlMana, Khaled S. Alsaad, Khalid AlSwat, Abdulrahman Aljumah, Ibrahim H. AlTraif, Bahaa E. Kailani and Khalid I. Bzeizi

    Citation: BMC Gastroenterology 2017 17:101

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  18. Content type: Research article

    Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and an...

    Authors: Fei-hu Zhang, Yu-han Sun, Kai-liang Fan, Xiao-bin Dong, Ning Han, Hao Zhao and Li Kong

    Citation: BMC Gastroenterology 2017 17:100

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  19. Content type: Research article

    Hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) have rarely been studied because they rarely accept interferon-based therapy (IBT) and have been difficult to follow up. We investiga...

    Authors: Ming-Shyan Lin, Tien-Hsing Chen, Wey-Yil Lin, Chi-Hung Liu, Yung-Yu Hsieh, Wen-Nan Chiu, Chih-Hsiang Chang, Mei-Yen Chen, Chang-Min Chung and Yu-Sheng Lin

    Citation: BMC Gastroenterology 2017 17:99

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  20. Content type: Research article

    As prognosis of patients with metastatic hepatocellular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE may result in improved OS, although it is not recommended...

    Authors: Dominik Bettinger, Renan Spode, Nicolas Glaser, Nico Buettner, Tobias Boettler, Christoph Neumann-Haefelin, Thomas Baptist Brunner, Eleni Gkika, Lars Maruschke, Robert Thimme and Michael Schultheiss

    Citation: BMC Gastroenterology 2017 17:98

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  21. Content type: Research article

    Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study exam...

    Authors: Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito…

    Citation: BMC Gastroenterology 2017 17:96

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  22. Content type: Case report

    Follicular nodular hyperplasia (FNH) is a common benign liver tumor for which conservative management is indicated. Surgical or interventional management is indicated in symptomatic cases. Transarterial emboli...

    Authors: Peter C. Ambe, Stefan Jansen and Hubert Zirngibl

    Citation: BMC Gastroenterology 2017 17:91

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  23. Content type: Research article

    Underlying causes in Chinese children with recurrent acute liver failure (RALF), including liver crises less than full acute liver failure, are incompletely understood. We sought to address this by searching f...

    Authors: Jia-Qi Li, Yi-Ling Qiu, Jing-Yu Gong, Li-Min Dou, Yi Lu, A. S. Knisely, Mei-Hong Zhang, Wei-Sha Luan and Jian-She Wang

    Citation: BMC Gastroenterology 2017 17:77

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  24. Content type: Research article

    The gut microbiome exerts extensive roles in metabolism of nutrients, pharmaceuticals, organic chemicals. Little has been known for the role of gut microbiota in regulating cholesterol and bile acids in associ...

    Authors: Qihan Wang, Long Jiao, Chuanqi He, Haidong Sun, Qu Cai, Tianquan Han and Hai Hu

    Citation: BMC Gastroenterology 2017 17:74

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  25. Content type: Research article

    The Tokyo guideline for acute cholecystitis recommended percutaneous transhepatic gallbladder drainage followed by cholecystectomy for severe acute cholecystitis, but the optimal timing for the subsequent chol...

    Authors: Koetsu Inoue, Tatsuya Ueno, Orie Nishina, Daisuke Douchi, Kentaro Shima, Shinji Goto, Michinaga Takahashi, Chikashi Shibata and Hiroo Naito

    Citation: BMC Gastroenterology 2017 17:71

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  26. Content type: Research article

    Endoscopic papillectomy (EP) is reported to be a relatively safe and reliable procedure for complete resection of ampullary neoplasms. The aim of this study was to evaluate the therapeutic outcomes and complic...

    Authors: Sung Hoon Kang, Kook Hyun Kim, Tae Nyeun Kim, Min Kyu Jung, Chang Min Cho, Kwang Bum Cho, Ji Min Han, Ho Gak Kim and Hyun Soo Kim

    Citation: BMC Gastroenterology 2017 17:69

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  27. Content type: Research article

    The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patient...

    Authors: Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Nobuaki Azemoto, Aki Hasebe, Hirotaka Seike, Mari Nishiyama, Nobu Inada, Naozumi Shibata, Hideki Miyata, Tomoe Kawamura, Yusuke Imai, Akiko Ueno-Toshimori, Yoshinori Tanaka, Takashi Terao, Yoshiki Imamura…

    Citation: BMC Gastroenterology 2017 17:66

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  28. Content type: Research article

    Mac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis st...

    Authors: Hongqin Xu, Wenli Kong, Lei Liu, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Xiuzhu Gao, Huan Wang, Limei Qu, Yue Qi, Yu Pan and Junqi Niu

    Citation: BMC Gastroenterology 2017 17:62

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  29. Content type: Research article

    To assess the clinical validity of controlled attenuation parameter (CAP) in the diagnosis of hepatic steatosis in a series of overweight or obese children by using the imperfect gold standard methodology.

    Authors: Giovanna Ferraioli, Valeria Calcaterra, Raffaella Lissandrin, Marinella Guazzotti, Laura Maiocchi, Carmine Tinelli, Annalisa De Silvestri, Corrado Regalbuto, Gloria Pelizzo, Daniela Larizza and Carlo Filice

    Citation: BMC Gastroenterology 2017 17:61

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  30. Content type: Research article

    Chronic kidney disease is a significant complication after liver transplantation (LT), but the role of pre-existing renal insufficiency and proteinuria remains unclear among LT recipients receiving sirolimus.

