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Hepatobiliary and pancreatic disorders

Section edited by Emmanuel A Tsochatzis and Rakesh Tandon

This section concerns all clinical and basic science aspects of hepatobiliary and pancreatic disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. ...

    Authors: Jie-wen Lei, Xiao-yu Ji, Jun-feng Hong, Wan-bin Li, Yan Chen, Yan Pan and Jia Guo

    Citation: BMC Gastroenterology 2017 17:171

    Content type: Research article

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  2. The burden of disease caused by Streptococcus agalactiae has increased significantly among older adults in the last decades. Group B streptococcus infection can be associated with invasive disease and severe clin...

    Authors: Pietro Achilli, Angelo Guttadauro, Paolo Bonfanti, Sabina Terragni, Luca Fumagalli, Ugo Cioffi, Francesco Gabrielli, Matilde De Simone and Marco Chiarelli

    Citation: BMC Gastroenterology 2017 17:170

    Content type: Case report

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  3. Chemokines/cytokines play important roles in the pathogenesis of chronic hepatitis C (CHC). However, their clinical characteristics and implications in treatment responses to pegylated interferon plus ribaviri...

    Authors: Chia-Chen Lin, Shih-Huan Su, Wen-Juei Jeng, Chien-Hao Huang, Wei Teng, Wei-Ting Chen, Yi-Cheng Chen, Chun-Yen Lin and I-Shyan Sheen

    Citation: BMC Gastroenterology 2017 17:169

    Content type: Research article

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  4. Hepatitis B virus (HBV) chronic infection affects up to 240 million people in the world and it is a common cause of cirrhosis and hepatocellular carcinoma (HCC). HBV covalently closed circular DNA (cccDNA) pla...

    Authors: Sonia Alonso, Adriana-René Guerra, Lourdes Carreira, Juan-Ángel Ferrer, María-Luisa Gutiérrez and Conrado M. Fernandez-Rodriguez

    Citation: BMC Gastroenterology 2017 17:168

    Content type: Review

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  5. Extramedullary plasmacytoma is a very rare tumor derived from plasma cells and found outside the bone marrow. Most have been identified in patients with the more aggressive anaplastic form of the disease. Only...

    Authors: Tao Lu, Hong Pu and Gaoping Zhao

    Citation: BMC Gastroenterology 2017 17:167

    Content type: Case report

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  6. The number of bariatric interventions for morbid obesity is increasing worldwide. Rapid weight loss is a major risk factor for gallstone development. Approximately 11 % of patients who underwent Roux-en-Y gast...

    Authors: Thomas C. C. Boerlage, Sylke Haal, L. Maurits de Brauw, Yair I. Z. Acherman, Sjoerd Bruin, Arnold W. J. M. van de Laar, Daan E. Moes, Bart A. van Wagensveld, Claire E. E. de Vries, Ruben van Veen, Ruben Schouten, Marcel G. Dijkgraaf, Paul Fockens, Victor E. A. Gerdes and Rogier P. Voermans

    Citation: BMC Gastroenterology 2017 17:164

    Content type: Study protocol

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  7. To assess the feasibility of noninvasive and quantitative evaluation of hepatic pathophysiological changes in rabbit hepatic warm ischemia-reperfusion injury (WIRI) models by using intravoxel incoherent motion...

    Authors: Qian Ji, Zhi Qiang Chu, Tao Ren, Shi Chao Xu, Long Jiang Zhang, Wen Shen and Guang Ming Lu

    Citation: BMC Gastroenterology 2017 17:161

    Content type: Research article

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  8. Infected pancreatic necrosis (IPN) is a serious local complication of acute pancreatitis, with high mortality. Minimally invasive therapy including percutaneous catheter drainage (PCD) has become the preferred...

    Authors: Pi Liu, Jun Song, Hua-jing Ke, Nong-hua Lv, Yin Zhu, Hao Zeng, Yong Zhu, Liang Xia, Wen-hua He, Ji Li, Xin Huang and Yu-peng Lei

    Citation: BMC Gastroenterology 2017 17:155

    Content type: Technical advance

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  9. The serum gradient of hepatitis B surface antigen (HBsAg) varies over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis B (CHB). The association between the time-va...

    Authors: Nai-Hsuan Chien, Yen-Tsung Huang, Chun-Ying Wu, Chi-Yang Chang, Ming-Shiang Wu, Jia-Horng Kao, Lein-Ray Mo, Chi-Ming Tai, Chih-Wen Lin, Tzeng-Huey Yang, Jaw-Town Lin and Yao-Chun Hsu

    Citation: BMC Gastroenterology 2017 17:154

    Content type: Research article

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  10. Non-alcoholic fatty liver disease (NAFLD) has been recently identified as a risk factor of gastrointestinal tract cancers, especially hepatocellular carcinoma, and colorectal cancer. Whether NAFLD is a risk fa...

    Authors: Nicha Wongjarupong, Buravej Assavapongpaiboon, Paweena Susantitaphong, Wisit Cheungpasitporn, Sombat Treeprasertsuk, Rungsun Rerknimitr and Roongruedee Chaiteerakij

    Citation: BMC Gastroenterology 2017 17:149

    Content type: Research article

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  11. Pancreatic hamartomas are extremely rare and may be misdiagnosed as malignant tumors. We report herein a case of a small, solid-type pancreatic hamartoma.

    Authors: Hiroaki Nagano, Masayuki Nakajo, Yoshihiko Fukukura, Yoriko Kajiya, Atsushi Tani, Sadao Tanaka, Mari Toyota, Toru Niihara, Masaki Kitazono, Toyokuni Suenaga and Takashi Yoshiura

    Citation: BMC Gastroenterology 2017 17:146

    Content type: Case report

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  12. Portal vein embolization is essential for patients with biliary cancer who undergo extended hepatectomy to induce hypertrophy of the future remnant liver. Over 830 patients have undergone the portal vein embol...

    Authors: Chun-Yi Tsai, Motoi Nojiri, Yukihiro Yokoyama, Tomoki Ebata, Takashi Mizuno and Masato Nagino

    Citation: BMC Gastroenterology 2017 17:144

    Content type: Case report

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  13. Pancreatic cancer occurs more frequently in older patients, but these are underrepresented in the phase III clinical studies that established the current treatment standards. This leads to uncertainty regardin...

    Authors: Anne Katrin Berger, Georg Martin Haag, Martin Ehmann, Anne Byl, Dirk Jäger and Christoph Springfeld

    Citation: BMC Gastroenterology 2017 17:143

    Content type: Research article

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  14. Alpha-fetoprotein (AFP) is a biomarker for hepatocellular carcinoma (HCC). The significance of pre-treatment AFP (pt-AFP) in non-viral HCC (nvHCC) is not clear.

    Authors: Siriwardana Rohan Chaminda, Thilakarathne Suchintha, Niriella Madunil Anuk, Dassanayake Anuradha Supun, Gunathilake Mahen Bhagya, Liyanage Chandika Anuruddha Habarakada and De Silva Hithadurage Janaka

    Citation: BMC Gastroenterology 2017 17:142

    Content type: Research article

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  15. The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcr...

    Authors: Zhan-Qing Zhang, Xiao-Nan Zhang, Wei Lu, Yan-Bing Wang, Qi-Cheng Weng and Yan-Ling Feng

    Citation: BMC Gastroenterology 2017 17:140

    Content type: Research article

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  16. The gut microbiota plays crucial roles in the development of non-alcoholic steatohepatitis (NASH). However, the precise mechanisms by which alterations of the gut microbiota and its metabolism contributing to ...

    Authors: Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai and Hidetsugu Saito

    Citation: BMC Gastroenterology 2017 17:136

    Content type: Research article

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  17. Nonalcoholic fatty liver disease (NAFLD) is a common problem across the world. We aimed to determine the prevalence of NAFLD and its associations in Sri Lankan adolescents living in an urban Sri Lankan community.

    Authors: Shaman Rajindrajith, Arunasalam Pathmeswaran, Chamilka Jayasinghe, Dulani Kottahachchi, Anuradhani Kasturiratne, Shamila T. de Silva, Madunil A. Niriella, Anuradha S. Dassanayake, Arjuna P. de Silva and H. Janaka de Silva

    Citation: BMC Gastroenterology 2017 17:135

    Content type: Research article

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  18. Liver stiffness measurement (LSM) has recently become available for assessment of liver fibrosis. We aimed to develop a prediction model for liver fibrosis using clinical variables, including LSM.