    Authors: Lung-Chih Li, Chien-Ning Hsu, Chih-Che Lin, Yu-Fan Cheng, Tsung-Hui Hu, Ding-Wei Chen, Chih-Hsiung Lee, Toshiaki Nakano and Chao-Long Chen

    Citation: BMC Gastroenterology 2017 17:58

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  31. Content type: Research article

    Advanced stages of liver cirrhosis lead to a dramatically increased mortality. For valid identification of these patients suitable biomarkers are essential. The most important biomarkers for liver function are...

    Authors: Thorsten Kaiser, Benedict Kinny-Köster, Michael Bartels, Thomas Berg, Markus Scholz, Cornelius Engelmann, Daniel Seehofer, Susen Becker, Uta Ceglarek and Joachim Thiery

    Citation: BMC Gastroenterology 2017 17:57

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  32. Content type: Research article

    Patients with chronic hepatitis C (HCV) infection have high prevalence of vitamin D deficiency. Genome-wide association study data has showed that several genetic variants within vitamin D cascade affect vitam...

    Authors: Kessarin Thanapirom, Sirinporn Suksawatamnuay, Wattana Sukeepaisarnjaroen, Pisit Tangkijvanich, Sombat Treeprasertsuk, Panarat Thaimai, Rujipat Wasitthankasem, Yong Poovorawan and Piyawat Komolmit

    Citation: BMC Gastroenterology 2017 17:54

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  33. Content type: Research article

    Controlled attenuation parameter (CAP) and liver stiffness (LS) measured by transient elastography (TE, Fibroscan®) have been used for steatosis and fibrosis assessment. We evaluated the effect of meal intake ...

    Authors: Kanittha Ratchatasettakul, Sasivimol Rattanasiri, Kwannapa Promson, Pranee Sringam and Abhasnee Sobhonslidsuk

    Citation: BMC Gastroenterology 2017 17:50

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  34. Content type: Research article

    Few studies have investigated the relationship between carotid-femoral pulse wave velocity (cfPWV) and serum alanine aminotransferase (ALT) normal-range levels across the world. The current analysis was design...

    Authors: Shihui Fu, Ying Lin, Leiming Luo and Ping Ye

    Citation: BMC Gastroenterology 2017 17:49

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  35. Content type: Research article

    Health care providers need solid evidence based data on cost differences between alternative surgical procedures for common surgical disorders. We aimed to compare small-incision open cholecystectomy (SIOC) an...

    Authors: Mats H. Rosenmüller, Erik Nilsson, Fredrik Lindberg, Sten-Olof Åberg and Markku M. Haapamäki

    Citation: BMC Gastroenterology 2017 17:48

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  36. Content type: Research article

    The long-term clinical outcomes of antiviral therapy for patients with chronic hepatitis C are uncertain in terms of hepatitis C virus (HCV)-related morbidity and mortality according to the response to antivir...

    Authors: Chang Seok Bang and Il Han Song

    Citation: BMC Gastroenterology 2017 17:46

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  37. Content type: Research article

    It has been shown that the proportion of natural killer T cells is markedly elevated during liver regeneration and their activation under different conditions can modulate this process. As natural killer T cel...

    Authors: Ami Ben Ya’acov, Hadar Meir, Lydia Zolotaryova, Yaron Ilan and Eyal Shteyer

    Citation: BMC Gastroenterology 2017 17:44

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  38. Content type: Research article

    Acute pancreatitis is a severe complication of endoscopic retrograde cholangiopancreatography (ERCP). Previous meta-analyses have shown that indomethacin effectively prevents this complication; however, the da...

    Authors: Jianhua Wan, Yuping Ren, Zhenhua Zhu, Liang Xia and Nonghua Lu

    Citation: BMC Gastroenterology 2017 17:43

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  39. Content type: Research article

    European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infectio...

    Authors: Jian-Hua Lei, Xu Yang, Xin-Qiang Xiao, Zi Chen and Feng Peng

    Citation: BMC Gastroenterology 2017 17:42

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  40. Content type: Research article

    There have been limited studies directly comparing the long-term efficacy between entecavir (ETV) and tenofovir disoproxil fumarate (TDF). This study was aimed to compare the long-term efficacy between them in...

    Authors: Ji Won Park, Kyeong Min Kwak, Sung Eun Kim, Myoung Kuk Jang, Ki Tae Suk, Dong Joon Kim, Sang Hoon Park, Myung Seok Lee, Hyoung Su Kim and Choong Kee Park

    Citation: BMC Gastroenterology 2017 17:39

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  41. Content type: Research article

    Endoscopic retrograde cholangiopancreatography (ERCP) is a technically challenging endoscopic procedure, harboring a wide range of complexities within every single investigation. Classifications of the complex...

    Authors: Greger Olsson, Urban Arnelo, Fredrik Swahn, Björn Törnqvist, Lars Lundell and Lars Enochsson

    Citation: BMC Gastroenterology 2017 17:38

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  42. Content type: Research article

    Acute pancreatitis is a potentially lethal disease, with a rising incidence in the Western world. Yet, no pharmacological prevention or specific treatment for acute pancreatitis exists. Also, the connection wi...

    Authors: Tomas S. Bexelius, Rickard Ljung, Fredrik Mattsson, Yunxia Lu and Mats Lindblad

    Citation: BMC Gastroenterology 2017 17:36

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  43. Content type: Research article

    NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental model...

    Authors: Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo and Carmine Vecchione

    Citation: BMC Gastroenterology 2017 17:35

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    The Correction to this article has been published in BMC Gastroenterology 2017 17:116

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