    Authors: Yusuke Mitsuka, Yutaka Midorikawa, Hayato Abe, Naoki Matsumoto, Mitsuhiko Moriyama, Hiroki Haradome, Masahiko Sugitani, Shingo Tsuji and Tadatoshi Takayama

    Citation: BMC Gastroenterology 2017 17:133

    Content type: Research article

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  19. Hypovitaminosis D is associated with many features of the metabolic syndrome, including non-alcoholic fatty liver disease. Vitamin D-enriched mushrooms extracts exert a synergistic anti-inflammatory effect. Th...

    Authors: A. Drori, D. Rotnemer-Golinkin, S. Avni, A. Drori, O. Danay, D. Levanon, J. Tam, L. Zolotarev and Y. Ilan

    Citation: BMC Gastroenterology 2017 17:130

    Content type: Research article

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  20. Hepatobiliary tuberculosis includes miliary, tuberculous hepatitis or localized forms. The localised form is extremely uncommon and can mimic malignancy. Still rarer is its presentation as sclerosing cholangitis.

    Authors: Aleena Jain, Rachana Chaturvedi, Chetan Kantharia, Amita Joshi, Mangesh Londhe and Mayura Kekan

    Citation: BMC Gastroenterology 2017 17:126

    Content type: Case report

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  21. Gut microbiota may be altered in patients with cirrhosis, and may further change after administration of lactulose. We studied the composition of gut microbiota in patients with cirrhosis and assessed the effe...

    Authors: Aditya Narayan Sarangi, Amit Goel, Ankur Singh, Avani Sasi and Rakesh Aggarwal

    Citation: BMC Gastroenterology 2017 17:125

    Content type: Research article

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  22. Acetaminophen (APAP) is a readily available and safe painkiller. However, its overdose is the most common cause of acute liver injury (ALI). Many predisposing factors contribute to susceptibility to APAP-induc...

    Authors: Tae Hyung Kim, Dahee Choi, Joo Young Kim, Jeong Hyeon Lee and Seung-Hoi Koo

    Citation: BMC Gastroenterology 2017 17:124

    Content type: Research article

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  23. Chronic hepatitis C virus (HCV) infection is associated with impairment of cognitive function and mood disorders. Our aim was to evaluate the impact of sustained virological response (SVR) on cognitive functio...

    Authors: Mary Ellen Dias Barbosa, Ana Luiza Zaninotto, Daniel Ferraz de Campos Mazo, Mario Guimarães Pessoa, Cláudia Pinto Marques Souza de Oliveira, Flair José Carrilho and Alberto Queiroz Farias

    Citation: BMC Gastroenterology 2017 17:122

    Content type: Research article

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  24. Minimally invasive pancreatoduodenectomy (MIPD) has been gradually attempted. However, whether MIPD is superior, equal or inferior to its conventional open pancreatoduodenectomy (OPD) is not clear.

    Authors: Ke Chen, Yu Pan, Xiao-long Liu, Guang-yi Jiang, Di Wu, Hendi Maher and Xiu-jun Cai

    Citation: BMC Gastroenterology 2017 17:120

    Content type: Research article

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  25. Eradication of hepatitis C virus (HCV) using direct-acting agents (DAA) has been associated with a financial burden to health authorities worldwide. We aimed to evaluate the guideline-based treatment costs by ...

    Authors: Hugo Perazzo, Marcelino Jose Jorge, Julio Castro Silva, Alexandre Monken Avellar, Patrícia Santos Silva, Carmen Romero, Valdilea Gonçalves Veloso, Ruben Mujica-Mota, Rob Anderson, Chris Hyde and Rodolfo Castro

    Citation: BMC Gastroenterology 2017 17:119

    Content type: Research article

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  26. Patients could develop endocrine and exocrine pancreatic insufficiency after acute pancreatitis (AP), but the morbidity, risk factors and outcome remain unclear. The aim of the present study was to evaluate th...

    Authors: Jianfeng Tu, Jingzhu Zhang, Lu Ke, Yue Yang, Qi Yang, Guotao Lu, Baiqiang Li, Zhihui Tong, Weiqin Li and Jieshou Li

    Citation: BMC Gastroenterology 2017 17:114

    Content type: Research article

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  27. Portal vein thrombosis (PVT) is a serious complication in liver cirrhosis with portal hypertension. We examined the treatment, recurrence and prognosis of PVT in cirrhotic patients.

    Authors: Shunichiro Fujiyama, Satoshi Saitoh, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Norio Akuta, Masahiro Kobayashi, Yoshiyuki Suzuki, Fumitaka Suzuki, Yasuji Arase, Kenji Ikeda and Hiromitsu Kumada

    Citation: BMC Gastroenterology 2017 17:112

    Content type: Research article

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  28. Prophylactic pancreatic stents after endoscopic retrograde cholangiopancreatography (ERCP) can help prevent post-ERCP pancreatitis. However most of the pancreatic stents need to be removed by another ERCP. The...

    Authors: Cheng Zhang, Yu-long Yang, Yue-feng Ma, Hong-wei Zhang, Jing-yi Li, Mei-ju Lin, Li-jun Shi and Chun-chun Qi

    Citation: BMC Gastroenterology 2017 17:108

    Content type: Technical advance

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  29. Spontaneous bacterial peritonitis (SBP) is often difficult to diagnose because bacteria in ascites cannot be detected accurately by conventional culture. In situ hybridization (ISH) was previously developed fo...

    Authors: Shingo Usui, Hirotoshi Ebinuma, Po-Sung Chu, Nobuhiro Nakamoto, Yoshiyuki Yamagishi, Hidetsugu Saito and Takanori Kanai

    Citation: BMC Gastroenterology 2017 17:106

    Content type: Research article

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  30. Self-expandable metal stents (SEMSs) are widely used for malignant biliary obstructions. Nitinol-covered SEMSs have been developed to improve stent patency. Currently, SEMSs may be uncovered, partially covered...

    Authors: Yudai Yokota, Mitsuharu Fukasawa, Shinichi Takano, Makoto Kadokura, Hiroko Shindo, Ei Takahashi, Sumio Hirose, Satoshi Kawakami, Yoshimitsu Fukasawa, Tadashi Sato and Nobuyuki Enomoto

    Citation: BMC Gastroenterology 2017 17:105

    Content type: Research article

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  31. Current treatments for chronic hepatitis B (CHB) include pegylated interferon alpha (PEG-IFN-α) which is an immune modulator, and nucleos(t)ide analogs (NAs) which directly inhibit HBV DNA polymerase. With the...

    Authors: Yan Xu, Xu Wang, Zhenhua Liu, Changyu Zhou, Wenqian Qi, Jian Jiao, Fan Yu, Honghua Guo, Ping Zhao and Jiangbin Wang

    Citation: BMC Gastroenterology 2017 17:102

    Content type: Research article

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  32. We evaluated the diagnostic accuracy of aspartate aminotransferase (AST)-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4), AST/alanine aminotransferase (ALT) ratio (AAR), and age-platelet index (API) f...

    Authors: Faisal M. Sanai, Taha Farah, Khalid Albeladi, Faisal Batwa, Yaser Dahlan, Mohammed A. Babatin, Hamad Al-Ashgar, Hadeel AlMana, Khaled S. Alsaad, Khalid AlSwat, Abdulrahman Aljumah, Ibrahim H. AlTraif, Bahaa E. Kailani and Khalid I. Bzeizi

    Citation: BMC Gastroenterology 2017 17:101

    Content type: Research article

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  33. Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and an...

    Authors: Fei-hu Zhang, Yu-han Sun, Kai-liang Fan, Xiao-bin Dong, Ning Han, Hao Zhao and Li Kong

    Citation: BMC Gastroenterology 2017 17:100

    Content type: Research article

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  34. Hepatitis C virus (HCV)-infected patients with chronic kidney disease (CKD) have rarely been studied because they rarely accept interferon-based therapy (IBT) and have been difficult to follow up. We investiga...

    Authors: Ming-Shyan Lin, Tien-Hsing Chen, Wey-Yil Lin, Chi-Hung Liu, Yung-Yu Hsieh, Wen-Nan Chiu, Chih-Hsiang Chang, Mei-Yen Chen, Chang-Min Chung and Yu-Sheng Lin

    Citation: BMC Gastroenterology 2017 17:99

    Content type: Research article

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  35. As prognosis of patients with metastatic hepatocellular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE may result in improved OS, although it is not recommended...

    Authors: Dominik Bettinger, Renan Spode, Nicolas Glaser, Nico Buettner, Tobias Boettler, Christoph Neumann-Haefelin, Thomas Baptist Brunner, Eleni Gkika, Lars Maruschke, Robert Thimme and Michael Schultheiss

    Citation: BMC Gastroenterology 2017 17:98

    Content type: Research article

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  36. Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study exam...

    Authors: Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito…

    Citation: BMC Gastroenterology 2017 17:96

    Content type: Research article

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  37. Follicular nodular hyperplasia (FNH) is a common benign liver tumor for which conservative management is indicated. Surgical or interventional management is indicated in symptomatic cases. Transarterial emboli...

    Authors: Peter C. Ambe, Stefan Jansen and Hubert Zirngibl

    Citation: BMC Gastroenterology 2017 17:91

    Content type: Case report

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  38. Underlying causes in Chinese children with recurrent acute liver failure (RALF), including liver crises less than full acute liver failure, are incompletely understood. We sought to address this by searching f...

    Authors: Jia-Qi Li, Yi-Ling Qiu, Jing-Yu Gong, Li-Min Dou, Yi Lu, A. S. Knisely, Mei-Hong Zhang, Wei-Sha Luan and Jian-She Wang

    Citation: BMC Gastroenterology 2017 17:77

    Content type: Research article

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  39. The gut microbiome exerts extensive roles in metabolism of nutrients, pharmaceuticals, organic chemicals. Little has been known for the role of gut microbiota in regulating cholesterol and bile acids in associ...

    Authors: Qihan Wang, Long Jiao, Chuanqi He, Haidong Sun, Qu Cai, Tianquan Han and Hai Hu

    Citation: BMC Gastroenterology 2017 17:74

    Content type: Research article

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  40. The Tokyo guideline for acute cholecystitis recommended percutaneous transhepatic gallbladder drainage followed by cholecystectomy for severe acute cholecystitis, but the optimal timing for the subsequent chol...

    Authors: Koetsu Inoue, Tatsuya Ueno, Orie Nishina, Daisuke Douchi, Kentaro Shima, Shinji Goto, Michinaga Takahashi, Chikashi Shibata and Hiroo Naito

    Citation: BMC Gastroenterology 2017 17:71

    Content type: Research article

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  41. Endoscopic papillectomy (EP) is reported to be a relatively safe and reliable procedure for complete resection of ampullary neoplasms. The aim of this study was to evaluate the therapeutic outcomes and complic...

    Authors: Sung Hoon Kang, Kook Hyun Kim, Tae Nyeun Kim, Min Kyu Jung, Chang Min Cho, Kwang Bum Cho, Ji Min Han, Ho Gak Kim and Hyun Soo Kim

    Citation: BMC Gastroenterology 2017 17:69

    Content type: Research article

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  42. The efficacy of chemotherapy for unresectable pancreatic cancer has improved. However, it is occasionally difficult to make treatment decisions for elderly patients. We reviewed the outcomes of elderly patient...

    Authors: Taira Kuroda, Teru Kumagi, Tomoyuki Yokota, Nobuaki Azemoto, Aki Hasebe, Hirotaka Seike, Mari Nishiyama, Nobu Inada, Naozumi Shibata, Hideki Miyata, Tomoe Kawamura, Yusuke Imai, Akiko Ueno-Toshimori, Yoshinori Tanaka, Takashi Terao, Yoshiki Imamura…

    Citation: BMC Gastroenterology 2017 17:66

    Content type: Research article

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  43. Mac-2 Binding Protein Glycosylation isomer (M2BPGi) is a novel serological glyco-biomarker for staging liver fibrosis. Here, we aimed to evaluate the efficiency of serum M2BPGi in identifying liver fibrosis st...

    Authors: Hongqin Xu, Wenli Kong, Lei Liu, Xiumei Chi, Xiaomei Wang, Ruihong Wu, Xiuzhu Gao, Huan Wang, Limei Qu, Yue Qi, Yu Pan and Junqi Niu

    Citation: BMC Gastroenterology 2017 17:62

    Content type: Research article

    Published on:

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